Review
Food Science & Technology
Joseph Festa, Aamir Hussain, Zakia Al-Hareth, Harprit Singh, Mariasole Da Boit
Summary: Anthocyanins, a type of flavonoid polyphenols, have been studied for their potential in improving cardiovascular health and preventing endothelial dysfunction. However, their poor bioavailability raises questions about the role of their metabolites in the observed biological activity. Recent studies have used different models and concentrations to better understand the mechanisms of action of these compounds. The review highlights the need for further research on improving the bioavailability of the metabolites and exploring the effects of metabolites in mixtures.
Article
Biochemistry & Molecular Biology
Xuanyou Liu, Aimin Wang, Zhiheng Chen, Yuqi Cui, Hong Hao, Timothy L. Domeier, Qinghua Sun, Zhenguo Liu
Summary: Exposure to ambient fine particulate matter (PM) is associated with an increased risk of cardiovascular diseases (CVDs). There are major sex differences between males and females in the epidemiology, pathophysiology, and outcome of CVDs. Endothelial progenitor cells (EPCs) play a vital role in the development and progression of CVDs. This study found that PM exposure-induced reduction of EPCs is observed in male, not female, mice with increased reactive oxygen species (ROS) production and oxidative stress.
Article
Environmental Sciences
Tingting Wei, Cuicui Chen, Yanjie Yang, Li Li, Jian Wang, Maosong Ye, Haidong Kan, Dong Yang, Yuanlin Song, Jing Cai, Dongni Hou
Summary: This study examined the effects of short-term exposure to multiple air pollutants on lung function and inflammatory markers. The results showed that high-level air pollution is associated with decreased small airway function and systemic inflammation. Specifically, PM2.5, SO2, and CO were associated with declines in FEF25-75%, and all examined pollutants were associated with declines in FEV1/FVC. These associations were stronger in males than females. Furthermore, all examined pollutants were associated with lower peripheral neutrophil count.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Environmental Sciences
Yingxin Li, Xueli Yuan, Jing Wei, Yuanying Sun, Wenqing Ni, Hongmin Zhang, Yan Zhang, Rui Wang, Ruijun Xu, Gongbo Chen, Yuewei Liu, Jian Xu
Summary: This study investigated the association between long-term exposure to ambient PM1, PM2.5, and PM10 and kidney function impairment in older adults. The results showed that exposure to these particulate matters was significantly associated with decreased estimated glomerular filtration rate (eGFR) and increased odds of chronic kidney disease (CKD) and proteinuria.
ATMOSPHERIC ENVIRONMENT
(2023)
Article
Environmental Sciences
Yan Wang, Ying Ma, Yongshuai Yao, Qing Liu, Yanting Pang, Meng Tang
Summary: This study assessed the dynamic autophagic state in human vascular endothelial cells exposed to ambient particulate matter by detecting autophagic marker proteins and turnover assays. The results showed that PM SRM1648a can induce excess autophagic vacuoles in cells, with differences in underlying causes based on exposure duration. It was found that LC3II upregulation was due to intensifying autophagic initiation after 6 hours of exposure, while longer exposure periods resulted in defective autophagy and lysosomal dysfunction.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Su Hoon Lee, Sun Mok Ha, Min Jae Jeong, Dong Jun Park, Carlos Noriega Polo, Young Joon Seo, Seong Heon Kim
Summary: Research on the toxicity and underlying mechanisms of PM in the middle ear is limited, making it crucial to identify toxic PM constituents based on season and region and investigate their health effects. Experimental findings show that PM exposure increases COX-2 and TNF-alpha mRNA expression, ROS generation, induces inflammatory responses, causes abnormalities in mitochondrial motility and function, and leads to cell apoptosis, particularly at a concentration of 100 μg/mL, reducing cell survival.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Wei Hu, Yanhua Wang, Ting Wang, Qianpeng Ji, Qiang Jia, Tao Meng, Sai Ma, Zhihu Zhang, Yanbo Li, Rui Chen, Yufei Dai, Yang Luan, Zhiwei Sun, Shuguang Leng, Huawei Duan, Yuxin Zheng
Summary: The study found that PM2.5 and total PAHs concentrations were significantly correlated with increased levels of urinary 8OHdG, 8-iso-PGF2α, and MDA. Essential metals showed exposure-response increase in 8-OHdG levels. Certain metals were significantly correlated with urinary 8-iso-PGF2α and MDA. Each one-unit increase in urinary total OH-PAHs resulted in increases in 8-OHdG, 8-iso-PGF2α, and MDA. Additionally, all 12 urinary metals showed significant and positive correlations with oxidative stress biomarkers in all subjects.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Construction & Building Technology
Brian Considine, John Gallagher, Prashant Kumar, Aonghus McNabola
Summary: Numerical analysis of commercial AHU inlets revealed that the design of AHU inlets has significant implications on indoor air quality and building energy consumption, with potential to positively impact both aspects through inlet design.
Article
Pharmacology & Pharmacy
Mengyu Gao, Yuanyuan Ma, Jing Luo, Daochuan Li, Menghui Jiang, Qixiao Jiang, Jingbo Pi, Rui Chen, Wen Chen, Rong Zhang, Yuxin Zheng, Lianhua Cui
Summary: Exposure to particulate matter is associated with vascular wall thickening, and Nrf2 knockout may exacerbate this effect, potentially through the regulation of the ACE/ANGII/AT1R axis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Materials Science, Textiles
Sabit Adanur, Ajay Jayswal
Summary: Face masks and respirators are different types of face covering devices, with masks providing protection against particulate matters and biological pathogens. However, wearing masks for a long period of time is not recommended. This article reviews the available types of masks, their filtration mechanisms, manufacturing methods, and decontamination methods, aiming to assist with the COVID-19 pandemic.
JOURNAL OF INDUSTRIAL TEXTILES
(2022)
Article
Multidisciplinary Sciences
Huasong Bai, Ying Wang, Peng Wu, Zhanzhong Wang
Summary: This study investigated the cellular injury in cat lung cells exposed to APM extracts, and found that VE, lycopene, and EPA: DHA can alleviate the damage. Treatment with EPA: DHA also increased antioxidant enzyme activities and decreased oxidative stress indices.
Article
Biochemistry & Molecular Biology
Xuanyou Liu, Yichao Xiao, Qingyi Zhu, Yuqi Cui, Hong Hao, Meifang Wang, Peter J. Cowan, Ronald J. Korthuis, Guangfu Li, Qinghua Sun, Zhenguo Liu
Summary: PM exposure increased inflammatory cytokine levels and oxidative stress in both male and female mice, but to a greater extent in males. Circulating EPC levels were significantly decreased in males but remained unchanged in females, with antioxidants effectively preventing these effects in male mice. Female mice, despite ovariectomy, showed no significant impact on circulating EPC levels with PM exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Lord Famiyeh, Chunrong Jia, Ke Chen, Yu-Ting Tang, Dongsheng Ji, Jun He, Qingjun Guo
Summary: This study investigates the association between oxidative potential (OP) and lung-deposited dose (LDD) of ambient particles in specific regions of human lungs. The results show that quasi-ultrafine particles have the highest OP deposition in the tracheobronchial and pulmonary regions, while coarse particles dominate in the extrathoracic region. Additionally, the study reveals that there is no strong relationship between extrinsic OP and PM doses.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Su-Yeon Oh, Yun-Ho Kim, Min-Kyung Kang, Eun-Jung Lee, Dong-Yeon Kim, Hyeongjoo Oh, Soo-Il Kim, Woojin Na, Il-Jun Kang, Young-Hee Kang
Summary: This study found that aesculetin can alleviate airway thickening and mucus hypersecretion induced by inhalation of uPM(10) by inhibiting TLR4 and EGFR induced by oxidative stress.
Article
Medicine, General & Internal
Diana Cervantes, Niccolette Schaunaman, Gregory P. Downey, Hong Wei Chu, Brian J. Day
Summary: Deployment related asthma-like symptoms have been observed in military personnel who served in Iraq and Afghanistan. This study aimed to investigate the effect of respiratory exposure to particulate matter from Afghanistan (PMa) on distal airway hyperresponsiveness (AHR) and the role of IL-13 and mitochondrial dysfunction in this process. The results suggest that PMa, in the presence of IL-13, increases AHR through oxidative stress and ATP signaling.
FRONTIERS IN MEDICINE
(2023)
Article
Environmental Sciences
Xinchen Lu, Yan Lin, Xinghua Qiu, Jinming Liu, Tong Zhu, Jesus A. Araujo, Oliver Fiehn, Yifang Zhu
Summary: This study provides mechanistic evidence on the effects of BPA exposure on lipid metabolism and the development of cardiometabolic disorders.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Engineering, Environmental
Zhen Cheng, Xinghua Qiu, Xiaodi Shi, Xing Jiang, Tong Zhu
Summary: Ambient air pollution is a significant risk to public health due to the presence of numerous known and unknown compounds. This study reviews the analytical techniques for air pollution, focusing on the omics approach, including sample preparation, analysis, compounds prioritization, and identification. High-resolution mass spectrometry combined with chromatography allows for the digitalization of complex environmental matrices into full-component data. Chemical fingerprints, suspect lists, and biological effects are essential strategies for screening critical and hazardous substances. The omics approach provides a paradigm for discovering emerging air pollutants, but further advancements in instruments and databases are needed to assess the health risks associated with key pollutants.
FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING
(2023)
Article
Biochemical Research Methods
Haonan Li, Yiqun Han, Teng Wang, Wu Chen, Yifan Xu, Ke Gao, Yanwen Wang, Jicheng Gong, Weiju Li, Hongyin Zhang, Junxia Wang, Xinghua Qiu, Tong Zhu
Summary: This study developed and validated a simple and rapid LC-MS/MS method for the quantification of low-abundance lysoglycerophospholipids (Lyso-GPLs) in plasma. The method showed good accuracy and sensitivity, and enabled the quantification of different types of Lyso-GPLs. The application of this method can improve understanding of the roles of circulating low-abundant Lyso-GPLs in health and diseases.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Meteorology & Atmospheric Sciences
Yan Ren, Hongsheng Zhang, Xiaoye Zhang, Bingui Wu, Xuhui Cai, Yu Song, Tong Zhu
Summary: This study investigates the characteristics of the stable boundary layer (SBL) in haze pollution events using observational data. The study finds that the decoupled SBL dominates in haze pollution events and has notable differences in turbulent structure compared to the coupled SBL. The existence of the decoupled SBL requires further research and attention to improve the accuracy of pollutant concentration forecasting.
ATMOSPHERIC RESEARCH
(2023)
Article
Environmental Sciences
Jiajianghui Li, Yutong Samuel Cai, Frank J. Kelly, Martin J. Wooster, Yiqun Han, Yixuan Zheng, Tianjia Guan, Pengfei Li, Tong Zhu, Tao Xue
Summary: The study found that PM2.5 from landscape fires had a stronger association with ARI among children under 5 years compared to PM2.5 from non-fire sources. Each 1 μg/m³ increment of fire-sourced PM2.5 was associated with a 3.2% increase in the risk of ARI. The proportion of fire-sourced particles significantly mediated the association between total PM2.5 concentration and ARI.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Pengfei Li, Jingyi Wu, Ruohan Wang, Hengyi Liu, Tong Zhu, Tao Xue
Summary: This study analyzed the association between long-term exposure to PM2.5 from different sources and under-five deaths (U5Ds) in vulnerable children in low- and middle-income countries (LMICs). The results showed that PM2.5 from desert dust, solid biofuel combustion, and open fires had the greatest impact on child health. Public health interventions should consider the source profile of PM2.5 to effectively protect child health.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Meteorology & Atmospheric Sciences
Tong Zhu, Mingjin Tang, Meng Gao, Xinhui Bi, Junji Cao, Huizheng Che, Jianmin Chen, Aijun Ding, Pingqing Fu, Jian Gao, Yang Gao, Maofa Ge, Xinlei Ge, Zhiwei Han, Hong He, Ru-Jin Huang, Xin Huang, Hong Liao, Cheng Liu, Huan Liu, Jianguo Liu, Shaw Chen Liu, Keding Lu, Qingxin Ma, Wei Nie, Min Shao, Yu Song, Yele Sun, Xiao Tang, Tao Wang, Tijian Wang, Weigang Wang, Xuemei Wang, Zifa Wang, Yan Yin, Qiang Zhang, Weijun Zhang, Yanlin Zhang, Yunhong Zhang, Yu Zhao, Mei Zheng, Bin Zhu, Jiang Zhu
Summary: In the past 25 years, atmospheric chemistry research in China has grown rapidly, focusing on the concept of air pollution complexity. Over 24,000 papers on air pollution, authored or co-authored by Chinese scientists, were published in 2021. This paper reviews representative studies on various aspects of atmospheric chemistry in China, providing a starting point for understanding the field. The advances discussed in this paper have established a theoretical framework for air pollution, supported effective air pollution control policies in China, and created opportunities for education and career development.
ADVANCES IN ATMOSPHERIC SCIENCES
(2023)
Article
Environmental Sciences
Pengfei Li, Jingyi Wu, Mingkun Tong, Jiajianghui Li, Ruohan Wang, Xueqiu Ni, Hong Lu, Jianyu Deng, Siqi Ai, Tao Xue, Tong Zhu
Summary: This study examined the effect of long-term exposure to PM2.5 from different sources on birthweight in low-and middle-income countries. The results showed that exposure to PM2.5 from sources such as international shipping, solvents, agricultural waste burning, road transportation, waste handling and disposal, and windblown dust was significantly associated with a decrease in birthweight. The changes in birthweight varied geographically and were determined by both the concentration and source profile of the PM2.5 mixture.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Engineering, Environmental
Bo Peng, Qianli Dong, Fangzhou Li, Teng Wang, Xinghua Qiu, Tong Zhu
Summary: This review summarizes the current knowledge on PAH derivatives in terms of their chemical species, levels, biotransformation patterns, chemical analytical methods, internal exposure routes, and toxicity. It also discusses the challenges and future directions for research in this field.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Ya-qi Yu, Tong Zhu
Summary: The health risk posed by ultrafine particles (UFPs) is potentially increased by the reducing substances present in lung fluid, mainly consisting of metals and quinones. The bioaccessible metal concentration and oxidative potential of UFPs were analyzed, and it was found that UFPs containing Mn had higher values than those containing Cu and Fe. Both endogenous and exogenous reductants can increase the bioaccessible metal concentration and oxidative potential, with greater increments observed for composite UFPs. The findings highlight the importance of the bioaccessible metal fraction in UFPs for inducing oxidative stress and provide novel insights into their toxicity and health risks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Microbiology
Qimao Yang, Shuai Le, Tongyu Zhu, Nannan Wu
Summary: Phage therapy, a century-old treatment for bacterial infection, was abandoned after the availability of antibiotics but revived due to antimicrobial resistance today. While there are many articles on its clinical application, little research has focused on phage therapy from a regulatory perspective. This study divides sections into different regions to explore the regulations of phage therapy, providing new insights into China's regulations. The authors hope to inspire ideas on how countries can learn from each other's legislation to overcome regulatory hurdles.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Qiang Zhang, Zhicong Yin, Xi Lu, Jicheng Gong, Yu Lei, Bofeng Cai, Cilan Cai, Qimin Chai, Huopo Chen, Hancheng Dai, Zhanfeng Dong, Guannan Geng, Dabo Guan, Jianlin Hu, Cunrui Huang, Jianing Kang, Tiantian Li, Wei Li, Yongsheng Lin, Jun Liu, Xin Liu, Zhu Liu, Jinghui Ma, Guofeng Shen, Dan Tong, Xuhui Wang, Xuying Wang, Zhili Wang, Yang Xie, Honglei Xu, Tao Xue, Bing Zhang, Da Zhang, Shaohui Zhang, Shaojun Zhang, Xian Zhang, Bo Zheng, Yixuan Zheng, Tong Zhu, Jinnan Wang, Kebin He
Summary: This study tracks and analyzes the progress of synergetic governance of air pollution and climate change in China by developing and monitoring 18 indicators. It provides policy recommendations for designing a synergetic roadmap of Carbon Neutrality and Clean Air for China.
ENVIRONMENTAL SCIENCE AND ECOTECHNOLOGY
(2023)
Article
Environmental Sciences
Tao Xue, Ruohan Wang, Mingkun Tong, Frank J. Kelly, Hengyi Liu, Jiajianghui Li, Pengfei Li, Xinghua Qiu, Jicheng Gong, Jing Shang, Tong Zhu
Summary: Long-term exposure to high concentrations of ozone poses a risk to under-5 mortality, and ozone exposure contributes significantly to mortality in children in LMICs.
LANCET PLANETARY HEALTH
(2023)
Article
Environmental Sciences
Mingkun Tong, Meng Wang, Pengfei Li, Jicheng Gong, Tong Zhu, Tao Xue
Summary: Joint exposure to ozone and high temperature can increase the risk of pregnancy loss. The adverse effect of ozone may be modified by ambient temperature. Controlling ozone pollution in high-latitude cities could protect maternal health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)