Review
Biochemistry & Molecular Biology
Igor Petrone, Everton Cruz dos Santos, Renata Binato, Eliana Abdelhay
Summary: Long noncoding RNAs (lncRNAs) are noncoding transcripts encoded by the mammalian genome, functioning as decoys, scaffolds, and enhancer RNAs. They play a vital role in regulating other molecules, including microRNAs. Abnormal expression of lncRNAs has been implicated in breast cancer (BC) initiation and progression, highlighting the need for a better understanding of lncRNA regulatory mechanisms. Specifically, this review focuses on the role of lncRNAs in ductal carcinoma in situ (DCIS) and their potential contribution to the progression of DCIS to invasive BC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Wuwen Zhang, Qinshi Wang, Yi Yang, Siyuan Zhou, Ping Zhang, Tongbao Feng
Summary: Exosomes play a crucial role in cell-cell communication within the cancer microenvironment. Exosomal long noncoding RNAs (lncRNAs) are key regulators in cancer development, involved in processes such as cancer cell proliferation, metastasis, drug resistance, and immunomodulation. Changes in exosomal lncRNAs levels often correlate with cancer occurrence and progression, making them valuable biomarkers for cancer diagnosis and prognosis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Dezhong Lv, Zhenghong Chang, Yangyang Cai, Junyi Li, Liping Wang, Qiushuang Jiang, Kang Xu, Na Ding, Xia Li, Juan Xu, Yongsheng Li
Summary: TransLnc is a database that provides experimentally supported and predicted lncRNA peptides in multiple species, with hundreds of thousands of peptides recorded. Various types of evidence supporting the coding potential of lncRNAs are integrated, and users can access lncRNA peptides in 34 tissues and predicted tumor neoantigens.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Medicine, Research & Experimental
Chen Luo, Kang Lin, Cegui Hu, Xiaojian Zhu, Jinfeng Zhu, Zhengming Zhu
Summary: The study reveals that LINC01094 is significantly overexpressed in pancreatic cancer tissues and promotes cell proliferation and metastasis by acting as an endogenous miR-577 sponge to upregulate LIN28B expression through the PI3K/AKT pathway.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Peng Wu, Chunxiang Li, Dong mei Ye, Kenan Yu, Yuxuan Li, Hailin Tang, Gaoshen Xu, Shuijing Yi, Zhiwei Zhan
Summary: In this study, circEPSTI1 was found to be significantly upregulated in cervical cancer and shown to impact cell ferroptosis. The circEPSTI1-miR-375/409-3P/515-5p-SLC7A11 axis was identified to affect proliferation in cervical cancer through the ceRNA mechanism and was linked to ferroptosis. The findings suggest circEPSTI1 as a potential new biomarker for monitoring and targeting treatment in cervical cancer.
Article
Cell Biology
Wentao Ma, Weihong Zhang, Bing Cui, Jing Gao, Qiuhong Liu, Mengying Yao, Hanbing Ning, Lihua Xing
Summary: This study reveals that EPCs derived EVs transmit TUG1 to alleviate sepsis by promoting macrophage M2 polarization. Additionally, TUG1 can competitively bind to miR-9-5p to upregulate SIRT1 expression, leading to the inhibition of miR-9-5p-mediated SIRT1 inhibition, which contributes to a more comprehensive understanding of the pathogenesis of sepsis.
CELL DEATH & DISEASE
(2021)
Editorial Material
Genetics & Heredity
Claire Wilson, Aditi Kanhere
Summary: This study speculates on the potential role of variants of lncRNAs in cancer development by drawing upon emerging research findings.
TRENDS IN GENETICS
(2021)
Article
Cell Biology
Jiwei Cheng, Haibo Ma, Ming Yan, Wenqun Xing
Summary: THAP9-AS1 is overexpressed in esophageal squamous cell carcinoma (ESCC) and is positively correlated with tumor size, TNM stage, lymph node metastasis, and prognosis. It functions as a competing endogenous RNA (ceRNA) for miR-133b, leading to the upregulation of SOX4 and promoting ESCC progression.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Qing Xia, Qibin Yan, Zehua Wang, Qinyuan Huang, Xinying Zheng, Jinze Shen, Lihua Du, Hanbing Li, Shiwei Duan
Summary: This study aimed to construct a prediction model for breast cancer subtypes based on disulfidptosis-related lncRNAs. The random forest algorithm was used to select important lncRNAs, and a prediction model was successfully established. The study also revealed that key lncRNAs were closely related to RNA methylation modification, angiogenesis, and immune infiltrating cells.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Razia Khalid, Hammad Naveed, Zoya Khalid
Summary: Long non-coding RNAs (lncRNAs) have emerged as important players in regulating biological processes and their mutations are associated with complex diseases. In this study, we developed a machine learning model that combines sequence and structure-based features to predict disease-related lncRNAs. Our model outperformed existing methods and achieved the highest F1 score of 76% on the SVM classifier. We also addressed limitations in previous methods by incorporating redundancy checking and oversampling techniques. Combining multiple features, particularly lncRNA sequence mutations, significantly contributed to the prediction of disease-related lncRNAs.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Xiaoying Jiang, Ronghui Lei
Summary: Exosomes are membrane-surrounded extracellular vesicles that mediate intercellular communication by delivering bioactive molecules. Long noncoding RNAs (lncRNAs), a class of non-protein-coding RNAs, play important roles in the development of cardiovascular diseases (CVDs). In this article, we review the current studies on exosomal lncRNAs secreted and absorbed by cardiomyocytes and their functional roles in CVDs, aiming to deepen our understanding of the pathological mechanisms of CVDs and their potential for clinical diagnosis and therapy.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Reproductive Biology
Bei-Bei Zhang, Meng-Xiao Li, Hong-Na Wang, Chao Liu, Yan-Yan Sun, Teng-He Ma
Summary: In this study, the expression of lncRNAs and mRNAs associated with ovarian follicle development in Taihang chickens was analyzed at the genome-wide level. The findings identified key pathways and regulatory factors related to follicle selection, providing a new foundation for future research on reproductive physiology in Taihang chickens and offering new opportunities to improve their laying performance.
Article
Oncology
Xiangdong Xu, Yang Liu, Yan Li, Huajian Chen, Yuxuan Zhang, Jie Liu, Shaokang Deng, Yaofeng Zheng, Xinlin Sun, Jihui Wang, Taoliang Chen, Min Huang, Yiquan Ke
Summary: MiR-375 expression is downregulated in gliomas, and it suppresses glioma proliferation, migration, and invasion by inhibiting the CTGF-EGFR signaling pathway. MiR-375-containing exosomes were found in human blood samples from glioma patients, with levels correlating with disease progression. Exosomal miR-375 secretion impacts the activity of the CTGF-EGFR pathway, and once secreted, exosomal miR-375 is not taken back up by glioma cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Immunology
Ping Jiang, Xiaopeng Li
Summary: Precise expression and regulation of genes in the immune system are crucial for generating strong immune responses and preventing autoimmune diseases. Recent studies have shown that long noncoding RNAs play a significant role in immune function by regulating immune cell differentiation, development, and function. These RNAs can control the polarization of immune cells, promote pro-inflammatory or anti-inflammatory effects, and contribute to the pathogenesis of various diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Yue Cui, Bozhong Shi, Zijie Zhou, Bo Chen, Xiaoyang Zhang, Cong Li, Kai Luo, Zhongqun Zhu, Jinghao Zheng, Xiaomin He
Summary: A long non-coding RNA (CFRL) associated with cardiac fibrosis has been identified, which can promote the proliferation and migration of cardiac fibroblasts. Silencing CFRL significantly alleviates cardiac fibrosis and improves ventricular function. Interfering with CFRL may be considered as a multitarget strategy for treating cardiac fibrosis and heart failure.
