Design and development of novel antibiotics based on FtsZ inhibition – in silico studies

Pharmacophore generation, atom-based 3D-QSAR, molecular docking and molecular dynamics simulation studies on benzamide analogues as FtsZ inhibitors

(2017) Swayansiddha Tripathy et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

The index of ideality of correlation: A criterion of predictive potential of QSPR/QSAR models?

(2017) Andrey A. Toropov et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

QSAR study of 2,4-dihydro-3H-1,2,4-triazol-3-ones derivatives as angiotensin II AT1 receptor antagonists based on the Monte Carlo method

(2017) Viktor Stoičkov et al.   STRUCTURAL CHEMISTRY

Be aware of error measures. Further studies on validation of predictive QSAR models

(2016) Kunal Roy et al.   CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS

Descriptors and their selection methods in QSAR analysis: paradigm for drug design

(2016) Danishuddin et al.   DRUG DISCOVERY TODAY

The Monte Carlo technique as a tool to predict LOAEL

(2016) Jovana B. Veselinović et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of agents targeting FtsZ assembly

(2016) Dulal Panda et al.   Future Medicinal Chemistry

Antibiotic Resistance: The Need For a Global Strategy

(2016) David P. Elder et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Selected 4-phenyl hydroxycoumarins: In vitro cytotoxicity, teratogenic effect on zebrafish (Danio rerio) embryos and molecular docking study

(2015) Jovana B. Veselinović et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Antimicrobial resistance: A global emerging threat to public health systems

(2015) Maurizio Ferri et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Application of SMILES Notation Based Optimal Descriptors in Drug Discovery and Design

(2015) Aleksandar Veselinovic et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Advances in the discovery of novel antimicrobials targeting the assembly of bacterial cell division protein FtsZ

(2015) Xin Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

QSAR as a random event: a case of NOAEL

(2014) Alla P. Toropova et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Antibacterial resistance: an emerging ‘zoonosis’?

(2014) Marie-Thérèse Labro et al.   Expert Review of Anti-Infective Therapy

After 2015: infectious diseases in a new era of health and development

(2014) C. Dye   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Progress of FtsZ Inhibitors as Novel Antibiotics Leads

(2013) Weiling Hong et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Overcoming Resistance to β-Lactam Antibiotics

(2013) Roberta J. Worthington et al.   JOURNAL OF ORGANIC CHEMISTRY

Strategies to Minimize Antibiotic Resistance

(2013) Chang-Ro Lee et al.   International Journal of Environmental Research and Public Health

Further exploring rm2 metrics for validation of QSPR models

(2011) Probir Kumar Ojha et al.   CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS

Therapeutic potential of FtsZ inhibition: a patent perspective

(2011) Divya Awasthi et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

3D-QSAR in Drug Design - A Review

(2010) Jitender Verma et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Discovery of anti-TB agents that target the cell-division protein FtsZ

(2010) Kunal Kumar et al.   Future Medicinal Chemistry

Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties

(2010) David J. Haydon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Best Practices for QSAR Model Development, Validation, and Exploitation

(2010) Alexander Tropsha   Molecular Informatics

Methicillin-ResistantStaphylococcus aureus: A Community Health Threat

(2010) Maria Adriana Cataldo et al.   POSTGRADUATE MEDICINE

Structure-Based Drug Design Strategies in Medicinal Chemistry

(2009) Adriano Andricopulo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Targeting FtsZ for antibacterial therapy: a promising avenue

(2009) Sonia Kapoor et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Novel β-lactam antibiotics and inhibitor combinations

(2008) Matteo Bassetti et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Exploring the impact of size of training sets for the development of predictive QSAR models

(2007) Partha Pratim Roy et al.   CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS