期刊
ORGANIC LETTERS
卷 20, 期 11, 页码 3399-3402出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01324
关键词
-
资金
- NSF of China [21573065, 21706058, 21273066]
- NSF of Hunan Province [2016JJ1017, 2018JJ3031]
A facile, general, and economical synthesis of diversely functionalized pyrimidines has been realized under basic conditions via the copper-catalyzed cyclization of ketones with nitriles. The reaction proceeds via a novel pathway involving the nitriles acting as electrophiles and consecutive C-C bond and two C-N bond formations and shows broad substrate scope and good tolerance of many important functional groups. This strategy represents a new platform for constructing pyrimidine structures.
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