期刊
ORGANIC LETTERS
卷 20, 期 13, 页码 3853-3857出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01440
关键词
-
资金
- TSRI
- Pfizer, Inc.
- National Institutes of Health [1R35GM125052]
- Bristol-Myers Squibb
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R35GM125052] Funding Source: NIH RePORTER
A palladium(II)-catalyzed beta,gamma-aminohydroxylation reaction of nonconjugated alkenyl carbonyl compounds has been developed. This reaction utilizes a cleavable bidentate directing group to achieve regioselective aminopalladation. The resulting chelation-stabilized alkylpalladium(II) intermediate is then hydroxylated using oxygen/2,6-dimethylbenzoquinone in HFIP as the mild oxidation system. Under the optimized conditions, various nucleophiles and alkene substrates are capable of delivering good yields and high diastereoselectivities of the aminohydroxylated products.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据