Increased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse model

Drp1-Mediated Mitochondrial Abnormalities Link to Synaptic Injury in Diabetes Model

(2014) Shengbin Huang et al.   DIABETES

Identification of human presequence protease (hPreP) agonists for the treatment of Alzheimer's disease

(2014) Jhansi Rani Vangavaragu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxidative stress-mediated activation of extracellular signal-regulated kinase contributes to mild cognitive impairment-related mitochondrial dysfunction

(2014) Xueqi Gan et al.   FREE RADICAL BIOLOGY AND MEDICINE

RAGE Inhibition in Microglia Prevents Ischemia-Dependent Synaptic Dysfunction in an Amyloid-Enriched Environment

(2014) N. Origlia et al.   JOURNAL OF NEUROSCIENCE

Mitochondria: hub of injury responses in the developing brain

(2014) Henrik Hagberg et al.   LANCET NEUROLOGY

Cyclophilin D deficiency rescues Aβ-impaired PKA/CREB signaling and alleviates synaptic degeneration

(2013) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons

(2013) Lan Guo et al.   PLoS One

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria-Specific Accumulation of Amyloid β Induces Mitochondrial Dysfunction Leading to Apoptotic Cell Death

(2012) Moon-Yong Cha et al.   PLoS One

Mitochondria and Cell Bioenergetics: Increasingly Recognized Components and a Possible Etiologic Cause of Alzheimer's Disease

(2011) Russell H. Swerdlow   ANTIOXIDANTS & REDOX SIGNALING

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Inhibition of Amyloid-  (A ) Peptide-Binding Alcohol Dehydrogenase-A  Interaction Reduces A  Accumulation and Improves Mitochondrial Function in a Mouse Model of Alzheimer's Disease

(2011) J. Yao et al.   JOURNAL OF NEUROSCIENCE

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein

(2010) Pavel F. Pavlov et al.   FASEB JOURNAL

Microglial Receptor for Advanced Glycation End Product-Dependent Signal Pathway Drives  -Amyloid-Induced Synaptic Depression and Long-Term Depression Impairment in Entorhinal Cortex

(2010) N. Origlia et al.   JOURNAL OF NEUROSCIENCE

Association of Omi/HtrA2 with γ-secretase in mitochondria

(2010) Homira Behbahani et al.   NEUROCHEMISTRY INTERNATIONAL

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

(2009) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease

(2009) Fang Fang et al.   FASEB JOURNAL

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

(2009) Heng Du et al.   NEUROBIOLOGY OF AGING

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RAGE-mediated signaling contributes to intraneuronal transport of amyloid-  and neuronal dysfunction

(2009) K. Takuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition

(2008) Magnus J. Hansson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

A rapid Percoll gradient procedure for preparation of synaptosomes

(2008) Peter R Dunkley et al.   Nature Protocols

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE