期刊
ORGANIC LETTERS
卷 20, 期 5, 页码 1473-1476出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b00337
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资金
- EPFL
- ERC [334840]
- European Research Council (ERC) [334840] Funding Source: European Research Council (ERC)
The C-H heteroarylation of benzaldehydes with indoles and pyrroles was realized using the benziodoxolone hypervalent iodine reagents indole- and pyrroleBX. Functionalization of the aldehyde C-H bond using either an o-hydroxy or amino directing group and catalyzed by an iridium or a rhodium complex allowed the synthesis of salicyloylindoles and (2-sulfonamino)benzoylindoles, respectively, with good to excellent yields (74-98%). This new transformation could be carried out under mild conditions (rt to 40 degrees C) and tolerated a broad range of functionalities, such as ethers, halogens, carbonyls, or nitro groups.
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