Article
Obstetrics & Gynecology
Kajsa Ugelvig Petersen, Katia Keglberg Haervig, Jens Peter Bonde, Karin Sorig Hougaard, Gunnar Toft, Cecilia Host Ramlau-Hansen, Johan Hoy Jensen, Laura Deen, Sandra Sogaard Tottenborg
Summary: This study aimed to explore the association between maternal stress during pregnancy and reproductive function in young men. Through a nested cohort study in the Danish National Birth Cohort, the authors found no overall negative associations between maternal stress and male reproductive function. However, maternal emotional stress was associated with higher total sperm count, serum estradiol, and calculated free testosterone. The study highlights the need for further validation of stress measurement during pregnancy and improving our understanding of the full spectrum of fetal stress exposures and their consequences for health.
FERTILITY AND STERILITY
(2022)
Article
Environmental Sciences
Kajsa Ugelvig Petersen, Katia Keglberg Haervig, Esben Meulengracht Flachs, Jens Peter Bonde, Christian Lindh, Karin Sorig Hougaard, Gunnar Toft, Cecilia Host Ramlau-Hansen, Sandra Sogaard Tottenborg
Summary: This study examined the impact of PFAS exposure on reproductive function in young adult males. The results showed a slight association between higher levels of PFAS and follicle-stimulating hormone (FSH) levels, but no consistent associations with semen quality and testicular volume were found.
ENVIRONMENTAL RESEARCH
(2022)
Review
Nutrition & Dietetics
Hsueh-Han Tsai, Jyh-Cherng Yu, Huan-Ming Hsu, Chi-Hong Chu, Tzu-Ming Chang, Zhi-Jie Hong, An-Chieh Feng, Chun-Yu Fu, Kuo-Feng Hsu, Ming-Shen Dai, Guo-Shiou Liao
Summary: Breast cancer is a global public health problem and there is increasing interest in prevention strategies as its incidence rises. A healthy dietary pattern, such as the Mediterranean diet, with high levels of fiber, phytochemicals, antioxidants, and advantageous fatty acids, is considered a promising approach to reduce breast cancer risk. This review summarizes the important active compounds in preventing breast cancer, including polyunsaturated fatty acids, fiber, phytochemicals, and alcohol. While the exact mechanism is not well understood, the combination of these elements in a healthy diet plays a role in reducing breast cancer risk.
Article
Environmental Sciences
Qing Chen, Furong Wang, Huan Yang, Xiaogang Wang, Aihua Zhang, Xi Ling, Lianbing Li, Peng Zou, Lei Sun, Linping Huang, Hongqiang Chen, Lin Ao, Jinyi Liu, Jia Cao, Niya Zhou
Summary: The study revealed that various components of PAHs may impact reproductive parameters differently. Inhalation of PAHs in air, especially high molecular weight (HMW) PAHs, may pose a potential risk factor for male reproductive health.
ENVIRONMENTAL POLLUTION
(2021)
Review
Nutrition & Dietetics
Magdalena Zielinska, Edyta Luszczki, Izabela Michonska, Katarzyna Deren
Summary: Depression is a common mental disorder that affects not only adults but also children and adolescents. Research shows that adopting the Mediterranean diet can reduce the risk of depression in adolescents, while a western eating style may increase the risk.
Article
Public, Environmental & Occupational Health
Anne Gaml-Sorensen, Nis Brix, Katia Keglberg Haervig, Christian Lindh, Sandra Sogaard Tottenborg, Karin Sorig Hougaard, Birgit Bjerre Hoyer, Andreas Ernst, Linn Hakonsen Arendt, Pernille Jul Clemmensen, Jens Peter Ellekilde Bonde, Tine Brink Henriksen, Gunnar Toft, Onyebuchi A. A. Arah, Cecilia Host Ramlau-Hansen
Summary: Maternal vitamin D levels during pregnancy may have an impact on reproductive health in male offspring, affecting testes volume and total sperm count. This study found that lower maternal vitamin D levels during pregnancy were associated with decreased testes volume and lower total sperm count in adult sons. The findings were supported by continuous models, spline plots, and instrumental variable analysis. Maternal vitamin D levels above 75 nmol/L during pregnancy may be beneficial for testes function in adult sons.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Andrology
Wei Zhang, Xiao Shi, Yuyang Zhang, Guodong Liu, Xu Wu, Houbao Huang, Hui Jiang, Xiansheng Zhang
Summary: The purpose of this study was to examine the effects of recovery sleep on male rats' fertility after sleep deprivation (SD). The results showed that 96 hours of SD resulted in decreased semen quality, disruption of testicular tissue structure, and decreased testosterone levels in rats. After 7 days of recovery sleep, semen quality and testosterone levels improved, but did not fully return to baseline levels compared to the control group.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Obstetrics & Gynecology
Nis Brix, Anne Gaml-Sorensen, Andreas Ernst, Linn Hakonsen Arendt, Lea Lykke Harrits Lunddorf, Gunnar Toft, Sandra S. Tottenborg, Katia Keglberg Haervig, Birgit Bjerre Hoyer, Karin S. Hougaard, Jens Peter E. Bonde, Cecilia Host Ramlau-Hansen
Summary: The timing of puberty is associated with semen characteristics, testicular volume, and reproductive hormone levels.
FERTILITY AND STERILITY
(2023)
Article
Virology
Ling Ma, Wen Xie, Danyang Li, Lei Shi, Guangming Ye, Yanhong Mao, Yao Xiong, Hui Sun, Fang Zheng, Zhimin Chen, Jyuling Qin, Jing Lyu, Yuanzhen Zhang, Ming Zhang
Summary: The study found that although the COVID-19 virus was not detected in the semen of male patients, there were abnormal levels of sex hormones in the COVID-19 group, with a negative correlation with white blood cell counts and C-reactive protein levels.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Endocrinology & Metabolism
Joseph Whittaker
Summary: Male reproductive health has declined in the twentieth century, with decreasing sperm counts and testosterone levels, and increasing reproductive pathologies. The rise in chronic diseases such as obesity, diabetes, and metabolic syndrome is also highly interconnected with these reproductive health trends, indicating that environmental factors are the primary cause rather than genetics.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Environmental Sciences
Xiaoli Shen, Ming Zhan, Yuqing Wang, Weifeng Tang, Qianlong Zhang, Jun Zhang
Summary: This study investigates the associations between individual paraben exposure and paraben mixture with semen quality parameters. The results suggest negative associations between paraben mixture and sperm concentration, total sperm count, and sperm motility.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biophysics
Govinthasamy Prabakar, Marappan Gopi, Gautham Kolluri, Jaydip Jaywant Rokade, Selvaraj Pavulraj, Beulah Pearlin, Gautham Sudamrao Khillare, Velusamy Madhupriya, Jagbir Singh Tyagi, Jag Mohan
Summary: A biological experiment was conducted on turkey and egg type chicken breeders to assess the seasonal influence on semen production and quality. The study found that the winter season had superior semen characteristics, hormonal profile, and antioxidant enzyme activity.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2022)
Review
Medicine, General & Internal
Elena Zambrano, Peter W. Nathanielsz, Guadalupe L. Rodriguez-Gonzalez
Summary: Developmental programming can predispose offspring to metabolic, behavioral, and reproductive dysfunction in adult life, with evidence showing a connection between aging phenotype and longevity. Maternal nutrition during development can have effects on the male reproductive system's aging, impacting factors like hormone production, oxidative stress, and sperm quality. Understanding these developmental programming aging interactions can improve male health, longevity, and future generations' health.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Obstetrics & Gynecology
Linn H. Arendt, Anne Gaml-Sorensen, Andreas Ernst, Nis Brix, Gunnar Toft, Sandra S. Tottenborg, Karin S. Hougaard, Jens Peter E. Bonde, Cecilia H. Ramlau-Hansen
Summary: This study aimed to investigate the relationship between parental subfecundity, assessed by time to pregnancy and use of medically-assisted reproduction, and the reproductive health of young men. The results showed that there were no significant differences in semen quality or reproductive hormone levels among sons conceived by subfertile couples or with the use of medically-assisted reproduction.
FERTILITY AND STERILITY
(2022)
Review
Engineering, Environmental
Xin Gao, Guangying Li, Xingchen Pan, Jiajia Xia, Di Yan, Yang Xu, Xiang Ruan, Huan He, Yu Wei, Jinxia Zhai
Summary: There is inconclusive evidence regarding the correlation between cadmium exposure and adverse male reproductive health outcomes, despite the abundance of epidemiological evidence and animal experiments. A literature search was conducted to analyze Cd levels in different biological materials and its correlation with semen parameters and sex hormones. The results showed that Cd was negatively correlated with semen parameters and positively correlated with sex hormones, with blood and urine showing significant correlations in both cases. This suggests that cadmium exposure may be associated with a decline in sperm quality and abnormal levels of sex hormones.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Review
Obstetrics & Gynecology
Hagai Levine, Niels Jorgensen, Anderson Martino-Andrade, Jaime Mendiola, Dan Weksler-Derri, Maya Jolles, Rachel Pinotti, Shanna H. Swan
Summary: This study reveals a significant decline in sperm count among men from all continents, with a more pronounced decrease observed post-2000. The decline in sperm count is not limited to North America-Europe-Australia, but also seen in South/Central America-Asia-Africa. Urgent research and action are needed to investigate the causes and prevent further disruption of male reproductive health.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Environmental Sciences
Louise Scheutz Henriksen, Hanne Frederiksen, Niels Jorgensen, Anders Juul, Niels E. Skakkebaek, Jorma Toppari, Jorgen Holm Petersen, Katharina M. Main
Summary: This study aimed to explore if there is an association between fetal phthalate exposure and markers of testicular function in young adult men. The results showed that higher maternal phthalate exposure was associated with higher luteinizing hormone (LH) but unchanged testosterone in adult sons. Additionally, higher maternal exposure was associated with lower total and free testosterone/LH ratios in adult sons.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Andrology
Laura Smidt Hansen, Laerke Priskorn, Stine A. Holmboe, Tina Kold Jensen, Ann Holm Hansen, Anna-Maria Andersson, Niels Jorgensen
Summary: This study found an association between testicular function and markers of metabolic and cardiovascular health in young men. Reproductive hormone levels and semen quality may serve as early biomarkers of cardiovascular health in healthy men.
Article
Biology
Marc K. Pedersen, Elvira V. Brauner, Ann H. Hansen, Laura S. Hansen, Tina K. Jensen, Niels Jorgensen, Laerke Priskorn
Summary: In this cross-sectional study, the association between self-reported asthma and testicular function was investigated. The results showed that men with self-reported asthma had poorer testicular function, specifically lower total sperm count and borderline lower sperm concentration compared to men without asthma. However, the causality cannot be determined due to the study's design limitations.
Article
Obstetrics & Gynecology
Makiko Mitsunami, Lidia Minguez-Alarcon, Andrea A. Florio, Siwen Wang, Jill A. Attaman, Irene Souter, Russ Hauser, Jorge E. Chavarro
Summary: This study aimed to investigate the association between intake of soy food and isoflavone with ovarian reserve. Previous studies on the relationship between soy intake and human fertility are inconsistent. However, no studies have evaluated the relationship between soy or isoflavone intake with markers of ovarian reserve other than follicle-stimulating hormone (FSH).
FERTILITY AND STERILITY
(2023)
Article
Endocrinology & Metabolism
Trine Holm Johannsen, Jakob Albrethsen, Vassos Neocleous, Federico Baronio, Martine Cools, Lise Aksglaede, Niels Jorgensen, Peter Christiansen, Meropi Toumba, Pavlos Fanis, Marie Lindhardt Ljubicic, Anders Juul
Summary: Congenital adrenal hyperplasia (CAH) is a recessive condition that affects the adrenal glands. Adult males with CAH, despite hormone replacement therapy, exhibit reduced levels of Leydig and Sertoli cell-derived hormones, including insulin-like factor 3 (INSL3) and testosterone. This study suggests that circulating INSL3 may serve as a biomarker to monitor Leydig cell function in CAH patients, particularly those with testicular adrenal rest tumors.
ENDOCRINE CONNECTIONS
(2023)
Article
Endocrinology & Metabolism
Hans Valdemar Lopez Krabbe, Jorgen Holm Petersen, Louise Laub Asserhoj, Trine Holm Johannsen, Peter Christiansen, Rikke Beck Jensen, Line Hartvig Cleemann, Casper P. Hagen, Laerke Priskorn, Niels Jorgensen, Katharina M. Main, Anders Juul, Lise Aksglaede
Summary: Adult patients with Klinefelter syndrome (KS) exhibit variable phenotypes and a high risk of metabolic disorders. Most adults require testosterone replacement therapy (TRT), but its use during puberty is debated. This study found that patients with KS have unfavorable body composition and impaired bone mineral status already during childhood and adolescence. Further research is needed to evaluate the effects of TRT during puberty on these parameters.
ENDOCRINE CONNECTIONS
(2023)
Article
Environmental Sciences
Nina Vogel, Rosa Lange, Phillipp Schmidt, Laura Rodriguez Martin, Sylvie Remy., Andrea Springer, Vladimira Puklova, Milena Cerna, Peter Rudnai, Szilvia Kozepesy, Beata Janasik, Danuta Ligocka, Lucia Fabelova, Branislav Kolena, Ida Petrovicova, Michal Jajcaj, Milada Estokova, Marta Esteban-Lopez, Argelia Castano, Janja Snoj Tratnik, Anja Stajnko, Lisbeth E. Knudsen, Jorma Toppari, Katharina M. Main, Anders Juul, Anna-Maria Andersson, Niels Jorgensen, Hanne Frederiksen, Cathrine Thomsen, Amrit Kaur Sakhi, Agneta Akesson, Christina Hartmann, Marie Christine Dewolf, Gudrun Koppen, Pierre Biot, Elly Den Hond, Stefan Voorspoels, Liese Gilles, Eva Govarts, Aline Murawski, Antje Gerofke, Till Weber, Maria Ruether, Arno C. Gutleb, Cedric Guignard, Tamar Berman, Holger M. Koch, Marike Kolossa-Gehring
Summary: Phthalates are widely used as plasticizers and can have negative impacts on reproductive functions. However, existing human biomonitoring studies on internal exposure to phthalates in Europe differ in many aspects, making comparability challenging. The HBM4EU initiative gathered data from 29 studies across Europe to describe the general population's exposure to phthalates from 2005 to 2019. This study is an important step towards making internal exposures to phthalates comparable across countries and provides suggestions for improved harmonization in future studies.
Article
Health Care Sciences & Services
Agnethe Berglund, Marie J. Ornstrup, Marie Lind-Holst, Morten Duno, Marie Baekvad-Hansen, Anders Juul, Luise Borch, Niels Jorgensen, Ase K. Rasmussen, Marianne Andersen, Katharina M. Main, Dorte Hansen, Claus H. Gravholt
Summary: This study aimed to describe diagnostic trends for all patients with CAH in Denmark. The prevalence of CAH combined was 15.1 and 9.0 per 100,000 newborn females and males, respectively. Diagnosis of NC-CAH increased significantly during the course of the study.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Public, Environmental & Occupational Health
Ernesto De la Cruz-Sanchez, Antonio Moreno-Llamas, Jaime Mendiola Olivares, Jesus Garcia-Mayor, Alberto Torres-Cantero, Emily Beth Devine
Summary: A study investigated the relationship between sources of information, vaccine safety/effectiveness, satisfaction with government vaccination strategy, and vaccination intent. It found that the coordinated effort by the EU to combat misinformation during the pandemic can serve as a model for future pandemics.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Obstetrics & Gynecology
Siwen Wang, Audrey J. Gaskins, Leslie V. Farland, Dan Zhang, Brenda M. Birmann, Janet W. Rich-Edwards, Yi-Xin Wang, Rulla M. Tamimi, Stacey A. Missmer, Jorge E. Chavarro
Summary: This prospective cohort study examined the association between infertility and the incidence of invasive cancer in women. It found that women who reported infertility had a higher risk of developing cancer, especially obesity-related reproductive cancers. The risk was also higher for women who first reported infertility at a younger age.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
N. Jimenez-Cardozo, M. Mitsunami, L. Minguez-Alarcon, E. Ortiz-Panozo, S. Wang, I Souter, R. Hauser, J. E. Chavarro
Summary: This study found that supplemental iron intake above 45 mg/day is associated with lower ovarian reserve among women seeking fertility care.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Robert B. Hood, Donghai Liang, Youran Tan, Jennifer B. Ford, Irene Souter, Jorge E. Chavarro, Dean P. Jones, Russ Hauser, Audrey J. Gaskins
Summary: This study identified the metabolic pathways and metabolites in the serum and follicular fluid that are associated with peak estradiol levels and the number of mature oocytes. The serum metabolome mainly involves fatty acid and amino acid pathways, while the follicular fluid metabolome mainly involves lipid, vitamin, and hormone pathways. These findings provide insights into the biological mechanisms underlying follicular and oocyte development.
HUMAN REPRODUCTION
(2023)
Article
Andrology
Rune Holt, Sam Kafai Yahyavi, Ireen Kooij, Nadia Nicholine Poulsen, Anders Juul, Niels Jorgensen, Martin Blomberg Jensen
Summary: This study aimed to investigate whether vitamin D supplementation has an impact on sex steroid production in infertile men with vitamin D insufficiency. The results showed that vitamin D supplementation did not alter sex steroid production in infertile men overall, but in men with vitamin D insufficiency, it significantly increased testosterone/luteinizing hormone ratio.