Review
Biochemistry & Molecular Biology
Sadia Hassan, Adeeb Shehzad, Shahid Ali Khan, Waheed Miran, Salman Khan, Young-Sup Lee
Summary: The advancements in molecular biology and genomics have accelerated early diagnosis and clinical management of cancer. Circulating-free DNA (cfDNA) and cellfree RNA (cfRNA) based liquid biopsies play crucial roles in cancer diagnosis, prognosis, prediction, and treatment, with their sensitivity and specificity clinically proven through multiple trials.
Review
Biochemistry & Molecular Biology
Alexey S. S. Rzhevskiy, Alina Y. Y. Kapitannikova, Denis V. V. Butnaru, Evgeniy V. V. Shpot, Simon A. A. Joosse, Andrei V. V. Zvyagin, Majid Ebrahimi Warkiani
Summary: Currently, there is a lack of sensitive and specific methods for the detection and prognosis of early stage prostate cancer. Liquid biopsy, a novel technique that extracts biomarkers such as circulating tumor cells, exosomal miRNAs, and circulating DNAs, has been investigated as a supplement or alternative to the traditional screening methods for prostate cancer.
Article
Oncology
Romina Silva, Bruce Moran, Anne-Marie Baird, Colm J. O'Rourke, Stephen P. Finn, Ray McDermott, William Watson, William M. Gallagher, Donal J. Brennan, Antoinette S. Perry
Summary: This study investigated the dynamics of personal DNA methylomic profiles of metastatic prostate cancer patients during disease progression and therapy administration. Longitudinal assessment of cfDNA methylation revealed dynamic patterns associated with disease progression and therapy administration, highlighting the potential of using liquid biopsies to study prostate cancer evolution at a methylomic level.
CLINICAL EPIGENETICS
(2021)
Article
Oncology
Dora Raos, Irena Abramovic, Miroslav Tomic, Alen Vrtaric, Tomislav Kulis, Marijana Coric, Monika Ulamec, Ana Katusic Bojanac, Davor Jezek, Nino Sincic
Summary: This study investigates copy number variations (CNVs) in specific genes of testicular seminoma and their potential as biomarkers. The research found evidence of CNVs in both tissue and seminal plasma, indicating their potential use as biomarkers for testicular seminoma.
Review
Biochemistry & Molecular Biology
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Rui Manuel Reis, Leticia Ferro Leal
Summary: Lung cancer, the most deadly cancer globally, can be diagnosed and molecularly stratified using tissue biopsy. Liquid biopsy, a minimally invasive approach, allows the detection of biomarkers from body fluids for diagnosis, prognosis, and treatment response prediction. Liquid biopsy options for managing lung cancer have emerged, including the detection of EGFR p.(Tyr790Met) mutation in plasma samples to predict response and monitor TKI-treated patients. Efforts are ongoing to improve the detection of clinically relevant biomarkers for lung cancer using more sensitive technologies. Liquid biopsy can also significantly reduce turnaround time for laboratory reports, accelerating treatment initiation and improving overall survival of lung cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Vera Mugoni, Yari Ciani, Caterina Nardella, Francesca Demichelis
Summary: The identification of prostate cancer biomarkers in patients' blood and urine can significantly improve PCa diagnosis and monitoring. Using EV-RNAs as biomarkers in PCa shows great potential, but faces challenges of EV heterogeneity and complexity.
Review
Biochemistry & Molecular Biology
Patricia Mondelo-Macia, Jorge Garcia-Gonzalez, Luis Leon-Mateos, Adrian Castillo-Garcia, Rafael Lopez-Lopez, Laura Muinelo-Romay, Roberto Diaz-Pena
Summary: Lung cancer is a leading cause of mortality worldwide, with small cell lung cancer being characterized by aggressiveness and short-lived treatment effects. Liquid biopsy has emerged as a new tool for the management of SCLC patients in recent years.
Article
Genetics & Heredity
Dora Raos, Davor Orsolic, Silvija Masic, Miroslav Tomic, Jure Krasic, Igor Tomaskovic, Nora Nikolac Gabaj, Nina Gelo, Zeljko Kastelan, Tomislav Kulis, Ana Katusic Bojanac, Anja Baresic, Monika Ulamec, Davor Jezek, Nino Sincic
Summary: This study investigated the potential of cfDNA methylation as noninvasive biomarkers for the management of seminoma patients. Specific CpG sites were identified as possible seminoma markers through comparison with samples from healthy volunteers. However, receiver operating characteristic curve analysis showed modest results. Further analysis revealed two DNA methylation panels that could potentially serve as screening markers for seminoma.
Article
Oncology
Alexey S. Rzhevskiy, Alina Y. Kapitannikova, Steven A. Vasilescu, Tamilla A. Karashaeva, Sajad Razavi Bazaz, Mark S. Taratkin, Dmitry Enikeev, Vladimir Y. Lekarev, Evgeniy Shpot, Denis Butnaru, Sergey M. Deyev, Jean Paul Thiery, Andrei Zvyagin, Majid Ebrahimi Warkiani
Summary: Prostate cancer is difficult to diagnose due to lack of reliable biomarkers and the invasiveness of obtaining tissue biopsies. This study developed a liquid biopsy technique to isolate tumor cells from semen samples, showing potential for improving diagnosis and prognosis of prostate cancer.
Review
Chemistry, Multidisciplinary
Yuqing Sun, Yongling Tang, Long Yu, Yuhao Wang, Shuang Peng, Xiang Zhou
Summary: Liquid biopsy using molecular information in body fluids is an important tool for early diagnosis and treatment of various diseases. Blood, urine, and bile can be used as samples for diagnosis. With the development of gene sequencing and bioinformatics technology, genetic, epigenetic, and fragtomics alterations in cfDNA as well as the expression level of miRNA and cf-mRNA can be quantified, providing insights into disease pathogenesis.
SCIENCE CHINA-CHEMISTRY
(2023)
Review
Clinical Neurology
Jessica B. Foster, Mateusz P. Koptyra, Stephen J. Bagley
Summary: Although blood-based biomarkers are not yet used in routine neuro-oncology practice, this field is advancing rapidly and holds great promise for improved and non-invasive management of patients with brain tumors. Prospective and adequately powered studies are needed to confirm the clinical utility of any blood biomarker prior to widespread clinical implementation.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2023)
Article
Oncology
Hector Martinez-Gregorio, Clara Diaz-Velasquez, Mario Esau Romero-Pina, Miguel Ruiz de la Cruz, Norma Laura Delgado-Buenrostro, Aldo De la Cruz-Montoya, Yolanda Irasema Chirino, Luis Ignacio Terrazas, Luis Alberto Medina, Felipe Vaca-Paniagua
Summary: This study aims to demonstrate the feasibility of using circulating free DNA (cfDNA) as a liquid biopsy for early detection of colorectal cancer (CRC). The researchers successfully detected mutations in liquid biopsies of early stages of tumor development, providing evidence for the potential use of this method.
Review
Andrology
Koji Hatano, Norio Nonomura
Summary: Understanding the genomic profiling of prostate cancer is crucial for guiding treatment, with a focus on liquid biopsy and actionable molecular alterations presenting as emerging areas of interest.
WORLD JOURNAL OF MENS HEALTH
(2021)
Article
Oncology
Razelle Kurzrock, Charu Aggarwal, Caroline Weipert, Lesli Kiedrowski, Jonathan Riess, Heinz-Josef Lenz, David Gandara
Summary: ARID1A abnormalities identified in blood samples are associated with immunotherapy responsiveness and have a frequency similar to that found in tissue samples. Furthermore, samples with functional ARID1A abnormalities show more co-alterations, potentially informing therapeutic strategies.
Review
Biochemistry & Molecular Biology
Wojciech A. Cieslikowski, Andrzej Antczak, Michal Nowicki, Maciej Zabel, Joanna Budna-Tukan
Summary: CTC enumeration shows promise in the management of prostate cancer, particularly in monitoring treatment outcomes. However, most data come from randomized studies of anticancer agents and may not directly translate into clinical practice. Further research is needed to understand the role of CTC in early-stage prostate cancer.
Article
Dermatology
Claudia Pezzini, Silvana Ciardo, Stefania Guida, Shaniko Kaleci, Johanna Chester, Alice Casari, Marco Manfredini, Caterina Longo, Francesca Farnetani, Ariadna Ortiz Brugues, Giovanni Pellacani
Summary: This study combines high-resolution, non-invasive imaging techniques to analyze age-related skin changes. The results show correlations between clinical manifestations of aging and skin cytoarchitecture observed through imaging. As age advances, certain features such as hyperpigmentation and wrinkles become more pronounced, while the skin's collagen fibers become more disrupted. This research provides valuable insights for future studies on skin aging assessment and treatment effectiveness.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
J. -M. L'Orphelin, J. Cassecuel, L. Kandolf, C. A. Harwood, P. Tookey, M. H. Junejo, S. Hogan, C. Lebbe, Z. Appalla, T. -M. Kraenke, G. Pellacani, D. Cerasuolo, B. Dujovic, V. Del Marmol, A. Forschner, C. Garbe, V. Bataille, J. M. Ressler, P. Sollena, A. Dompmartin, K. Peris, B. Dreno
Summary: This study investigates cutaneous immune-related adverse events (IrAEs) in patients treated with immune checkpoint inhibitors across Europe, aiming to characterize and evaluate their reactions. The results show that inflammatory benign dermatoses are the most common type of reaction, with the majority of patients able to continue immunotherapy. Severe late-onset cutaneous IrAEs are not uncommon, highlighting the crucial role of dermatological follow-up in mitigating life-threatening adverse events.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Dermatology
Caterina Longo, Riccardo Pampena, Elvira Moscarella, Johanna Chester, Michela Starace, Elisa Cinotti, Bianca Maria Piraccini, Giuseppe Argenziano, Ketty Peris, Giovanni Pellacani
Summary: Effective cancer screening detects early-stage tumours, leading to a lower incidence of late-stage disease over time. Dermoscopy is the gold standard for skin cancer diagnosis due to improved diagnostic accuracy compared to naked eye examinations. Knowing the specific dermoscopic melanoma criteria according to different body sites is crucial for accurate diagnosis.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Andrea Maurichi, Francesco Barretta, Roberto Patuzzo, Rosalba Miceli, Gianfranco Gallino, Ilaria Mattavelli, Andrea Leva, Catherine Harwood, Daniele Bergamaschi, Tiffanie-Marie Borg, Michal Shimonovitz-Moore, Giuseppe Spadola, Elena Tolomio, Consuelo Barbieri, Paola Queirolo, Ausilia Maria Manganoni, Giovanni Pellacani, Vittoria Espeli, Cristina Mangas, Sandra Leoni-Parvex, Mara Cossa, Alessia Belotti, Barbara Valeri, Umberto Cortinovis, Mario Santinami
Summary: Narrower excision margins for T1 radial growth phase melanoma on the head and neck, including the face, are not associated with worse overall survival or increased local recurrence compared to wider margins. However, caution may be required in the presence of lentigo maligna melanoma.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
S. Michelini, G. Caro, M. Di Fraia, M. Fortuna, F. Magri, V. V. Gomes, T. Grieco, M. Carlesimo, A. Rossi, G. Pellacani
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Caterina Longo, Nicola Lippolis, Michela Lai, Marco Spadafora, Shaniko Kaleci, Alessandra Grazia Condorelli, Mara Lombardi, Riccardo Pampena, Giuseppe Argenziano, Gianluca Nazzaro, Massimiliano Scalvenzi, Bengu Nisa Akay, Paolo Broganelli, Maria Concetta Fargnoli, John Paoli, Oriol Yelamos, Giovanni Pellacani, Stefania Borsari, Aimilios Lallas
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Giovanni Pellacani, Ketty Peris, Silvana Ciardo, Claudia Pezzini, Sara Tambone, Francesca Farnetani, Caterina Longo, Camilla Chello, Salvador Gonzalez
Summary: This study investigates the effectiveness of self-administered sun protection, topical treatment, and topical + oral treatment in managing Actinic Keratosis (AK) in elderly individuals with severe actinic damage. The results suggest that the combination of topical and oral treatment provides the best improvement in clinical and anatomical outcomes compared to other treatment options.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2023)
Article
Dermatology
Paolo Romita, Carlo A. Maronese, Aurora De Marco, Riccardo Balestri, Anna Belloni Fortina, Valeria Brazzelli, Cristiana Colonna, Vito Di Lernia, May El Hachem, Gabriella Fabbrocini, Caterina Foti, Lucretia A. Frasin, Claudio Guarneri, Cristina Guerriero, Stefania Guida, Andrea Locatelli, Iria Neri, Corrado Occella, Annamaria Offidani, Teresa Oranges, Giovanni Pellacani, Giuseppe Stinco, Luca Stingeni, Tania Barbagallo, Anna Campanati, Serafinella P. Cannavo, Francesca Caroppo, Riccardo Cavalli, Alessio Costantini, Rosa Cucchia, Andrea Diociaiuti, Cesare Filippeschi, Mariangela Francomano, Simona Giancristoforo, Roberta Giuffrida, Emanuela Martina, Nicola A. Monzani, Paola Nappa, Carlotta Pastorino, Annalisa Patrizi, Francesca Peccerillo, Ketty Peris, Sebastiano Recalcati, Laura Rizzoli, Oriana Simonetti, Maria Vastarella, Annalucia Virdi, Angelo V. Marzano, Domenico Bonamonte
Summary: Since the COVID-19 pandemic started, dermatological manifestations have been observed quite often among infected and non-infected patients, especially in children. This study reveals a possible association between acral cyanosis and nasopharyngeal swab positivity in children and teenagers.
ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Luca Bianchi, Giacomo Caldarola, Elena Campione, Annunziata Dattola, Clara D. E. Simone, Giovanni Pellacani, Antonio G. Richetta, Nevena Skroza
ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Marco Ardigo, Luca Bianchi, Carmen Cantisani, Carlo Cota, Cosimo Di Raimondo, Alessandro Di Stefani, Maria C. Fargnoli, Chiara Franceschini, Giovanni Pellacani, Ketty Peris, Severino Persechino, Sara Plebani, Concetta Potenza, Ilaria Proietti, Laura Quattrini, Maria Cantonetti
ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Stefania Guida, Antonio Alma, Flavio Fiorito, Andrea Megna, Johanna Chester, Shaniko Kaleci, Silvana Ciardo, Marco Manfredini, Franco Rongioletti, Jean L. Perrot, Pietro Rubegni, Camilla Chello, Carmen Cantisani, Giovanni Pellacani, Elisa Cinotti, Francesca Farnetani
Summary: This study aims to validate the dermoscopic predictors for lentigo maligna melanoma (LMM) and identify the reflectance confocal microscopy (RCM) patterns in LMM. The study confirms previously reported dermoscopic features for LMM subtypes and discovers other features significantly associated with LMM diagnosis. Additionally, correlations between dermoscopic and RCM features in LMM are found, and RCM three-dimensional analysis allows the identification of invasive components in the dermal epidermal junction and dermis.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Medicine, General & Internal
Marco Manfredini, Alberto Sticchi, Nicola Lippolis, Gioia Pedroni, Matteo Giovani, Silvana Ciardo, Camilla Chello, Stefania Guida, Francesca Farnetani, Giovanni Pellacani
Summary: Previous studies have shown that acne-prone skin exhibits microscopic abnormalities such as microcomedos and infundibular hyperkeratosis. In this study, treatment with probiotics and a topical product led to a reduction in both clinical and microscopic acne features. Reflectance confocal microscopy and dynamic optical coherence tomography were effective tools for monitoring subclinical changes in acne-prone skin.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Stefania Guida, Caterina Longo, Simone Amato, Anthony M. Rossi, Marco Manfredini, Silvana Ciardo, Marco Spadafora, Steven P. Nistico, Santo R. Mercuri, Franco Rongioletti, Nicola Zerbinati, Giovanni Pellacani
Summary: Laser treatments are popular in Dermatology, and non-invasive skin imaging techniques like reflectance confocal microscopy (RCM) are being used to explore skin characteristics without the need for skin biopsies. This systematic review article provides an overview of current applications of RCM in laser treatment monitoring, specifically focusing on variations in epidermis and dermis, and pigmentary and vascular characteristics of the skin. The review includes studies on human subjects treated with lasers, and identifies five groups of treatments: skin rejuvenation, scar tissue, pigmentary disorders, vascular disorders, and others.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Teresa Grieco, Martina Caviglia, Giuseppina Cusano, Alvise Sernicola, Camilla Chello, Ester Del Duca, Carmen Cantisani, Alberto Taliano, Nicolo Sini, Gianluca Ianiro, Giovanni Pellacani
Summary: JAK inhibitors have shown efficacy in treating immune-related diseases such as ulcerative colitis and atopic dermatitis. This case report demonstrates the successful management of a patient with overlapping conditions of ulcerative colitis and atopic dermatitis using upadacitinib, resulting in complete and persistent clinical remission. These findings suggest that upadacitinib may be an optimal treatment strategy for individuals with coexisting Th1 and Th2-mediated conditions.
MEDICINA-LITHUANIA
(2023)
Article
Dermatology
Maria Mannino, Alfredo Piccerillo, Emi Dika, Sabina Vaccari, Pietro Quaglino, Marco Rubatto, Caterina Longo, Stefania Borsari, Giovanni Pellacani, Maria Concetta Fargnoli, Chiara Caponio, Giuseppe Argenziano, Giulia Briatico, Luca Bianchi, Cosimo Di Raimondo, Pier Giacomo Calzavara Pinton, Iris Zalaudek, Alessandro Di Stefani, Ketty Peris
Summary: This study describes the clinical characteristics and treatment strategies of a real-life Italian cohort of advanced cutaneous squamous cell carcinoma (aCSCC) patients. The majority of patients received surgical and radiation treatments, while only a small number of patients received immunotherapy.
