期刊
ORGANIC LETTERS
卷 20, 期 13, 页码 4116-4120出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01675
关键词
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资金
- National Key Research and Development Program of China [2017YFC1704007]
- Ten Thousand Plan, a National High-Level Talents Special Support Plan
Two monoterpenoid indole alkaloid erchinines A (1) and B (2), possessing unique 1,4-diazepine fused with oxazolidine architecture and three hemiaminals, were isolated from Ervatamia chinensis. Their structures were elucidated on the basis of intensive spectroscopic analysis, and a plausible biosynthetic pathway from ibogaine was proposed. Both compounds exhibited significant antimicrobial activity against Trichophyton rubrum and Bacillus subtilis, and their activities were comparable to the first line antifungal drug griseofulvin and antibiotic cefotaxime.
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