期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 16, 期 8, 页码 1367-1374出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob00055g
关键词
-
资金
- National Natural Science Foundation of China [21572200]
- Fundamental Research Funds for the Central Universities [2017QNA3013]
An enantioselective aza-Friedel-Crafts reaction of trifluoromethyl dihydrobenzoazepinoindoles with pyrroles catalyzed by a chiral spirocyclic phosphoric acid was developed. This methodology provides a facile route to CF3- and pyrrole-containing benzazepinoindoles bearing quaternary stereocenters in good yields and with moderate to excellent enantioselectivities (up to 93% ee). Indoles were also investigated as electron-rich aromatic substrates to afford the corresponding chiral heterocycles with good yields and considerable enantioselectivities. The introduction of CF3 shows a remarkable fluorine effect and increases the activation and stereoinduction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据