Loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore

Physiological roles of the mitochondrial permeability transition pore

(2016) Nelli Mnatsakanyan et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death

(2015) Arezu Jahani-Asl et al.   HUMAN MOLECULAR GENETICS

Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury

(2015) Giampaolo Morciano et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection

(2015) Paolo Bernardi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth

(2015) Jennifer A. Kashatus et al.   MOLECULAR CELL

Mitochondrial control by DRP1 in brain tumor initiating cells

(2015) Qi Xie et al.   NATURE NEUROSCIENCE

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

(2015) Paolo Bernardi et al.   PHYSIOLOGICAL REVIEWS

Oxidative stress-induced mitochondrial fragmentation and movement in skeletal muscle myoblasts

(2014) Sobia Iqbal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning

(2014) Theodore Kalogeris et al.   Redox Biology

The C Ring of the F1Fo ATP Synthase Forms the Mitochondrial Permeability Transition Pore: A Critical Appraisal

(2014) Andrew P. Halestrap   Frontiers in Oncology

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

(2012) Yuqing Wang et al.   Autophagy

Level of cdk5 expression predicts the survival of relapsed multiple myeloma patients

(2012) Zachary Levacque et al.   CELL CYCLE

Mitochondrial chaperone DnaJA3 induces Drp1-dependent mitochondrial fragmentation

(2012) Adam N. Elwi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

DNA damage by reactive species: Mechanisms, mutation and repair

(2012) N R Jena   JOURNAL OF BIOSCIENCES

RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5

(2011) Y. X. Zhu et al.   BLOOD

Expression analysis and molecular targeting of cyclin-dependent kinases in advanced melanoma

(2011) Christopher Abdullah et al.   CELL CYCLE

Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function

(2011) J C Fitzgerald et al.   CELL DEATH AND DIFFERENTIATION

The impact of cyclin-dependent kinase 5 depletion on poly(ADP-ribose) polymerase activity and responses to radiation

(2011) Celeste Bolin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins

(2011) Shengnan Wu et al.   FEBS Journal

Is mPTP the gatekeeper for necrosis, apoptosis, or both?

(2010) Kathleen W. Kinnally et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma

(2010) V. V. Leshchenko et al.   BLOOD

Inhibiting the Cyclin-Dependent Kinase CDK5 Blocks Pancreatic Cancer Formation and Progression through the Suppression of Ras-Ral Signaling

(2010) Georg Feldmann et al.   CANCER RESEARCH

Expression of CDK5/p35 in resected patients with non-small cell lung cancer: relation to prognosis

(2010) Jun-Li Liu et al.   MEDICAL ONCOLOGY

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial calcium and the permeability transition in cell death

(2009) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

What is the mitochondrial permeability transition pore?

(2009) Andrew P. Halestrap   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

(2008) Nicholas C Turner et al.   EMBO JOURNAL

Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction

(2008) Kai-Hui Sun et al.   JOURNAL OF NEUROCHEMISTRY

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA