Article
Critical Care Medicine
Sadia Haider, Sara Fontanella, Anhar Ullah, Stephen Tumer, Angela Simpson, Graham Roberts, Clare S. Murray, John W. Holloway, John A. Curtin, Paul Cullinan, Syed Hasan Arshad, Guillem Hurault, Raquel Granell, Adnan Custovic
Summary: The study found significant variation in the patterns of eczema, wheeze, and rhinitis morbidity, with multimorbidity being rare but significantly overrepresented. Infantile eczema was associated with subsequent multimorbidity, but the majority of children with eczema did not progress to any comorbidities.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Environmental Sciences
Derek Werthmann, Berna van Wendel de Joode, Michael T. Cuffney, Brian J. Reich, Manuel E. Soto-Martinez, Andrea Corrales-Vargas, Luis Palomo-Cordero, Jorge Penaloza-Castanedac, Jane A. Hoppin
Summary: This study evaluated the association between medical conditions and environmental exposures with fractional exhaled nitric oxide (FeNO) as a marker of airway inflammation. The results showed that rhinitis and wheeze were associated with elevated FeNO, and smoke from waste burning and para-occupational pesticide exposure may contribute to the increase of FeNO in rural communities.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Abigail Gaylord, Emily S. Barrett, Sheela Sathyanarayana, Shanna H. Swan, Ruby H. N. Nguyen, Nicole R. Bush, Kecia Carroll, Drew B. Day, Kurunthachalam Kannank, Leonardo Trasande
Summary: This study investigated the influence of prenatal exposure to the endocrine disrupting chemical bisphenol A on childhood atopic disease. The results showed that there were inverse associations between first trimester bisphenol A concentration and food allergy, while second trimester bisphenol A concentration was positively associated with food allergy. Additionally, prenatal exposure to bisphenol S was found to increase the risk of asthma among males.
ENVIRONMENTAL RESEARCH
(2023)
Article
Clinical Neurology
Ji-xing Zhou, Yufan Guo, Yu-zhu Teng, Lin-lin Zhu, Jingru Lu, Xue-mei Hao, Shuang-qin Yan, Fang-biao Tao, Kun Huang
Summary: Maternal anxiety during pregnancy may impact the fetal immune system and increase the risk of childhood asthma. This study found that prenatal anxiety in the first, second, and third trimesters was associated with an elevated risk of asthma in children from 12 to 48 months of age. Additionally, a cumulative effect was observed, with longer durations of anxiety increasing the risk.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Infectious Diseases
Yankun Lu, Yichao Wang, Jing Wang, Adrian J. J. Lowe, Luke E. E. Grzeskowiak, Yanhong J. J. Hu
Summary: Early-life antibiotic exposure is common and can affect the development of the child's microbiome and immune system. This study investigated the impact of early-life antibiotics exposure on childhood asthma development using data from the Australian Longitudinal Study of Australian Children. The results showed that any early-life antibiotic exposure increased the risk of early-persistent asthma among all children by 2.3-fold.
Article
Critical Care Medicine
Brian Hallmark, Ganesa Wegienka, Suzanne Havstad, Dean Billheimer, Dennis Ownby, Eneida A. Mendonca, Lisa Gress, Debra A. Stern, Jocelyn Biagini Myers, Gurjit K. Khurana Hershey, Lori Hoepner, Rachel L. Miller, Robert F. Lemanske, Daniel J. Jackson, Diane R. Gold, George T. O'Connor, Dan L. Nicolae, James E. Gern, Carole Ober, Anne L. Wright, Fernando D. Martinez
Summary: This study explored the association between wheezing phenotypes and 17q12-21 genetic variants in children, revealing four latent classes of wheezing and highlighting the genetic locus as relevant to wheezing. Differences in genetic associations between European American and African American children were also observed, suggesting potential racial/ancestral influences on wheezing phenotypes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Allergy
Sima K. Ramratnam, Alexandre Lockhart, Cynthia M. Visness, Agustin Calatroni, Daniel J. Jackson, Peter J. Gergen, Leonard B. Bacharier, George T. O'Connor, Megan T. Sandel, Meyer Kattan, Robert A. Wood, James E. Gern
Summary: Maternal stress and depression in early life are positively associated with respiratory illnesses and a moderate-wheeze-low-atopy phenotype in urban children, indicating the importance of addressing these factors to reduce viral respiratory illnesses and recurrent wheeze during early childhood.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Chloe I. Bloom, Courtney Franklin, Andrew Bush, Sejal Saglani, Jennifer K. Quint
Summary: The study found that preschool wheeze in the United Kingdom causes a significant healthcare burden, affecting around 7.7% of preschool children. Wheeze events were least common in August and most common in late-autumn/early-winter. Various factors such as wheeze frequency and severity, atopy, maternal asthma, were associated with progression to asthma in preschool children.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Pediatrics
Idun Holmdahl, Anastasia Filiou, Katarina Stenberg Hammar, Anna Asarnoj, Magnus P. Borres, Marianne van Hage, Gunilla Hedlin, Cilla Soderhall, Jon R. Konradsen
Summary: This study followed children with acute wheeze during early childhood to age 7 and found that acute wheeze caused by rhinovirus infection at inclusion was the main associated factor for developing persistent asthma. Cases who developed asthma also required more hospital time and care after inclusion.
Article
Allergy
W. Gerald Teague, Monica G. Lawrence, Sanford Williams, Andrea S. Garrod, Deborah Froh, Stephen V. Early, William Brand, Jeremy P. Middleton, Michael V. Mendoza, Kerry A. Hollis, Kristin Wavell, Peter W. Heymann, John W. Steinke, Larry Borish
Summary: Preschool children with treatment-refractory wheeze were classified into four clusters based on lung lavage variables, including airway malacia, gastroesophageal reflux, indolent human rhinovirus bronchoalveolitis, and type-2 high inflammation. The results provide insights into diagnosing the causes of treatment-refractory wheeze and developing novel therapies targeting airway malacia, human rhinovirus infection, and BAL neutrophilia in preschool children.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Review
Allergy
Arthur H. Owora, Yijia Zhang
Summary: This study systematically reviewed and meta-analyzed childhood wheeze trajectory studies to identify childhood wheeze trajectory group-specific risk factors among children from birth through to adolescence.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Allergy
Kiwako Yamamoto-Hanada, Kyongsun Pak, Mayako Saito-Abe, Miori Sato, Yukihiro Ohya
Summary: The study suggests that poor maternal prenatal quality of life and depression may increase the risk of wheezing, asthma, and food allergy in offspring at 3 years of age. Maternal depression and anxiety during pregnancy were also associated with offspring's wheezing, asthma, and food allergy.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2021)
Article
Pediatrics
You Wang, Xiumei Hong, Tsung-Chieh Yao, Hui-Ju Tsai, Xiaobin Wang
Summary: This study found an interactive relationship between maternal folate level during pregnancy and child asthma risk, depending on maternal asthma history. Children born to mothers with asthma history and low maternal folate level had the highest risk of developing asthma.
PEDIATRIC PULMONOLOGY
(2021)
Article
Allergy
Ji Soo Park, Dong In Suh, Dae Jin Song, Hey-Sung Baek, Meeyong Shin, Young Yoo, Ji-Won Kwon, Gwang Cheon Jang, Hyeon-Jong Yang, Eun Lee, Hwan Soo Kim, Ju-Hee Seo, Sung-Il Woo, Hyung Young Kim, Youn Ho Shin, Ju Suk Lee, Jisun Yoon, Sungsu Jung, Minkyu Han, Eunjin Eom, Jinho Yu, Woo Kyung Kim, Dae Hyun Lim, Jin Tack Kim
Summary: This study aimed to predict exacerbation-prone asthma (EPA) in children. The findings suggest that in addition to asthma control level, baseline lung function and white blood cell count are important factors for predicting EPA.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Environmental Sciences
Garthika Navaranjan, Miriam L. Diamond, Shelley A. Harris, Liisa M. Jantunen, Sarah Bernstein, James A. Scott, Tim K. Takaro, Ruixue Dai, Diana L. Lefebvre, Meghan B. Azad, Allan B. Becker, Piush J. Mandhane, Theo J. Moraes, Elinor Simons, Stuart E. Turvey, Malcolm R. Sears, Padmaja Subbarao, Jeffrey R. Brook
Summary: The study found an association between DEHP exposure in the first year of life and increased risks of asthma and recurrent wheezing among children at 5 years. These findings suggest the need to assess whether more stringent regulations are required to protect children's health, which can be informed by future work exploring the main sources of DEHP exposure.
ENVIRONMENTAL RESEARCH
(2021)
Article
Allergy
Tomoyuki Kiguchi, Kiwako Yamamoto-Hanada, Mayako Saito-Abe, Tatsuki Fukuie, Yukihiro Ohya
Summary: This study aimed to investigate how eczema phenotypes impact IgE component sensitization patterns. The results showed that persistent eczema phenotype in adolescence was strongly associated with allergic symptoms and IgE sensitization, while late-onset eczema showed no such associations. Early-onset eczema was closely connected to the later allergic march, while late-onset eczema differed from the phenotype of allergic march.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Dermatology
Yumiko Miyaji, Kiwako Yamamoto-Hanada, Tatsuki Fukuie, Masami Narita, Yukihiro Ohya
Summary: This study retrospectively analyzed the long-term prognosis of school children with atopic dermatitis treated with topical corticosteroids. The results showed that the dermatitis was well-controlled, but poor adherence was the biggest risk factor.
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Makoto Irahara, Kiwako Yamamoto-Hanada, Miori Sato, Mayako Saito-Abe, Yumiko Miyaji, Limin Yang, Minaho Nishizato, Natsuhiko Kumasaka, Hidetohi Mezawa, Yukihiro Ohya
Summary: This study found that children with lower endotoxin exposure in house dust had a lower prevalence of eczema at the ages of 1.5 and 3 years. Additionally, children whose mattresses had higher endotoxin concentrations had less sleep disturbance caused by itchy rash at age 3.
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Yukio Matsumoto, Naoko Mochimaru, Hazuki Yasuda, Kyongsun Pak, Tohru Kobayashi, Kiwako Yamamoto-Hanada, Yukihiro Ohya, Megumi Kiuchi, Masashi Kurokawa, Kazue Yoshida
Summary: The physiological properties of the skin in neonates and infants, including the ceramide content in the stratum corneum, were evaluated using confocal Raman spectroscopy. The water content and other factors in the skin of infants at different ages were measured, showing changes over time.
SKIN RESEARCH AND TECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Makoto Irahara, Kiwako Yamamoto-Hanada, Miori Sato, Mayako Saito-Abe, Yumiko Miyaji, Limin Yang, Minaho Nishizato, Natsuhiko Kumasaka, Hidetoshi Mezawa, Yukihiro Ohya
Summary: This study investigated the association between household endotoxin concentration and an already-developed food allergy. The results suggest that there is no significant difference in the prevalence of tolerance to certain food allergens based on household endotoxin levels. However, subgroup analyses revealed that lower endotoxin levels were associated with lower prevalence of tolerance and lower allergen-specific immunoglobulin G4 levels in some cases.
Article
Nutrition & Dietetics
Limin Yang, Miori Sato, Mayako Saito-Abe, Yumiko Miyaji, Mami Shimada, Chikako Sato, Minaho Nishizato, Natsuhiko Kumasaka, Hidetoshi Mezawa, Kiwako Yamamoto-Hanada, Yukihiro Ohya
Summary: This study aimed to evaluate the influence of low maternal dietary zinc intake during pregnancy on developing pediatric allergic diseases. The results showed no significant association between zinc intake during pregnancy and allergic diseases in offspring.
Article
Dermatology
Amy S. S. Paller, Barry Ladizinski, Pedro Mendes-Bastos, Elaine Siegfried, Weily Soong, Vimal H. H. Prajapati, Peter Lio, Jacob P. P. Thyssen, Eric L. L. Simpson, Andrew M. M. Platt, Eliza M. M. Raymundo, Jianzhong Liu, Brian M. M. Calimlim, Xiaohong Huang, Yihua Gu, Xiaofei Hu, Yang Yang, John C. C. Su, Min Zheng, Kiwako Yamamoto-Hanada, Henrique D. D. Teixeira, Alan D. D. Irvine
Summary: Atopic dermatitis commonly starts in childhood and persists into adolescence and adulthood. Evaluating new treatment options in adolescents is crucial due to the high unmet need in this population. This study assessed the efficacy and safety of Upadacitinib in adolescents aged 12-17 with moderate-to-severe atopic dermatitis.
Article
Pediatrics
Mayako Saito-Abe, Minaho Nishizato, Kiwako Yamamoto-Hanada, Liming Yang, Maki Fukami, Yoshiya Ito, Kenji Ihara, Atsushi Iwabuchi, Shingo Okamoto, Yasuhiro Naiki, Yukihiro Ohya, Reiko Horikawa
Summary: This study aimed to assess the reliability of judging pubertal onset in Japanese children using a self-assessment sheet. The results showed good agreement between self-assessment and physician's assessment for girls, but poor agreement for boys, especially those in the early pubertal stage. Therefore, conducting large-scale epidemiological studies for early pubertal boys is challenging.
FRONTIERS IN PEDIATRICS
(2023)
Review
Allergy
Elizabeth Huiwen Tham, Agnes Sze Yin Leung, Kiwako Yamamoto-Hanada, Lamia Dahdah, Thulja Trikamjee, Vrushali Vijay Warad, Matthew Norris, Elsy Navarrete, Daria Levina, Miny Samuel, Andre van Niekerk, Santiago Martinez, Anne K. Ellis, Leonard Bielory, Hugo van Bever, Dana Wallace, Derek K. Chu, Daniel Munblit, Mimi L. K. Tang, James Sublett, Gary Wing Kin Wong
Summary: This study conducted a comprehensive assessment of Clinical Practice Guidelines (CPGs) for primary prevention of food allergy and atopic dermatitis. It found that although some guidelines had high quality, they performed poorly in terms of global applicability. The study calls for guideline developers to consider stakeholders' preferences, local applicability, and adapt existing recommendations to different geographical settings.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Article
Allergy
Yuri E. Kram, Miori Sato, Kiwako Yamamoto-Hanada, Kenji Toyokuni, Satoko Uematsu, Takahiro Kudo, Yoshiyuki Yamada, Yoshikazu Ohtsuka, Kenji Matsumoto, Katsuhiro Arai, Tatsuki Fukuie, Ichiro Nomura, Yukihiro Ohya
Summary: Reports of FPIES in Japan are increasing, but knowledge about the disease and its treatment options is limited. This study aims to develop an action plan for acute FPIES in Japan, involving caregivers and medical professionals. Feedback from participants was utilized to improve the plan, which was finalized using the Delphi method. The revised FPIES action plan reached a consensus and may improve management of acute FPIES in Japan.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Article
Medicine, General & Internal
Hidehisa Saeki, Yukihiro Ohya, Hisakatsu Nawata, Kazuhiko Arima, Miho Inukai, Ana B. Rossi, Gaelle Bego-Le-Bagousse
Summary: This study investigated the impact of pediatric atopic dermatitis (AD) on family quality of life in Japanese patients. The results showed that the severity of AD was negatively correlated with family quality of life, especially in families with children under the age of 6, where sleep and tiredness were the most affected aspects. The study also found that family and household environments, such as family history of allergic conditions, residency, second-hand smoke exposure, and household pets, can influence AD prevalence and severity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Yumiko Miyaji, Kiwako Yamamoto-Hanada, Limin Yang, Mayako Saito-Abe, Miori Sato, Hidetoshi Mezawa, Minaho Nishizato, Masayuki Ochiai, Shouichi Ohga, Masako Oda, Hiroshi Mitsubuchi, Masayuki Shimono, Reiko Suga, Nathan Mise, Makiko Sekiyama, Shoji F. Nakayama, Yukihiro Ohya
Summary: This study investigated the association between sex steroid hormones and allergic diseases in Japanese children. The findings suggest that sex hormones may play an important role in the development of allergic diseases in prepubertal children.
Article
Allergy
Yumiko Miyaji, Kiwako Yamamoto-Hanada, Limin Yang, Tatsuki Fukuie, Masami Narita, Yukihiro Ohya
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Letter
Allergy
Hiroki Yasudo, Kiwako Yamamoto-Hanada, Masayuki Mikuriya, Fumitoshi Ogino, Tatsuki Fukuie, Yukihiro Ohya
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Allergy
Nagisa Ito, Kiwako Yamamoto-Hanada, Limin Yang, Yusuke Inuzuka, Fumi Ishikawa, Tatsuki Fukuie, Yukihiro Ohya
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)