Article
Surgery
Erman Akpinar, Ronald S. L. Liem, Simon Nienhuijs, Jan Willem M. Greve, Perla J. Marang-van de Mheen
Summary: This study compared the extent of weight recurrence between patients who received Sleeve Gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) after adequate weight loss at 1-year follow-up. The results showed that patients undergoing SG had a higher likelihood of weight recurrence up to 5 years and were less likely to achieve remission of comorbidities such as type 2 diabetes, hypertension, dyslipidemia, gastroesophageal reflux, and obstructive sleep apnea syndrome.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Endocrinology & Metabolism
Marco Castellana, Filippo Procino, Elisa Biacchi, Roberta Zupo, Luisa Lampignano, Fabio Castellana, Rodolfo Sardone, Andrea Palermo, Roberto Cesareo, Pierpaolo Trimboli, Gianluigi Giannelli
Summary: This study compared the efficacy of RYGB and SG for T2D remission and found that RYGB had a higher chance of achieving remission at 1 year compared to SG, while only showing a significant difference in achieving broad criteria for remission at 5 years. No other differences were found between the two procedures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Georgios-Ioannis Verras, Francesk Mulita, Sjaak Pouwels, Chetan Parmar, Nikolas Drakos, Konstantinos Bouchagier, Charalampos Kaplanis, George Skroubis
Summary: Morbid obesity is a chronic disease with a rising incidence, and surgical treatment has shown superior outcomes compared to conventional weight loss measures. This study evaluated the long-term weight loss outcomes, comorbidity reduction, and adverse effects of Roux-en-Y Gastric Bypass (RYGB), Biliopancreatic Diversion (BPD), and Sleeve Gastrectomy (SG) at 10 years. RYGB and BPD resulted in significant weight loss, with no observed differences in diabetes resolution and adverse outcomes. Longer follow-up reports are important for comparing the outcomes of different bariatric operations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Michael O'Laughlin, Jorge Cornejo, Alba Zevallos, Alisa Coker, Michael Schweitzer, Gina Adrales, Christina Li, Raul Sebastian
Summary: Background: The rates of secondary bariatric surgery have increased, with sleeve gastrectomy to gastric bypass conversion being the most common. This study evaluates the outcomes of this conversion compared to primary Roux-en-Y gastric bypass (RYGB) surgery using MBSAQIP data. Methods: The study analyzed the data of patients who underwent sleeve gastrectomy to RYGB conversion and primary laparoscopic RYGB, matching them based on preoperative characteristics. Results: The analysis showed that the conversion from sleeve gastrectomy to RYGB was associated with higher readmissions, interventions, conversion to open surgery, longer hospital stay, and longer operative time compared to primary RYGB. However, there were no significant differences in mortality or rates of bariatric complications. Conclusion: The study concludes that conversion from sleeve gastrectomy to RYGB is a safe and feasible procedure with reasonable outcomes compared to primary RYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Robert A. Li, Liyan Liu, David Arterburn, Karen J. Coleman, Anita P. Courcoulas, David Fisher, Sebastien Haneuse, Eric Johnson, Mary Kay Theis, Tae K. Yoon, Heidi Fisher, James R. Fraser, Lisa J. Herrinton
Summary: This study compared the long-term risks of reintervention following sleeve gastrectomy and Roux-en-Y gastric bypass, and found that sleeve gastrectomy was associated with significantly lower risk of reintervention in all categories at the 5-year follow-up. Patients undergoing sleeve gastrectomy had better outcomes in subsequent interventions when compared with those undergoing Roux-en-Y gastric bypass.
Review
Medicine, General & Internal
Gonzalo-Martin Perez-Arana, Jose Fernandez-Vivero, Alonso Camacho-Ramirez, Alfredo Diaz Gomez, Jose Bancalero de los Reyes, Antonio Ribelles-Garcia, David Almorza-Gomar, Carmen Carrasco-Molinillo, Jose-Arturo Prada-Oliveira
Summary: This study focuses on the effects of pancreatic-cell populations after sleeve gastrectomy and Roux-en-Y gastric bypass, aiming to explain the pathophysiological mechanisms underlying these surgeries and improve their outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Hassan Nasser, Tommy Ivanics, Arthur M. Carlin
Summary: The decision to perform LRYGB is primarily driven by obesity-associated comorbidities and higher BMI, whereas LSG is more likely to be performed in higher risk patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Pharmacology & Pharmacy
Nele Steenackers, Tim Vanuytsel, Patrick Augustijns, Ellen Deleus, Wies Deckers, Christophe M. Deroose, Gwen Falony, Matthias Lannoo, Ann Mertens, Raf Mols, Roman Vangoitsenhoven, Lucas Wauters, Bart Van der Schueren, Christophe Matthys
Summary: This study investigated the effects of sleeve gastrectomy and Roux-en-Y gastric bypass on gastrointestinal motility, pH, and bile acid concentration. The findings showed that both surgeries increased pouch emptying and gastric emptying, and also led to higher pH levels and bile acid concentrations in the intestines. These results highlight the significant impact of these surgeries on gastrointestinal physiology.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Surgery
Grace F. Chao, Jie Yang, Jyothi Thumma, Karan R. Chhabra, David E. Arterburn, Andrew Ryan, Dana A. Telem, Justin B. Dimick
Summary: The study found that patients who underwent laparoscopic RYGB by surgeons with lower volumes had slightly increased risks of complications and readmissions at 30 days and within 1 year, but overall, surgeon RYGB volume did not have a significant impact on patient outcomes. Patients can safely pursue RYGB in this early phase of the sleeve gastrectomy era.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Medicine, General & Internal
Chunlan Zhang, Jingjing Zhang, Zhiguang Zhou
Summary: The fasting bile acid levels, especially 12a-hydroxylated bile acid levels, were found to increase significantly after Roux-en-Y gastric bypass (RYGB). However, no significant changes in fasting bile acid levels were observed following sleeve gastrectomy (SG).
Article
Surgery
Eileen Roach, Simon Laplante, Shannon Stogryn, Azusa Maeda, Timothy Jackson, Allan Okrainec
Summary: The study aimed to determine the weight-loss outcomes of patients who underwent laparoscopic Roux-en-Y gastric bypass (LRYGB) after laparoscopic sleeve gastrectomy (LSG) and whether outcomes differed according to indications for conversion. The study found that patients who underwent LRYGB after previous LSG had a consistent weight-loss outcome regardless of the reason for conversion.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Kristina H. Lewis, David E. Arterburn, Fang Zhang, Katherine Callaway, Jamie Wallace, Adolfo Fernandez, Dennis Ross-Degnan, James F. Wharam
Summary: This study compared diabetes outcomes following vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB). The results showed that RYGB patients were more likely to discontinue all diabetes medications, but VSG patients had lower total diabetes medication dose by the second year postoperatively.
Article
Surgery
Olivier Degrandi, Anamaria Nedelcu, Marius Nedelcu, Agathe Simon, Denis Collet, Caroline Gronnier
Summary: This study reported the experience of 17 patients undergoing RYGBP for chronic leak after LSG. Results showed that surgery should be considered in case of failure of endoscopic treatment, and the RYGBP approach including the leak site offered a low morbidity rate in our experience.
Article
Nutrition & Dietetics
Maria-Jose Castro, Jose-Maria Jimenez, Maria Lopez, Maria-Jose Cao, Gilberto Gonzalez-Ramirez, Maria de Lourdes Bolanos-Munoz, Jaime Ruiz-Tovar
Summary: This study compared the analytical and densitometric changes 2 years after RYGB and SG. The results showed no significant difference in weight loss between the two procedures. However, the RYGB group had a significantly greater increase in PTH values and a greater decrease in bone mineral density compared to the SG group.
Article
Surgery
Alexandra L. L. Strauss, Joseph R. R. Triggs, Colleen M. M. Tewksbury, Ian Soriano, David S. S. Wernsing, Kristoffel R. R. Dumon, Noel N. N. Williams, Jenny M. M. Shao
Summary: The objective of this study was to characterize the patients who underwent conversion from laparoscopic sleeve gastrectomy (LSG) to Roux-En-Y Gastric Bypass (RYGB) and to better understand pre-operative predictors of gastroesophageal reflux disease (GERD) and revision. The study found that the majority of patients who underwent the conversion surgery experienced significant improvements in GERD symptoms and outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Naga P. Chalasani, Kyle Porter, Abhik Bhattacharya, Adam J. Book, Brenda M. Neis, Kong M. Xiong, Tiruvidaimarudur S. Ramasubramanian, V. David K. Edwards, Irene Chen, Scott Johnson, Lewis R. Roberts, John B. Kisiel, K. Rajender Reddy, Amit G. Singal, Marilyn C. Olson, Janelle J. Bruinsma
Summary: The study found that multitarget HCC blood test may significantly improve early stage HCC detection, providing more treatment opportunities for patients and reducing mortality.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Srikanth Vedachalam, Sajid Jalil, Somashaker G. Krishna, Kyle Porter, Na Li, Sean G. Kelly, Lanla Conteh, Khalid Mumtaz
Summary: Patients with cirrhosis often undergo percutaneous cholecystostomy tube (PCT) placement instead of cholecystectomy for the treatment of acute calculous cholecystitis (ACC). Initial PCT in cirrhotic patients is associated with increased healthcare utilization and decreased rates of subsequent cholecystectomy.
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2022)
Article
Immunology
Rosie Shrout, Annelise A. Madison, Megan E. Renna, Catherine M. Alfano, Stephen P. Povoski, Adele M. Lipari, Doreen M. Agnese, William E. Carson, William B. Malarkey, Michael T. Bailey, Janice K. Kiecolt-Glaser
Summary: Satisfying relationships among breast cancer survivors are associated with lower gut permeability and inflammation levels, leading to improved physiological health. This type of relationship can help reduce disease risks and enhance quality of life.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Ross M. Maltz, Pedro Marte-Ortiz, Therese A. Rajasekera, Brett R. Loman, Tamar L. Gur, Michael T. Bailey
Summary: Stressor exposure increases colonic inflammation and leads to anxiety-like behavior. Mice recovering from colitis showed increased anxiety-like behavior after exposure to stressor, which correlated with elevated IL-17A levels in the serum and hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Andrew J. Kruger, Marwan S. Abougergi, Sajid Jalil, Lindsay A. Sobotka, Michael R. Wellner, Kyle M. Porter, Lanla F. Conteh, Sean G. Kelly, Khalid Mumtaz
Summary: This study evaluated hospital outcomes of cirrhosis patients with nonvariceal upper gastrointestinal bleeding (NVUGIB) using the 2014 Nationwide Readmission Database. The results showed that patients with decompensated cirrhosis had higher readmission rates, mortality rates, and healthcare utilization compared to those with compensated cirrhosis and no cirrhosis. Early esophagogastroduodenoscopy was a modifiable factor associated with reduced readmission rates. Early identification of high-risk patients and adherence to guidelines may improve clinical outcomes.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)
Article
Surgery
Dahlia M. Kenawy, Lindsay M. Breslin, J. C. Chen, Muna M. Tamimi, Joann K. North, Mahmoud Abdel-Rasoul, Sabrena F. Noria
Summary: High-quality post-discharge phone calls may help mitigate early non-urgent hospital returns in patients who have undergone primary bariatric surgery. Care coaching represents a potential intervention to decrease high rates of non-urgent hospital returns in these patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Keeley J. Pratt, Andrew S. Hanks, Harvey J. Miller, Michael Outrich, Lindsay Breslin, Jamie Blalock, Sabrena Noria, Stacy Brethauer, Bradley Needleman, Brian Focht
Summary: By integrating electronic health records, census data, and county data, this study explores disparities in social determinants of health (SDoH) and weight loss among bariatric surgery patients in Ohio. The findings suggest that proximity to food stores is associated with better weight loss over a two-year period, and lower poverty levels do not negatively affect weight loss in Black patients.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Surgery
Haley M. Kiser, Ashleigh A. Pona, Brian C. Focht, Lorraine Wallace, Natasha Slesnick, Sabrena Noria, Bradley Needleman, Keeley J. Pratt
Summary: This study aimed to investigate the association between patients' initial preoperative psychological evaluation outcomes and current psychiatric diagnoses with postoperative outcomes. The results showed that patients who received a clinical decision of RFU had higher weights over 12 months compared to those in the NFU group, but this association was not found for percent total weight loss and other psychiatric variables.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Gastroenterology & Hepatology
Emily B. Hill, Li Chen, Michael T. Bailey, Amrik Singh Khalsa, Ross Maltz, Kelly Kelleher, Colleen K. Spees, Jiangjiang Zhu, Brett R. Loman
Summary: Low-resource individuals are at higher risk of obesity and cardiovascular disease due to poor dietary patterns and dysfunctional microbiota. This study targeted low-resource caregiver-child dyads and conducted a multifaceted lifestyle intervention, which showed improvements in dietary patterns, reduced CVD risk factors, and altered microbiome composition.
Review
Endocrinology & Metabolism
Sabrena F. Noria, Rita D. Shelby, Katelyn D. Atkins, Ninh T. Nguyen, Kishore M. Gadde
Summary: Although bariatric surgery is the most effective treatment for severe obesity, a proportion of patients experience weight regain after surgery. The causes of weight regain are not well-defined, but dysregulated/maladaptive eating behaviors, lifestyle factors, and physiological compensatory mechanisms are believed to contribute. Current interventions, including dietary, supportive, behavioral, and exercise approaches, have not shown significant impact on weight regain. Future studies should aim to better understand the etiologies of weight regain and develop non-surgical interventions with demonstrated efficacy in rigorous trials.
CURRENT DIABETES REPORTS
(2023)
Article
Pediatrics
Mecklin V. Ragan, Samantha J. Wala, Nitin Sajankila, Audrey F. Duff, Yijie Wang, Samuel G. Volpe, Ameer Al-Hadidi, Zachary Dumbauld, Nanditha Purayil, Joseph Wickham, Miriam R. Conces, Belgacem Mihi, Steven D. Goodman, Michael T. Bailey, Gail E. Besner
Summary: This article introduces an enteral-feed only piglet model of NEC and introduces a new multifactorial D-NEC scoring system to assess the severity of the disease. Piglets with NEC had microbiome changes consistent with clinical cases. This model can be used to test novel therapies for treating and preventing this devastating disease.
FRONTIERS IN PEDIATRICS
(2023)
Article
Surgery
Anna Chee, Mahmoud Abdel-Rasoul, Kaeli Zoretich, Kayla Diaz, Sabrena F. Noria
Summary: This study analyzed patient engagement with a virtual patient navigation platform (VPNP) designed to guide bariatric surgery candidates through the pre-operative workup. The study found that the majority of patients did not engage with the app, and non-engagement was associated with lower rates of private insurance. The SUS survey showed high perceived usability of the VPNP, but future work will focus on addressing reasons for non-engagement to improve patient participation.
Editorial Material
Surgery
Sabrena F. Noria
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Gastroenterology & Hepatology
Stephen A. Firkins, Phil A. Hart, Kyle Porter, ChienWei Chiang, Jordan M. Cloyd, Mary Dillhoff, Luis F. Lara, Andrei Manilchuk, Georgios Papachristou, Timothy M. Pawlik, Allan Tsung, Darwin L. Conwell, Somashekar G. Krishna
Summary: The incidence of new-onset diabetes mellitus (NODM) after resection of pancreatic cystic lesions (PCLs) is high, with 1 in 5 patients developing diabetes within 2 years. Older age, features of metabolic syndrome, and cardiovascular disease are independent predictors of NODM.
Article
Gastroenterology & Hepatology
Amit G. Singal, Benjamin Haaland, Neehar D. Parikh, A. Burak Ozbay, Carol Kirshner, Shubham Chakankar, Kyle Porter, Jagpreet Chhatwal, Turgay Ayer
Summary: The sensitivity of ultrasound-based surveillance for early detection of hepatocellular carcinoma (HCC) in patients with cirrhosis is suboptimal. This study compared the performance of a novel multitarget HCC blood test (Mt-HBT) with ultrasound with or without alpha-fetoprotein (AFP) for early HCC detection. The results showed that Mt-HBT had higher sensitivity than ultrasound alone and similar sensitivity to ultrasound with AFP, suggesting that Mt-HBT could be a comparable alternative for HCC surveillance in at-risk patients.
HEPATOLOGY COMMUNICATIONS
(2022)
