期刊
ORGANIC LETTERS
卷 20, 期 8, 页码 2164-2167出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b00423
关键词
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资金
- National Natural Science Foundation of China [81673305, 81773573]
- Jiangsu Province Funds for Distinguished Young Scientists [BK20160033]
- College Students Innovation Project for the R&D of Novel Drugs [201710316236]
A class of O-2-alkyl derived diazeniumdiolates 3a-f and 4a-c were designed and synthesized as new bioorthogonal NO precursors, which can be effectively uncaged in the presence of a palladium catalyst via bioorthogonal bond cleavage reactions to generate NO in living cancer cells, eliciting potent antiproliferative activity.
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