Article
Endocrinology & Metabolism
Wei-Liang Shih, Yi-Ching Tung, Luan-Yin Chang, Chi-Tai Fang, Wen-Yu Tsai
Summary: In Taiwan, the incidence of T1D increased in children aged 0-6 years but decreased in adolescents aged 13-19 years. Children aged 0-6 years with enterovirus infection had a significantly higher risk of T1D than noninfected subjects. The incidence of T1D in children aged 0-6 years was significantly correlated with the isolation rates of coxsackievirus A species.
Article
Immunology
Ya-Ning Huang, Hsin Chi, Nan -Chang Chiu, Ching-Ying Huang, Sung-Tse Li, Jin-Yuan Wang, Daniel Tsung-Ning Huang
Summary: The study found that vitamin D supplementation may have a small preventative effect against influenza infection in preschool children, but does not affect enterovirus infection. High-dose short-term vitamin D intervention might be a way to elevate children's serum vitamin D levels.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Genetics & Heredity
Watip Tangjittipokin, Pichakorn Umjai, Khwanhatai Khemaprasit, Parichat Charoentawornpanich, Chutima Chanprasert, Nipaporn Teerawattanapong, Tassanee Narkdontri, Jeerunda Santiprabhob
Summary: The study aimed to investigate genetic polymorphisms of vitamin D-related genes in children with T1D and their association with vitamin D and cytokine levels. Significant relationships were found between T1D and CYP2R1 polymorphism, as well as different VDR haplotypes between T1D patients and controls. Vitamin D gene-related variations were associated with vitamin D and circulating cytokine levels in children with T1D.
Article
Pediatrics
Xiaofang Chen, Jia Fu, Ying Qian, Xiufang Zhi, Linjie Pu, Chunyu Gu, Jianbo Shu, Ling Lv, Chunquan Cai
Summary: Low vitamin D levels may be associated with susceptibility to type 1 diabetes, and genetic polymorphisms such as SNP may modulate the risk of the disease. This study found that Chinese children carrying the C allele of the CYP2R1 gene's rs1993116 SNP had a higher risk of developing T1D, and there was a significant interaction between rs1993116 and rs12794714 of CYP2R1.
FRONTIERS IN PEDIATRICS
(2022)
Review
Endocrinology & Metabolism
Benjamin Udoka Nwosu
Summary: A recent randomized controlled trial showed that vitamin D can protect beta-cells during the honeymoon phase of type 1 diabetes and prolonging the partial clinical remission phase can improve glycemic control and reduce complications. It is recommended to estimate 25(OH)D concentration at the time of T1D diagnosis and supplement with vitamin D if necessary.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lars Krogvold, Ida Maria Mynarek, Erica Ponzi, Freja Barrett Mork, Trine Witzner Hessel, Trine Roald, Nina Lindblom, Jacob Westman, Peter Barker, Heikki Hyoety, Johnny Ludvigsson, Kristian F. Hanssen, Jesper Johannesen, Knut Dahl-Jorgensen
Summary: The results suggest that antiviral treatment may help preserve insulin production in children and adolescents with new-onset type 1 diabetes.
Review
Biochemistry & Molecular Biology
Josephine Yu, Preeti Sharma, Christian M. Girgis, Jenny E. Gunton
Summary: The prevalence of type 1 diabetes is rising steadily and vitamin D may contribute to this increase. This systematic review examined studies on vitamin D and type 1 diabetes, finding strong associations between low vitamin D levels and type 1 diabetes. Animal studies and human trials also suggest that vitamin D treatment or supplementation can be beneficial in reducing the risk of type 1 diabetes. Maintaining optimal circulating 25-hydroxyvitamin D levels may help to prevent or delay the development of type 1 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Shengxin Liu, Tyra Lagerberg, Jonas F. Ludvigsson, Mark J. Taylor, Zheng Chang, Brian M. D'Onofrio, Henrik Larsson, Paul Lichtenstein, Soffia Gudbjornsdottir, Ralf Kuja-Halkola, Agnieszka Butwicka
Summary: This cohort study examined the trends and patterns of psychotropic medication dispensation among children and adolescents with type 1 diabetes (T1D) in Sweden from 2006 to 2019. The study found an increasing trend in psychotropic medication dispensation, which was consistently higher than those without T1D. These findings highlight the importance of further investigations into the benefits and risks of psychotropic medications in this population, as well as the integration of pediatric diabetes care and mental health care.
Article
Nutrition & Dietetics
Silvia Savastio, Erica Pozzi, Valentina Mancioppi, Valentina Boggio Sola, Deborah Carrera, Valentina Antoniotti, Paola Antonia Corsetto, Gigliola Montorfano, Angela Maria Rizzo, Marco Bagnati, Ivana Rabbone, Flavia Prodam
Summary: This study aimed to explore the relationship between metabolic control, vitamin D status, and the AA/EPA ratio in children with type 1 diabetes (T1D). The study found that the AA/EPA ratio has an impact on insulin demand and vitamin D levels in T1D children. Additionally, the composition of the diet may affect the severity of T1D onset.
Review
Endocrinology & Metabolism
Kan Wang, Fei Ye, Yong Chen, Jianxin Xu, Yufang Zhao, Yeping Wang, Tian Lan
Summary: This meta-analysis suggests that there is an association between enterovirus infection and type 1 diabetes (T1D). The association was observed in various populations and sample types, with blood and tissue samples showing a correlation while stool samples did not.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Shengxin Liu, Jonas F. Ludvigsson, Paul Lichtenstein, Soffia Gudbjornsdottir, Mark J. Taylor, Henrik Larsson, Ralf Kuja-Halkola, Agnieszka Butwicka
Summary: This study aims to investigate educational outcomes in children and adolescents with type 1 diabetes (T1D) with and without psychiatric disorders. The findings suggest that while children with T1D alone have minor difficulties with their educational outcomes, those with both T1D and psychiatric disorders experience universal long-term educational underachievement.
Article
Endocrinology & Metabolism
Yunsoo Choe, Yun Jeong Lee, Jae Hyun Kim, Kyunghoon Lee, Choong Ho Shin, Young Ah Lee, Junghan Song
Summary: It was found that T1DM patients had lower total 25OHD levels but higher free 25OHD levels. Patients with DKA had significantly lower bioavailable 25OHD levels at diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Despoina Manousaki, Adil Harroud, Ruth E. Mitchell, Stephanie Ross, Vince Forgetta, Nicholas J. Timpson, George Davey Smith, Constantin Polychronakos, J. Brent Richards
Summary: By applying a Mendelian randomization study design, researchers found no substantial impact of vitamin D levels on the risk of type 1 diabetes. The results suggest that previous epidemiological associations may be influenced by confounding factors, and do not support increasing vitamin D levels as a strategy to decrease the risk of type 1 diabetes.
Review
Public, Environmental & Occupational Health
Sen Yang, BiYing Zhao, Zhen Zhang, XiaoLin Dai, YiLi Zhang, LanWei Cui
Summary: The study found a significant association between EV infection and clinical type 1 diabetes mellitus, with statistical heterogeneity mainly attributed to factors such as methods of EV detection and age distribution.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Nutrition & Dietetics
Beata I. Sinska, Alicja Kucharska, Katarzyna Czarnecka, Anna Harton, Agnieszka Szypowska, Iwona Traczyk
Summary: Taste function impairment is commonly observed in people with type 1 diabetes, especially in relation to sweet taste. This impairment is associated with factors such as diabetic neuropathy, smoking, age, disease duration, and dietary restrictions. A study comparing healthy children and adolescents with those with type 1 diabetes found that children and adolescents with diabetes were more likely to correctly recognize sweet taste even at lower concentrations, while healthy individuals were better at identifying salty taste.
Article
Biochemistry & Molecular Biology
Giulio Poli, Gian Carlo Demontis, Andrea Sodi, Alessandro Saba, Stanislao Rizzo, Marco Macchia, Tiziano Tuccinardi
Summary: A combined strategy of molecular dynamics simulations and bioinformatics was used to evaluate the pathogenicity of hRPE65 missense mutations. The results may support the reclassification of VUS and assist clinicians in determining the eligibility for gene therapy of patients with such variants.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Reham Shareef, Aryel Furman, Yui Watanabe, Ryan Bruellman, Mohammed A. A. Abdullah, Alexandra M. M. Dumitresu, Samuel Refetoff, Andrea Bertolini, Marco Borso, Alessandro Saba, Riccardo Zucchi, Roy E. E. Weiss
Summary: A novel mutation in iodotyrosine deiodinase (IYD) was identified in individuals from two Sudanese families through whole exome sequencing. Mass spectrometry analysis revealed significantly elevated levels of monoiodotyrosine (MIT) and diiodotyrosine (DIT) in the homozygous subjects, indicating that measurement of DIT and MIT in serum and urine was more sensitive in assessing the effect of the IYD mutation than urine iodine or serum thyroid function tests.
Article
Endocrinology & Metabolism
G. Agresta, A. Campione, P. Veiceschi, D. Gallo, E. Agosti, L. Massimi, G. Piatelli, A. Consales, S. Linsler, J. Oertel, F. Pozzi, M. L. Tanda, P. Castelnuovo, D. Locatelli
Summary: This study compared the outcomes of a staged surgical approach and a single-stage radical approach in children with craniopharyngiomas. The results showed that a staged approach led to higher rates of gross total resection and progression-free survival compared to the single-stage approach, with no significant differences in other outcomes.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Daniela Gallo, Denisa Baci, Natasa Kustrimovic, Nicola Lanzo, Bohdan Patera, Maria Laura Tanda, Eliana Piantanida, Lorenzo Mortara
Summary: Vitamin D plays a vital role in bone health and is involved in various cellular processes. It has been found to have clinical implications in immune surveillance against infections and autoimmune/inflammatory diseases. Recent research has focused on the role of innate immune cells and their interaction with vitamin D and acquired immune cells in the onset and regulation of certain autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Anello Marcello Poma, Diana Bonuccelli, Elisabetta Macerola, Sara Niballi, Alessio Basolo, Ferruccio Santini, Fulvio Basolo, Antonio Toniolo
Summary: Altered gene expression in endocrine organs is observed in COVID-19, with enhanced interferon response and specific changes in endocrine-specific genes. Adipose tissue shows independent enhanced interferon response regardless of virus presence. Important genes such as insulin, thyroid-stimulating hormone receptor, and leptin are affected in COVID-19.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Chemistry, Analytical
Mariagrazia Lettieri, Simona Scarano, Laura Caponi, Andrea Bertolini, Alessandro Saba, Pasquale Palladino, Maria Minunni
Summary: We developed a simple and low-cost assay for copper in urine using a serotonin-derived fluorophore. The assay showed good reproducibility and low detection limits in buffer and artificial urine, and demonstrated excellent analytical performances in human urine samples. This is the first example of copper ion detection exploiting the fluorescence quenching of a biopolymer, offering a potential diagnostic tool for copper-dependent diseases.
Article
Microbiology
Marco Calvigioni, Andrea Bertolini, Simone Codini, Diletta Mazzantini, Adelaide Panattoni, Mariacristina Massimino, Francesco Celandroni, Riccardo Zucchi, Alessandro Saba, Emilia Ghelardi
Summary: In this study, nine common probiotic strains were tested for their ability to secrete short-chain fatty acids (SCFAs) using a sensitive and specific HPLC-MS-MS method. All tested microorganisms were shown to secrete acetic acid, with only B. clausii and S. boulardii additionally able to produce propionic and butyric acids. This experimental approach contributes to the characterization of probiotics as SCFA-producing organisms and has implications for addressing SCFA deficiency.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Daniela Gallo, Antonino Bruno, Matteo Gallazzi, Simona Antonia Maria Cattaneo, Giovanni Veronesi, Angelo Genoni, Maria Laura Tanda, Luigi Bartalena, Alberto Passi, Eliana Piantanida, Lorenzo Mortara
Summary: This study suggests that supplementation with vitamin D and selenium in patients with Graves' disease receiving MMI treatment can modulate the frequency of Treg and NK cells, leading to better control of hyperthyroidism symptoms.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Daniela Gallo, Yusuf Ali
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Polymer Science
Pawel Kubik, Daniela Gallo, Maria Laura Tanda, Jerzy Jankau, Raffaele Rauso, Wojciech Gruszczynski, Aleksandra Pawlowska, Pawel Chrapczynski, Maciej Malinowski, Dariusz Grzanka, Marta Smolinska, Paulina Antosik, Maria-Luiza Piesiakow, Bartlomiej Lukasik, Agnieszka Pawlowska-Kubik, Giorgio Stabile, Stefania Guida, Lukasz Kodlubanski, Tom Decates, Nicola Zerbinati
Summary: The study aimed to test the effect of Neauvia Stimulate on patients with Hashimoto's disease, which is a contraindication for hyaluronic acid fillers and calcium hydroxyapatite biostimulants. Histopathological analysis showed a significant reduction in inflammatory infiltration and T lymphocytes after the procedure, with no effect on antibody levels. Risk analysis confirmed the safety of using hyaluronic acid fillers cross-linked with polyethylene glycol in patients with Hashimoto's disease.
Article
Biochemistry & Molecular Biology
Doretta Cuffaro, Diana Pinto, Ana Margarida Silva, Andrea Bertolini, Simone Bertini, Alessandro Saba, Marco Macchia, Francisca Rodrigues, Maria Digiacomo
Summary: This study investigates the antioxidant effects of high-value polyphenol oleocanthal (OC) and its main metabolites, tyrosol (Tyr) and oleocanthalic acid (OA), as well as their impact on cell viability. The results demonstrate the promising properties of OC, OA, and Tyr against oxidative diseases, including their ability to scavenge reactive oxygen species and permeate the intestinal membrane.
Article
Nutrition & Dietetics
Doretta Cuffaro, Andrea Bertolini, Simone Bertini, Claudio Ricci, Maria Grazia Cascone, Serena Danti, Alessandro Saba, Marco Macchia, Maria Digiacomo
Summary: This study aims to investigate the polyphenolic composition and nutraceutical properties of olive mill wastewaters (OMWWs) from two Tuscan olive cultivars. The results show that OMWW extracts exhibit antioxidant, antiradical, and anti-inflammatory activities, and could serve as potential functional ingredients in dietary supplements, pharmaceuticals, and cosmetics.
Editorial Material
Endocrinology & Metabolism
Antonio Toniolo
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Natasa Kustrimovic, Daniela Gallo, Eliana Piantanida, Luigi Bartalena, Adriana Lai, Nicola Zerbinati, Maria Laura Tanda, Lorenzo Mortara
Summary: Maintaining the delicate balance between immune response and tolerance is crucial for health. T regulatory cells play a pivotal role in preserving self-tolerance and suppressing inflammation. In Graves' disease, these cells are likely impaired or reduced in frequency. Understanding the role of Tregs in Graves' disease is important for developing new treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Daniela Gallo, Annarosaria De Vito, Rossella Roncoroni, Antonino Bruno, Eliana Piantanida, Luigi Bartalena, Maria Laura Tanda, Lorenzo Mortara, Francesco Acquati
Summary: This study found that the levels of RNASET2 protein were significantly higher in patients with Graves' disease compared to healthy controls, and after methimazole treatment, the levels decreased and became similar to those in healthy controls. These preliminary results suggest that RNASET2 may serve as an alarm signal to alert the immune system under specific conditions.