Article
Anatomy & Morphology
Kevin Puertas-Neyra, Nadia Galindo-Cabello, Leticia A. Hernandez-Rodriguez, Fernando Gonzalez-Perez, Jose Carlos Rodriguez-Cabello, Rogelio Gonzalez-Sarmiento, Jose Carlos Pastor, Ricardo Usategui-Martin, Ivan Fernandez-Bueno
Summary: Retinal neurodegenerative diseases are the leading causes of visual impairment and irreversible blindness worldwide. The development of broad-spectrum neuroprotective therapies is essential as current therapeutic options are limited. This study aims to understand the role of cell death mechanisms and autophagy in retinal neurodegenerative diseases, providing new insights for future therapeutic options.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Biochemistry & Molecular Biology
Elisabetta Catalani, Silvia Bongiorni, Anna Rita Taddei, Marta Mezzetti, Federica Silvestri, Marco Coazzoli, Silvia Zecchini, Matteo Giovarelli, Cristiana Perrotta, Clara De Palma, Emilio Clementi, Marcello Ceci, Giorgio Prantera, Davide Cervia
Summary: The absence of full-length dystrophin leads to structural damages and impaired autophagy in the retina, affecting neuronal survival and visual properties. Reactivation of autophagy can prevent cell death and structural changes, improving the response to light in mutant flies. Overall, functional dystrophin is crucial for synapsis stabilization and proper neuronal survival in the retina.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Aiwen Jiang, Hongyun Guo, Wangjun Wu, Honglin Liu
Summary: This study found that during myogenic differentiation, the level of autophagy was consistent with apoptosis, with increased apoptosis activating autophagy, which in turn inhibited apoptosis to prevent excessive cell death and maintain cell stability. The interaction between autophagy and apoptosis determines the balance of cell death and survival during skeletal muscle cell differentiation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Immunology
Emilio G. Vozza, Michelle E. Mulcahy, Rachel M. McLoughlin
Summary: The success of Staphylococcus aureus as a human commensal and opportunistic pathogen lies in its ability to adapt to various niches within the host. Evading the host's innate immune response, S. aureus can parasitize phagocytes and manipulate the autophagy pathway to create an intracellular survival niche. Neutrophils play a critical role in S. aureus infection, with the bacterium surviving and potentially impacting host signaling pathways for its own benefit.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Elisabetta Catalani, Simona Del Quondam, Kashi Brunetti, Agnese Cherubini, Silvia Bongiorni, Anna Rita Taddei, Silvia Zecchini, Matteo Giovarelli, Clara De Palma, Cristiana Perrotta, Emilio Clementi, Giorgio Prantera, Davide Cervia
Summary: This study evaluated the effects of plumbagin on retina homeostasis in a hyperglycemic fruit fly model. The results showed that plumbagin improved visual performance, repaired damaged eye structures, and reduced neuronal impairment and eye damage induced by high glucose through various mechanisms, such as Nrf2 signaling activation and inhibition of mitochondrial-endoplasmic reticulum stress and unfolded protein response pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Minsu Jang, Rackhyun Park, Ayane Yamamoto, Yea-In Park, Yeonjeong Park, Siyun Lee, Junsoo Park
Summary: A study has found that an inhibitor called compound C can effectively inhibit the replication of the human coronavirus OC43 strain. This finding suggests that compound C may be a potential drug candidate for COVID-19.
Article
Biochemistry & Molecular Biology
Junmei Li, Lin Qi, Ziyang Diao, Mengyu Zhang, Bin Li, Yunyi Zhai, Mingyue Hao, Dong Zhou, Wei Liu, Yaping Jin, Aihua Wang
Summary: Studies have shown that the Brucella effector BtpB manipulates host cell infection by promoting apoptosis and inhibiting autophagy. In addition, the autophagy inhibitor chloroquine can reduce intracellular survival of Brucella.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria Consiglia Trotta, Sami Gharbia, Hildegard Herman, Bianca Mladin, Andrei Hermenean, Cornel Balta, Coralia Cotoraci, Victor Eduard Peteu, Carlo Gesualdo, Francesco Petrillo, Marilena Galdiero, Roberto Alfano, Mihaela Gherghiceanu, Michele D'Amico, Settimio Rossi, Anca Hermenean
Summary: The study found that aged mice had decreased endogenous levels of RvD1 in the retina, as well as sex-related differences in neuroinflammation and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Kai Kaarniranta, Janusz Blasiak, Paloma Liton, Michael Boulton, Daniel J. Klionsky, Debasish Sinha
Summary: Age-related macular degeneration (AMD) is a leading cause of visual impairment in the aging population. The progression of AMD is characterized by atrophic alterations in the retinal pigment epithelium and the formation of lipofuscin and deposits. Chronic oxidative stress, protein aggregation, and inflammation may contribute to the development of AMD.
Article
Cell Biology
Noemi Anna Pesce, Alessio Canovai, Emma Lardner, Maurizio Cammalleri, Anders Kvanta, Helder Andre, Massimo Dal Monte
Summary: The study found that autophagy plays a crucial role during retinal development in rats, particularly during the hypoxic phase. Autophagy activity was heightened in the early postnatal days, but decreased in later stages of development, reaching a normal level between post-natal days 14-18.
Article
Neurosciences
Koushik Mondal, Hunter Porter, Jerome Cole, Hemang K. Pandya, Sandip K. Basu, Sufiya Khanam, Chi-Yang Chiu, Vinay Shah, Daniel J. Stephenson, Charles E. Chalfant, Nawajes Mandal
Summary: This article investigates the toxic effects of hydroxychloroquine (HCQ) on the inner retina and its impact on visual functions. Through a clinical study and a mouse model, the researchers found that chronic HCQ toxicity results in the loss of inner retinal neurons and retinal ganglion cells, leading to compromised visual functions. They also provided insights into the underlying molecular mechanisms involving autophagy-lysosomal defects and alterations in sphingolipid metabolism.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yujia Li, Qi Yang, Hui Chen, Xiaotian Yang, Jingru Han, Xiaojuan Yao, Xiajie Wei, Jiaoyang Si, Huanling Yao, Hongliang Liu, Lixin Wan, Hushan Yang, Yanming Wang, Dengke Bao
Summary: Mitochondrial biogenesis disruption leads to mtDNA stress, activating the cGAS-STING pathway and autophagy to promote ESCC growth.
Article
Biochemistry & Molecular Biology
Mina Jang, Shuta Hara, Gun-Hee Kim, Seung Min Kim, Sangkeun Son, Mincheol Kwon, In-Ja Ryoo, Hyemin Seo, Min Jung Kim, Nam-Doo Kim, Nak-Kyun Soung, Yong Tae Kwon, Bo Yeon Kim, Hiroyuki Osada, Jae-Hyuk Jang, Sung-Kyun Ko, Jong Seog Ahn
Summary: The study demonstrates a novel autophagy enhancer, dutomycin (DTM), that induces autophagy and eventually apoptosis by activating serine protease inhibitor B6 (SERPINB6). The inhibitory effects of DTM on SERPINB6 function were confirmed, and this research provides new insights for future studies on the relationship between cancer and autophagy.
ACS CHEMICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elisabetta Catalani, Giuseppina Fanelli, Federica Silvestri, Agnese Cherubini, Simona Del Quondam, Silvia Bongiorni, Anna Rita Taddei, Marcello Ceci, Clara De Palma, Cristiana Perrotta, Sara Rinalducci, Giorgio Prantera, Davide Cervia
Summary: The study evaluated the beneficial and antioxidant properties of food supplementation with Lisosan G in a fruit fly model of hyperglycemia-induced retinal damage, finding positive effects on the visual system, apoptosis reduction, and activation of protective autophagy. Lisosan G also decreased levels of ROS and peroxynitrite, and impacted key oxidative stress-related metabolites, providing robust antioxidant effects on retinal neurons and efficacious neuroprotection of hyperglycemic eye.
Article
Biochemistry & Molecular Biology
Yen-Tze Liu, Hsin-Yu Ho, Chia-Chieh Lin, Yi-Ching Chuang, Yu-Sheng Lo, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: Platyphyllenone can induce both autophagy and apoptosis in oral cancer cells by regulating multiple signaling pathways, providing a potential therapeutic option for chemoprevention against oral cancer proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)