Activating the translational repressor 4E-BP or reducing S6K-GSK3β activity prevents accelerated axon growth induced by hyperactive mTORin vivo

Altered white matter connectivity as a neural substrate for social impairment in Autism Spectrum Disorder

(2015) Stephanie H. Ameis et al.   CORTEX

Reconciling abnormalities of brain network structure and function in schizophrenia

(2015) Alex Fornito et al.   CURRENT OPINION IN NEUROBIOLOGY

Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy

(2015) Jae Seok Lim et al.   NATURE MEDICINE

Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2

(2014) Márcia A Liz et al.   BMC BIOLOGY

SRF Phosphorylation by Glycogen Synthase Kinase-3 Promotes Axon Growth in Hippocampal Neurons

(2014) C. L. Li et al.   JOURNAL OF NEUROSCIENCE

MEK-ERK1/2-Dependent FLNA Overexpression Promotes Abnormal Dendritic Patterning in Tuberous Sclerosis Independent of mTOR

(2014) Longbo Zhang et al.   NEURON

Visual Circuit Development Requires Patterned Activity Mediated by Retinal Acetylcholine Receptors

(2014) Timothy J. Burbridge et al.   NEURON

Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex

(2014) Shin Yasuda et al.   Scientific Reports

Selective Activation of mTORC1 Signaling Recapitulates Microcephaly, Tuberous Sclerosis, and Neurodegenerative Diseases

(2014) Hidetoshi Kassai et al.   Cell Reports

Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation

(2014) Candi L. LaSarge et al.   Frontiers in Molecular Neuroscience

Altered neural connectivity in excitatory and inhibitory cortical circuits in autism

(2013) Basilis Zikopoulos et al.   Frontiers in Human Neuroscience

Rheb Activation in Subventricular Zone Progenitors Leads to Heterotopia, Ectopic Neuronal Differentiation, and Rapamycin-Sensitive Olfactory Micronodules and Dendrite Hypertrophy of Newborn Neurons

(2013) C. A. Lafourcade et al.   JOURNAL OF NEUROSCIENCE

Glycogen Synthase Kinase 3 Beta (GSK3β) at the Tip of Neuronal Development and Regeneration

(2013) Oscar Seira et al.   MOLECULAR NEUROBIOLOGY

Focal malformations of cortical development: New vistas for molecular pathogenesis

(2013) K.-C. Lim et al.   NEUROSCIENCE

mTORC1 Targets the Translational Repressor 4E-BP2, but Not S6 Kinase 1/2, to Regulate Neural Stem Cell Self-Renewal In Vivo

(2013) Nathaniel W. Hartman et al.   Cell Reports

Mammalian Target of Rapamycin (mTOR) Pathways in Neurological Diseases

(2013) Michael Wong   Biomedical Journal

Fetal Brain mTOR Signaling Activation in Tuberous Sclerosis Complex

(2012) Victoria Tsai et al.   CEREBRAL CORTEX

Liver-specific p70 S6 Kinase Depletion Protects against Hepatic Steatosis and Systemic Insulin Resistance

(2012) Eun Ju Bae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-132 Enhances Dendritic Morphogenesis, Spine Density, Synaptic Integration, and Survival of Newborn Olfactory Bulb Neurons

(2012) Manavendra Pathania et al.   PLoS One

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

GSK3 controls axon growth via CLASP-mediated regulation of growth cone microtubules

(2011) E.-M. Hur et al.   GENES & DEVELOPMENT

Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice

(2011) David M. Feliciano et al.   JOURNAL OF CLINICAL INVESTIGATION

Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome

(2011) Madeline A Lancaster et al.   NATURE MEDICINE

Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin

(2011) Robert P. Carson et al.   NEUROBIOLOGY OF DISEASE

Role of GSK3 Signaling in Neuronal Morphogenesis

(2011) Yun Tai Kim et al.   Frontiers in Molecular Neuroscience

Mammalian Target of Rapamycin (mTOR) Activation Increases Axonal Growth Capacity of Injured Peripheral Nerves

(2010) Namiko Abe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GSK3  Regulates Myelin-Dependent Axon Outgrowth Inhibition through CRMP4

(2010) Y. Z. Alabed et al.   JOURNAL OF NEUROSCIENCE

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

(2010) Kai Liu et al.   NATURE NEUROSCIENCE

GSK3 signalling in neural development

(2010) Eun-Mi Hur et al.   NATURE REVIEWS NEUROSCIENCE

Specification of Neuronal Polarity Regulated by Local Translation of CRMP2 and Tau via the mTOR-p70S6K Pathway

(2009) Tsuyoshi Morita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice

(2009) J. Zhou et al.   JOURNAL OF NEUROSCIENCE

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tuberous sclerosis complex proteins control axon formation

(2008) Y.-J. Choi et al.   GENES & DEVELOPMENT

RalA Functions as an Indispensable Signal Mediator for the Nutrient-sensing System

(2008) Tomohiko Maehama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rheb and mTOR Regulate Neuronal Polarity through Rap1B

(2008) Ying-Hua Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function

(2008) L. Meikle et al.   JOURNAL OF NEUROSCIENCE

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE