Article
Biochemistry & Molecular Biology
Claudia Ardino, Filomena Sannio, Carolina Pasero, Lorenzo Botta, Elena Dreassi, Jean-Denis Docquier, Ilaria D'Agostino
Summary: Trifluoroacetic acid (TFA) is commonly used in synthetic strategies due to its strong acidity and low boiling point. However, residual amounts of TFA may affect the accuracy of cellular assays. This study evaluates the effect of different counterions on the biological activity of an antibacterial compound and optimizes the preparation methods.
MOLECULAR DIVERSITY
(2023)
Article
Chemistry, Medicinal
Evgeniy S. Izmest'ev, Svetlana V. Pestova, Alena I. Kolesnikova, Diana R. Baidamshina, Airat R. Kayumov, Svetlana A. Rubtsova
Summary: This study synthesized terpene-containing conjugates of fluoroquinolones and evaluated their antibacterial and antifungal activities. The compounds with a linker between a fluoroquinolone and a terpene fragment showed high activity against Staphylococcus aureus, with ciprofloxacin derivatives demonstrating the best performance. Camphor sulfonamides exhibited high antifungal activity against Candida albicans.
Article
Biochemistry & Molecular Biology
Leticia Ribeiro de Assis, Reinaldo dos Santos Theodoro, Maria Beatriz Silva Costa, Julyanna Andrade Silva Nascentes, Miguel Divino da Rocha, Meliza Arantes de Souza Bessa, Ralciane de Paula Menezes, Guilherme Dilarri, Giovane Boerner Hypolito, Vanessa Rodrigues dos Santos, Cristiane Duque, Henrique Ferreira, Carlos Henrique Gomes Martins, Luis Octavio Regasini
Summary: Isobavachalcone (IBC) is a natural compound with antibacterial activity, active against Staphylococcus aureus and mycobacterial species, but ineffective against Gram-negative bacteria. Additionally, IBC has the ability to inhibit biofilm formation and shows no toxicity to human keratinocytes.
Article
Chemistry, Organic
Radhe Shyam, Christiane Forestier, Nicolas Charbonnel, Olivier Roy, Claude Taillefumier, Sophie Faure
Summary: The study combined submonomer synthesis in solution and block-coupling protocols to prepare amphiphilic peptoid hexamers. The amphipathic character was attributed to the hydrophobic aliphatic tert-butyl side-chains and periodically introduced cationic side-chains. Evaluation of the compound's effects on bacterial strains, biofilm formation, and toxicity highlighted the potential of a short constrained peptoid carrying triazolium-type cationic pendant groups.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Kainat Mirza, Farha Naaz, Tokeer Ahmad, Nikhat Manzoor, Meryam Sardar
Summary: In this study, selenium nanoparticles were synthesized in situ on alkali-activated cotton fabric using guava leaf extract as a reducing agent. The synthesis was confirmed by the change in color of the fabric and analyzed using characterization techniques such as UV-DRS, XRD, FT-IR, and SEM-EDX. The coated fabric exhibited excellent antibacterial, antifungal, and antibiofilm activities, making it a potential material for medicinal applications that is ecofriendly and cost effective.
FERMENTATION-BASEL
(2023)
Article
Chemistry, Physical
Fabio M. S. Costa, M. Lucia M. F. S. Saraiva, Marieta L. C. Passos
Summary: Antimicrobial resistance is a growing concern caused by the overuse and misuse of antimicrobial drugs, as well as the lack of development of new drugs. It leads to significant economic costs and challenges in the healthcare system. Inadequate conditions and poor sanitation further contribute to the spread of drug-resistant pathogens. Strategies to combat antimicrobial resistance include the synthesis and evaluation of new compounds, combination therapy, and nanotechnology.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Petr Jaros, Elizaveta Timkina, Jana Michailidu, Dominik Marsik, Marketa Kulisova, Irena Kolouchova, Katerina Demnerova
Summary: Boswellic acids, derived from Boswellia sp. plants, have positive effects on human health, especially in treating inflammation, arthritis, or asthma. This study found that boswellic acids have antimicrobial and antibiofilm effects, and they synergize with commonly available antibiotics.
Article
Chemistry, Multidisciplinary
Ya-Meng Wu, Pei-Chen Zhao, Bin Jia, Zhe Li, Shuai Yuan, Cheng-Hui Li
Summary: Silver nanoparticles have broad spectrum antimicrobial activities, but their tendency to aggregate reduces their antibacterial effectiveness. A metal-organic framework modified with Ag(i) shows highly effective antibacterial activity against E.coli and S. aureus.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Engineering, Environmental
Gonzalo A. Lascano, Cecilia F. Spuches, M. Ines Gomez, Marcela A. Ferrero, Adriana Sales, Cintia M. Romero, Carolina Navarro
Summary: Magnetic support of NdFeO3 nanoparticles was synthesized to remove inorganic arsenic contamination in water. The nanoparticles demonstrated high adsorption capacity for As (III) and As (V), with better performance for the latter. By combining with Microbacterium oxydans AE038-20 biofilm, the removal efficiency for both As species was significantly improved.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Engineering, Environmental
Yachao Jiang, Anna Zheng, Yong Guan, Dafu Wei, Xiang Xu, Wuling Gong
Summary: The study successfully synthesized a gene reconstruction spandex spinning solution using polyhexamethylene guanidine hydrochloride as a functional gene, and obtained a composite spandex with superior antimicrobial properties through dry-spinning. The composite spandex showed inhibition rates exceeding 99.99% against E. coli and S. aureus, and maintained excellent antimicrobial performance even after soaking in acetic acid solution at 95 degrees C.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Medicine, Research & Experimental
Sundos Suleman Ismail Abdalla, Haliza Katas, Jie Yee Chan, Pavitra Ganasan, Fazren Azmi, Mh Busra Fauzi
Summary: A novel gelatin hydrogel incorporated with bio-nanosilver and lactoferrin was successfully developed, showing promising antimicrobial effects against S. aureus and P. aeruginosa without interfering with normal cellular functions. This new approach may accelerate healing of chronic wounds by targeting biofilms in infected wounds.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Maja Beus, Leentje Persoons, Dirk Daelemans, Dominique Schols, Kirsi Savijoki, Pekka Varmanen, Jari Yli-Kauhaluoma, Kristina Pavic, Branka Zorc
Summary: In this study, novel amide-type hybrid molecules based on anthranilic acid and quinoline or beta-carboline heterocyclic scaffolds were designed and synthesized. Three types of biological screenings were performed, revealing high activity of several compounds against cancer cells and viruses. These findings suggest the potential application of these compounds as anticancer and antiviral agents.
MOLECULAR DIVERSITY
(2022)
Article
Cell Biology
Adrian Bekier, Malwina Kawka, Jakub Lach, Jaroslaw Dziadek, Agata Paneth, Justyna Gatkowska, Katarzyna Dzitko, Bozena Dziadek
Summary: The re-emergence of tuberculosis as a global pandemic due to the rapid spread of drug-resistant strains of Mycobacterium tuberculosis highlights the urgent need to develop new drugs that can inhibit its growth and biofilm formation.
Article
Chemistry, Multidisciplinary
Shuwen Guo, Qiaoxian Huang, Yuan Chen, Jianwen Wei, Jun Zheng, Leyong Wang, Yitao Wang, Ruibing Wang
Summary: A novel guanidinium-functionalized pillar[5]arene, GP5, was designed and synthesized to effectively combat bacterial biofilms. GP5 showed high antibacterial potency against Gram-negative and Gram-positive strains and successfully disrupted preformed biofilms by penetrating biofilm barriers and destroying biofilm-enclosed bacteria. Additionally, host-guest complexation between GP5 and cefazolin sodium exhibited synergistic disruption activity against biofilms, providing a novel supramolecular platform for biofilm eradication.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Paper & Wood
Rahul Khose, Mahesh P. Bondarde, Surajit Some
Summary: The study synthesized a novel bioinspired deep eutectic solvent (DES) functionalized with graphene to prepare G-DES, and tested the flame retardancy of DES and G-DES coated cotton fabrics. Results showed that G-DES exhibited superior flame retardant properties.
Article
Ophthalmology
Parthasarathi Kalaiselvan, Muhammad Yasir, Ajay Kumar Vijay, Mark D. P. Willcox, Shyam Tummanapalli
Summary: This study evaluated the persistence of disinfection of three different hand sanitizers. The results showed that hand sanitizers containing capric acid or alcohol had better microbial inhibitory effects, which could help reduce the spread of microbes.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2023)
Article
Infectious Diseases
Rajesh Kuppusamy, Muhammad Yasir, Tsz Tin Yu, Florida Voli, Orazio Vittorio, Michael J. Miller, Peter Lewis, David StC Black, Mark Willcox, Naresh Kumar
Summary: There is an urgent need for new antimicrobial agents to address the global increase in antibiotic resistance. This study focused on producing short amphiphilic antibacterial and antibiofilm agents by modifying the hydrophobic and cationic groups of anthranilamide peptidomimetics. The addition of a lysine cationic group at the tail position significantly enhanced activity against E. coli and reduced cytotoxicity against mammalian cells. These compounds demonstrated notable disruption of preformed biofilms of S. aureus at micromolar concentrations.
Article
Biochemistry & Molecular Biology
Katrina Browne, Rajesh Kuppusamy, William R. Walsh, David StC Black, Mark D. P. Willcox, Naresh Kumar, Renxun Chen
Summary: Antibiotic resistance is a global challenge, and combination therapies using antibiotics and antimicrobial peptidomimetics can mitigate the development of resistance in bacteria. This strategy demonstrates synergistic activity against both Gram-positive and Gram-negative bacteria and has significant potential in clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Anuja Dahal, Kamal Shrestha, Rashmi Karki, Saraswati Bhattarai, Shiva Aryal, Satish Kumar Deo, Balmukunda Regmi, Mark Willcox, Shyam Kumar Mishra
Summary: This study analyzed the antibiotic sensitivity and biofilm-forming ability of urinary tract infection strains from renal disease patients. The results showed that the most common uropathogens in renal disease patients were Escherichia coli, Klebsiella pneumoniae, and Enterococcus spp. Some antibiotics such as amikacin, meropenem, and cefoperazone-sulbactam were effective against Gram-negative bacteria, while doxycycline, nitrofurantoin, and tetracycline were effective against Gram-positive bacteria. Additionally, most strains were capable of forming biofilms, and 70.8% were multidrug-resistant. Therefore, aminoglycoside, carbapenem, beta-lactam combination agents, and nitrofuran group of antibiotics may be the optimal first-line empirical therapies for uropathogens in hospitalized renal disease patients. Regular surveillance of resistance patterns and the study of biofilm formation in uropathogens are important for effective management of the patients.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2023)
Article
Chemistry, Physical
Sudip Chakraborty, Georgio Katsifis, Iman Roohani, Cyrille Boyer, David McKenzie, Mark D. P. Willcox, Renxun Chen, Naresh Kumar
Summary: This study demonstrates the efficacy of an antibacterial polymer as a coating material for hydroxyapatite and glass surfaces, which are widely used in orthopedics and biomedical sciences. Both physical and covalent attachment modes of the polymer to the material surfaces were explored. The modified surfaces showed significant antibacterial activity against Gram-negative bacterium E. coli, and the activity persisted for a prolonged period on the covalently modified materials' surfaces.
Article
Crystallography
Christopher E. Marjo, Anne M. Rich, Mohan M. Bhadbhade, Saroj Bhattacharyya, Songyan Yin, David M. Miskovic, Vina R. Aldilla, Naresh Kumar
Summary: This study investigates a layered crystal system with hydrogen-bonded chloro-s-triazine rings functionalised with alkyl or fluoroalkyl chains. The results show that the crystal undergoes a thermally-induced phase transition when substituted with N-propyl chains, but the phase transition is successfully suppressed when replaced with fluorinated N-propyl chains. The study also suggests that short-chain fluoroalkanes can exert strong control over the assembly and stability of an organic crystal.
Article
Biochemistry & Molecular Biology
Floriana Cappiello, Sudhir Verma, Xiao Lin, Isabel Y. Moreno, Bruno Casciaro, Debarun Dutta, Alison M. McDermott, Mark Willcox, Vivien J. Coulson-Thomas, Maria Luisa Mangoni
Summary: The corneal epithelium is essential for both vision and immune defense. Corneal abrasion can lead to severe eye infections, but recent research has discovered peptides that not only treat keratitis but also promote corneal wound healing, which could have potential clinical applications.
Article
Infectious Diseases
Sahil Shandil, Tsz Tin Yu, Shekh Sabir, David StC. Black, Naresh Kumar
Summary: As bacteria develop resistance against antimicrobials, alternative methods to tackle this issue must be developed. In this study, quinazolinone inhibitors were designed using molecular docking to target the pqs system in P. aeruginosa. Compound 6b showed the highest pqs inhibitory activity and no bacterial growth inhibition.
Review
Infectious Diseases
Shakeel Shahzad, Mark D. P. Willcox, Binod Rayamajhee
Summary: The global rise in antibiotic resistance in bacteria has become a major challenge in treating infectious diseases. This literature review aims to decipher the evolving mechanisms of resistance to polymyxins among clinically significant pathogens. Understanding these mechanisms may help develop suitable methods for detecting polymyxin resistance determinants and the development of novel antimicrobial molecules.
Article
Infectious Diseases
Umme Laila Urmi, Samuel Attard, Ajay Kumar Vijay, Mark D. P. Willcox, Naresh Kumar, Salequl Islam, Rajesh Kuppusamy
Summary: The development of potent antiviral agents is crucial for combating viral infections worldwide. In this study, the antiviral potential of 17 peptidomimetic compounds was evaluated against MHV-1 and HSV-1. Compounds 11 and 14 showed the most potent inhibitory effects, and they were found to directly influence the viral envelope. These findings suggest that peptidomimetic compounds could offer a new approach for the development of potent antiviral agents.
Article
Materials Science, Multidisciplinary
Zeyu Shao, Karen Hakobyan, Jiangtao Xu, Renxun Chen, Naresh Kumar, Mark Willcox, Edgar H. H. Wong
Summary: This study reports the development of a smart antimicrobial polymer that can be activated under UV light to exhibit antimicrobial activity. The polymer showed bacteriostatic and bactericidal effects against multidrug-resistant bacteria, as well as the ability to disrupt bacterial membranes and kill biofilms. Furthermore, the polymer effectively killed cancer cells, demonstrating its potential in cancer therapy.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)