Article
Agriculture, Multidisciplinary
Runyu Yang, Hanxi Yu, Jiaxi Chen, Jianwei Zhu, Changqin Song, Lvqi Zhou, Yang Sun, Qi Zhang
Summary: Limonin can protect against LPS-induced liver injury by inhibiting pyroptosis signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Cell Biology
Jianye Yang, Leilei Qin, Jiaxing Huang, Yuwan Li, Sha Xu, Hai Wang, Sizheng Zhu, Jiawei Wang, Bo Zhu, Feilong Li, Wei Huang, Xuan Gong, Ning Hu
Summary: Astragalus polysaccharide (APS) has demonstrated the ability to inhibit osteoclast formation and differentiation, regulate inflammatory osteolysis, and potentially become an effective treatment for disorders associated with osteoclasts.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Hye Rin Kim, Mi Na Kim, Eun Gyul Kim, Ji Su Leem, Seung Min Baek, Yu Jin Lee, Kyung Won Kim, Min-Jong Kang, Tae Won Song, Myung Hyun Sohn
Summary: This study found that a genetic deficit in NLRX1 can suppress hyperoxia-induced apoptosis, suggesting that NLRX1 acts as a pivotal regulator of hyperoxic acute lung injury (HALI).
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Xinglin Gao, Qian Su, Hang Pan, Yanli You, Zhiyan Ruan, Yuhan Wu, Zhaoxin Tang, Lianmei Hu
Summary: Arsenic is highly toxic and can cause liver damage. This study reveals that ferroptosis is involved in arsenic-induced liver injury, which is regulated by mitochondrial ROS.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Medicine, Research & Experimental
Hsin-Yu Ho, Chia-Chieh Lin, Yi-Ching Chuang, Yu-Sheng Lo, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: Dehydrocrenatidine has been shown to induce apoptosis in human oral cancer cells through both extrinsic and intrinsic pathways, involving various proteins. Co-treatment with MAPK inhibitors suggests that dehydrocrenatidine induces apoptosis via activation of ERK and JNK signaling pathways. These findings shed light on the potential of dehydrocrenatidine in molecular regulation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Pan Shen, Liang Han, Guang Chen, Zhe Cheng, Qiong Liu
Summary: Emodin can protect the liver from acetaminophen (APAP)-induced hepatotoxicity through various pathways, including upregulation of the Nrf2-mediated antioxidative stress pathway, inhibition of the NLRP3 inflammasome, and downregulation of the cGAS-STING signaling pathway.
Article
Biochemistry & Molecular Biology
Chen-Yu Cao, Ying-Xiang Yang, Zhao Xie, Xin Chen, Xin-Wei Shi, Xia Yin, Jin-Ming Gao
Summary: This study found that a natural cyathane diterpenoid sarcodonin A derived from the mushroom Sarcodon scabrosus and its derivatives could inhibit neuroinflammation by reversing M1 polarization of microglia. The underlying mechanism may involve the regulation of inflammatory molecular expression and signaling pathway inhibition.
BIOORGANIC CHEMISTRY
(2022)
Article
Immunology
Donghui Bai, Yujie Sun, Qiong Li, Haihua Li, Yuerun Liang, Ximing Xu, Jiejie Hao
Summary: This study found that leonurine, extracted from Herba leonuri, has a protective effect on asthma by regulating the p38 MAPK/NF-κB signaling pathway to reduce inflammation and mucus overproduction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Linqing Wu, Zengbin Wang, Xiaoli He, Yayuan Jiang, Ruizhu Pan, Shi Chen, Yizhong Chen, Yanfei Han, Huahui Yu, Tao Zhang
Summary: Arsenic is a known carcinogen, and GJA1, a multifunctional protein, plays an important role in cancer recurrence and metastasis. This study demonstrated that chronic exposure to sodium arsenite promotes epithelial-mesenchymal transition (EMT) and reduces GJA1 expression. Forced expression of GJA1 inhibits EMT induced by sodium arsenite by suppressing the MAPK/ERK signaling pathway. In addition, chronic exposure to sodium arsenite increases autophagy flux, which decreases GJA1 expression. These findings suggest that GJA1 restrains the carcinogenic effect of sodium arsenite by limiting MAPK/ERK signaling, and interventions targeting GJA1 may have preventive and therapeutic potential for cancer treatment.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Basma G. Eid, Nagla A. El-Shitany
Summary: Pre-treatment with Cap effectively protects against Cis-induced liver toxicity by reducing inflammation and apoptosis, and enhancing the antioxidant system.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Boran Ni, Yi Liu, Xue Gao, Mengru Cai, Jing Fu, Xingbin Yin, Jian Ni, Xiaoxv Dong
Summary: This study demonstrated that ISL can protect cells from EMO-induced liver injury, which may be associated with the activation of Nrf2, reduction of ROS generation, and enhancement of detoxification enzyme expression.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hyun Min Ko, Seung-Han Choi, Wona Jee, Seung-Hyeon Lee, Doil Park, Ji Hoon Jung, Beom-Joon Lee, Kwan-Il Kim, Hee-Jae Jung, Hyeung-Jin Jang
Summary: This study demonstrated the anti-inflammatory effects of Rosa laevigata (RL) in asthma models exacerbated by water-soluble particulate matter (WPM) exposure. Oral and intratracheal administration of RL reduced the secretion of Th2-related cytokines, pro-inflammatory cytokines, and IgE by downregulating the MAPK pathway. RL showed potential for development as an oral and inhaled therapeutic for asthma symptoms exacerbated by WPM exposure.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Yan Lu, Meiling Yang, Meizhong Peng, Lingling Xie, Aling Shen, Shan Lin, Bin Huang, Jianfeng Chu, Jun Peng
Summary: The study showed that Kuanxiong aerosol (KXA) has a protective effect on isoproterenol-induced myocardial injury (MI) in rats by inhibiting apoptosis through the MAPK signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Qijing Wu, Juan Chen, Xiyin Zheng, Jing Song, Lulu Yin, Hai Guo, Qian Chen, Yi Liu, Qianli Ma, Hong Zhang, Qianqian Yang
Summary: The study aimed to evaluate the protective effect of kaempferol (KPF) in doxorubicin (DOX)-induced nephrotoxicity. The results showed that KPF could alleviate DOX-induced renal injury, improve proteinuria and renal function, restore antioxidant activity in kidneys, suppress oxidative stress, and inhibit the activation of the MAPK signaling pathway. In cell experiments, KPF also inhibited DOX-induced ROS overproduction, reduced cell damage and loss of viability. Therefore, KPF may provide a viable solution to lessen renal toxicity in cancer patients receiving DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Lichen Chen, Jixiang Yuan, Hang Li, Yi Ding, Xuejia Yang, Ziwei Yuan, Zujian Hu, Yuanyuan Gao, Xilong Wang, Hong Lu, Yong Cai, Yongheng Bai, Xiaodong Pan
Summary: Trans-cinnamaldehyde (TCA) extracted from cinnamon bark has anti-inflammatory properties and can attenuate renal ischemia-reperfusion injury (IRI) through inhibiting the JNK/p38 MAPK signaling pathway, thus reducing kidney pathological changes and dysfunction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Megha Jethwa, Aditi Gangopadhyay, Achintya Saha
Summary: Epidermal growth factor receptor (EGFR), a crucial receptor in cancer therapy, was selected as a potential target for this study. A ligand-based pharmacophore model was developed and validated, and candidate molecules were screened using molecular docking and molecular dynamics simulation.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Aditi Gangopadhyay, Achintya Saha
Summary: This study aimed to repurpose FDA approved drugs against the RNA-dependent RNA polymerase (RDRP) domain of dengue virus serotype 3 (DENV3) using structure-based virtual screening and molecular dynamics (MD) simulations. The results showed that polydatin and betiatide exhibited stable interactions with the RDRP domain and higher binding affinity than the standard inhibitor. These findings may contribute to the development of serotype-selective drugs against dengue in the future.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Tarun Kumar Dua, Simran Giri, Gouranga Nandi, Ranabir Sahu, Tapan Kumar Shaw, Paramita Paul
Summary: The green synthesis of silver nanoparticles (AgNPs) using an aqueous Eupatorium adenophorum leaf extract as a bioreductant is reported in this article. The E. adenophorum extract not only served as a bioreductant but also acted as a capping agent to stabilize the nanoparticles. Various characterization techniques were adopted to analyze the biosynthesized AgNPs. The AgNPs showed improved antioxidant, antibacterial and photocatalytic activities, suggesting their potential applications in various fields.
Article
Chemistry, Medicinal
Khushboo Pandey, Kiran Bharat Lokhande, Achintya Saha, Arvind Goja, Kakumani Venkateswara Swamy, Shuchi Nagar
Summary: This study aimed to search for potential lead compounds from the ZINC database through in silico approaches. The results indicated that the selected compounds may serve as potential anti-aromatase drug candidates, providing a valuable approach in developing novel anti-aromatase inhibitors for the treatment of ER+ breast cancer.
CURRENT COMPUTER-AIDED DRUG DESIGN
(2023)
Article
Nanoscience & Nanotechnology
Purna K. Boruah, Priyakshree Borthakur, Gayatri Neog, Benjamin Le Ouay, Nazim Uddin Afzal, Prasenjit Manna, Manash R. Das
Summary: This article describes the synthesis of porous 3D nitrogen-doped crumpled graphene nanoparticles (CGNPs) and their use as a platform for the sensitive detection of dopamine (DA) in complex biological media such as blood serum. The CGNPs were prepared by doping graphene oxide (GO) using ammonium hydroxide in a hydrothermal treatment. The system selectively detected DA with a limit of detection of 1.15 μM and a linearity range of 1 to 20 μM, and it showed good selectivity in the presence of various interfering species and in human blood serum.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biology
Aditi Gangopadhyay, Achintya Saha
Summary: Despite the lack of definitive therapy against dengue, this study aimed to discover inhibitors against the dengue virus by targeting the NS2B-NS3 serine protease. Through virtual screening, ten hits were identified and molecular dynamics simulations confirmed the stability of three hits bound to the allosteric site. Analyses of hit-receptor interactions and MM-GBSA energy showed high binding affinity of the hits to the allosteric site. These findings contribute to the identification of novel serotype-specific inhibitors for dengue protease.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Bhuvi Sachdeva, Punya Sachdeva, Arvind Negi, Shampa Ghosh, Sungsoo Han, Saikat Dewanjee, Saurabh Kumar Jha, Rakesh Bhaskar, Jitendra Kumar Sinha, Ana Claudia Paiva-Santos, Niraj Kumar Jha, Kavindra Kumar Kesari
Summary: Chitin is a biopolymer derived from marine crustaceans and organisms like bacteria, fungi, and algae, which offers biodegradability and biocompatibility properties suitable for biomedical applications. Its deacetylated derivative, chitosan, also possesses similar properties and can be used as a support material in biomedical applications. Additionally, both chitin and chitosan have intrinsic material properties such as antioxidant, antibacterial, and antitumor activities. This paper focuses on the use of chitin and chitosan biopolymers in drug delivery strategies for cancer treatment.
Review
Biochemistry & Molecular Biology
Nilanjan Ghosh, Leena Chacko, Hiranmoy Bhattacharya, Jayalakshmi Vallamkondu, Sagnik Nag, Abhijit Dey, Tanushree Karmakar, P. Hemachandra Reddy, Ramesh Kandimalla, Saikat Dewanjee
Summary: Diabetes mellitus (DM) and cardiovascular complications often occur together, creating a challenging situation. The development of diabetic cardiomyopathy (DCM) involves complex pathophysiological pathways at the metabolic and molecular level, leading to structural and functional alterations of the heart. Glucagon-like peptide-1 (GLP-1) analogues and sodium-glucose cotransporter-2 (SGLT-2) inhibitors have shown promising results in improving cardiovascular outcomes in diabetes. This article highlights the pathways contributing to DCM and discusses potential future therapies.
Article
Horticulture
Donato Castronuovo, Vincenzo De Feo, Laura De Martino, Loriana Cardone, Rita Sica, Lucia Caputo, Giuseppe Amato, Vincenzo Candido
Summary: Soil fumigation is an effective method for controlling soilborne pests, but it has limited use due to its non-selectivity and environmental problems. This study evaluates the effects of soil solarization on organic pumpkin yield and antioxidant levels. The results show that solarization increases antioxidant activity and improves yield.
Review
Biochemistry & Molecular Biology
Hafiza Padinharayil, Jinsu Varghese, Mithun Chacko John, Golgodu Krishnamurthy Rajanikant, Cornelia M. Wilson, Minnatallah Al-Yozbaki, Kaviyarasi Renu, Saikat Dewanjee, Rupa Sanyal, Abhijit Dey, Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Abilash Valsala Gopalakrishnan, Alex George
Summary: Continuous revision of the histologic and stage-wise classification of lung cancer by the World Health Organization (WHO) supports therapeutic advances and accurate diagnosis. Cancer epidemiologic data provide helpful information for cancer prevention and management. Global cancer mortality projections indicate that cancer will become the leading cause of death, particularly non-small cell lung cancer (NSCLC) which accounts for a significant portion of lung cancers. Early diagnosis and proper management play crucial roles in NSCLC therapies. Advanced techniques, such as immune checkpoint inhibitors (ICIs) and targeted molecular therapies, have improved the treatment of late-stage NSCLC. However, the improvement of cancer biomarkers and the development of prospective studies are needed for better therapeutic outcomes.
Article
Biochemical Research Methods
Gouhar Jahan Ashraf, Priya Das, Ranabir Sahu, Gouranga Nandi, Paramita Paul, Tarun Kumar Dua
Summary: This study investigated and optimized the ultrasonic-assisted extraction and quantification of caffeine and polyphenols from green tea using 2(3)-full factorial design and high-performance thin-layer chromatography. The results showed that sonication can simplify the extraction process and achieve higher extractive yield and concentration of caffeine and polyphenols compared to traditional methods. Scanning electron microscopy images revealed physical alterations and cell wall disintegration in the matrix, which accelerated the extraction process.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Biochemistry & Molecular Biology
Shovonlal Bhowmick, Tapan Kumar Mistri, Mohammad Rizwan Khan, Pritee Chunarkar Patil, Rosa Busquets, Abu Md Ashif Ikbal, Ankita Choudhury, Dilip Kumar Roy, Partha Palit, Achintya Saha
Summary: The novel coronavirus disease 2019 (Covid-19) outbreak caused by SARS-CoV-2 virus is still posing a threat to global health. Effective chemical compounds to combat Covid-19 are urgently needed. In this study, potential Amaryllidaceae alkaloids were screened and Galantamine, Lycorenine, and Neronine were identified as potential modulators of SARS-CoV-2 main protease and host TMPRSS2 protein.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Ranit Pariary, Sandip Dolui, Gourav Shome, Sk Abdul Mohid, Achintya Saha, Bhisma N. Ratha, Amaravadhi Harikishore, Kuladip Jana, Atin K. Mandal, Anirban Bhunia, Nakul C. Maiti
Summary: Our studies demonstrate that Coomassie Brilliant Blue G-250 shows promise as a chemical chaperone for stabilising the alpha-helical native human insulin conformers, preventing their aggregation and increasing insulin secretion. This multipolar effect, along with its non-toxic nature, could be valuable for the development of highly bioactive, targeted, and biostable therapeutic insulin.
CHEMICAL COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Simran Giri, G. Dey, R. Sahu, Paramita Paul, G. Nandi, T. K. Dua
Summary: Woodfordia fruticosa is a traditional medicinal plant with numerous therapeutic properties. Phytochemical investigations have identified 61 compounds belonging to various classes, such as glycosides, terpenes, flavonoids, tannins, sterols, phenolics, and essential oils. Pharmacological studies have shown that the plant possesses antihyperglycemic, antioxidant, anti-inflammatory, analgesic, hepatoprotective, antibacterial, gastroprotective, and wound healing properties. However, further studies on the isolated compounds are needed to fully explore the plant's potential applications.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Food Science & Technology
Subhajit Mandal, Md. Latifur Rahman, Priya Das, Gouhar Jahan Ashraf, Tarun Kumar Dua, Paramita Paul, Gouranga Nandi, Ranabir Sahu
Summary: This study investigated the effects of maceration, ultrasonic, and microwave-assisted extraction on the phenolic compounds of Tulaipanji rice flour. It was found that microwave-assisted extraction showed the highest phenolic content and antioxidant activity, particularly in bound phenolics.
INTERNATIONAL JOURNAL OF FOOD ENGINEERING
(2023)