NEDD8-mediated neddylation is required for human endometrial stromal proliferation and decidualization

Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition

(2015) Annette M Vogl et al.   NATURE NEUROSCIENCE

Protein neddylation: beyond cullin–RING ligases

(2015) Radoslav I. Enchev et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target

(2015) Qiang Gao et al.   Oncotarget

Induction of p21-Dependent Senescence by an NAE Inhibitor, MLN4924, as a Mechanism of Growth Suppression

(2015) Lijun Jia et al.   NEOPLASIA

Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy

(2014) Yongchao Zhao et al.   ANTIOXIDANTS & REDOX SIGNALING

Cyclic Decidualization of the Human Endometrium in Reproductive Health and Failure

(2014) Birgit Gellersen et al.   ENDOCRINE REVIEWS

Constitutive STAT3 activation in epidermal keratinocytes enhances cell clonogenicity and favours spontaneous immortalization by opposing differentiation and senescence checkpoints

(2014) Valeria Orecchia et al.   EXPERIMENTAL DERMATOLOGY

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Coculturing human endometrial epithelial cells and stromal fibroblasts alters cell-specific gene expression and cytokine production

(2013) Joseph C. Chen et al.   FERTILITY AND STERILITY

Physiological and molecular determinants of embryo implantation

(2013) Shuang Zhang et al.   MOLECULAR ASPECTS OF MEDICINE

Liver receptor homolog-1 is essential for pregnancy

(2013) Cong Zhang et al.   NATURE MEDICINE

Fetomaternal immune cross-talk and its consequences for maternal and offspring's health

(2013) Petra C Arck et al.   NATURE MEDICINE

CUL1 promotes trophoblast cell invasion at the maternal–fetal interface

(2013) Q Zhang et al.   Cell Death & Disease

A Positive Feedback Loop Involving Gcm1 and Fzd5 Directs Chorionic Branching Morphogenesis in the Placenta

(2013) Jinhua Lu et al.   PLOS BIOLOGY

Inhibition of the NEDD8 Conjugation Pathway by shRNA to UBA3, the Subunit of the NEDD8-Activating Enzyme, Suppresses the Growth of Melanoma Cells

(2012) Fang Cheng et al.   Asian Pacific Journal of Cancer Prevention

Wnt6 Is Essential for Stromal Cell Proliferation During Decidualization in Mice1

(2012) Qiang Wang et al.   BIOLOGY OF REPRODUCTION

Cullin 7 and Fbxw 8 expression in trophoblastic cells is regulated via oxygen tension: implications for intrauterine growth restriction?

(2012) Fabian B. Fahlbusch et al.   Journal of Maternal-Fetal & Neonatal Medicine

Regulation of Human Endometrial Stromal Proliferation and Differentiation by C/EBPβ Involves Cyclin E-cdk2 and STAT3

(2012) Wei Wang et al.   MOLECULAR ENDOCRINOLOGY

Mechanisms of implantation: strategies for successful pregnancy

(2012) Jeeyeon Cha et al.   NATURE MEDICINE

Cell Cycle Regulation of Human Endometrial Stromal Cells During Decidualization

(2012) Philip C. Logan et al.   Reproductive Sciences

Quantitative Proteomic Analysis of Cellular Protein Modulation upon Inhibition of the NEDD8-Activating Enzyme by MLN4924

(2011) Hua Liao et al.   MOLECULAR & CELLULAR PROTEOMICS

Biochemical and cellular effects of inhibiting Nedd8 conjugation

(2010) Yee Chin Leck et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF- B-dependent lymphoma

(2010) M. A. Milhollen et al.   BLOOD

Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia

(2010) R. T. Swords et al.   BLOOD

Dynamics of Cullin-RING Ubiquitin Ligase Network Revealed by Systematic Quantitative Proteomics

(2010) Eric J. Bennett et al.   CELL

Cullin Mediates Degradation of RhoA through Evolutionarily Conserved BTB Adaptors to Control Actin Cytoskeleton Structure and Cell Movement

(2009) Yuezhou Chen et al.   MOLECULAR CELL

Ubiquitylation in innate and adaptive immunity

(2009) Vijay G. Bhoj et al.   NATURE

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Novel substrates and functions for the ubiquitin-like molecule NEDD8: Figure 1

(2008) Dimitris P. Xirodimas   BIOCHEMICAL SOCIETY TRANSACTIONS

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL