Review
Oncology
Elisabetta Macerola, Anello Marcello Poma, Paola Vignali, Alessio Basolo, Clara Ugolini, Liborio Torregrossa, Ferruccio Santini, Fulvio Basolo
Summary: Thyroid tumors derived from follicular cells are heterogeneous in nature, with variable morphological appearance and differentiation levels. Molecular markers play a significant role in both diagnostic and prognostic stratification, especially in the presurgical setting and for identifying genetic alterations related to prognosis. The advent of targeted drugs has further emphasized the importance of molecular characterization in guiding therapeutic strategies for patients with advanced tumors.
Editorial Material
Multidisciplinary Sciences
Tikvah K. K. Hayes, Matthew Meyerson
Summary: Assessing genetic and cellular changes in human lung cancer during its progression can contribute to the development of treatments, as reported by the TRACERx project.
Review
Pathology
Jeehoon Ham, Bin Wang, Joseph William Po, Amandeep Singh, Navin Niles, Cheok Soon Lee
Summary: The 'seed and soil' theory proposed by Stephen Paget in 1989 highlighted the importance of the stromal environment in cancer growth and metastasis. A paradigm shift is needed in research to decipher the molecular events and networks in the stromal environment for effective cancer growth inhibition.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Gastroenterology & Hepatology
Andreas Geier, Dina Tiniakos, Helmut Denk, Michael Trauner
Summary: Non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease worldwide. Understanding its pathological and molecular hallmarks is crucial for appropriate clinical management and research. This disease has evolved from a nebulous entity in the 19th century to a vigorously investigated liver disease today.
Article
Gastroenterology & Hepatology
Korsuk Sirinukunwattana, Enric Domingo, Susan D. Richman, Keara L. Redmond, Andrew Blake, Clare Verrill, Simon J. Leedham, Aikaterini Chatzipli, Claire Hardy, Celina M. Whalley, Chieh-Hsi Wu, Andrew D. Beggs, Ultan McDermott, Philip D. Dunne, Angela Meade, Steven M. Walker, Graeme Murray, Leslie Samuel, Matthew Seymour, Ian Tomlinson, Phil Quirke, Timothy Maughan, Jens Rittscher, Viktor H. Koelzer
Summary: This study utilized deep learning to analyze histological images of colorectal cancer tissue samples and successfully predicted consensus molecular subtypes, addressing the issue of molecular classification. The image-based classification method accurately identified samples that were unclassifiable by RNA expression analysis, showing potential for biological stratification.
Review
Biochemistry & Molecular Biology
Joon Hyuk Choi, Swan N. Thung
Summary: Hepatocellular carcinoma is a primary liver cancer with molecular heterogeneity. Accurate diagnosis of HCC is crucial for patient management and prognosis. This review provides an update on HCC pathology.
Review
Medicine, General & Internal
Roy S. Herbst, Dara L. Aisner, Joshua R. Sonett, Andrew T. Turk, Joshua L. Weintraub, Neal I. Lindeman
Summary: Genomic profiling for advanced non-small cell lung cancer patients is becoming increasingly important to guide treatment selection and provide more targeted therapeutic options. A multidisciplinary advisory board was held to address the challenges faced in establishing institutional genomic screening programs for NSCLC, with potential solutions devised to overcome these barriers.
FRONTIERS IN MEDICINE
(2021)
News Item
Multidisciplinary Sciences
Heidi Ledford
Summary: Studies in mice indicate that tumor growth can be initiated by inflammation induced by tiny particles.
Review
Biochemistry & Molecular Biology
Yi Liu, Yiqiu Xia, Jillian Smollar, Wenjun Mao, Yuan Wan
Summary: sEVs are submicron-sized particles released from cells, carrying tissue-specific molecules and playing important roles in tumors. Research indicates their potential for diagnosis, staging, and treatment monitoring in cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Editorial Material
Oncology
Kristopher K. Frese, Kathryn L. Simpson, Caroline Dive
Summary: Gay et al. present a molecular classification of small cell lung cancers in Cancer Cell, extending previous studies on personalized treatments. Their identification of an "inflamed" subtype suggests potential susceptibility to immunotherapy after acquired chemoresistance.
Article
Pathology
Roman E. Zyla, Elan Hahn, Anjelica Hodgson
Summary: STK11 gene plays a crucial role in tumorigenesis, with mutations associated with Peutz-Jeghers syndrome, lung adenocarcinoma, and potentially affecting prognosis and response to immunotherapy in cancer patients. Further studies are needed to validate STK11 mutations as a routine clinical biomarker.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Oncology
Giuseppe Giaccone, Yongfeng He
Summary: Lung cancer is the leading cause of cancer related death, with two major histological subtypes, NSCLC and SCLC. Transformation from NSCLC to SCLC can cause treatment resistance, potentially due to therapy-induced changes or clonal selection. This article discusses the potential mechanisms, cell of origin, and genomic alterations in both de novo and transformed SCLC, as well as treatment options including chemotherapy, radiotherapy, TKIs, immunotherapy, and antiangiogenic agents.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Pengkun Yin, Bin Hu, Qiang Li, Yixiang Duan, Qingyu Lin
Summary: The study proposed an innovative method for diagnostic analysis of clinical lung cancer tissues based on label-free imaging. Laser-induced breakdown spectroscopy imaging was used to obtain the heterogeneity of multielements and molecular fragments in three types of clinical samples. Results revealed differential distribution of Ca, Mg, Na, and Cu in different tissues, as well as spatial heterogeneity of molecular fragments between tumor and necrosis regions.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2021)
Article
Oncology
Caicun Zhou, Suresh S. Ramalingam, Tae Min Kim, Sang-We Kim, James Chih-Hsin Yang, Gregory J. Riely, Tarek Mekhail, Danny Nguyen, Maria R. Garcia Campelo, Enriqueta Felip, Sylvie Vincent, Shu Jin, Celina Griffin, Veronica Bunn, Jianchang Lin, Huamao M. Lin, Minal Mehta, Pasi A. Janne
Summary: This study evaluated the treatment outcomes and safety of mobocertinib in patients with previously treated EGFRex2Oins-positive mNSCLC, showing clinically meaningful benefit and manageable safety profile in this patient population.
Review
Biology
Alessandro Ottaiano, Monica Ianniello, Mariachiara Santorsola, Raffaella Ruggiero, Roberto Sirica, Francesco Sabbatino, Francesco Perri, Marco Cascella, Massimiliano Di Marzo, Massimiliano Berretta, Michele Caraglia, Guglielmo Nasti, Giovanni Savarese
Summary: Cancer is a complex disease characterized by aberrant cellular behaviors and genetic variances, leading to tumor heterogeneity. This heterogeneity poses challenges in cancer prognosis and treatment, and understanding and quantifying it is crucial. This review emphasizes the significance of comprehending tumor heterogeneity to raise awareness about this elusive characteristic of cancer.
Article
Medicine, Research & Experimental
Sandra Caramujo-Balseiro, Carlos Faro, Lina Carvalho
Summary: This study discusses the link between dietary habits, genes, and colorectal cancer occurrence, proposing four fundamental metabolic pathways and analyzing related gene polymorphisms. It also highlights the association between diet and genes, as well as the importance in CRC prevention or treatment.
MEDICAL HYPOTHESES
(2021)
Review
Pathology
Jasna Metovic, Marco Barella, Fabrizio Bianchi, Paul Hofman, Veronique Hofman, Myriam Remmelink, Izidor Kern, Lina Carvalho, Linda Pattini, Angelica Sonzogni, Giulia Veronesi, Sergio Harari, Fabien Forest, Mauro Papotti, Giuseppe Pelosi
Summary: The discussion in the article revolves around the morphological and molecular classification of lung neuroendocrine neoplasms, focusing on supervised and unsupervised approaches. It emphasizes the strengths and weaknesses of the current classification of lung NENs and provides an alternative outlook based on biological data.
Article
Oncology
Mariana Amaral, Adilia J. Charmier, Ricardo A. Afonso, Jose Catarino, Pedro Faisca, Lina Carvalho, Lia Ascensao, Joao M. P. Coelho, M. Manuela Gaspar, Catarina Pinto Reis
Summary: Anaplastic thyroid carcinoma (ATC) is a highly lethal subtype of thyroid cancer that does not respond well to traditional treatments. This study developed specialized gold nanoparticles (AuNPs) for photothermal therapy (PTT) targeted specifically at ATC. The functionalized holo-transferrin AuNPs showed the best efficacy for PTT against ATC and demonstrated good safety and biodistribution when administered in vivo. These results suggest that AuNPs-mediated-PTT could be a promising treatment for ATC in the future.
Article
Oncology
P. Hofman, M. Ilie, E. Chamorey, P. Brest, R. Schiappa, V Nakache, M. Antoine, M. Barberis, H. Begueret, F. Bibeau, C. Bonnetaud, P. Bostroem, P. Brousset, L. Bubendorf, L. Carvalho, G. Cathomas, A. Cazes, L. Chalabreysse, M-P Chenard, M-C Copin, J-F Cote, D. Damotte, L. de Leval, P. Delongova, V. Thomas de Montpreville, A. de Muret, A. Dema, W. Dietmaier, M. Evert, A. Fabre, F. Forest, A. Foulet, S. Garcia, M. Garcia-Martos, L. Gibault, G. Gorkiewicz, D. Jonigk, J. Gosney, A. Hofman, I Kern, K. Kerr, M. Kossai, M. Kriegsmann, S. Lassalle, E. Long-Mira, A. Lupo, A. Mamilos, R. Matej, J. Meilleroux, C. Ortiz-Villalon, L. Panico, A. Panizo, M. Papotti, P. Pauwels, G. Pelosi, F. Penault-Llorca, O. Pop, N. Pote, S. R. Y. Cajal, J-C Sabourin, I Salmon, M. Sajin, S. Savic-Prince, H-U Schildhaus, P. Schirmacher, I Serre, E. Shaw, D. Sizaret, A. Stenzinger, J. Stojsic, E. Thunnissen, W. Timens, G. Troncone, C. Werlein, H. Wolff, J-P Berthet, J. Benzaquen, C-H Marquette, V Hofman, F. Calabrese
Summary: This study evaluated the impact of the COVID-19 outbreak on pathology laboratories in Europe, finding a significant decrease in workload in clinical and molecular pathology, a high proportion of employees working remotely, and the adoption of virtual meetings for training in most laboratories. Improved harmonization of biosafety procedures is needed.
Article
Dentistry, Oral Surgery & Medicine
Jose P. Martinho, Ana Coelho, Barbara Oliveiros, Salome Pires, Ana Margarida Abrantes, Siri Paulo, Ana Catarina Carvalho, Eunice Carrilho, Anabela Paula, Lina Carvalho, Raquel Seica, Maria Filomena Botelho, Carlos Miguel Marto, Gianrico Spagnuolo, Paulo Matafome, Manuel Marques Ferreira
Summary: The study found that diabetes has a significant impact on the success rate of root canal treatment, with diabetic patients having a significantly lower success rate than the control group. Diabetic rats in the experiment showed metabolic abnormalities and tissue damage.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Pathology
Raffaella Santi, Roberta Ballestriero, Vincenzo Canzonieri, Jacek Gulcznsky, Rosa Henriques de Gouveia, Aurelio Ariza, Lina Carvalho, Gabriella Nesi
Summary: Pathology museums have both biological value for scientific research and cultural value as artistic heritage. A European Pathology Museum Network would facilitate the study and access of antique pathology collections.
Article
Oncology
Matteo Bulloni, Giada Sandrini, Irene Stacchiotti, Massimo Barberis, Fiorella Calabrese, Lina Carvalho, Gabriella Fontanini, Greta Ali, Francesco Fortarezza, Paul Hofman, Veronique Hofman, Izidor Kern, Eugenio Maiorano, Roberta Maragliano, Deborah Marchiori, Jasna Metovic, Mauro Papotti, Federica Pezzuto, Eleonora Pisa, Myriam Remmelink, Gabriella Serio, Andrea Marzullo, Senia Maria Rosaria Trabucco, Antonio Pennella, Angela De Palma, Giuseppe Marulli, Ambrogio Fassina, Valeria Maffeis, Gabriella Nesi, Salma Naheed, Federico Rea, Christian H. Ottensmeier, Fausto Sessa, Silvia Uccella, Giuseppe Pelosi, Linda Pattini
Summary: Lung neuroendocrine neoplasms (lung NENs) are classified based on morphology, lacking the ability to fully reflect clinical outcomes. Subjectivity and poor reproducibility in diagnosis and prognosis assessment are common in all NENs. A machine learning framework is proposed for tumor prognosis assessment by evaluating the spatial distribution of Ki-67-positive cells in an automated and repeatable manner.
Article
Biochemistry & Molecular Biology
Tania Ferreira-Goncalves, Maria Manuela Gaspar, Joao M. P. Coelho, Vanda Marques, Ana S. Viana, Lia Ascensao, Lina Carvalho, Cecilia M. P. Rodrigues, Hugo Alexandre Ferreira, David Ferreira, Catarina Pinto Reis
Summary: Breast cancer is a burdensome malignancy for society, and researchers have developed a strategy using gold nanoparticles combined with near infrared irradiation as a photothermal therapy for diagnosis and treatment. The synthesized gold nanoparticles have favorable properties and are safe for use.
Editorial Material
Respiratory System
Raquel Viana, Lina Carvalho, Claudia Santos
Summary: This paper presents a clinical image of a complex developmental anomaly that is typically diagnosed prenatally or during childhood. Its occurrence in adult life is extremely rare, as seen in this particular case.
RESPIROLOGY CASE REPORTS
(2022)
Article
Medicine, General & Internal
Joao Gama, Rui Caetano Oliveira, Roberto Jarimba, Vitor Sousa
Summary: Leiomyomas of the paratesticular region, especially the subtype called bizarre nuclei leiomyoma, are rare. It is important to recognize the histological features of bizarre nuclei leiomyoma in order to differentiate it from its malignant counterpart, leiomyosarcoma.
Article
Medicine, General & Internal
Joao Miguel Santos, Joana A. Marques, Margarida Esteves, Vitor Sousa, Paulo J. Palma, Sergio Matos
Summary: Intentional replantation is a valid treatment modality for post-treatment apical periodontitis. It can promote tooth preservation and achieve bone regeneration and hypoesthesia resolution in properly selected cases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Rheumatology
Ana R. Prata, Helena Assuncao, Gisela Eugenio, Vitor Sousa, Catia Duarte
RHEUMATOLOGY ADVANCES IN PRACTICE
(2022)
Article
Pathology
Rosa Henriques de Gouveia, Raffaella Santi, Roberta Ballestriero, Francesco M. Galassi, Lina Carvalho, Gabriella Nesi
Summary: During the 19th century, wax models of normal and diseased organs were crucial for medical education in European university hospitals, particularly highlighting heart diseases and pathology. The wax models exhibited congenital malformations, infectious and inflammatory disorders, as well as cardiac hypertrophy, dilation, valvular pathology, and adiposity, emphasizing their importance in both historical and contemporary medical education.
POLISH JOURNAL OF PATHOLOGY
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Joana Espirito Santo, Ana Ladeirinha, Ana Alarcao, Lia Neves, Eugeniu Strelet, Marco Reis, Rui Santos, Lina Carvalho
Meeting Abstract
Gastroenterology & Hepatology
Joana Espirito Santo, Ana Ladeirinha, Ana Alarcao, Lia Neves, Eugeniu Strelet, Marco Reis, Rui Santos, Lina Carvalho