Article
Marine & Freshwater Biology
Jie Li, Yao Li, Xia Liang, Zhiru Yang, Ye Peng, Yiran Zhang, Xianhui Ning, Kai Zhang, Jie Ji, Tao Wang, Guosong Zhang, Shaowu Yin
Summary: This study investigated tissue damage, HIF activation, and blood flow changes in different organs of Pelteobagrus vachelli under hypoxia. The results showed tissue specificity in the fish's response to hypoxic stress. Cerebral blood flow increased with less damage, suggesting a potential blood redistribution mechanism. Severe hypoxia led to increased brain tissue damage, while higher dissolved oxygen levels reduced brain damage. This study provides important data for understanding hypoxic stress in fish.
AQUATIC TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lu Xu, Hua Song, Qi Qiu, Ting Jiang, Pingyun Ge, Zaiji Su, Wenhui Ma, Ran Zhang, Caihua Huang, Shanhua Li, Donghai Lin, Jiaxing Zhang
Summary: The study investigated the hypoxic sensitivity of organs in mice exposed to different oxygen concentrations and found that the liver exhibited the highest hypoxic sensitivity, followed by the kidney and brain. Different metabolic profiles were observed in the liver, kidney, and brain under hypoxia, suggesting metabolic disorders underlying physiological function changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Arjun Sapkota, Sebok K. Halder, Richard Milner
Summary: Exposure to chronic mild hypoxia (CMH; 8-10% O2) promotes a strong vascular remodeling response in the brain, increasing vessel density by 50%. However, other organs do not show similar responses. While CMH strongly promotes endothelial proliferation in the brain, it reduces proliferation in the heart and liver. CMH also induces expression of the MECA-32 endothelial activation marker in the brain but has no effect on its expression in peripheral organs.
MICROVASCULAR RESEARCH
(2023)
Article
Oncology
Anna S. Berghoff, Yunxiang Liao, Matthia A. Karreman, Ayseguel Ilhan-Mutlu, Katharina Gunkel, Martin R. Sprick, Christian Eisen, Tobias Kessler, Matthias Osswald, Susanne Wunsche, Manuel Feinauer, Brunhilde Gril, Frederic Marme, Laura L. Michel, Zuszanna Bago-Horvath, Felix Sahm, Natalia Becker, Michael O. Breckwoldt, Gergely Solecki, Miriam Gommel, Lulu Huang, Petra Rubmann, Carina M. Thome, Miriam Ratliff, Andreas Trumpp, Patricia S. Steeg, Matthias Preusser, Wolfgang Wick, Frank Winkler
Summary: The study found that brain metastases are mainly derived from a small subpopulation of slow-cycling breast cancer cells with cellular stemness markers. Upregulation of NDRG1 was associated with the slow-cycling BMIC subpopulation, and downregulation of NDRG1 expression completely suppressed brain metastasis.
MOLECULAR CANCER RESEARCH
(2021)
Review
Cell Biology
Wu Zhou, Lihong Zhao, Zelu Mao, Zhihua Wang, Zhixiong Zhang, Meihua Li
Summary: Substances released by the brain can affect other organs, and substances produced by organs like bone marrow or adipose tissue can impact the brain. Research on the function of molecular mediators carried by extracellular vesicles is still in its early stages.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Zhengda Sun, Jiqing Song, Qijun Song, Lin Li, Xinxin Tian, Lijun Wang
Summary: The neuroprotection of recombinant human erythropoietin (rhEPO) against hypoxic/ischemic (HI) insult in three-day-old rats was investigated. The intervention of rhEPO was found to alleviate brain pathological damage and cognitive impairment caused by HI injury in rats. This neuroprotective activity may involve inhibiting inflammation and apoptosis through activation of the PI3K/Akt signaling pathway.
Article
Multidisciplinary Sciences
Yinmon Htun, Shinji Nakamura, Yasuhiro Nakao, Tsutomu Mitsuie, Kenichi Ohta, Makoto Arioka, Takayuki Yokota, Eri Inoue, Kota Inoue, Toi Tsuchiya, Kosuke Koyano, Yukihiko Konishi, Takanori Miki, Masaki Ueno, Takashi Kusaka
Summary: Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in newborns worldwide. This study investigated the efficacy of hydrogen gas (H-2) in reducing cerebral vascular leakage using albumin immunohistochemistry in piglets subjected to a hypoxic-ischemic insult. Although histological images suggested signs of improvement, H-2 therapy did not significantly reduce albumin leakage in this study. Further investigations are needed to determine the effectiveness of H-2 gas for vascular leakage in neonatal HIE.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Liam McFarlane, Pierce Nelson, George J. Dugbartey, Alp Sener
Summary: Ischemia-reperfusion injury (IRI) is a major concern in solid organ transplantation, and current preservation strategies are not effective. However, pre-treatment with hydrogen sulfide (H2S) has shown promise in reducing IRI and could be applied to other IRI-related conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pediatrics
A. G. Sandoval Karamian, S. Mercimek-Andrews, K. Mohammad, E. J. Molloy, T. Chang, Vann Chau, D. M. Murray, Courtney J. Wusthoff
Summary: Neonatal encephalopathy (NE) is a clinical syndrome of abnormal brain function in newborns that may result from various etiologies. It is important to differentiate HIE from other causes of neonatal encephalopathy using data from history, physical and neurological examinations. Identifying the underlying cause of encephalopathy is crucial for treatment, and this review discusses conditions that cause NE and may be confused with HIE, along with their clinical features, pathophysiology, investigations, and treatments.
SEMINARS IN FETAL & NEONATAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Shahrzad Azizi, Reza Kheirandish, Shahriar Dabiri, Mina Lakzaee
Summary: This study investigated the histopathological effects of methamphetamine on the brains, hearts, livers, testes, and kidneys of rats using animal models. The results showed that methamphetamine induced degenerative changes and necrosis in these organs. Immunohistochemical analyses revealed an increase in reactive microglia and astrocytes in the brain. The findings suggest that methamphetamine has toxic effects on vital organs and can lead to neurotoxicity, cardiomyopathy, renal damage, and male infertility.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jee In Choi, Joo-Wan Choi, Kyu-Ho Shim, Jin Seung Choung, Hyun-Jin Kim, Hye Ryeong Sim, Mi Ri Suh, Joo Eun Jung, MinYoung Kim
Summary: The study demonstrated that the synergistic therapeutic effect induced by co-administering rhEPO and hUCB could enhance anti-inflammatory and anti-apoptotic responses, leading to improved outcomes in children with cerebral palsy. This combination therapy showed increased neuroprotection through phosphorylation of Akt.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Jiawei Huang, Kin U. Pong, Fuyuan Yang, Zeyuan Ji, Jiacheng Lin, Zhihui Weng, Lai Ling Tsang, Tobias D. Merson, Ye Chun Ruan, Chao Wan, Gang Li, Xiaohua Jiang
Summary: The use of hPSC-EMSCs shows potential as a treatment avenue for HIE, as they exhibit higher neuroprotective effects compared to hUC-MSCs. These stem cells promote endogenous neurogenesis, alleviate astrogliosis and microgliosis, and enhance brain functional recovery in rats with HIE.
Article
Neurosciences
Dawei Sun, Fuxin Lu, Ann Sheldon, Xiangning Jiang, Donna M. Ferriero
Summary: The study investigated the role of neuronal HIF-2 alpha in brain HI injury, showing that its loss exacerbated brain injury in acute and subacute phases, without impacting adult brain volume loss or coordinated movement and recognition memory function. Neuronal HIF-2 alpha promotes cell survival in the immature mouse brain, possibly through partially overlapping or distinct transcriptional targets with HIF-1 alpha.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Joo-Wan Choi, Su Jung Kang, Jee In Choi, KyuBum Kwack, MinYoung Kim
Summary: This study analyzed the mechanisms underlying the effect of combination treatment with EPO and UCB for hypoxic-ischemic encephalopathy (HIE). The results suggested that the synergistic neuroprotective effect of UCB and EPO combination treatment is mediated through the regulation of Nurr1 via the Wnt/β-catenin pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Lin Du, Yuying Jiang, Ying Sun
Summary: This study aimed to investigate the protective effect and mechanism of astrocyte-derived exosomes on neonatal rats with hypoxic-ischemic brain damage. The results showed that exosomes carried miR-17-5p to negatively regulate BNIP-2 expression, reducing brain damage and improving cell viability.
Article
Endocrinology & Metabolism
Joelcio Abbade, Miira Marjuska Klemetti, Abby Farrell, Leonardo Ermini, Taylor Gillmore, Julien Sallais, Andrea Tagliaferro, Martin Post, Isabella Caniggia
BMJ OPEN DIABETES RESEARCH & CARE
(2020)
Article
Endocrinology & Metabolism
Mervi Jokelainen, Beata Stach-Lempinen, Kristiina Rono, Arja Nenonen, Hannu Kautiainen, Kari Teramo, Miira M. Klemetti
DIABETES RESEARCH AND CLINICAL PRACTICE
(2020)
Editorial Material
Public, Environmental & Occupational Health
Elina Keikkala, Sanna Mustaniemi, Sanna Koivunen, Jenni Kinnunen, Matti Viljakainen, Tuija Mannisto, Hilkka Ijas, Anneli Pouta, Risto Kaaja, Johan G. Eriksson, Hannele Laivuori, Mika Gissler, Tiina-Liisa Erkinheimo, Ritva Keravuo, Merja Huttunen, Jenni Metsala, Beata Stach-Lempinen, Miira M. Klemetti, Minna Tikkanen, Eero Kajantie, Marja Vaarasmaki
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2020)
Article
Endocrinology & Metabolism
Cedric Korpijaakko, Niko Wasenius, Kari Teramo, Miira M. Klemetti, Hannu Kautiainen, Johan G. Eriksson, Merja K. Laine
Summary: The study found no difference in skin autofluorescence values between young adult offspring of women with type 1 diabetes and offspring born to mothers without diabetes. Surprisingly, young women showed higher levels of skin autofluorescence than men in both case and control groups.
Article
Endocrinology & Metabolism
Jelena Meinila, Miira M. Klemetti, Emilia Huvinen, Elina Engberg, Sture Andersson, Beata Stach-Lempinen, Saila Koivusalo
Summary: The study found that maternal macronutrient intake during pregnancy is associated with offspring adiposity at 5 years old, and gestational diabetes may modify the relationship between prenatal n-3 PUFA intake and offspring anthropometrics.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Endocrinology & Metabolism
Miira M. Klemetti, Kari Teramo, Hannu Kautiainen, Niko Wasenius, Johan G. Eriksson, Merja K. Laine
Summary: The study found that fetal hypoxia exposure in offspring of women with type 1 diabetes is associated with increased adiposity and elevated glucose levels in young adults. Participants with high amniotic fluid erythropoietin concentrations, indicating fetal hypoxia, had higher BMI and increased waist circumference and body fat percentage.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Emilia Huvinen, Jari Lahti, Miira M. Klemetti, Paula H. Bergman, Katri Raikkonen, Marju Orho-Melander, Hannele Laivuori, Saila B. Koivusalo
Summary: This study aimed to assess the interaction between genetic risk and lifestyle intervention on the occurrence of gestational diabetes mellitus (GDM) and postpartum diabetes. The results demonstrated an interaction between genetic risk and lifestyle intervention, suggesting that lifestyle intervention may need to be tailored according to genetic risk.
Article
Cardiac & Cardiovascular Systems
Cedric A. Korpijaakko, Mia D. Eriksson, Niko S. Wasenius, Miira M. Klemetti, Kari Teramo, Hannu Kautiainen, Johan G. Eriksson, Merja K. Laine
Summary: This study found that young adult offspring of mothers with type 1 diabetes show signs of increased arterial stiffness compared to offspring of mothers without diabetes. The findings suggest that exposure to an adverse intrauterine environment of type 1 diabetes mothers may affect the vascular health of offspring already in young adulthood.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Nutrition & Dietetics
Tiina Jaaskelainen, Miira M. Klemetti
Summary: Gestational diabetes (GDM) is a global health challenge with significant impacts on maternal and fetal cardiovascular health. Recent studies have shown significant phenotypic and genotypic heterogeneity in GDM, and adverse obstetric and perinatal outcomes differ between GDM subtypes. However, current GDM treatment protocols do not differentiate between these subtypes, highlighting the need for research on the genetic architecture of GDM and accurate phenotypic and genotypic definitions to personalize treatment and assess long-term prognosis.
Article
Obstetrics & Gynecology
Mervi Jokelainen, Beata Stach-Lempinen, Kari Teramo, Arja Nenonen, Hannu Kautiainen, Miira M. Klemetti
Summary: This study examined the associations and interactions between maternal early-pregnancy waist circumference (WC), height, and pre-pregnancy body mass index (BMI) with plasma glucose concentrations. The results showed that a large waist circumference and short height are associated with higher glucose levels, and a waist-to-height ratio above 0.5 is correlated with both fasting and post-load glucose concentrations.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Endocrinology & Metabolism
Erik Somersalo, Krista Kuuliala, Antti Kuuliala, Niko S. Wasenius, Miira M. Klemetti, Anne S. Kivimaki, Hannu Kautiainen, Johan G. Eriksson, Merja K. Laine
Summary: This study investigated the cytokine levels in young adult offspring of women with type 1 diabetes. The results showed that, although the levels of interferon-gamma were lower in the case group, cytokine levels were generally similar between the groups. Therefore, this study did not support the association between serum cytokine profile and cardiovascular disease risk in offspring of women with type 1 diabetes. Further research is needed to explore whether cytokines could serve as early biomarkers or be used to monitor CVD progression in this population.
Article
Biochemistry & Molecular Biology
Miira M. M. Klemetti, Sruthi Alahari, Martin Post, Isabella Caniggia
Summary: Disturbances in lipid metabolism are common in diabetes. This study compared the placental sphingolipid metabolism in type 1 and type 2 diabetic pregnancies and non-diabetic controls. The results showed that placental ceramide levels were lower in diabetic pregnancies, but higher in cases of preeclampsia and poor glycemic control. Sphingosine kinases (SPHK) and sphingoid-1-phosphates (S1P) were elevated in diabetic pregnancies, especially in cases of fetal macrosomia.
Article
Endocrinology & Metabolism
Cedric A. Korpijaakko, Johan G. Eriksson, Hannu Kautiainen, Miira M. Klemetti, Merja K. Laine
Summary: The study found that there was no difference in fatty liver index between young adult offspring of women with type 1 diabetes and offspring of women without diabetes. Additionally, there were no significant metabolic characteristic differences between the two groups. Further research on the impact of pregestational type 1 diabetes on offspring's risk of nonalcoholic fatty liver disease is needed.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Endocrinology & Metabolism
Sruthi Alahari, Jonathan Ausman, Tyler Porter, Chanho Park, Ante B. Pettersson, Miira M. Klemetti, Jianhong Zhang, Martin Post, Isabella Caniggia
Summary: Preeclampsia (PE) is a difficult-to-predict obstetric complication. This study investigates the potential of glycoprotein fibronectin (FN) and oxygen sensor JMJD6 in placental small extracellular vesicles (sEVs) as markers for early- and late-onset PE (E-PE and L-PE). The results suggest that FN and JMJD6 content in circulating placental sEVs can serve as early molecular signatures for the detection of different hypertensive disorders of pregnancy and their severity.
Meeting Abstract
Obstetrics & Gynecology
Miira M. Klemetti, Porter R. Tyler, Ante B. V. Pettersson, Martin Post, Isabella Caniggia
REPRODUCTIVE SCIENCES
(2020)