期刊
ONCOLOGY REPORTS
卷 40, 期 3, 页码 1554-1564出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2018.6573
关键词
UCA1; radiosensitivity; migration; EMT; colorectal cancer; CCL244
类别
资金
- National Natural Science Foundation of China [81672970, 81301933, 81472917, 81572345]
- Natural Science Foundation of Jiangsu Province [BK20160338]
- projects of Suzhou Technology Bureau [SZS201618, SYS201552, SYSD2015034]
- Focus of Clinical Disease Treatment Technology Special Funds of Suzhou City [LCZX201505]
- Second Affiliated Hospital of Soochow University Preponderant Clinic Discipline Group Project Funding
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and common cause of cancer-related deaths. Radiotherapy has become a routine treatment for CRC. However, radioresistance affects therapeutic efficacy. Long non-coding RNA urothelial carcinoma associated 1 (UCA1) has been demonstrated to be overexpressed in several tumors and predicts a poor prognosis. In the present study, we revealed that lncRNA-UCA1 was overexpressed in colorectal cancer tissue and colon cancer cells when compared to normal tissue and cells. Quantitative real-time PCR revealed that the expression of UCA1 was significantly higher in CRC tissues after chemoradiotherapy. Downregulation of UCA1 enhanced the radiosensitivity of CCL244 cells via inhibition of the colony formation, proliferation and promotion of radiation-induced apoptosis and G2/M arrest. Moreover, downregulation of UCA1 suppressed the epithelial-mesenchymal transition (EMT) in CCL244 cells.
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