Article
Gastroenterology & Hepatology
Arthur J. Kastl, Kimberly N. Weaver, Xian Zhang, Jennifer A. Strople, Jeremy Adler, Marla C. Dubinsky, Athos Bousvaros, Runa Watkins, Xiangfeng Dai, Wenli Chen, Raymond K. Cross, Peter D. R. Higgins, Ryan C. Ungaro, Meenakshi Bewtra, Emanuelle A. Bellaguarda, Francis A. Farraye, Kelly Y. Chun, Michael Zikry, Manory Fernando, Monique Bastidas, Cristian G. Hernandez, Riley G. Craig, Margie E. Boccieri, Anne Firestine, Millie D. Long, Michael D. Kappelman
Summary: Children with IBD show a robust immune response to COVID-19 vaccination with low adverse events, providing a high level of reassurance to the medical community and patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Immunology
Julia Faura, Alejandro Bustamante, Francesc Miro-Mur, Joan Montaner
Summary: Stroke-induced immunosuppression increases the risk of stroke-associated infections in stroke patients, particularly stroke-associated pneumonia, but there are currently no accurate biomarkers for early diagnosis and prevention. Efforts are being made to explore local immunomodulation as a potential approach for preventive therapy of stroke-associated pneumonia.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Nanoscience & Nanotechnology
Ao Chen, Fan Yang, Jing Kuang, Yuan Xiong, Bo-Bin Mi, Ying Zhou, Jing-Jing Hu, Shu-Jun Song, Tao Wan, Zhong-Zhong Wan, Hong-Yang Huang, Xin-Run Li, Wen Song, Wen-Xiu Qiu
Summary: A nanoplatform was constructed to reverse tumor acidosis and hypoxia through alkali and oxygen generation triggered by tumor acidosis, polarizing tumor-associated macrophages to anti-tumor M1 phenotype macrophages and enhancing tumor immune response. Furthermore, under regional light irradiation, reactive oxygen species produced by photosensitizers in the nanoplatform could increase the immunogenicity of tumors, transitioning tumors from immunosuppressive cold tumors to immunogenic hot tumors and amplifying the effect of immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Filip Cvetkovski, J. Mark Hexham, Erik Berglund
Summary: Liver transplant recipients require lifelong immunosuppression therapy to preserve allograft function, which may lead to increased risks of malignancy, infection, renal impairment, and other toxicities. Although rare cases may achieve operational tolerance, predicting successful withdrawal of immunosuppression is difficult and requires long-term study.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Deshka S. Foster, Michael Januszyk, Daniel Delitto, Kathryn E. Yost, Michelle Griffin, Jason Guo, Nicholas Guardino, Andrea E. Delitto, Malini Chinta, Austin R. Burcham, Alan T. Nguyen, Khristian E. Bauer-Rowe, Ashley L. Titan, Ankit Salhotra, R. Ellen Jones, Oscar da Silva, Hunter G. Lindsay, Charlotte E. Berry, Kellen Chen, Dominic Henn, Shamik Mascharak, Heather E. Talbott, Alexia Kim, Fatemeh Nosrati, Dharshan Sivaraj, R. Chase Ransom, Michael Matthews, Anum Khan, Dhananjay Wagh, John Coller, Geoffrey C. Gurtner, Derrick C. Wan, Irene L. Wapnir, Howard Y. Chang, Jeffrey A. Norton, Michael T. Longaker
Summary: This study investigates the heterogeneity of cancer-associated fibroblasts (CAFs) using a comprehensive multiomics approach, identifying three superclusters of CAFs. The study finds that disrupting mechanical force or immune checkpoint inhibition therapy leads to changes in the distribution of CAF subpopulations and affects tumor growth. The results of this research are important for expanding our understanding of CAF biology, identifying regulatory pathways in CAF differentiation, and discovering therapeutic targets for tumor treatment.
Article
Biochemistry & Molecular Biology
Maria Teresa Pagano, Katia Fecchi, Marina Pierdominici, Elena Ortona, Daniela Peruzzu
Summary: Silibinin exhibits immunosuppressive activity by inhibiting the maturation and activation of human dendritic cells, suggesting its potential application as an adjuvant therapy for autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Zide Wang, Hanlin Zhong, Xiaohong Liang, Shilei Ni
Summary: This article discusses the role of TAMs in glioblastoma, the formation of immunosuppressive tumor microenvironment, the regulation of TAM function in clinical trials, and evaluates the implications of existing and novel translational approaches for treating glioblastoma in clinical practice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Ben Koszegi, Corey Stone, Dedee F. Murrell
Summary: Pemphigus patients receiving rituximab infusions and COVID-19 vaccinations had mild COVID-19 infections, suggesting the importance of vaccination in this population. Antibody response to COVID-19 vaccines should be confirmed before initiating rituximab therapy.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Lulu Ni, Ping Sun, Sujuan Zhang, Bin Qian, Xu Chen, Mengrui Xiong, Bing Li
Summary: This study identified four subtypes in GBM patients based on TME-related gene expression characteristics and found an immunosuppressive subtype characterized by high expression of immunosuppressive factors, low lymphocyte infiltration, and IDH1 mutation. Three co-expressed gene modules associated with the immunosuppressive subtype were also identified, involving inflammatory response, angiogenesis, hypoxia, and carbon metabolism. The findings provide new insights for improving personalized immunotherapy in GBM.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Respiratory System
Sakhee Kotecha, Steven Ivulich, Gregory Snell
Summary: Lung transplantation has seen significant advancements in immunosuppression management over the past three decades, moving towards a more personalized approach. As the demographics of lung transplant recipients change and survival rates improve, the management of immunosuppression related comorbidities becomes increasingly important.
JOURNAL OF THORACIC DISEASE
(2021)
Review
Cell Biology
Antero Salminen
Summary: Tissue-resident fibroblasts possess plasticity and can modify their properties according to the microenvironment. Different phenotypes of fibroblasts are associated with various tissue pathological conditions, and they can be subdivided into fibrogenic, nonfibrogenic, inflammatory, immunosuppressive, and senescent subsets. The differentiation of myofibroblasts, a major activated fibroblast phenotype, can be induced by multiple stresses associated with aging, and anti-aging treatments can inhibit this differentiation. The versatile plasticity and structural importance of fibroblasts suggest that they play a significant role in the aging process.
AGEING RESEARCH REVIEWS
(2023)
Article
Ophthalmology
Justine R. Smith, Janet M. Matthews, Diana Conrad, Anthony J. Hall, Rachael L. Niederer, Davinder Singh-Grewal, Mei-Ling Tay-Kearney, Jane M. Wells, Sophia L. Zagora, Peter J. McCluskey
Summary: The Australian and New Zealand-based uveitis-specialized ophthalmologists have developed 18 consensus statements for managing chronic anterior uveitis in children with JIA, providing regionally applicable advice for ophthalmic care.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Engineering, Biomedical
Hong Wang, Jie Li, Zhiwan Wang, Yuqi Wang, Xiaoxuan Xu, Xiang Gong, Jiaoying Wang, Zhiwen Zhang, Yaping Li
Summary: This study introduces a bioinspired tumor-responsive theranostic nanovehicle (BTN) with remarkable tumor-penetrating capability, designed to relieve the profound immunosuppression in tumor and effectively suppress tumor growth.
Review
Gastroenterology & Hepatology
Luckshi Rajendran, Tommy Ivanics, Marco P. A. W. Claasen, Hala Muaddi, Gonzalo Sapisochin
Summary: The annual incidence of hepatocellular carcinoma (HCC) is increasing, and liver transplantation is the preferred treatment. However, there is currently no consensus on post-transplantation cancer surveillance and recurrence management for HCC. Early tumor detection, re-evaluation of immunosuppression regimens, and staging are important for guiding decision-making and maximizing treatment effect. Treatment recommendations specific to recurrence type are provided.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Review
Transplantation
Benjamin Wooden, Blanca Tarragon, Mariela Navarro-Torres, Andrew S. Bomback
Summary: Over the past two decades, there has been an improved understanding of the role of complement in kidney diseases, leading to the development of new complement-targeting therapies. The activation of complement across all three pathways has been recognized to play a significant role in both rare and common glomerular lesions, providing opportunities for precise interventions. This review examines the evidence on complement inhibition, from small-scale studies focusing on C5-targeting agents to recent large, randomized trials targeting the complement pathway at the C3 level, and discusses future directions in complement targeting therapy.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)