期刊
PEDIATRIC CLINICS OF NORTH AMERICA
卷 65, 期 4, 页码 783-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.pcl.2018.04.003
关键词
Chronic nonbacterial osteomyelitis; Chronic recurrent multifocal osteomyelitis; DIRA; Majeed syndrome; NSAID; Whole-body MRI
类别
资金
- CARRA
- Bristol-Myers Squibb [IM101-691_Zhao]
- NIH/NIAMS [R01AR059703]
Chronic nonbacterial osteomyelitis (CNO) is an innate immune system disorder that predominantly affects children. It can present as part of a syndrome or in isolation. It presents as bone pain with or without fever or objective swelling at the site. It is difficult to diagnose. Laboratory studies can be normal, whereas a biopsy reveals sterile osteomyelitis. Osteolytic or sclerotic bone changes may be seen on radiographs. However, MRI is more sensitive for detecting CNO and is considered the gold standard for monitoring the disease. Treatment depends on disease severity and includes nonsteroidal antiinflammatory drugs, bisphosphonates, and cytokine inhibitors.
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