Review
Clinical Neurology
Frederick Ewbank, Jacqueline Birks, Diederik Bulters
Summary: There is an association between aspirin use and subarachnoid hemorrhage in patients with intracranial aneurysms, but this protective relationship is not seen in the general population. Prospective randomized studies are required to further investigate the effect of aspirin on unruptured intracranial aneurysms.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Mark K. Bakker, Ynte M. Ruigrok
Summary: Genetic studies on intracranial aneurysms have progressed significantly in the past decade, revealing more genetic risk factors and enhancing our understanding of the disease. Family studies, sequencing, and genome-wide association studies provide opportunities for better understanding, prevention, and treatment of this condition.
Review
Clinical Neurology
Gabriel J. E. Rinkel, Ynte M. Ruigrok
Summary: This review discusses high-risk groups who may benefit from screening for unruptured intracranial aneurysms to prevent aneurysmal subarachnoid hemorrhage. It outlines the advantages and disadvantages of screening, as well as the importance of counseling. Additional research is needed to identify more high-risk groups and improve the efficiency of screening.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Multidisciplinary Sciences
Karim Mostafa, Fernando Bueno Neves, Friederike Gaertner, Soenke Peters, Johannes Hensler, Naomi Larsen, Tristan Klintz, Justus Mahnke, Olav Jansen, Fritz Wodarg
Summary: The Contour device is an effective alternative to coil embolization for the treatment of narrow-neck aneurysms. In a retrospective analysis, it was found that the Contour group achieved faster aneurysm embolization and required less radiation dosage compared to the coiling group. The rate of complications and reinterventions were also lower in the Contour group.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Josefin Grabert, Stefanie Huber-Petersen, Tim Lampmann, Lars Eichhorn, Hartmut Vatter, Mark Coburn, Markus Velten, Erdem Gueresir
Summary: Our retrospective analysis of 17 patients who underwent rapid ventricular pacing during surgical reconstruction of complex aneurysms suggests RVP to be feasible in surgery for ruptured intracranial aneurysms with minimal complications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
Cheng Yang, Zhulin Zhang, Rongjie Liao, Yuhong Li
Summary: This study analyzed the relationship between preoperative external ventricular drainage (preop-EVD) and preoperative rebleeding in aneurysmal subarachnoid hemorrhage. The results showed that preop-EVD does not significantly increase the risk of preoperative rebleeding prior to aneurysm repair. Patients with poorer clinical status on admission and aneurysms larger than 1 cm are more likely to experience preoperative rebleeding.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Review
Immunology
Sajjad Muhammad, Shafqat Rasul Chaudhry, Gergana Dobreva, Michael T. Lawton, Mika Niemela, Daniel Hanggi
Summary: Aneurysmal subarachnoid hemorrhage is a fatal type of hemorrhagic stroke caused by the rupture of intracranial aneurysms. Macrophages play a key role in the inflammatory response within the ICA wall, and interventions targeting macrophage response can reduce the risk of aneurysm rupture.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Giacomo Pavesi, Davide Nasi, Elisa Moriconi, Riccardo Stanzani, Annette Puzzolante, Lucio Lucchesi, Selene Marika Cavallo, Corrado Iaccarino
Summary: This study retrospectively analyzed the use of intraoperative external ventricular drainage in patients with aneurysmal subarachnoid hemorrhage (aSAH). The results showed that intraoperative external ventricular drainage is a safe technique that facilitates dissection during early surgery.
ACTA NEUROCHIRURGICA
(2022)
Review
Clinical Neurology
Joanna Palasz, Linda D'Antona, Sarah Farrell, Mohamed A. Elborady, Laurence D. Watkins, Ahmed K. Toma
Summary: This study compared the effects of continuous vs. intermittent CSF drainage and rapid vs. gradual weaning in external ventricular drainage procedures. The results showed that intermittent CSF drainage reduced the incidence of EVD-related infections and blockages, while patients who underwent rapid weaning had a shorter hospital stay.
NEUROSURGICAL REVIEW
(2022)
Review
Biochemistry & Molecular Biology
Tonglin Pan, Yuan Shi, Guo Yu, Abdureshid Mamtimin, Wei Zhu, Robert V. Stahelin, Jorge Joven
Summary: Vascular diseases, including intracranial aneurysms, are often associated with lipid metabolism disorders, leading to degenerative changes in the vascular wall and impaired vascular function.
Article
Neurosciences
Sen Wei, Yin Yuan, Dongdong Li, Xinbin Guo, Sheng Guan, Yuming Xu
Summary: This study retrospectively reviewed patients with intracranial aneurysms and subarachnoid hemorrhage and found an association between homocysteine levels and aneurysm rupture.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Clinical Neurology
Matthias Gawlitza, Joachim Klisch, Daniel P. O. Kaiser, Jennifer Linn, Laurent Pierot, Donald Lobsien
Summary: This study analyzed the clinical application of flow diverters coated with anti-thrombotic substances in patients with ruptured intracranial aneurysms. The results showed that although the risk of hemorrhagic complications was low, a significant number of patients experienced thromboembolic complications.
WORLD NEUROSURGERY
(2023)
Review
Clinical Neurology
Dingke Wen, Yuqi Chen, Wei Zhu, Zongjun Peng, Lu Ma
Summary: A meta-analysis was conducted to evaluate the risk of hemorrhage and rupture in ischemic stroke patients with concomitant unruptured aneurysm. The results showed that the rate of intracranial hemorrhage related to unruptured aneurysms was low, and the risk of rupture was relatively small compared to stroke patients without aneurysms.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Charlotte C. M. Zuurbier, Rob Molenberg, Liselore A. Mensing, Marieke J. H. Wermer, Seppo Juvela, Antti E. Lindgren, Juha E. Jaaskelainen, Timo Koivisto, Tomosato Yamazaki, Maarten Uyttenboogaart, J. Marc C. van Dijk, Marlien W. Aalbers, Akio Morita, Shinjiro Tominari, Hajime Arai, Kazuhiko Nozaki, Yuichi Murayama, Toshihiro Ishibashi, Hiroyuki Takao, Renato Gondar, Philippe Bijlenga, Gabriel J. E. Rinkel, Jacoba P. Greving, Ynte M. Ruigrok
Summary: Women have a higher risk of intracranial aneurysm rupture than men, and this sex difference is not explained by differences in patient- and aneurysm-related risk factors. Future studies should focus on elucidating the factors underlying the increased risk of aneurysmal rupture in women.
Article
Clinical Neurology
Walid Albanna, Louisa Merkelbach, Gerrit Alexander Schubert, Christian Stoppe, Nicole Heussen, Alexander Riabikin, Martin Wiesmann, Christian Blume, Fidaa Jablawi, Johannes Schiefer, Hans Clusmann, Georg Neuloh
Summary: The study identified a higher rate of minor postprocedural hemorrhage associated with standard antiplatelet therapy (such as aspirin, clopidogrel) in the context of aneurysmal subarachnoid hemorrhage. However, this did not lead to major hemorrhages or unfavorable clinical outcomes. Future prospective studies are needed to confirm these findings and explore hemorrhage risks associated with extended anticoagulation regimes.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Review
Clinical Neurology
Paolo Perrini, Yury Anania, Federico Cagnazzo, Nicola Benedetto, Riccardo Morganti, Davide Tiziano Di Carlo
Summary: Foramen magnum decompression (FMD) is considered the standard treatment for syringomyelia associated with Chiari type I malformation (CMI) in adults. A systematic review and meta-analysis found that decompression with the extra-arachnoidal technique and arachnoid dissection provided similar results in post-operative shrinkage of syringomyelia, while decompression with splitting of the dura had a lower rate of syrinx reduction. Complications and infections were similar among the different surgical groups.
NEUROSURGICAL REVIEW
(2021)
Review
Clinical Neurology
Davide Tiziano Di Carlo, Nicola Montemurro, Giandomenico Petrella, Gabriele Siciliano, Roberto Ceravolo, Paolo Perrini
Summary: A variety of neurological symptoms have been reported in COVID-19 patients, including headache, dizziness, hyposmia/anosmia, gustatory dysfunction, and muscular injury. Further studies are needed to investigate the pathophysiology of these associations.
JOURNAL OF NEUROLOGY
(2021)
Review
Genetics & Heredity
Giuseppe Nicolo Fanelli, Dario Grassini, Valerio Ortenzi, Francesco Pasqualetti, Nicola Montemurro, Paolo Perrini, Antonio Giuseppe Naccarato, Cristian Scatena
Summary: Glioblastoma is the most common primary malignant brain tumor in adults, with poor prognosis despite novel therapeutical approaches. It is a polymorphic tumor consisting of different cells and a complex microenvironment containing various cell types and immune cells, playing a crucial role in tumor progression and treatment response. An in-depth investigation of GBM's microenvironment may lead to novel therapeutic opportunities to improve patient outcomes, especially in the field of immunotherapy.
Review
Chemistry, Multidisciplinary
Nicola Montemurro, Paolo Perrini, Walter Marani, Bipin Chaurasia, Massimo Corsalini, Antonio Scarano, Biagio Rapone
Summary: Oral microbiota plays a crucial role in various oral diseases and systemic infections, including multiple brain abscesses with odontogenic origin. Further studies are needed to better understand the role of microbiota in the development of multiple brain abscesses.
APPLIED SCIENCES-BASEL
(2021)
Review
Clinical Neurology
Davide Tiziano Di Carlo, Nicola Benedetto, Walter Marani, Nicola Montemurro, Paolo Perrini
Summary: Trigeminal neuralgia caused by vertebrobasilar artery compression has a low occurrence rate of 3.4%, with a high success rate of pain relief post-MVD. The majority of patients were pain-free immediately after surgery, with around 93% showing good outcomes at last follow-up. However, hearing impairment and facial numbness were common long-term complications following MVD. Further studies are needed to assess long-term results and pain recurrence rates in this population.
NEUROSURGICAL REVIEW
(2022)
Article
Environmental Sciences
Nicola Montemurro, Antonino Indaimo, Davide Tiziano Di Carlo, Nicola Benedetto, Paolo Perrini
Summary: This study retrospectively analyzed the surgical experience of 31 patients with LOVA, showing different clinical features, treatment modalities, and outcomes before and after surgery. Gait disturbances were the most common clinical manifestation, and ETV and VPS were the main surgical treatments. The age and follow-up duration of surgery were associated with treatment outcomes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Editorial Material
Clinical Neurology
Paolo Perrini
OPERATIVE NEUROSURGERY
(2021)
Article
Clinical Neurology
Nicola Montemurro, Paolo Perrini, Michael T. Lawton
Summary: In this article, we present a rare case of basilar trunk aneurysm and compare the surgical details with anatomical dissection findings, which helps to improve the skills and theory for treating complex aneurysms.
BRITISH JOURNAL OF NEUROSURGERY
(2022)
Article
Genetics & Heredity
Francesco Pasqualetti, Celeste Giampietro, Nicola Montemurro, Noemi Giannini, Giovanni Gadducci, Paola Orlandi, Eleonora Natali, Paolo Chiarugi, Alessandra Gonnelli, Martina Cantarella, Cristian Scatena, Giuseppe Nicolo Fanelli, Antonio Giuseppe Naccarato, Paolo Perrini, Gaetano Liberti, Riccardo Morganti, Maria Franzini, Aldo Paolicchi, Giovanni Pellegrini, Guido Bocci, Fabiola Paiar
Summary: This study found that systemic immunity and inflammation indexes (SI) may serve as potential biomarkers for survival in patients with glioblastoma. The results of univariate and multivariate regression analyses showed that certain indexes had a statistically significant impact on overall survival.
Article
Genetics & Heredity
Lorenzo Innocenti, Valerio Ortenzi, Rosa Scarpitta, Nicola Montemurro, Francesco Pasqualetti, Roberta Asseri, Stefano Lazzi, Anna Szumera-Cieckiewicz, Katia De Ieso, Paolo Perrini, Antonio Giuseppe Naccarato, Cristian Scatena, Giuseppe Nicolo Fanelli
Summary: Despite novel therapeutical approaches, outcomes for glioblastoma (GBM) patients remain poor. This study investigated the prognostic impact of clinico-pathological and molecular features, as well as the role of the cellular immune response in GBM. CD4+ and CD8+ tumor-infiltrating lymphocytes (TILs) were examined and found to have prognostic roles in GBM. Other clinico-pathological features and factors such as treatment, MGMT promoter methylation, and age also influence prognosis in GBM.
Review
Medicine, General & Internal
Paolo Perrini, Daniele Lorenzini, Alberto Vercelli, Alessandra Perrone, Davide Tiziano Di Carlo
Summary: Despite extensive investigations, the choice of graft material for duraplasty after foramen magnum decompression for CMI is still debated. In this systematic review and meta-analysis, the authors evaluated the post-operative complications in adult patients with CMI who underwent FMDD with different dural substitutes. The most common complications were pseudomeningocele and CSF leak, with a lower occurrence observed in autologous duraplasty compared to synthetic or non-autologous dural graft.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Anatomy & Morphology
Davide Tiziano Di Carlo, Maria Elena Filice, Arianna Fava, Francesca Quilici, Beatrice Fuochi, Paolo Cecchi, Graziella Donatelli, Laura Restani, Vincenzo Nardini, Emanuela Turillazzi, Mirco Cosottini, Paolo Perrini
Summary: The study aimed to describe the anatomical variations of the major associational bundles during fetal and early postnatal periods. Through the analysis of formalin-fixed fetal human brains and dissection using Klingler's technique, the study found distinctions between different fascicles starting from the early preterm period. The results suggest that a stepwise development of associational fiber tracts exists, and further investigations are needed.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Clinical Neurology
Paolo Perrini, Nicola Benedetto, Alberto Vercelli, Davide Tiziano Di Carlo
Summary: Surgical treatment of syringomyelia can be done through a procedure called syringopleural shunt (SPS), which connects the syrinx with the pleural space using a lumboperitoneal shunt. This allows for drainage of fluid from the syrinx by creating a negative pressure in the pleural compartment.
ACTA NEUROCHIRURGICA
(2023)