Article
Biochemistry & Molecular Biology
Nguyet Le, Timothy M. Hufford, Jong S. Park, Rachel M. Brewster
Summary: Organisms rely on oxygen for cellular energy production, but severe hypoxia or excessive oxygen can lead to cell damage. To adapt to oxygen level fluctuations, organisms have evolved mechanisms. Zebrafish embryos exhibit hypoxia tolerance and the N-myc Downstream Regulated Gene (ndrg) family may play a role in this adaptation.
Article
Cell & Tissue Engineering
Xiaoli Shi, Yunzhu Cen, Liying Shan, Lijie Tian, Endong Zhu, Hairui Yuan, Xiaoxia Li, Ying Liu, Baoli Wang
Summary: The study revealed that NDRG1 negatively regulated cell growth and modulated the differentiation of marrow stromal progenitor cells towards adipocytes, impacting the osteoblast differentiation. NDRG1 interacted with LRP6 and inactivated the canonical Wnt/beta-catenin signaling cascade in stromal progenitor cells. In vivo transfection of Ndrg1 siRNA prevented inactivation of Wnt signaling and improved osteoblasts reduction and fat accumulation in ovariectomized mice.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biology
Jong S. Park, Austin M. Gabel, Polina Kassir, Lois Kang, Prableen K. Chowdhary, Afia Osei-Ntansah, Neil D. Tran, Soujanya Viswanathan, Bryanna Canales, Pengfei Ding, Young-Sam Lee, Rachel Brewster
Summary: Lack of oxygen can be detrimental to cell function and survival, and this study demonstrates the role of the ndrg1a gene in hypoxia adaptation in zebrafish embryos. ndrg1a is involved in degrading ATPase, which helps maintain cellular energy homeostasis.
Article
Biochemistry & Molecular Biology
Anisha Valluri, Jessica Wellman, Chelsea L. McCallister, Kathleen C. Brown, Logan Lawrence, Rebecca Russell, James Jensen, James Denvir, Monica A. Valentovic, Krista L. Denning, Travis B. Salisbury
Summary: Using proteomic analysis, we identified increased phosphorylation of NDRG1 (Thr346) in clinically resected ccRCC tissue. This phosphorylation is mediated by mTORC2 and promotes cell viability in ccRCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Felix Orben, Katharina Lankes, Christian Schneeweis, Zonera Hassan, Hannah Jakubowsky, Lukas Krauss, Fabio Boniolo, Carolin Schneider, Arlett Schaefer, Janine Murr, Christoph Schlag, Bo Kong, Rupert Oellinger, Chengdong Wang, Georg Beyer, Ujjwal M. Mahajan, Yonggan Xue, Julia Mayerle, Roland M. Schmid, Bernhard Kuster, Roland Rad, Christian J. Braun, Matthias Wirth, Maximilian Reichert, Dieter Saur, Guenter Schneider
Summary: Systemic therapies for pancreatic ductal adenocarcinoma (PDAC) are unsatisfactory, especially for subtypes with aberrations in the MYC pathway. This study discovered that PRMT5 inhibitors triggered a MYC-associated dependency in PDAC, suggesting their potential as a therapeutic target for this type of cancer.
Article
Biochemistry & Molecular Biology
Ting Tang, Handong Wang, Yanling Han, Hanyu Huang, Wenhao Niu, Maoxing Fei, Yihao Zhu
Summary: The NDRG family plays an important role in glioma, with differential expression potentially impacting patient prognosis and tumor grade. Additionally, NDRGs may be crucial in signal transduction, energy metabolism, and intercellular communication in glioma.
DNA AND CELL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Annalisa Roberti, Agustin F. Fernandez, Mario F. Fraga
Summary: NNMT acts as a key link between cellular metabolism and epigenetic gene regulation, playing a central role in various pathologies. Targeting NNMT pathways represents a current pharmaceutical challenge for treating a range of metabolic-related diseases and cancers.
MOLECULAR METABOLISM
(2021)
Article
Neurosciences
Hang Guo, Anqi Yin, Yulong Ma, Ze Fan, Liang Tao, Wenhong Tang, Yaqun Ma, Wugang Hou, Guohong Cai, Lixia Zhuo, Jian Zhang, Yan Li, Lize Xiong
Summary: The lack of NDRG2 leads to severe brain edema and astrocyte swelling, but alleviation can be achieved by restoring the expression of Na+-K+-ATPase beta 1. Upregulation of NDRG2 by lentiviral constructs protects the brain from ischemic edema.
Review
Cell Biology
Jack Crouch, Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Vladimir Botchkarev, Daniel Roh
Summary: Senescence is a complex cellular stress response that leads to loss of proliferative capacity and changes in secretory pattern. Transcriptional regulation of multiple genes and epigenetic alterations to DNA and chromatin play crucial roles in the induction and maintenance of senescence. This review highlights the changes in chromatin, DNA methylation, histone alterations, and the specific epigenetic regulation of the senescence-associated secretory phenotype (SASP).
Article
Biotechnology & Applied Microbiology
Rui-Bing Feng, Qiao-Zhi Zhou, Rui Cheng, Peng Li, Sheng-Tao Zhu, Li Min, Shu-Tian Zhang
Summary: This study demonstrated that the expression of NDRG2 differed between early ESCC and advanced ESCC, with a gradual decrease in positive expression rate as the disease progressed. The detection of NDRG2 plays a significant role in early diagnosis and prognosis.
Article
Plant Sciences
Kay Zin Kyaw, Woong Sub Byun, Yern-Hyerk Shin, Thanh-Hau Huynh, Ji Yun Lee, Eun Seo Bae, Hyen Joo Park, Dong-Chan Oh, Sang Kook Lee
Summary: Piceamycin (1), a macrocyclic lactam isolated from the silkworm's gut, has been found to possess antibacterial activity. This study investigates the potential anticancer activity of 1 and its underlying mechanisms in colorectal cancer (CRC) cells. The results show that 1 inhibits CRC cell growth by upregulating NDRG1, inducing cell cycle arrest and apoptosis, and inhibiting cell migration. The disruption of the interaction between NDRG1 and c-Myc is also observed. This suggests that 1 may serve as a potential candidate for CRC treatment by regulating NDRG1-mediated functionality.
JOURNAL OF NATURAL PRODUCTS
(2022)
Review
Neurosciences
Yukiko Nakahara, Hiroshi Ito, Hiroki Namikawa, Takashi Furukawa, Fumitaka Yoshioka, Atsushi Ogata, Jun Masuoka, Tatsuya Abe
Summary: This literature review focuses on the critical role of NDRG1 in glioblastoma and discusses its potential as a therapeutic target. Previous studies have shown that deregulated expression of NDRG1 affects tumor growth and clinical outcomes in patients with glioblastoma, highlighting the significance of understanding its regulation and signaling.
Article
Oncology
Yi-Xiao He, Hong Shen, Yu-Zhu Ji, Hai-Rong Hua, Yu Zhu, Xiang-Fei Zeng, Fang Wang, Kai-Xin Wang
Summary: In this study, it was found that NDRG1 could inhibit the proliferation of Caco2 cells by arresting the cell cycle and promote early cell apoptosis. Moreover, over-expression of NDRG1 could extensively inhibit cell invasion and migration.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Oncology
Ana P. Kutschat, Feda H. Hamdan, Xin Wang, Alexander Q. Wixom, Zeynab Najafova, Christine S. Gibhardt, Waltraut Kopp, Jochen Gaedcke, Philipp Strobel, Volker Ellenrieder, Ivan Bogeski, Elisabeth Hessmann, Steven A. Johnsen
Summary: Gemcitabine-resistant PDAC tumors show coamplification of RRM1 and STIM1, where RRM1 is required for resistance while high STIM1 levels lead to increased cytosolic calcium levels. This calcium influx impairs ER stress response and activates NFAT signaling, revealing a potential target for therapy in PDAC.
Article
Oncology
Jinshou Yang, Bo Ren, Jie Ren, Gang Yang, Yuan Fang, Xing Wang, Feihan Zhou, Lei You, Yupei Zhao
Summary: Metabolic remodelling and epigenetic reprogramming play important roles in PDAC tumorigenesis and metastasis. This study focused on guanidinoacetic acid (GAA) and revealed its association with PDAC liver metastasis through the GAA-c-Myc-HMGA axis and transcription-activating histone modifications reprogramming.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)