Article
Medicine, General & Internal
Yun-Suk Choi, Seong-Woon Choi, Jin-Wook Yi
Summary: This study identified TERT promoter mutations in PTC and found that they are associated with more aggressive behavior. Patients with TERT promoter mutations were older, had larger tumors, and exhibited other adverse clinical features, resulting in a poorer prognosis compared to those with wild-type TERT gene status.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Pengyu Li, Yang Liu, Tao Wei, Xiaofei Wang, Jingqiang Zhu, Rui Yang, Yanping Gong, Wanjun Zhao
Summary: The aim of this study was to investigate the risk factors affecting lymph node metastasis in patients with papillary thyroid carcinoma (PTC) and Hashimoto thyroiditis (HT), as well as the interaction effect of the B-Raf proto-oncogene (BRAF). The results showed that BRAF was a risk factor for lymph node metastasis in PTC with HT, and there were potential interactions between BRAF and age, BMI, hypertension, and calcification.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Oncology
Joonseon Park, Solji An, Kwangsoon Kim, Ja Seong Bae, Jeong Soo Kim
Summary: BRAF(V600E) positivity is associated with increased aggressiveness of papillary thyroid cancer (PTC). Younger patients with BRAF(V600E)-positive PTC have a higher risk of recurrence compared to older patients.
Article
Biochemistry & Molecular Biology
Irena Ivkovic, Zgjim Limani, Antonia Jakovcevic, Srecko Gajovic, Sven Seiwerth, Ana Danic Hadzibegovic, Drago Prgomet
Summary: By analyzing tissue samples from 146 patients with papillary thyroid cancer, we found that the BRAF V600E mutation and CPSF2 protein expression are associated with recurrence and disease-free survival. Patients with low CPSF2 protein expression and the BRAF V600E mutation were at higher risk for recurrence, while patients with high CPSF2 protein expression had longer disease-free survival. These findings provide important prognostic factors for papillary thyroid cancer.
Article
Endocrinology & Metabolism
Yin-zhu Zhao, Nian-an He, Xian-jun Ye, Fu Jin, Meng-xue Li, Xianxian Jiang
Summary: This study aimed to explore predictors of CLNM in PTC patients with cT1a and cT1b stage disease, revealing differences between the two groups and emphasizing the importance of a comprehensive assessment of risk factors for designing personalized treatment regimens.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Guodong Fu, Ronald S. Chazen, Christina MacMillan, Ian J. Witterick
Summary: This diagnostic study developed a sensitive molecular assay for detection and quantification of BRAF V600E variation in residual tissue from thyroid FNA biopsies to identify patients with cancer harboring BRAF V600E in a cost-effective manner, highlighting the clinical value of molecular assay of the remaining FNA tissue in the management of thyroid nodules.
Article
Biochemistry & Molecular Biology
Agata M. Gawel, Maciej Ratajczak, Ewa Gajda, Malgorzata Grzanka, Agnieszka Paziewska, Marta Cieslicka, Maria Kulecka, Malgorzata Oczko-Wojciechowska, Marlena Godlewska
Summary: The study revealed enhanced expression of FRMD5 in BRAF V600E thyroid tumor specimens and cells; Depletion of FRMD5 resulted in significant alterations in migration, invasiveness, adhesion, and spheroid formation potential of PTC-derived cells; Knockdown of FRMD5 significantly affected the expression of multidrug resistant genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Yan Lin, Zhao-rong Wu, Yao-ping Shi, Min Ding, Xiao-yin Tang, Yi He, Bo Zhai, Ping Li
Summary: This study evaluates the efficiency, safety, and prognosis of ultrasound-guided percutaneous radiofrequency ablation (RFA) for unifocal papillary thyroid microcarcinomas (PTMCs) with BRAF V600E mutation. The results show that RFA is an effective and safe treatment option for unifocal PTMCs with BRAF V600E mutation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Ziheng Ye, Xiaotian Xia, Peipei Xu, Wenfei Liu, Shoufei Wang, Youben Fan, Minggao Guo
Summary: This study found that the BRAF V600E mutation is associated with age, tumor multifocality, TNM stage, and prevalence of Hashimoto's thyroiditis in patients with papillary thyroid cancer. Survival analysis showed significant differences in survival between patients with positive and negative BRAF V600E mutation. Additionally, tumor size, extrathyroidal extension, and lymph node metastasis were found to be associated with a higher probability of recurrence in patients with the BRAF V600E mutation.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Oncology
Sheng Li Zhou, Yan Ping Guo, Lei Zhang, Tao Deng, Zi Guang Xu, Chao Ding, Wen Cong Sun, Yue Wu Zhao, Ling Fei Kong
Summary: Male, younger age (<= 30 years), large tumor size (> 5 mm), and coexistent HT are independent predictive factors for CLNM. The BRAF(V600E) mutation is associated with tumor size and absence of HT in PTMC patients, age > 30 years in the PTC > 10 mm group. The BRAF(V600E) mutation was an independent risk factor for CLNM when the tumor was <= 5 mm. These features should be considered for optimal management of PTC patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Qizhi Tang, Weiyu Pan, Liangyue Peng
Summary: This study assessed the association between Hashimoto thyroiditis (HT) and clinical outcomes of papillary thyroid carcinoma (PTC). The results showed that PTC patients with HT had lower risks of lymph node metastasis, distant metastasis, extrathyroidal extension, recurrence, vascular invasion, and a better 20-year survival rate, while had higher risks of multifocality, perineural infiltration, and bilaterality. This suggests that PTC patients with HT may have favorable clinicopathologic characteristics.
Article
Oncology
Theodora Pappa, Sara Ahmadi, Ellen Marqusee, Hannah L. Johnson, Matthew A. Nehs, Nancy L. Cho, Justine A. Barletta, Jochen H. Lorch, Gerard M. Doherty, Neal I. Lindeman, Erik K. Alexander, Inigo Landa
Summary: Routine genomic sequencing was used to identify additional oncogenic alterations in BRAF(v600E)-mutant papillary thyroid carcinoma (PTC) patients, which were associated with increased risk of recurrence, larger tumor size, and more advanced stage at presentation. Independent oncogenic mutations in the PI3K/AKT/mTOR pathway were also found to be significantly associated with disease-specific mortality (DSM), highlighting the importance of genomic profiling for prognosis and clinical strategy in PTC.
CLINICAL CANCER RESEARCH
(2021)
Article
Endocrinology & Metabolism
Tomoe Nakao, Michiko Matsuse, Vladimir Saenko, Tatiana Rogounovitch, Aya Tanaka, Keiji Suzuki, Miyoko Higuchi, Hisanori Sasai, Tsutomu Sano, Mitsuyoshi Hirokawa, Akira Miyauchi, Atsushi Kawakami, Norisato Mitsutake
Summary: The study found a high concordance rate of TERT-p mutations between preoperative fine-needle aspiration samples and postoperative formalin-fixed and paraffin-embedded specimens in papillary thyroid carcinomas (PTCs) aged 55 years or older. The TERT-p mutation was significantly associated with age, tumor size, extrathyroidal extension, and the Ki-67 labelling index in both FNA and FFPE samples, indicating potential clinical utility in predicting disease aggressiveness and guiding PTC management.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Oncology
Liudmyla Zurnadzhy, Tetiana Bogdanova, Tatiana I. Rogounovitch, Masahiro Ito, Mykola Tronko, Shunichi Yamashita, Norisato Mitsutake, Serhii Chernyshov, Sergii Masiuk, Vladimir A. Saenko
Summary: The frequency of BRAF(V600E) in young Ukrainian patients with radiogenic and sporadic papillary thyroid carcinomas increases with age, but does not confer a more aggressive course regardless of tumor etiology. Major clinicopathological differences between radiogenic and sporadic PTCs are observed among the BRAF(V600E)-negative tumors.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jingjia Cao, Xiaolu Zhu, Yaru Sun, Xiao Li, Canhua Yun, Wei Zhang
Summary: This study found that BRAF V600E and TERT promoter mutations are significantly correlated with poor curative effect of radioiodine therapy in papillary thyroid cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Pathology
Xiaobo Zhang, Chen Wang, Danhua Shen
Summary: This study investigated the Clinicopathological features and FH mutation in FH-dUL. FH-dUL is rare and the combination of predictive Clinicopathological evaluation, FH and 2SC IHC test, and molecular test were helpful for the screening of FH-dUL or even HLRCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Gaurav Dubey, Mithilesh Singh, Himmat Singh, Mohit Agarwal, Shailendra Singh Chandel, Anurag Mishra, Ravindra Pal Singh, Neelima Kukreti
Summary: SnoRNAs play a crucial role in autoimmune diseases, influencing gene expression, immune cell development, and immune regulation. They have the potential to be biomarkers or therapeutic targets for disease management. However, further research is needed to elucidate their precise molecular mechanisms.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
P. Suhaj, D. Do, T. Olejar, R. Pichova, O. Lang, R. Matej
Summary: Pancreatic polypeptide cell hyperplasia (PPY-H) is a multiplication of neuroendocrine cells producing pancreatic polypeptide (PPY). The development and role of PPY-H still need to be further elucidated. This study analyzed 12 cases of PPY-H accompanying pancreatic neuroendocrine neoplasias (NEN) and found that gastrointestinal symptoms may be more related to PPY-H rather than NEN hormonal production. Strong SSTR2 expression in PPY-H suggests the potential utility of radiotracers in clinical diagnostics, but further studies are needed.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ruyun Zhang, Xiaofei Liao, Bin Zhang, Xiaohong Huang, Guanjie Qin, Xiangyun Kong, Yuan Xie, Yunyan Mo, Jinxuan Dai, Chunqiao Gan, Zan Luo, Jingyan Lu, Wei Jiang
Summary: This study found that patients with high COV+TIL score had worse prognosis in nasopharyngeal carcinoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Waleed Hassan Almalki
Summary: Understanding the molecular pathways behind cardiovascular illnesses is crucial. Recent studies have revealed the role of Xist RNA in cardiovascular diseases, including epigenetic changes, gene expression, cellular identity, and sex chromosomal inactivation. Dysregulation of Xist RNA expression is associated with conditions such as atherosclerosis, hypertrophy, and cardiac fibrosis.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Yanxin Dong, Boshi Fan, Mingyang Li, Jiale Zhang, Shun Xie, Shouyin Dia, Qingge Jia, Taiqian Gong
Summary: Tescalcin (TESC) is upregulated in esophageal squamous carcinoma (ESCC) and is associated with poor prognosis, tumor infiltration, staging, and lymph node metastasis. TESC promotes proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) progression in ESCC, as well as activates the AKT pathway. TESC may serve as a prognostic factor and provide a new therapeutic strategy for ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ozge Sukruoglu Erdogan, Demet Akdeniz Odemis, Zubeyde Yalniz Kayim, Orkun Gurbuz, Seref Bugra Tuncer, Seda Kilic, Betul Celik, Samuray Tuncer, Sema Buyukkapu Bay, Rejin Kebudi, Hulya Yazici
Summary: This study found that methylation of the RB1 gene promoter does not influence the hereditary transmission of familial retinoblastoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Syam Mohan, Mohammed Ageeli Hakami, Hamad Ghaleb Dailah, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Maryam A. Halawi, Thaifallah Munahi Alotaibi
Summary: Cancer is a complex disease caused by multiple factors, and miR-155 plays a significant role as a regulator of the NF-kappa B signaling pathway, contributing to cancer development and progression.
PATHOLOGY RESEARCH AND PRACTICE
(2024)