Article
Biochemistry & Molecular Biology
Adrian Zajac, Joanna Sumorek-Wiadro, Ewa Langner, Iwona Wertel, Aleksandra Maciejczyk, Bozena Pawlikowska-Pawlega, Jaroslaw Pawelec, Magdalena Wasiak, Monika Hulas-Stasiak, Dorota Badziul, Wojciech Rzeski, Michal Reichert, Joanna Jakubowicz-Gil
Summary: Inhibition of the PI3K/Akt/mTOR pathway sensitizes glioma cells to apoptosis with temozolomide treatment, while Hsp27 increases resistance to cell death. Different cell lines showed varying responses to LY294002 and temozolomide treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Austin D. Fergusson, Rui Zhang, Judy S. Riffle, Richey M. Davis
Summary: Flash nanoprecipitation (FNP) is a reliable method for producing polymer nanoparticles loaded with hydrophobic drugs. By incorporating ion pairing agents (IPs) into the FNP formulation, hydrophobic drug salts can be efficiently precipitated. In this study, we investigated the effects of two hydrophobic IPs, palmitic acid (PA) and hexadecylphosphonic acid (HDPA), on the loading and size of LY294002-loaded nanoparticles. HDPA resulted in well-defined colloidally stable particles, while PA resulted in ill-defined aggregates. This approach opens up possibilities for intravenous administration of previously unusable hydrophobic drugs.
Article
Environmental Sciences
Garam An, Taeyeon Hong, Hahyun Park, Whasun Lim, Gwonhwa Song
Summary: In this study, the developmental toxicity of the carbamate insecticide oxamyl on zebrafish larvae was examined. Oxamyl was found to have adverse effects on the development of the neuron, notochord, and vascular system. Furthermore, it was found to impact the mitochondrial electron transport chain and the PI3K/Akt and p38 Mapk signaling pathways in zebrafish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Kyle J. Horning, Xueqi Tang, Morgan G. Thomas, Michael Aschner, Aaron B. Bowman
Summary: Manganese is a biologically essential metal that is crucial for enzyme function, but neurotoxic in excess. Prolonged occupational exposure to manganese can lead to Parkinsonian conditions. Understanding the mechanisms of manganese transport and homeostasis, and identifying small molecules that can modulate intracellular manganese levels, have important pharmacological and scientific implications.
Article
Immunology
Dalia A. Nawwar, Hala F. Zaki, Rabab H. Sayed
Summary: This study investigates the effects of aripiprazole and sertindole on the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in ketamine-induced schizophrenia in rats. Both aripiprazole and sertindole significantly ameliorated ketamine-induced schizophrenic-like behavior and oxidative stress, while activating the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways. These findings suggest that targeting these signaling pathways may offer a new therapeutic approach for treating schizophrenia in humans.
INFLAMMOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Dongying Yan, Liang Gao, Jing Lang, Xianhui Gao, Honglin Ma
Summary: Excessive exposure to manganese can lead to neurological diseases characterized by behavioral and motor impairments. Microglia-mediated neuroinflammation plays a key role in the pathogenesis of neurodegenerative diseases. SIRT1, PGC-1 alpha, NF-kappa B, and STAT3 are important factors in the regulation of neuroinflammatory responses and microglial polarization in mice exposed to manganese.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Zhigao Yi, Huxin Gao, Xianglin Ji, Xin-Yi Yeo, Suet Yen Chong, Yujie Mao, Baiwen Luo, Chao Shen, Sanyang Han, Jiong-Wei Wang, Sangyong Jung, Peng Shi, Hongliang Ren, Xiaogang Liu
Summary: Chemotherapy can induce neurotoxicity, affecting patient quality of life. There is a lack of research on predicting, identifying, and offsetting drug-induced neurotoxicity. New imaging technology can help track intraneuronal transport in real time, improving the efficiency of diagnosing and treating neurotoxicity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Immunology
Xinyang Wu, Lijun Pu, Wei Chen, Qi Zhao, Geping Wu, Di Li, Hongyan Zhu
Summary: LY294002 improves inflammation in endotoxin-induced uveitis by downregulating JAK3 and inactivating the PI3K/Akt signaling pathway.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alexey A. Tinkov, Monica M. B. Paoliello, Aksana N. Mazilina, Anatoly V. Skalny, Airton C. Martins, Olga N. Voskresenskaya, Jan Aaseth, Abel Santamaria, Svetlana V. Notova, Aristides Tsatsakis, Eunsook Lee, Aaron B. Bowman, Michael Aschner
Summary: Recent research has uncovered various mechanisms of Mn-induced neurotoxicity, including the role of Mn transporters, metabolic pathways, autophagic flux, synaptic dysfunction, and neuroinflammation, among others. Further studies are needed to fully understand the critical targets and pathways involved in Mn-induced neurotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Wei Wang, Da Liu, Liyun Yang, Lixia Chen, Mengdan Miao, Yongsheng Liu, Yajuan Yin, Mei Wei, Gang Liu, Yonghui An, Mingqi Zheng
Summary: This study aimed to investigate whether Compound Kushen injection (CKI) alleviates heart failure (HF) by attenuating cardiomyocyte apoptosis via the inhibition of the PI3K/Akt pathway. The results showed that CKI promoted healthy cardiac function, reduced myocardial structural damage, and attenuated the rate of cardiomyocyte apoptosis. CKI significantly suppressed the expression of apoptosis-related proteins in the PI3K/Akt pathway. In conclusion, CKI reduces cardiomyocyte apoptosis, improves cardiac function, and attenuates Ang II-mediated HF, possibly through the inhibition of the PI3K/Akt pathway.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Review
Medicine, Research & Experimental
Jingjing Liu, Xin Zhang, Hui Wang
Summary: Heavy metal pollution, particularly manganese exposure, poses a global health challenge and can lead to neurodegenerative diseases characterized by inflammation and Tau hyperphosphorylation. The cGAS-STING/NLRP3 pathway may play a crucial role in the neurotoxicity of manganese exposure, offering potential insights for future research.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Wenwen Zhang, Shuofei Yang, Datian Chen, Daolu Yuwen, Juan Zhang, Xiaowei Wei, Xin Han, Xiaoxiang Guan
Summary: The study revealed that PAI-1 induced lncRNA SOX2-OT can promote TNBC cell metastasis and activate the PI3K/Akt signaling pathway through the miR-942-5p/PIK3CA signaling pathway. These findings highlight the potential of developing new therapies for TNBC based on targeting SOX2-OT.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medicine, Research & Experimental
Sherien M. El-Daly, Mahmoud T. Abo-elfadl, Jihan Hussein, Mona A. M. Abo-Zeid
Summary: This study investigates the impact of suppressing the activity of the PI3K/Akt/mTOR signaling pathway on the chemosensitivity of colorectal cancer cells to 5-FU. The results demonstrate that combining a low dose of 5-FU with a PI3K inhibitor can significantly enhance cytotoxicity and reduce the expression of specific drug transporters. Additionally, the recommended combination treatment induces cell apoptosis and reduces cell migration ability.
Article
Toxicology
Wenmin Lu, Danni Li, Shengtao Wei, Jie Yang, Chuanqiao Tang, Xiaoli Ma, Yunfeng Zou
Summary: This study reveals the role of lncRNAs in Mn-induced neurotoxicity, identifying lncSh2d3c as a key regulatory factor that is involved in Mn-induced neuronal apoptosis through the mmu-miR-675-5p/Chmp4b/Bax pathway. This finding suggests a novel mechanism of Mn-induced neurotoxicity and highlights the potential of lncSh2d3c as a therapeutic target.
TOXICOLOGY LETTERS
(2022)
Article
Public, Environmental & Occupational Health
Lin Lin, Yunan Gao, Xiaochen Hu, Jiabao Ouyang, Chunbo Liu
Summary: Pentamidine inhibits proliferation, migration, and invasion of endometrial cancer cells through the suppression of the PI3K/AKT signaling pathway. These findings suggest that Pentamidine may be a potential candidate for treating endometrial cancer.
Article
Biochemistry & Molecular Biology
Miles R. Bryan, Michael T. O'Brien, Kristen D. Nordham, Daniel I. R. Rose, Audra M. Foshage, Piyush Joshi, Rachana Nitin, Michael A. Uhouse, Alba Di Pardo, Ziyan Zhang, Vittorio Maglione, Michael Aschner, Aaron B. Bowman
HUMAN MOLECULAR GENETICS
(2019)
Article
Neurosciences
Miles R. Bryan, Kristen D. Nordham, Daniel I. R. Rose, Michael T. O'Brien, Piyush Joshi, Audra M. Foshage, Filipe M. Goncalves, Rachana Nitin, Michael A. Uhouse, Michael Aschner, Aaron B. Bowman
MOLECULAR NEUROBIOLOGY
(2020)
Article
Clinical Neurology
Hiral Master, Jacquelyn S. Pennings, Rogelio A. Coronado, Abigail L. Henry, Michael T. O'Brien, Christine M. Haug, Richard L. Skolasky, Lee H. Riley, Brian J. Neuman, Joseph S. Cheng, Oran S. Aaronson, Clinton J. Devin, Stephen T. Wegener, Kristin R. Archer
Article
Surgery
Scott Ninokawa, Danielle Tatum, Eman Toraih, Kristen Nordham, Michael Ghio, Sharven Taghavi, Chrissy Guidry, Patrick McGrew, Rebecca Schroll, Charles Harris, Juan Duchesne
Summary: This study evaluated the predictive ability of the potassium/ionized calcium ratio (K/iCa) on mortality in trauma patients receiving massive transfusion protocol (MTP). The results showed that an elevated K/iCa ratio was significantly associated with mortality in these patients.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Critical Care Medicine
Mary K. Bryant, Leah C. Tatebe, Nandini Rajaram Siva, Pascal O. Udekwu, Mary Wurzelmann, Marie L. Crandall, Yohan Diaz Zuniga, Virginia Tran, Ariel Santos, Cassandra Krause, David Turay, Kristen D. Nordham, Sharven Taghavi, Elizabeth B. Dreesen, Sara Scarlet, Andrew Snyder, Megan Applewhite, Pooja Patel, Thomas J. Schroeppel, Jennifer Rodriquez, Lucy Z. Kornblith, Marissa A. Boeck, Stephanie Bonne, Ann Tufariello, Rebecca G. Maine
Summary: This multicenter study aimed to describe the acute care surgery needs of incarcerated individuals. The study found that incarcerated patients with a range of trauma and emergency general surgery conditions often required admission and had low follow-up rates after hospitalization. The vulnerability of this population was highlighted by high rates of self-harm, assaults, mental health, and substance use disorders. Interventions from hospitals and correctional facilities are needed to decrease self-inflicted injuries and assaults among incarcerated individuals.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Clinical Neurology
Alejandra N. Martinez, Giovane G. Tortelote, Crissey L. Pascale, Isabella G. McCormack, Kristen D. Nordham, Natalie J. Suder, Mitchell W. Couldwell, Aaron S. Dumont
Summary: Using single-cell RNA sequencing, this study comprehensively analyzed the heterogeneity and transcriptional profiles of vascular cells in the circle of Willis (CoW) of mice with and without cerebral aneurysms. The results revealed distinct cell lineages and transcriptional signatures, and showed an increased population of macrophages and a massive spike of neutrophils in aneurysmal vessels. These findings provide valuable insights into the pathogenesis of cerebral aneurysms.
Article
Emergency Medicine
Kristen D. Nordham, Scott Ninokawa, Ayman Ali, Jacob M. Broome, Scott McCraney, John T. Simpson, Danielle Tatum, Olan Jackson-Weaver, Sharven Taghavi, Patrick McGrew, Juan Duchesne
Summary: This study compared the outcomes of traumatic brain injury patients treated with and without resuscitative endovascular balloon occlusion of the aorta (REBOA), and found that there was no difference in mortality and prognosis between the two groups.
JOURNAL OF ENDOVASCULAR RESUSCITATION AND TRAUMA MANAGEMENT
(2023)
Meeting Abstract
Emergency Medicine
K. Nordham, S. Ninokawa, J. Duchesne
ANNALS OF EMERGENCY MEDICINE
(2021)
Meeting Abstract
Emergency Medicine
K. D. Nordham, S. Ninokawa, L. Myers, J. C. Duchesne
ANNALS OF EMERGENCY MEDICINE
(2020)