期刊
PARKINSONISM & RELATED DISORDERS
卷 51, 期 -, 页码 55-60出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2018.02.046
关键词
Diffusion tensor imaging; Neurite orientation dispersion and density imaging; Parkinson's disease; Nigrostriatal pathway; Retrograde degeneration; Tract-profile analysis
资金
- Hitachi, Ltd.
- Japan Agency for Medical Research and Development (AMED)
- Japan Society for the Promotion of Science (JSPS) KAKENHI [JP16K19854]
- Grants-in-Aid for Scientific Research [17K07797, 16K19854] Funding Source: KAKEN
Introduction: Parkinson's disease (PD) is marked by the degeneration of dopaminergic neurons in the nigrostriatal pathway (NSP). We aimed to identify the microstructural changes in the NSP of PD patients using neurite orientation dispersion and density imaging (NODDI). Methods: NSPs of 29 PD patients, who were retrospectively selected from patients previously admitted to our institution, and 29 age- and gender-matched healthy controls were isolated via deterministic tractography. The NODDI indices, intracellular volume fraction (Vic), orientation dispersion index (OD), and isotropic volume fraction (Viso) were compared between the two groups. The significant results were assessed with a tract-profile analysis. The correlation between indices and disease duration or motor symptom severity was evaluated with the Pearson's correlation test. Results: The contralateral distal Vic (p = 0.00028) of the nigrostriatal pathway was significantly lower in PD patients than in healthy controls. No correlations were detected between any of the indices and disease duration or motor symptom severity. Conclusions: NODDI can be used to identify retrograde degeneration of the NSP in PD patients and might be useful for monitoring the disease progression of PD. (C) 2018 The Authors. Published by Elsevier Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据