期刊
HUMAN BRAIN MAPPING
卷 36, 期 10, 页码 3793-3804出版社
WILEY
DOI: 10.1002/hbm.22878
关键词
nicotine; DTI-FA; white matter; acute change; cognition; processing speed; attention
资金
- National Institute of Health [R01MH085646, R01DA027680, R01MH094520, R01EB015611, P50MH103222, T32MH067533]
- NIH
- NIBIB
- NCI [U54 EB020403]
Reduced speed of cerebral information processing is a cognitive deficit associated with schizophrenia. Normal information processing speed (PS) requires intact white matter (WM) physiology to support information transfer. In a cohort of 107 subjects (47/60 patients/controls), we demonstrate that PS deficits in schizophrenia patients are explained by reduced WM integrity, which is measured using diffusion tensor imaging, mediated by the mismatch in WM/gray matter blood perfusion, and measured using arterial spin labeling. Our findings are specific to PS, and testing this hypothesis for patient-control differences in working memory produces no explanation. We demonstrate that PS deficits in schizophrenia can be explained by neurophysiological alterations in cerebral WM. Whether the disproportionately low WM integrity in schizophrenia is due to illness or secondary due to this disorder deserves further examination. (C) 2015 Wiley Periodicals, Inc.
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