Article
Multidisciplinary Sciences
Mustafa J. Musa
Summary: This article investigates the effect of hypertension on renal cortical size and compares it with normotensives. The study finds that hypertensive individuals have thinner cortical thickness compared to those with normal blood pressure, and duration of hypertension and age are important factors influencing cortical size. Ultrasound measurement of cortical thickness can be used as an indicator for evaluating renal function and the progression of hypertension.
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
(2022)
Article
Medicine, General & Internal
Michel Azizi, Manish Saxena, Yale Wang, J. Stephen Jenkins, Chandan Devireddy, Florian Rader, Naomi D. L. Fisher, Roland E. Schmieder, Felix Mahfoud, Jason Lindsey, Kintur Sanghvi, Thomas M. Todoran, John Pacella, John Flack, Joost Daemen, Andrew S. P. Sharp, Philipp Lurz, Michael J. Bloch, Michael A. Weber, Melvin D. Lobo, Jan Basile, Lisa Claude, Helen Reeve-Stoffer, Candace K. McClure, Ajay J. Kirtane
Summary: Two studies showed that ultrasound renal denervation can reduce blood pressure in patients with mild to moderate hypertension and treatment-resistant hypertension. This study aimed to investigate the efficacy and safety of ultrasound renal denervation without the influence of antihypertensive medications. The results of a randomized clinical trial demonstrated that ultrasound renal denervation can significantly reduce daytime ambulatory systolic blood pressure in hypertensive patients at 2 months.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Ilenia Martinelli, Daniele Tomassoni, Proshanta Roy, Lorenzo Di Cesare Mannelli, Francesco Amenta, Seyed Khosrow Tayebati
Summary: Hypertension leads to organ damage through oxidative stress, which can be reduced by antioxidant supplementation such as (+)-ALA. In spontaneously hypertensive rats, (+)-ALA showed greater effectiveness in reducing oxidative stress, cardiac, and renal damages compared to (+/-)-ALA. Therefore, (+)-ALA is proposed as a more appropriate antioxidant to prevent renal and cardiac alterations associated with hypertension.
Article
Medicine, General & Internal
Shatha J. Almushayt, Alisa Pham, Bethan E. Phillips, John P. Williams, Maarten W. Taal, Nicholas M. Selby
Summary: Renal contrast-enhanced ultrasound can be used to quantify renal cortical perfusion and assess its change over time, with good intra-individual repeatability and inter-operator correlation. However, the repeatability for AI and WiR is lower.
Review
Urology & Nephrology
Kenneth Guber, Ajay J. Kirtane
Summary: Arterial hypertension, the most prevalent global modifiable risk factor for cardiovascular morbidity and mortality, is often not effectively managed with pharmacologic treatments. Renal sympathetic denervation (RDN), a nonpharmacologic approach involving catheter-directed techniques, has been extensively investigated as a complementary treatment option.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Clinical Neurology
Maria Giovanna Bianco, Andrea Quattrone, Alessia Sarica, Federica Aracri, Camilla Calomino, Maria Eugenia Caligiuri, Fabiana Novellino, Rita Nistico, Jolanda Buonocore, Marianna Crasa, Maria Grazia Vaccaro, Aldo Quattrone
Summary: This study aimed to compare the differences in MRI findings between essential tremor (ET) and rest tremor (rET) patients. The results showed that rET patients had increased roughness and mean curvature in certain frontal and temporal areas compared to healthy controls and ET patients, which were correlated with cognitive scores. Additionally, the cortical volume in the left pars opercularis was lower in rET patients than in ET patients. The machine learning approach successfully distinguished between rET and ET patients based on structural cortical features.
JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tiantian Zhou, Shengnan Zhang, Chunyu Du, Kun Wang, Xiabing Gu, Shijin Sun, Xianrui Zhang, Yayan Niu, Can Wang, Meng Liu, Ningzheng Dong, Qingyu Wu
Summary: This study demonstrates the importance of renal Corin function in enhancing natriuresis upon high salt intake and the inability of cardiac Corin function to compensate for it.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wen-Bin Cai, Ji-Kai Yin, Qiao-ying Li, Yi-Lin Yang, Yun-You Duan, Li Zhang
Summary: This study evaluated the severity of portal hypertension (PHT) through hepatic ultrasonography by analyzing the acoustic structure quantification (ASQ) parameters. The results showed significant correlations between ASQ parameters and the presence of PHT as well as liver function. The ASQ analysis may have an important role in assessing the severity of PHT.
BMC MEDICAL IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Sebastian Rosch, Karl-Philipp Rommel, Stephan Blazek, Karl-Patrik Kresoja, Anne Schoeber, Maximilian von Roeder, Steffen Desch, Holger Thiele, Philipp Lurz, Karl Fengler
Summary: This study pooled data from two previous studies on endovascular ultrasound-based renal denervation (uRDN) and found that uRDN effectively lowered blood pressure for up to 24 months after treatment, with low rates of adverse events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Siyu Wang, Sijie Zhang, Yan Li, Na Ma, Mengpu Li, Hu Ai, Hui Zhu, Junhong Ren, Yongjun Li, Peng Li
Summary: This study aimed to observe the correlation between renal cortical blood perfusion (CBP) parameters and blood pressure (BP) response in patients with severe renal artery stenosis (RAS) who underwent stenting. The results showed that patients in the nonresponse group had a higher prevalence of diabetes, longer duration of hypertension, significantly reduced glomerular filtration rate, and heavier renal artery stenosis compared to the response group. CBP parameters were closely related to 24-hour average systolic blood pressure (SBP), and preoperative maximum intensity (IMAX) and postoperative area under the curve (AUC2) were markers for a positive BP response.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Qingyao Liao, Fang Yang, Bo Xiong, Xiaoyu Zheng, Yue Wang, Jun Qian, Zhao Qiao, Jing Huang
Summary: This study demonstrates that the efficacy of RDN is dependent on the energy dose delivered, with 200-250 W being effective and safe in normal-sized canines.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Paul Spiesecke, Frederic Muench, Thomas Fischer, Bernd Hamm, Markus H. Lerchbaumer
Summary: This study investigates the use of contrast-enhanced ultrasound (CEUS) in identifying typical imaging features of renal cortical necrosis (RCN), a rare cause of acute kidney failure. CEUS allows dynamic assessment of renal circulation with nonnephrotoxic contrast agent and plays a key role in differentiating RCN from renal vein thrombosis (RVT) based on parameters such as reverse rim sign and resistance index (RI).
SCIENTIFIC REPORTS
(2021)
Article
Biology
Alberto Sanchez-Bonaste, Luis F. S. Merchante, Carlos Gonzalez-Bravo, Alberto Carnicero
Summary: This article proposes a mechanism that can measure the thickness of the entire bone surface and align and orient all the images to reduce human intervention. With classical morphological and deep learning segmentation, the algorithm is able to measure the cortical thickness accurately. The experimental results show that the algorithm provides thickness values with an average difference of 0.25 millimeters and a standard deviation of 0.2 compared to measurements done by a radiologist.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonio Giulio Gennari, Dorottya Cserpan, Ilona Stefanos-Yakoub, Raimund Kottke, Ruth O'Gorman Tuura, Georgia Ramantani
Summary: This study investigated the potential of diffusion tensor imaging (DTI) in paediatric structural epilepsy associated with focal cortical dysplasia (FCD). The results showed that DTI indices can differentiate between FCD and contralateral brain parenchyma (CBP), and that clinical features have an impact on these indices.
INSIGHTS INTO IMAGING
(2023)
Article
Neurosciences
Matthew K. Defenderfer, Pinar Demirayak, Leland L. Fleming, Dawn K. DeCarlo, Paul Stewart, Kristina M. Visscher
Summary: Late-stage macular degeneration often impairs central vision, causing individuals to rely on peripheral vision. Patients with macular degeneration develop a preferred retinal locus to compensate for the loss of central vision. This study found that the thickness of the cortex associated with the preferred retinal locus was thinner in patients with macular degeneration compared to controls. However, there were no significant differences in cortical thickness, neurite density, or orientation dispersion between the preferred retinal locus and control regions.
HUMAN BRAIN MAPPING
(2023)