Intravitreal delivery of a novel AAV vector targets ON bipolar cells and restores visual function in a mouse model of complete congenital stationary night blindness

LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation

(2015) Marion Neuillé et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

ON pathway mutations increase susceptibility to form-deprivation myopia

(2015) Ranjay Chakraborty et al.   EXPERIMENTAL EYE RESEARCH

Targeting Channelrhodopsin-2 to ON-bipolar Cells With Vitreally Administered AAV Restores ON and OFF Visual Responses in Blind Mice

(2015) Emilie Macé et al.   MOLECULAR THERAPY

Congenital stationary night blindness: An analysis and update of genotype–phenotype correlations and pathogenic mechanisms

(2015) Christina Zeitz et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool

(2015) Michiel van Wyk et al.   PLOS BIOLOGY

Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter

(2014) T. Cronin et al.   EMBO Molecular Medicine

Genetic disruption of the On visual pathway affects cortical orientation selectivity and contrast sensitivity in mice

(2014) Rashmi Sarnaik et al.   JOURNAL OF NEUROPHYSIOLOGY

GPR179 Is Required for High Sensitivity of the mGluR6 Signaling Cascade in Depolarizing Bipolar Cells

(2014) T. A. Ray et al.   JOURNAL OF NEUROSCIENCE

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial

(2014) Robert E MacLaren et al.   LANCET

Intrinsically different retinal progenitor cells produce specific types of progeny

(2014) Connie Cepko   NATURE REVIEWS NEUROSCIENCE

Lrit3 Deficient Mouse (nob6): A Novel Model of Complete Congenital Stationary Night Blindness (cCSNB)

(2014) Marion Neuillé et al.   PLoS One

Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells

(2014) Benjamin M. Gaub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type 1 interferon gene transfer enhances host defense against pulmonary Streptococcus pneumoniae infection via activating innate leukocytes

(2014) Daniela Damjanovic et al.   Molecular Therapy-Methods & Clinical Development

A Comprehensive Review of Retinal Gene Therapy

(2013) Shannon E Boye et al.   MOLECULAR THERAPY

Sensory Experience Shapes the Development of the Visual System’s First Synapse

(2013) Felice A. Dunn et al.   NEURON

Targeting Photoreceptors via Intravitreal Delivery Using Novel, Capsid-Mutated AAV Vectors

(2013) Christine N. Kay et al.   PLoS One

GPR179 Is Required for Depolarizing Bipolar Cell Function and Is Mutated in Autosomal-Recessive Complete Congenital Stationary Night Blindness

(2012) Neal S. Peachey et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Whole-Exome Sequencing Identifies Mutations in GPR179 Leading to Autosomal-Recessive Complete Congenital Stationary Night Blindness

(2012) Isabelle Audo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Whole-Exome Sequencing Identifies LRIT3 Mutations as a Cause of Autosomal-Recessive Complete Congenital Stationary Night Blindness

(2012) Christina Zeitz et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation

(2012) Neal S. Peachey et al.   JOURNAL OF NEUROPHYSIOLOGY

Gene Therapy for Leber Congenital Amaurosis Caused by RPE65 Mutations

(2011) Samuel G. Jacobson   ARCHIVES OF OPHTHALMOLOGY

mGluR6 deletion renders the TRPM1 channel in retina inactive

(2011) Ying Xu et al.   JOURNAL OF NEUROPHYSIOLOGY

A Role for Nyctalopin, a Small Leucine-Rich Repeat Protein, in Localizing the TRP Melastatin 1 Channel to Retinal Depolarizing Bipolar Cell Dendrites

(2011) J. N. Pearring et al.   JOURNAL OF NEUROSCIENCE

TRPM1 Forms Complexes with Nyctalopin In Vivo and Accumulates in Postsynaptic Compartment of ON-Bipolar Neurons in mGluR6-Dependent Manner

(2011) Y. Cao et al.   JOURNAL OF NEUROSCIENCE

Virally delivered Channelrhodopsin-2 Safely and Effectively Restores Visual Function in Multiple Mouse Models of Blindness

(2011) M Mehdi Doroudchi et al.   MOLECULAR THERAPY

Molecular Anthropology Meets Genetic Medicine to Treat Blindness in the North African Jewish Population: Human Gene Therapy Initiated in Israel

(2010) Eyal Banin et al.   HUMAN GENE THERAPY

Functional and Behavioral Restoration of Vision by Gene Therapy in the Guanylate Cyclase-1 (GC1) Knockout Mouse

(2010) Shannon E. Boye et al.   PLoS One

A regulatory toolbox of MiniPromoters to drive selective expression in the brain

(2010) E. Portales-Casamar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in TRPM1 Are a Common Cause of Complete Congenital Stationary Night Blindness

(2009) Maria M. van Genderen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

TRPM1 Is Mutated in Patients with Autosomal-Recessive Complete Congenital Stationary Night Blindness

(2009) Isabelle Audo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Recessive Mutations of the Gene TRPM1 Abrogate ON Bipolar Cell Function and Cause Complete Congenital Stationary Night Blindness in Humans

(2009) Zheng Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

(2009) S. A. Bustin et al.   CLINICAL CHEMISTRY

A Transient Receptor Potential-Like Channel Mediates Synaptic Transmission in Rod Bipolar Cells

(2009) Y. Shen et al.   JOURNAL OF NEUROSCIENCE

Inner Limiting Membrane Barriers to AAV-mediated Retinal Transduction From the Vitreous

(2009) Deniz Dalkara et al.   MOLECULAR THERAPY

TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells

(2009) Catherine W. Morgans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade

(2009) C. Koike et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Postreceptoral contributions to the light-adapted ERG of mice lacking b-waves

(2008) Suguru Shirato et al.   EXPERIMENTAL EYE RESEARCH

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

(2008) Albert M. Maguire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis

(2008) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

(2008) A. V. Cideciyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA