☆ 4.8 Article

General Synthesis of Alkenyl Sulfides by Palladium-Catalyzed Thioetherification of Alkenyl Halides and Tosylates

ORGANIC LETTERS (2018)

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ORGANIC LETTERS

卷 20, 期 10, 页码 2848-2852

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AMER CHEMICAL SOC

DOI: 10.1021/acs.orglett.8b00854

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Chemistry, Organic

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Junta de Castilla y Leon
FEDER [BU076U16, CTQ2016-75023-C2-1-P]
Ministerio de Economia y Competitividad (MINECO)
Universidad de Burgos

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The cross-coupling reaction of alkenyl bromides with thiols catalyzed by palladium complexes derived from inexpensive dppf ligand is reported. These reactions occur under low catalyst loading and in high yields and display wide scope, including the coupling of bulky thiols and trisubstituted bromoolefins, and functional group tolerance. In addition, the thioetherification of less reactive chloroalkenes and, for the first time, alkenyl tosylates was accomplished using a catalyst generated from CyPFtBu alkylbisphosphine ligand.

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Cannata Andia, Manuel Naves Diaz, Jose Luis Fernandez Martin, Natalia Carrillo Lopez, Sara Panizo Garcia, Cristina Alonso Montes, Minerva Rodriguez Garcia, Inigo Lozano Martinez Luengas, Emilio Sanchez Alvarez, Laura Martinez Arias, Beatriz Martin Carro, Julia Martin Virgala, Miguel Garcia Gonzalez, Jose Maria Lamas Barreiro, Miguel Perez Fontan, Alfonso Otero Gonzalez, Luz Maria Cuina Barja, Alejandro Sanchez Barreiro, Beatriz Pazos Arias, Angel Alonso Hernandez, Maria Pardo Perez, Jesus Calvino Varela, Jorge Amigo Lechuga, Candido Diaz Rodriguez, Maria Garcia Murias, Ana Maria Barcia de la Iglesia, Pablo Bouza Pineiro, Adrian Cordido Eijo, Noa Carrera Cachaza, Marta Vizoso Gonzalez, Nuria Lloberas Blanch, Ana Maria Sola Martinez, Miguel Hueso Val, Juliana Bordignon Draibe, Edoardo Melilli, Anna Manonelles Montero, Nuria Montero Perez, Xavier Fulladosa Oliveras, Marta Crespo Barrio, Julio Pascual Santos, Clara Barrios Barrera, Maria Jose Perez Saez, Maria Dolores Redondo Pachon, Carlos Arias Cabrales, Anna Buxeda Porras, Eva Rodriguez Garcia, Vanesa Palau Gonzalez, Laura Llinas Mallol, Marta Riera Oliva, Diego Rodriguez Puyol, Maria Piedad Ruiz Torres, Susana Lopez Ongil, Laura Calleros Basilio, Gemma Olmos Centenera, Patricia Martinez de Miguel, Loreto Fernandez Rodriguez, Hanane Bouarich Nadah, Maria Perez Fernandez, Manuel Rafael Ramirez Chamond, Patricia Sequera Ortiz, Nuria Garcia Fernandez, Alberto Benito Boillos, Nerea Varo Cenarruzabeitia, Maria Asuncion Fernandez Seara, Ines Diaz Dorronsoro, Paloma Martin Moreno, Francisco Javier Lavilla, Armando Torres, Domingo Marrero Miranda, Aurelio Pastor Rodriguez Hernandez, Eduardo De Bonis Redondo, Esteban Porrini, Maria de los Angeles Cobo Caso, Maria Lourdes Perez Tamajon, Margarita Rufino Hernandez, Maria Sagrario Garcia Rebollo, Patricia Delgado Mallen, Alejandra Alvarez Gonzalez, Ana Maria Gonzalez Rinne, Rosa Miquel Rodriguez, Sara Estupinan Torres, Diego Alvarez Sosa, Beatriz Escamilla Cabrera, Nayara Zamora Rodriguez, Arminda Farina Hernandez, Maria Jose Rodriguez Gamboa, Cobo Caso Maria de los Angeles, Perez Tamajon Maria Lourdes, Rufino Hernandez Margarita, Garcia Rebollo Maria Sagrario, Delgado Mallen Patricia, Alvarez Gonzalez Alejandra, Gonzalez Rinne Ana Maria, Miquel Rodriguez Rosa, Estupinan Torres Sara, Alvarez Sosa Diego, Escamilla Cabrera Beatriz, Zamora Rodiguez Nayara, Farina Hernandez Arminda, Rodriguez Gamboa Maria Jose, Maria Laura Garcia Bermejo, Milagros Fernandez Lucas, Elisa Conde Moreno, Laura Salinas Munoz, Silvia Serrano Huertas, Esperanza Macarena Rodriguez Serrano, Miren Edurne Ramos Munoz, Lorena Crespo Toro, Carolina Pilar Blanco Agudo, Cristina Galeano Alvarez, Jose Portoles, Maria Marques, Esther Rubio, Beatriz Sanchez-Sobrino, Estefanya Garcia-Menendez, Alberto Lazaro Fernandez, Patrocinio Rodriguez Benitez, Maria Angeles Gonzalez-Nicolas Gonzalez, Meritxell Lopez Gallardo, Gema Maria Fernandez Juarez, Eduardo Gutierrez Martinez, Manuel Praga Terente, Ana Tato Ribera, Teresa Cavero Escribano, Fernando Caravaca Fontan, Amir Shabaka Fernandez, Nicolas Roberto Robles Perez-Monteoliva, Enrique Luna Huerta, Guillermo Gervasini Rodriguez, Sergio Barroso Hernandez, Sonia Mota Zamorano, Juan Manuel Lopez Gomez, Alvaro Gil Gonzalez

Summary: The awareness of chronic kidney disease (CKD) is low among the public, physicians, and health authorities, with many still confusing it with chronic kidney insufficiency or failure. There is a prevailing view that CKD is mainly associated with kidney replacement therapy, but in reality, its main burden is accelerated aging and premature death from all causes, especially cardiovascular diseases. Researchers are calling for increased investment in CKD research to prevent it from becoming the second leading cause of death globally by 2040.

NEFROLOGIA (2022)

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Review Chemistry, Organic

Deoxygenation reactions in organic synthesis catalyzed by dioxomolybdenum(vi) complexes

Samuel Suarez-Pantiga, Roberto Sanz

Summary: Dioxomolybdenum complexes have shown great potential in deoxygenation reactions of various compounds, including sulfoxides, N-O bonds, and nitro functional groups.

ORGANIC & BIOMOLECULAR CHEMISTRY (2021)

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