Article
Neurosciences
Alberto Failla, Lauryna Filatovaite, Xiaowan Wang, Sampsa Vanhatalo, Jeroen Dudink, Linda S. de Vries, Manon Benders, Nathan Stevenson, Maria Luisa Tataranno
Summary: The study aimed to investigate the association between bursting interhemispheric synchrony (bIHS) and microstructural development of the corpus callosum (CC) in extremely preterm infants during the first week of life. Results indicated that early cortical synchrony may be affected by morphine, but is not associated with the microstructural development of the CC.
HUMAN BRAIN MAPPING
(2022)
Article
Multidisciplinary Sciences
Joo Young Lee, Yong-Ho Choi, Jong Ho Cha, Ji Young Lee, Young-Jun Lee, Bo-Hyun Kim, Il-Kewon Kim, Jong-Min Lee, Hyun Ju Lee
Summary: The study found altered lateralization of fronto-limbic neural circuitry in preterm infants, indicating potential involvement in the early development of social-emotional disorders.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Risto A. Kauppinen, Jeromy Thothard, Henri P. P. Leskinen, Pramod K. Pisharady, Eppu Manninen, Mikko Kettunen, Christophe Lenglet, Olli H. J. Grohn, Michael Garwood, Mikko J. Nissi
Summary: Recent studies have shown that the T-1 relaxation time in white matter is affected by fiber orientation. This study investigated the relationship between axon fiber orientation in the corpus callosum and T-1 relaxation time in vivo and ex vivo. The results showed that changes in axon orientation in the corpus callosum were associated with corresponding changes in T-1 relaxation time. The study also demonstrated that the same results could be obtained from ex vivo experiments as in vivo experiments.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Pediatrics
Mary Anne J. Ryan, Sean R. Mathieson, Vicki Livingstone, Marc Paul O'Sullivan, Eugene M. Dempsey, Geraldine B. Boylan
Summary: This prospective observational study examines the nocturnal sleep architecture of healthy moderate to late preterm infants at 36 weeks post menstrual age. The study finds that sleep state architecture is dependent on birth GA, with infants born at lower GA having less active sleep and more quiet sleep. These findings may have implications for the neurodevelopment of the infants.
PEDIATRIC RESEARCH
(2023)
Review
Nutrition & Dietetics
Luise Marino, Simone Paulson, James J. Ashton, Charlotte Weeks, Aneurin Young, John Pappachan, Jonathan Swann, Mark J. Johnson, Robert Mark Beattie
Summary: This scoping review explored the available evidence on urinary markers of metabolic maturation and their relationship with growth in infants born preterm. The findings indicate significant gaps in our understanding of factors associated with metabolic instability in preterm infants, the normal maturation of preterm infants, and how the development of reference phenome age z scores for specific metabolites of interest could improve nutritional and growth outcomes.
Article
Pediatrics
Chih-Chia Chen, Chi-Hsiang Chu, Yung-Chieh Lin, Shan-Tair Wang, Chao-Ching Huang
Summary: The study aimed to examine the risks and mortality outcomes of oliguric and non-oliguric acute kidney injury (AKI) in very preterm infants. It was found that oliguric AKI had significantly higher mortality risks than non-oliguric AKI and no AKI.
PEDIATRIC RESEARCH
(2023)
Article
Immunology
Jose M. Lemme-Dumit, Yang Song, Hnin Wai Lwin, Claudia Hernandez-Chavez, Sripriya Sundararajan, Rose M. Viscardi, Jacques Ravel, Marcela F. Pasetti, Bing Ma
Summary: This study investigated the fecal cytokine profile and gut microbiota in preterm neonates, and found that both immunological and microbiological factors play a critical role in the early development of intestinal barrier.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Isadora Beghetti, Monica Barone, Patrizia Brigidi, Alessandra Sansavini, Luigi Corvaglia, Arianna Aceti, Silvia Turroni
Summary: Premature infants are at high risk of both gut microbiota dysbiosis and neurodevelopmental impairment. The developmental windows of gut microbiota and the nervous system in early life have a significant overlap. Animal models and recent research have shown a potential connection between gut microbiota features and neurodevelopmental disorders in humans. Future studies combining larger human cohorts with animal models may provide more evidence and help identify predictive biomarkers and potential therapeutic targets for healthy neurodevelopment in preterm infants.
FRONTIERS IN NUTRITION
(2023)
Review
Pediatrics
Antoine Giraud, Carol M. Stephens, Geraldine B. Boylan, Brian H. Walsh
Summary: This study aimed to summarise the association between perinatal inflammation exposure and electroencephalography (EEG) features in preterm infants. The results showed that perinatal inflammation exposure was associated with a decrease in amplitude and a reduced incidence of sleep-wake cycling patterns.
PEDIATRIC RESEARCH
(2022)
Article
Microbiology
Bing Ma, Sripriya Sundararajan, Gita Nadimpalli, Michael France, Elias McComb, Lindsay Rutt, Jose M. Lemme-Dumit, Elise Janofsky, Lisa S. Roskes, Pawel Gajer, Li Fu, Hongqiu Yang, Mike Humphrys, Luke J. Tallon, Lisa Sadzewicz, Marcela F. Pasetti, Jacques Ravel, Rose M. Viscardi
Summary: Despite advancements in neonatal intensive care, necrotizing enterocolitis (NEC) remains a significant cause of morbidity and mortality. Leaky gut, characterized by immature intestinal barrier and increased permeability, is the main cause of susceptibility to NEC. Early detection and intervention to prevent leaky gut in preterm neonates is crucial for reducing the risk of life-threatening complications. This study investigated the role of breastmilk feeding and intestinal microbiota in the maturation of the intestinal barrier. The results provide insights into potential preventive and therapeutic strategies for NEC and other adverse health conditions in preterm infants.
Article
Pharmacology & Pharmacy
Yunjiao Wu, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons, Elke H. J. Krekels, Catherijne A. J. Knibbe, Swantje Voller
Summary: Describing the maturation of glomerular filtration rate (GFR) in preterm and term neonates and infants is crucial for predicting drug clearance. This study evaluated GFR maturation models and optimized the best model using individual inulin clearance data. The findings suggest that GFR at birth is determined by birthweight, and the rate of maturation depends on postnatal age and gestational age, with higher gestational age showing faster maturation.
Article
Pediatrics
Ira Winkler, Maria Sappler, Elke Ruth Gizewski, Ursula Kiechl-Kohlendorfer, Vera Neubauer, Elke Griesmaier
Summary: This study reveals a correlation between functional and microstructural brain maturation in preterm infants, suggesting that early monitoring of functional brain development may predict microstructural brain development, particularly in the corpus callosum, and its relation to neurodevelopmental outcomes.
Article
Nutrition & Dietetics
Elise Mank, Dewi van Harskamp, Letty van Toledo, Johannes B. van Goudoever, Henk Schierbeek
Summary: The study aimed to develop a protocol for assessing intestinal permeability and lactase activity in human-milk-fed preterm infants through a sugar absorption test. A new GC-MS method was developed to analyze lactulose, lactose, and mannitol in urine and milk samples collected during the sugar absorption test. The protocol and GC-MS method provide valuable tools for monitoring the effects of nutritional interventions in preterm infants.
CLINICAL NUTRITION
(2021)
Article
Clinical Neurology
Rhodri O. Lloyd, John M. O'Toole, Vicki Livingstone, Peter M. Filan, Geraldine B. Boylan
Summary: The study found that the EEG similarities in preterm twins are subtle but clearly evident through mathematical analysis, with monochorionic-diamniotic twins showing stronger EEG concordance, confirming a strong genetic influence on preterm EEG activity at this early development stage.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Kiran Kumar Balegar, Gary K. K. Low, Ralph K. H. Nanan
Summary: This study aimed to investigate the correlation between low haemoglobin and symptoms of anaemia with cerebral and splanchnic fractional tissue oxygen extraction (FTOE). The results showed no significant correlation between haemoglobin and cerebral or splanchnic FTOE. These findings suggest that pre-transfusion haemoglobin and symptoms of anaemia may not accurately reflect oxygen delivery-consumption imbalances.
Article
Pediatrics
Alexandra Adam-Darque, Lorena Freitas, Frederic Grouiller, Julien Sauser, Francois Lazeyras, Dimitri Van de Ville, Philippe Pollien, Clara L. Garcia-Rodenas, Gabriela Bergonzelli, Petra S. Hueppi, Russia Ha-Vinh Leuchter
Summary: The study investigates the neural mechanisms of infant colic by examining newborns' brain responses to sensory stimuli, finding that infants who develop colic exhibit distinct brain activation patterns compared to non-colicky infants. This early sensitivity to stimuli explains a significant portion of subsequent crying behavior. The findings have implications for understanding and potentially advising families with colicky infants.
PEDIATRIC RESEARCH
(2021)
Article
Pediatrics
Kristina Wendel, Helle Cecilie Viekilde Pfeiffer, Drude Merete Fugelseth, Eirik Nestaas, Magnus Domelloef, Bjorn Steen Skalhegg, Katja Benedikte Presto Elgstoen, Helge Rootwelt, Rolf Dagfinn Pettersen, Are Hugo Pripp, Tom Stiris, Sissel J. Moltu
Summary: This study aims to investigate the effects of early supply of ARA and DHA on brain maturation and neonatal outcomes in infants born before 29 weeks of gestation. Infants will receive a fatty acid supplement from the second day of life to 36 weeks' postmenstrual age, with the primary outcome being brain maturation assessed by MRI.
Article
Neurosciences
Joana Sa de Almeida, Djalel-Eddine Meskaldji, Serafeim Loukas, Lara Lordier, Laura Gui, Francois Lazeyras, Petra S. Huppi
Summary: Prematurity disrupts brain development and network organization, leading to increased segregation and decreased integration capacity in preterm infants. Compared to full-term infants, preterm infants demonstrate delayed transition in brain network architecture and decreased connectivity strength in specific regions, potentially underlying behavioral and social cognition difficulties.
Article
Neurosciences
O. De Wel, S. Van Huffel, M. Lavanga, K. Jansen, A. Dereymaeker, J. Dudink, L. Gui, P. S. Huppi, L. S. de Vries, G. Naulaers, M. J. N. L. Benders, M. L. Tataranno
Summary: The study explored the relationship between early brain function and brain morphology, finding that continuity and complexity of EEG gradually increase with postnatal age and are associated with cerebellar size, which undergoes significant development in preterm infants. Brain activity is important for later structural brain development.
Article
Clinical Neurology
N. Ceren Askin Incebacak, Yao Sui, Laura Gui Levy, Laura Merlini, Joana Sa de Almeida, Sebastien Courvoisier, Tess E. Wallace, Antoine Klauser, Onur Afacan, Simon K. Warfield, Petra Huppi, Francois Lazeyras
Summary: The study compares the image quality of 2D high-resolution image acquisition with 3D reconstruction from low-resolution images in neonatal subjects, finding that they have comparable quality for clinical and morphometric assessments, with no loss of anatomical details and similar edge definition. Quantitative assessments show the reconstructed images accurately detect fine anatomical structures and allow for comparable morphometric measurements.
JOURNAL OF NEUROIMAGING
(2022)
Review
Pediatrics
Elodie Zana-Taieb, Jacques Sizun, Pierre Kuhn, Audrey Reynaud
Summary: This article investigates the impact of neonatal unit design on the neurodevelopment of hospitalized neonates and the well-being of parents and healthcare staff. It provides recommendations regarding the minimum area required for a hospital room for a single neonate and their family.
Article
Obstetrics & Gynecology
Vanessa Siffredi, Maria Chiara Liverani, Mariana Magnus Smith, Djalel Eddine Meskaldji, Francoise Stuckelberger-Grobety, Lorena G. A. Freitas, Jiske De Albuquerque, Emilie Savigny, Fanny Gimbert, Petra Susan Hueppi, Arnaud Merglen, Cristina Borradori Tolsa, Russia Ha-Vinh Leuchter
Summary: This study aimed to explore the feasibility and acceptability of an 8-week mindfulness-based intervention program to enhance executive and socio-emotional competences in very preterm young adolescents through a randomized controlled trial and pre-post intervention designs. Results indicated that the MBI program was feasible and well-received by participants, showing high attendance rates and positive feedback evaluation.
EARLY HUMAN DEVELOPMENT
(2021)
Article
Neurosciences
Ingrid Dudink, Petra S. Huppi, Stephane V. Sizonenko, Margie Castillo-Melendez, Amy E. Sutherland, Beth J. Allison, Suzanne L. Miller
Summary: Fetal growth restriction (FGR) is mainly caused by suboptimal placental function, leading to limited nutrient and oxygen supply to the developing fetus, particularly affecting brain development. FGR results in altered brain morphology, disrupted connectivity, and region-specific brain network disturbances, which are associated with cognitive and behavioral impairments.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Serafeim Loukas, Lara Lordier, Djalel-Eddine Meskaldji, Manuela Filippa, Joana Sa de Almeida, Dimitri Van de Ville, Petra S. Hueppi
Summary: Research indicates that even during the newborn period, familiar music and unfamiliar music are processed differently by the brain. After music listening, functional connectivity between brain regions in all newborns is modulated. Premature infants exposed to music experience enhanced functional connectivity between brain regions after listening to music.
HUMAN BRAIN MAPPING
(2022)
Article
Pediatrics
Mark Adams, Sven M. Schulzke, Giancarlo Natalucci, Juliane Schneider, Thomas Riedel, Cristina Borradori Tolsa, Riccardo Pfister, Dirk Bassler
Summary: The study found differences in patent ductus arteriosus treatment between Swiss perinatal centers, with infants who underwent surgical ligation having higher odds of major morbidities and neurodevelopmental impairment compared to those who received pharmacologic treatment. In centers with higher rates of surgical ligation, infants had increased odds of major morbidities.
JOURNAL OF PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Vanessa Siffredi, Maria Chiara Liverani, Petra Susan Huppi, Lorena G. A. Freitas, Jiske De Albuquerque, Fanny Gimbert, Arnaud Merglen, Djalel Eddine Meskaldji, Cristina Borradori Tolsa, Russia Ha-Vinh Leuchter
Summary: The study aimed to evaluate the effectiveness of mindfulness-based intervention (MBI) in improving executive, behavioral, and socio-emotional abilities in very preterm (VPT) children and adolescents. The results showed a beneficial effect of MBI on these competencies, especially in enhancing executive abilities. The findings suggest that MBI could be a valuable tool for reducing the detrimental consequences of prematurity in young adolescents.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Multidisciplinary
Filippa Manuela, Francisca Barcos-Munoz, Maria Grazia Monaci, Lara Lordier, Marice Pereira Camejo, Joana Sa De Almeida, Didier Grandjean, Petra S. Hueppi, Cristina Borradori-Tolsa
Summary: The study did not find significant differences in postnatal depression, stress, and attachment between mothers during the COVID-19 pandemic and before the pandemic. However, there was a trend of increased depression symptoms in mothers during the pandemic, which correlated significantly with attachment and stress scores.
FRONTIERS IN PSYCHOLOGY
(2021)
Editorial Material
Pediatrics
Petra S. Huppi, Manuela Filippa
PEDIATRIC RESEARCH
(2023)
Article
Neuroimaging
Veronica Ravano, Michaela Andelova, Mario Joao Fartaria, Mazen Fouad A-Wali Mahdi, Benedicte Marechal, Reto Meuli, Tomas Uher, Jan Krasensky, Manuela Vaneckova, Dana Horakova, Tobias Kober, Jonas Richiardi
Summary: The translational potential of MR-based connectivity modelling is limited by the need for advanced diffusion imaging not commonly used in clinical protocols. Tractography algorithms used for brain connectivity analyses are sensitive to white matter lesions and acquisition parameters, impacting interpretation accuracy and comparability in clinical applications like multiple sclerosis. An atlas-based approach was proposed to study structural disconnectivity and lesions without individual diffusion imaging, showing promise in approximating individual disconnectomes and stratifying MS patients based on global graph properties and lesion volume.
NEUROIMAGE-CLINICAL
(2021)
Article
Neuroimaging
Lorena G. A. Freitas, Maria Chiara Liverani, Vanessa Siffredi, Armin Schnider, Cristina Borradori Tolsa, Russia Ha-Vinh Leuchter, Dimitri Van de Ville, Petra S. Huppi
Summary: Preterm birth can affect brain development and functioning, leading to differences in tasks like reality filtering. The involvement of the orbitofrontal cortex in cognitive tasks may vary between preterm and full-term individuals.
NEUROIMAGE-CLINICAL
(2021)