Review
Biochemistry & Molecular Biology
Tomoko Tadokoro, Asahiro Morishita, Tsutomu Masaki
Summary: Significant progress has been made in the treatment and control of hepatitis B and C viral infections. However, fundamental treatments for liver fibrosis-related diseases are still under development. Researchers are currently focusing on the role of miRNAs and exosomes in the pathogenesis of liver fibrosis, as well as their potential application as biomarkers or therapeutic agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Eman K. Aldous, Salman M. Toor, Aijaz Parray, Yasser Al-Sarraj, Ilhame Diboun, Essam M. Abdelalim, Abdelilah Arredouani, Omar El-Agnaf, Paul J. Thornalley, Naveed Akhtar, Sajitha Pananchikkal, Ashfaq Shuaib, Nehad M. Alajez, Omar M. E. Albagha
Summary: This study conducted comprehensive circulating miRNA profiling in patients with ischemic stroke and identified a panel of miRNAs with potential diagnostic and prognostic significance. A multivariate classifier based on this miRNA panel showed high sensitivity and specificity in differentiating between stroke patients and healthy controls, and it outperformed other available biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Sotiris Mastoridis, Vishal Patel, Sofia Christakoudi, Juan Jose Lozano, Siamak Salehi, Ada Kurt, Cathleen Grossart, Elisavet Kodela, Marc Martinez-Llordella, Alberto Sanchez-Fueyo
Summary: This study investigates the impact of liver injury and dysfunction on the circulating EV-miRNA profile. The degree of hepatic dysfunction is found to be the main determinant of changes in circulating sEV-miRNA profile. ACLF patients have a distinct miRNA profile that is associated with diagnosis and prognosis, and downstream gene targets were established.
HEPATOLOGY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jen-Tai Lin, Kuo-Wang Tsai
Summary: The study showed that certain miRNAs in urine could potentially serve as noninvasive biomarkers for diagnosing bladder cancer, with implications for early detection and patient survival. Further validation in larger cohorts is necessary to confirm the clinical utility of urinary miRNAs in bladder cancer diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Chunxian Cai, Anhua Xiao, Xiaoqing Luo, Enze Zheng, Yiyu Li, Yu Lei, Shan Zhong, Yaxi Chen, Ping Yang, Zhurong Tang, Zhi Zhou
Summary: Circulating soluble CD36 could be used as a novel noninvasive biomarker for predicting liver failure and prognosis in chronic HBV-infected patients.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Health Care Sciences & Services
Jiang Li, Anshul Tiwari, Hooman Mirzakhani, Alberta L. Wang, Alvin T. Kho, Michael J. McGeachie, Augusto A. Litonjua, Scott T. Weiss, Kelan G. Tantisira
Summary: MicroRNAs show potential as biomarkers for incident asthma, particularly when considering vitamin D levels. Meta-analysis across cohorts and logistic regression models were used to predict asthma occurrence based on miRNA expression levels and vitamin D interactions. A specific miRNA, hsa-miR-574-5p, showed good prognostic ability for incident asthma.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Lisa Padroni, Laura De Marco, Lucia Dansero, Valentina Fiano, Lorenzo Milani, Paolo Vasapolli, Luca Manfredi, Saverio Caini, Claudia Agnoli, Fulvio Ricceri, Carlotta Sacerdote
Summary: Breast cancer is a multifactorial disease influenced by genetic predisposition and environmental exposures. MicroRNAs, a group of small non-coding RNA molecules, may act as tumor suppressor genes or oncogenes and play a role in cancer risk. A systematic review and meta-analysis were conducted to identify circulating microRNAs associated with breast cancer diagnosis, with emphasis on methodological issues. The analysis included 75 studies, and meta-analysis was performed for microRNAs analyzed in at least three independent studies. The study found that MIR21, MIR155, and MIR10b were differentially expressed in breast cancer patients compared to healthy controls, but there was little consistency among the included studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Kholoud Baraka, Rania R. Abozahra, Eman Badr, Sarah M. Abdelhamid
Summary: This study aimed to investigate the potential relevance of some cytokines, miR-122 and miR-221 for the diagnosis of liver disease progression associated to HCV infection.
Article
Cardiac & Cardiovascular Systems
Salman M. Toor, Eman K. Aldous, Aijaz Parray, Naveed Akhtar, Yasser Al-Sarraj, Essam M. Abdelalim, Abdelilah Arredouani, Omar El-Agnaf, Paul J. Thornalley, Sajitha V. Pananchikkal, Ghulam Jeelani Pir, Raheem Ayadathil Thazhhe Kuni, Ashfaq Shuaib, Nehad M. Alajez, Omar M. E. Albagha
Summary: This study conducted comprehensive circulating miRNA profiling in ischemic stroke patients with and without type 2 diabetes mellitus, identifying 5 differentially regulated miRNAs between the two groups. The findings offer insights into potential pathways associated with stroke and diabetes comorbidity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cell Biology
Amila Iriskic Atic, Maja Thiele, Alexander Munk, Louise Torp Dalgaard
Summary: MicroRNAs (miRNAs) secreted by the liver have the potential to be important biomarkers for nonalcoholic liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Several miRNAs, including miR-122, miR-21, miR-34a, miR-192, miR-193, and the miR-17-92 miRNA-cluster, are consistently associated with NAFLD/NASH. These miRNAs show potential as diagnostic markers for NAFLD/NASH, although more research is needed to understand their specificity and regulation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Martin Brundin, Dick Wagsater, Urban Alehagen, Carl-Johan Carlhall
Summary: This study compared serum levels of specific miRs and cardiac magnetic resonance imaging parameters between patients with DCM and IHD, finding that miR-29-5p levels were increased in DCM and miR-320a levels were elevated in DCM compared to healthy controls.
Article
Biochemistry & Molecular Biology
Andrey Zhelankin, Liliia N. Iulmetova, Elena Sharova
Summary: The type of anticoagulant in blood collection tubes has a significant impact on the circulating plasma miRNA profiles. This study found that EDTA samples have distinct miRNA profiles compared to samples obtained using other anticoagulants, primarily due to an increased level of hemolysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Microbiology
Gokulakannan Venkatesan, Wan Suriana Wan Ab Rahman, Wan Nazatul Shima Shahidan, Salfarina Iberahim, Alwi bin Muhd Besari Hashim
Summary: Early disease diagnosis is crucial for effective management and treatment. Diagnostic methods should be accurate, consistent, low-cost, and non-invasive. Exosomal microRNA (miRNA) has shown potential as biomarkers for various diseases, but its application in vector-borne diseases is limited. This review focuses on discussing miRNAs derived from exosomal plasma that may serve as disease biomarkers for early detection of vector-borne diseases.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Hematology
Ton Lisman, Virginia Hernandez-Gea, Maria Magnusson, Lara Roberts, Simon Stanworth, Jecko Thachil, Armando Tripodi
Summary: Patients with liver diseases experience complex alterations in their hemostatic system, leading to a fragile balance between bleeding and thrombotic events. Although traditionally classified as acquired bleeding disorders, laboratory observations have shown that they are also prone to developing both bleeding and thrombotic events.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Cardiac & Cardiovascular Systems
Xiao-long Mi, Yu-ping Gao, Da-jie Hao, Zhi-jun Zhang, Zheng Xu, Tong Li, Xue-wen Li
Summary: This study aimed to determine the diagnostic accuracy of circulating miR-21-5p and miR-126 as biomarkers for patients with AMI and IR-ATO. The results showed that miR-21-5p and miR-126 exhibited considerable diagnostic accuracy for IR-ATO AMI, suggesting their potential as promising prognostic biomarkers for AMI and IR-ATO patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Surgery
Humberto Fenner Lyra Junior, Leonardo de Lucca Schiavon, Igor Kunze Rodrigues, Daniella Serafin Couto Vieira, Roberta de Paula Martins, Bruna Lenfers Turnes, Alexandra Susana Latini, Armando Jose D'Aceimpora
JOURNAL OF SURGICAL RESEARCH
(2019)
Article
Materials Science, Biomaterials
Milene Dalmina, Frederico Pittella, Jelver Alexander Sierra, Gabriela Regina Rosa Souza, Adny Henrique Silva, Andre Avelino Pasa, Tania Beatriz Creczynski-Pasa
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Laura Sartori Assuncao, Iara Fabricia Kretzer, Jelver Alexander Sierra Restrepo, Leonidas Joao de Mello Junior, Adny Henrique Silva, Eliana de Medeiros Oliveira, Misael Ferreira, Marcus Mandolesi Sa, Tania Beatriz Creczynski-Pasa
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2019)
Article
Multidisciplinary Sciences
Julia Cisilotto, Alex Evangelista do Amaral, Daiane Rosolen, Michele Patricia Rode, Adny Henrique Silva, Evelyn Winter, Telma Erotides da Silva, Josiane Fischer, Camila Matiollo, Elayne Cristina de Morais Rateke, Janaina Luz Narciso-Schiavon, Leonardo de Lucca Schiavon, Tania Beatriz Creczynski-Pasa
SCIENTIFIC REPORTS
(2020)
Article
Gastroenterology & Hepatology
Camila Matiollo, Elayne Cristina de Moraes Rateke, Karina Ghisoni de Oliveira, Bruna Lenfers Turnes, Telma Erotides da Silva, Claudia Maccali, Alexandra Susana Latini, Janaina Luz Narciso-Schiavon, L. L. Schiavon
DIGESTIVE AND LIVER DISEASE
(2020)
Article
Cell Biology
Geison Vicente, Yeo Jim Kinoshita Moon, Daniela Weingartner Rosa, Luise Azevedo Lima, Najla Adel Saleh, Julia Salvan da Rosa, Tania Beatriz Creczynski-Pasa, Maique Weber Biavatti, Eduardo Monguilhott Dalmarco, Tania Silvia Frode
MEDIATORS OF INFLAMMATION
(2020)
Article
Integrative & Complementary Medicine
Stephane Zingue, Abel Joel Gbaweng Yaya, Julia Cisilotto, Larissa Vanelle Kenmogne, Emmanuel Talla, Anupam Bishayee, Dieudonne Njamen, Tania Beatriz Creczynski-Pasa, Derek Tantoh Ndinteh
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Article
Chemistry, Organic
Laieli S. Munaretto, Misael Ferreira, Daniela P. Gouvea, Adailton J. Bortoluzzi, Laura S. Assuncao, Juliana Inaba, Tania B. Creczynski-Pasa, Marcus M. Sa
Article
Biotechnology & Applied Microbiology
Najla Adel Saleh, Michele Patricia Rode, Jelver Alexander Sierra, Adny Henrique Silva, Juliano Andreoli Miyake, Fabiola Branco Filippin-Monteiro, Tania Beatriz Creczynski-Pasa
Summary: The study used a three-dimensional co-culture model to mimic and study the tumor microenvironment of malignant melanoma. It was found that M2 macrophages induced an anti-inflammatory microenvironment in heterospheroids, fibroblast cells supported the formation of the extracellular matrix, and a higher percentage of melanoma CD271 was observed in this model. Additionally, melanoma spheroids responded differently to dacarbazine compared to 2D melanoma culture.
Article
Environmental Sciences
Stephane Zingue, Julia Cisilotto, Robinson Charly Mbe Fogang, Edwige Nana Tchoupang, Derek Tantoh Ndinteh, Nestor-Fernand Tchuenguem Fohouo, Dieudonne Njamen, Tania Beatriz Creczynski-Pasa
Summary: Ethanol-extracted Cameroonian propolis demonstrated anti-mammary tumor effects by inducing apoptosis through the mitochondrial pathway, inhibiting MMP-2 activity, and down-regulating certain key proteins. It also prevented tumor migration and invasion, highlighting its potential as a natural treatment for breast cancer.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Okunola A. Alabi, Adny H. Silva, Michele P. Rode, Carine dal Pizzol, Angela Machado de Campos, Fabiola B. Filippin-Monteiro, Adekunle A. Bakare, Tania B. Creczynski-Pasa
Summary: Increased production and use of different types of nanoparticles have led to increased environmental release and potential detrimental effects. Co-exposure to solid lipid nanoparticles (SLNs) and superparamagnetic iron oxide nanoparticles (SPIONs) showed synergistic, antagonistic, and additive effects on cytotoxicity, with apoptosis triggered by ROS and disturbances in Delta psi M as probable mechanisms. Possible cytotoxic interaction between the two types of nanoparticles was observed.
TOXICOLOGY AND INDUSTRIAL HEALTH
(2021)
Article
Parasitology
Maria Luiza Carneiro Buchele, Fabiola Branco Filippin-Monteiro, Barbara de Lima, Carolina de Jesus Camargo, Jelver Alexander Sierra Restrepo, Liliete Canes Souza, Tania Beatriz Creczynski-Pasa, Karin Silva Caumo
Summary: The study demonstrated that preheating Amphotericin B and combining it with a thermoreversible in situ gelling ophthalmic system showed promising results in the treatment of Acanthamoeba keratitis, with high efficacy and low cytotoxicity.
Article
Chemistry, Multidisciplinary
Flavio Augusto Rocha Barbosa, Michele Patricia Rode, Romulo Faria Santos Canto, Adny Henrique Silva, Tania Beatriz Creczynski-Pasa, Antonio Luiz Braga
Summary: In this study, design, synthesis, and evaluation of DHPMs-cinnamic acids hybrids as potential anti-cancer compounds were reported. The results indicated that the hybridization was effective, leading to compounds with much more cytotoxicity than DHPMs and cinnamic acids evaluated separately. Compound 3a was the most potent hybrid and further optimization led to the discovery of three new analogues. Moreover, compound 8 was found to inhibit autophagic flux, which could be linked to its antiproliferative activity.
Article
Genetics & Heredity
Tania S. De Liz, Ana Paula Freund Winneschhofer, Amanda Ibagy, Iara Fabricia Kretzer, Michele P. Rode, Tania B. Creczynski-Pasa
