Article
Obstetrics & Gynecology
Eda Adeviye Sahin, Serhat Toprak, Hasan Berkan Sayal, Tekin Ekinci, Ercan Yilmaz, Kadir Bakay, Rauf Melekoglu, Burak Sezgin, Yusuf Aytac Tohma, Hanifi Sahin
Summary: This study aimed to investigate the prognostic factors of G3EEC patients. LVSI was identified as an independent prognostic factor for decreased DFS and OS in G3EEC patients.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Medicine, Research & Experimental
Fariba Yarandi, Elham Shirali, Setare Akhavan, Fatemeh Nili, Sara Ramhormozian
Summary: The study aimed to evaluate the impact of lymphovascular space invasion (LVSI) on survival in patients with early stage endometrioid endometrial cancer. The analysis of data from 415 patients with stage I and grade 1-2 endometrial cancer showed that LVSI significantly correlated with 3-year and 5-year survival rates and acted as a strong prognostic factor. Therefore, LVSI should be implemented in endometrial cancer staging systems.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Oncology
Valerio Mais, Maria Luisa Fais, Michele Peiretti, Daniela Fanni, Elena Massa, Giulia Carboni, Giuseppina Fais, Giuseppe Deo, Stefano Angioni
Summary: The search for immunohistochemical prognostic markers for relapse in low-risk/low-grade endometrioid endometrial cancers is still ongoing. Human epididymis protein 4 (HE4) has been identified as a potential marker, but current assays cannot distinguish between different protein isoforms of HE4.
Article
Medicine, General & Internal
Seong Eun Bak, Ji Geun Yoo, Sung Jong Lee, Joo Hee Yoon, Dong Choon Park, Sang Il Kim
Summary: This study investigates the risk factors for recurrence in patients with low-risk endometrial cancer and identifies histological grade as an independent risk factor.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Oncology
Logan Blankenship, Uday P. Pratap, Xue Yang, Zexuan Liu, Kristin A. Altwegg, Bindu Santhamma, Kumaraguruparan Ramasamy, Swapna Konda, Yidong Chen, Zhao Lai, Siyuan Zheng, Gangadhara R. Sareddy, Philip T. Valente, Edward R. Kost, Hareesh B. Nair, Rajeshwar R. Tekmal, Ratna K. Vadlamudi, Suryavathi Viswanadhapalli
Summary: The study demonstrates that obese conditions upregulate LIF/LIFR signaling, promoting progression of endometrioid endometrial cancer (EEC). The LIFR inhibitor EC359 shows potential in suppressing tumor progression in obese patients.
Article
Medicine, General & Internal
Andreas Zouridis, Kianoush Zarrindej, Joshua Rencher, Christina Pappa, Ammara Kashif, Sarah Louise Smyth, Negin Sadeghi, Alisha Sattar, Stephen Damato, Federico Ferrari, Antonio Simone Lagana, Mostafa Abdalla, Sean Kehoe, Susan Addley, Hooman Soleymani Majd
Summary: High grade endometrioid endometrial cancer (HGEEC) is a heterogeneous group of tumors with unclear prognostic features. Cervical stromal involvement is independently related to recurrence and cancer-related death. The recurrence pattern suggests the potential use of patient-initiated follow-up (PIFU) for HGEEC survivors, especially for patients without cervical involvement and after two years from treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Nida S. Safdar, Marina Stasenko, Pier Selenica, Axel S. Martin, Edaise M. da Silva, Ana Paula Martins Sebastiao, Melissa Krystel-Whittemore, Nadeem R. Abu-Rustum, Jorge S. Reis-Filho, Robert A. Soslow, Ronglai Shen, Jennifer J. Mueller, Esther Oliva, Britta Weigelt
Summary: Using genomic sequencing techniques, this study identified chromosome 1q gain, PIK3CA mutation, and DNA mismatch repair-deficient molecular subtype as independent predictors of early recurrences in low-stage, low-grade endometrioid endometrial carcinoma patients.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Zhao Liu, Jinghe Lang, Ming Wu, Lei Li
Summary: Staging surgeries should be considered in patients with apparent stage IA endometrioid endometrial carcinoma who have larger, higher grade tumors, positive lymph-vascular space invasion, or lower uterine segment involvement.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pathology
Ignacio Ruz-Caracuel, Alvaro Lopez-Janeiro, Victoria Heredia-Soto, Jorge L. Ramon-Patino, Laura Yebenes, Alberto Berjon, Alicia Hernandez, Alejandro Gallego, Patricia Ruiz, Andres Redondo, Alberto Pelaez-Garcia, Marta Mendiola, David Hardisson
Summary: The study found that CTNNB1 exon 3 mutation in low-grade, early-stage endometrioid endometrial carcinomas has a negative impact on disease-free survival, but no effect on overall survival; and nuclear beta-catenin shows better predictive value for CTNNB1 exon 3 mutation in these tumors.
Article
Oncology
Marko Hojnik, Snjezana Frkovic Grazio, Ivan Verdenik, Tea Lanisnik Rizner
Summary: The study found that AKR1B1 and AKR1B10 play protective roles in endometrioid endometrial cancer and have the potential as prognostic biomarkers. Patients with higher immunohistochemical levels of both AKR1B1 and AKR1B10 showed better survival rates. However, no significant differences were observed in patients with serous endometrial cancer.
Article
Biotechnology & Applied Microbiology
Xiaofei Liu, Junbo Zhao, Zhiwei Sun, Guangwei Wang
Summary: A retrospective analysis was conducted on data from 11,519 patients with G3 EACs to construct a nomogram for decision-making and prognosis prediction. Cox regression analysis identified age, race, tumor size, lymph node resection, stage, and adjuvant therapy as prognostic factors. The nomogram accurately predicted survival rates and will aid clinicians in managing patients more effectively.
Article
Oncology
Mary Katherine Montes de Oca, Benjamin B. Albright, Angeles Alvarez Secord, Laura J. Havrilesky, Haley A. Moss
Summary: This retrospective cohort study found that the combination of adjuvant chemotherapy and radiation therapy significantly improved overall survival for patients with stage IIIA grade 1 endometrial adenocarcinoma. Additionally, older age, increasing comorbidity count, and lymphovascular space invasion status were significant negative predictors of survival.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Oncology
Dimitrios Nasioudis, Spyridon A. Mastroyannis, Emily M. Ko, Ashley F. Haggerty, Lori Cory, Robert L. Giuntoli, Sarah H. Kim, Nawar A. Latif
Summary: This study found that ovarian preservation is rarely performed for patients with stage I grade 2 and 3 endometrioid endometrial carcinoma undergoing hysterectomy, however, it does not have a significant negative effect on overall survival.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Biochemistry & Molecular Biology
Changho Song, Kyoung Bo Kim, Gi Su Lee, Soyoung Shin, Byoungje Kim
Summary: This study found that the overexpression of the HOXA5 gene is associated with poor overall survival in patients with endometrioid adenocarcinoma (EAEC) and is an independent risk factor for poor prognosis in EAEC. The overexpression of HOXA5 is also associated with a higher histological grade of EAEC and TP53 mutation or high copy number of EC. These findings suggest the potential of HOXA5 as a novel biomarker for predicting poor survival outcomes in patients with EAEC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Stephanie W. Vrede, Jenneke Kasius, Johan Bulten, Steven Teerenstra, Jutta Huvila, Eva Colas, Antonio Gil-Moreno, Dorry Boll, Maria Caroline Vos, Anne M. van Altena, Jasmin Asberger, Sanne Sweegers, Willem Jan van Weelden, Louis J. M. van Der Putten, Frederic Amant, Nicole C. M. Visser, Marc P. L. M. Snijders, Heidi V. N. Kusters-Vandevelde, Roy Kruitwagen, Xavier Matias-Guiu, Vit Weinberger, Casper Reijnen, Johanna M. A. Pijnenborg
Summary: Patients with low-grade endometrial cancer have a favorable prognosis independent of molecular subgroup. Routine molecular profiling is not supported for patients with low-grade endometrial cancer, highlighting the importance of primary diagnostic tumor grading and selective profiling.
Article
Surgery
Ariane C. Youssefzadeh, Maximilian Klar, Gabriel J. Seifert, Rachel S. Mandelbaum, Rauvynne N. Sangara, Lauren E. McCarthy, Vincent Cheng, Kazuhide Matsushima, Joseph G. Ouzounian, Koji Matsuo
Summary: This retrospective cohort study assessed the trends, characteristics, and outcomes of pregnancy after bariatric surgery in the United States. The study found a gradual increase in pregnancy after bariatric surgery in recent years. Women with a history of bariatric surgery were more likely to experience severe maternal morbidity and receive blood product transfusion during pregnancy. Rating: 8 out of 10.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Letter
Oncology
Koji Matsuo, Andrew Vallejo, Alesandra R. R. Rau, Marcia A. A. Ciccone, Lynda D. D. Roman, Maximilian Klar
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
Koji Matsuo, Alesandra R. Rau, Hiroko Machida, Lynda D. Roman, Jason D. Wright
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Review
Oncology
Caroline J. Violette, Ravi Agarwal, Rachel S. Mandelbaum, Jose L. Gonzalez, Kurt M. Hong, Lynda D. Roman, Maximilan Klar, Jason D. Wright, Richard J. Paulson, Andreas Obermair, Koji Matsuo
Summary: This article summarizes recent studies on the risk factors for the development of malignant endometrial pathology, such as obesity, PCOS, and T2DM. The efficacy of fertility-sparing treatment is discussed, and a potential new adjunct treatment approach is explored. The authors propose a need for personalized treatment and suggest that GLP-1 receptor agonists may play a role in fertility-sparing treatment for obese patients with malignant endometrial pathology.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Article
Oncology
Hiroko Machida, Koji Matsuo, Masayuki Tanaka, Kanae Kitatani, Akinori Takase, Keiko Yokoyama, Hiroshi Kajiwara, Miwa Yasaka, Masae Ikeda, Hiroshi Yoshida, Takeshi Hirasawa, Mikio Mikami
Summary: This study aimed to explore the molecular characteristics of cervical adenocarcinoma in a Japanese population. The results suggest that ROS1 gene alteration may be a prognostic biomarker for cervical adenocarcinoma in Japanese patients.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Koji Matsuo, Rachel S. Mandelbaum, Andrew Vallejo, Maximilian Klar, Lynda D. Roman, Jason D. Wright
Summary: This cohort study examined the gender-specific COVID-19 case fatality risks among patients with a malignant neoplasm. The results showed that both gender and malignant neoplasm were associated with increased COVID-19 in-hospital case fatality risk. The study also found that certain types of cancer had a greater than 2-fold increased COVID-19 in-hospital case mortality risk.
Letter
Medicine, General & Internal
Koji Matsuo, Jessica M. Green, Sarah A. Herrman, Rachel S. Mandelbaum, Joseph G. Ouzounian
Summary: This cohort study investigates the patient characteristics and maternal outcomes related to COVID-19 infection in pregnant patients during the early stage of the pandemic in the US.
Article
Medicine, General & Internal
Koji Matsuo, Shinya Matsuzaki, Michihide Maeda, Alesandra R. Rau, Kosuke Yoshihara, Ryo Tamura, Muneaki Shimada, Hiroko Machida, Mikio Mikami, Maximilian Klar, Lynda D. Roman, Jason D. Wright, Anil K. Sood, David M. Gershenson
Summary: This study investigates the use and survival outcomes of neoadjuvant chemotherapy (NACT) in less common histologic subtypes of epithelial ovarian cancer. The results show that NACT use has gradually increased, but for patients with low-grade serous carcinoma, NACT is associated with worse survival compared with primary debulking surgery.
Article
Medicine, General & Internal
Jason D. Wright, Ling Chen, Yukio Suzuki, Koji Matsuo, Dawn L. Hershman
Summary: This study examines the trends of gender-affirming surgery (GAS) in the US and finds a substantial increase in the performance of GAS. Breast and chest procedures are the most common, with younger patients more likely to undergo these procedures and older patients more likely to undergo genital surgery.
Article
Medicine, General & Internal
Jessica M. Green, Sonya P. Fabricant, Christina J. Duval, Viraj R. Panchal, Sigita S. Cahoon, Rachel S. Mandelbaum, Joseph G. Ouzounian, Jason D. Wright, Koji Matsuo
Summary: This study found that the number of pregnant women experiencing homelessness gradually increased in the US during the 5-year study period, and they were identified as a high-risk pregnancy group.
Meeting Abstract
Obstetrics & Gynecology
Alesandra R. Rau, Ariane C. Youssefzadeh, Shinya Matsuzaki, Rachel S. Mandelbaum, Joseph G. Ouzounian, Koji Matsuo
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Amin Tavakoli, Viraj Panchal, Genevieve R. Mazza, Rachel S. Mandelbaum, Joseph G. Ouzounian, Koji Matsuo
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Genevieve R. Mazza, Ariane C. Youssefzadeh, Rachel S. Mandelbaum, Joseph G. Ouzounian, Kazuhide Matsushima, Koji Matsuo
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Syem K. Barakzai, Ailene Nguyen, Sanchala Sehgal, Koji Matsuo, Wenjing Shi, Sonia Veran-Taguibao, Melissa L. Wilson, Brian J. Gordon
Summary: The aim of this study was to evaluate the clinical relevance of HR-HPV negativity at the time of unsatisfactory cervical cytology. The study found that patients with unsatisfactory cervical cytology and negative HR-HPV testing showed high concordance with negative results on follow-up satisfactory cervical cytology, and had a low risk of CIN 2 or greater.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Koji Matsuo, Maximilian Klar, Syem K. Barakzai, Neda D. Jooya, David J. Nusbaum, Muneaki Shimada, Lynda D. Roman, Jason D. Wright
Summary: This study examined the trends, characteristics, and outcomes related to sentinel lymph node (SLN) biopsy in early stage ovarian cancer. The study found that SLN biopsy was rarely performed in this population, and there was insufficient evidence to determine its impact on survival. Further research and evaluation are needed to assess the feasibility and oncologic outcomes of SLN biopsy in early ovarian cancer.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
