Review
Clinical Neurology
Danielle Golub, Jonathan Hyde, Siddhant Dogra, Joseph Nicholson, Katherine A. Kirkwood, Paulomi Gohel, Stephen Loftus, Theodore H. Schwartz
Summary: The study compared the efficacy of 5-ALA and IMRI in optimizing EOR in HGG, finding both to be superior to conventional neuronavigation. However, no clear difference in effectiveness was found between IMRI and 5-ALA.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Louise Carstam, Alba Corell, Anja Smits, Anna Denes, Hanna Barcheus, Klara Modin, Helene Sjogren, Sandra Ferreyra Vega, Thomas Olsson Bontell, Helena Caren, Asgeir Store Jakola
Summary: This study found that WHO grade is not a reliable prognostic factor in molecularly well-defined diffuse lower-grade glioma (dLGG). However, preoperative tumor volume remains associated with prognosis in IDH-mutated astrocytomas and oligodendrogliomas.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Asfand Baig Mirza, Jose Pedro Lavrador, Loannis Christodoulides, Timothy Martyn Boardman, Amisha Vastani, Qusai Al Banna, Irena C. F. Norman, Christopher Murphy, Sharmila Devi, Francesco Vergani, Richard Gullan, Ranjeev Bhangoo, Keyoumars Ashkan, Razna Ahmed, Anastasios Giamouriadis
Summary: This study investigated the use of 5-aminolevulinic acid (5-ALA) in assisting the resection of grade III gliomas. The results showed that 5-ALA did not have significant benefits in grade III tumors, except for a subgroup of patients who achieved gross total resection (GTR). Additionally, worse postoperative outcomes and 6-month performance status were observed in the 5-ALA group, mainly due to poorer outcomes in the subtotal resection subgroup.
OPERATIVE NEUROSURGERY
(2022)
Article
Oncology
Jonas Ort, Hussam Aldin Hamou, Julius M. Kernbach, Karlijn Hakvoort, Christian Blume, Philipp Lohmann, Norbert Galldiks, Dieter Henrik Heiland, Felix M. Mottaghy, Hans Clusmann, Georg Neuloh, Karl-Josef Langen, Daniel Delev
Summary: PET-guided gross total resection (< 1 cm(3) residual BTV) is associated with better overall survival in patients with WHO grade III or IV gliomas. Multimodal imaging including FET-PET for surgical planning may improve the oncological outcomes in glioma patients.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Oncology
Jasmin Jo, Martin J. van den Bent, Burt Nabors, Patrick Y. Wen, David Schiff
Summary: For IDH-mutant gliomas, there is still confusion on how to conduct long-term surveillance and imaging follow-up. Existing guidelines do not clearly specify individualized imaging guidelines based on treatment and tumor recurrence. In this study, we review current knowledge and propose recommended MRI surveillance intervals, as well as summarize situations where additional imaging studies may be advisable outside of the specified intervals.
Article
Oncology
Thara Tunthanathip
Summary: Malignant transformation of low-grade astrocytoma has a poor prognosis. This study identified supratentorial tumor, midline shift greater than 5mm, and non-total resection as risk factors for malignant transformation.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Review
Oncology
Tiffany A. Eatz, Daniel G. Eichberg, Victor M. Lu, Long Di, Ricardo J. Komotar, Michael E. Ivan
Summary: 5-aminolevulinic acid (5-ALA) has been shown to enhance the outcomes of high-grade glioma (HGG) surgery, including extent of resection and patient survival. However, its impact on postoperative neurological function remains inconclusive.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Review
Oncology
Dennis Lee, Robert A. Riestenberg, Aden Haskell-Mendoza, Orin Bloch
Summary: Patients with DAG-G tend to be older than typical IDH-mutant diffuse astrocytoma patients, have tumors that are more diffuse with focal deficits, and experience significantly shorter overall survival.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Review
Oncology
Maximilian J. Mair, Marjolein Geurts, Martin J. van den Bent, Anna S. Berghoff
Summary: WHO grade II-III gliomas are rare primary brain tumors with longer median survival compared to grade IV glioblastoma. Treatment involves maximal safe resection and adjuvant therapies, with challenges in conducting clinical trials due to rarity and long follow-up times. The 2016 WHO Classification introduced a molecular diagnostic framework for more homogenous subgroups. Available evidence for adjuvant treatment was generated pre-molecular era, emphasizing the need for further research in this field.
CANCER TREATMENT REVIEWS
(2021)
Review
Clinical Neurology
Benjamin T. Whitfield, Jason T. Huse
Summary: In the past decade, advancements in molecular profiling have significantly impacted the way cancer types, including primary brain tumors, are diagnosed, classified, and managed. Molecular alterations have allowed for a more refined classification of brain tumors, deviating from the traditional reliance on morphological characteristics. This shift towards molecular classification is evident in the 2021 WHO classification of central nervous system tumors. This review focuses on the recent updates regarding the classification of adult-type diffuse gliomas, which are highly infiltrative and mostly incurable malignancies of the central nervous system. The refinement of molecular criteria holds promise for improving the diagnosis, prognostication, and eventual treatment of these devastating tumors.
Editorial Material
Clinical Neurology
Ben A. Strickland, Gabriel Zada
Summary: Glioblastoma multiforme is the most common primary brain tumor in adults, often treated with maximal safe resection, chemotherapy, and radiation. Intraoperative use of blue light endoscopy can enhance tumor fluorescence visualization, aiding in achieving a more accurate resection.
WORLD NEUROSURGERY
(2021)
Review
Clinical Neurology
Emily J. Smith, Kavita Gohil, Charee M. Thompson, Anant Naik, Wael Hassaneen
Summary: This meta-analysis demonstrates that fluorescein-guided surgery improves GTR rates of HGGs compared to non-fluorescence guided surgery, while showing similar GTR rates compared to reported 5-ALA-guided resection rates.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Asgeir S. Jakola, Lars Kjelsberg Pedersen, Anne J. Skjulsvik, Kristin Myrmel, Kristin Sjavik, Ole Solheim
Summary: This study aimed to provide extended follow-up data on IDH-mutant dLGGs and compare the outcomes of early resection and biopsy wait-and-scan approaches. The results showed that early resection was associated with longer survival and did not appear to reduce health-related quality of life.
JOURNAL OF NEUROSURGERY
(2022)
Article
Oncology
Sergey A. Goryaynov, Svetlana B. Buklina, Ivan V. Khapov, Artyom I. Batalov, Alexander A. Potapov, Igor N. Pronin, Artem U. Belyaev, Andrey A. Aristov, Vadim U. Zhukov, Galina V. Pavlova, Evgenii Belykh
Summary: The simultaneous use of 5-ALA fluorescence and awake speech mapping in patients with left frontal gliomas can enhance the extent of resection for infiltrative high-grade gliomas and identify foci of anaplasia in non-enhancing gliomas, while maintaining safe limits of functional resection based on speech mapping. Positive 5-ALA fluorescence in diffuse Grade 2 gliomas may indicate a more aggressive disease course.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Wajd N. Al-Holou, Dima Suki, Tiffany R. Hodges, Richard G. Everson, Jacob Freeman, Sherise D. Ferguson, Ian E. McCutcheon, Sujit S. Prabhu, Jeffrey S. Weinberg, Raymond Sawaya, Frederick F. Lang
Summary: This study describes the sulcus-guided resection (SGR) technique used for resecting low-grade gliomas (LGGs) and shows that SGR is independently associated with significantly higher rates of complete resection without an increase in neurological complications compared to the inside-out piecemeal resection (PMR) technique.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Rajiv Pathak, Francesca Zin, Christian Thomas, Susanne Bens, Tenzin Gayden, Jason Karamchandani, Roy W. Dudley, Karolina Nemes, Pascal D. Johann, Florian Oyen, Uwe Kordes, Nada Jabado, Reiner Siebert, Werner Paulus, Marcel Kool, Michael C. Fruhwald, Steffen Albrecht, Ganjam V. Kalpana, Martin Hasselblatt
Summary: Mutations in the tumor suppressor gene SMARCB1 can lead to cytoplasmic localization of the SMARCB1 protein in certain tumors, impacting tumor suppressor function. Inhibiting the nuclear export of mutant SMARCB1 protein may be a potential targeted therapy in these cases.
ACTA NEUROPATHOLOGICA
(2021)
Article
Clinical Neurology
Arnault Tauziede-Espariat, Melanie Pages, Julien Masliah-Planchon, Franck Bourdeaut, Francois Doz, Kevin Beccaria, Nathalie Boddaert, Lauren Hasty, Emmanuele Lechapt, Christian Thomas, Werner Paulus, Pascale Varlet, Martin Hasselblatt
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Bendix Labeit, Thalia Grond, Achim G. Beule, Maik Boehmer, Christian Thomas, Paul Muhle, Inga Claus, Malte Roderigo, Claudia Rudack, Heinz Wiendl, Rainer Dziewas, Tobias Warnecke, Sonja Suntrup-Krueger
Summary: The specific diagnostic algorithm presented in this study helps identify patients with an IIM-compatible dysphagia pattern and provides further IIM-focused diagnostic and therapeutic procedures. Treatment of patients diagnosed with IIM resulted in improvement of dysphagia in some cases post-therapy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Martin Hasselblatt, Christian Thomas, Aniello Federico, Susanne Bens, Mats Hellstrom, Olivera Casar-Borota, Uwe Kordes, Julia E. Neumann, Matthias Dottermusch, Fausto J. Rodriguez, Andrea C. Lo, Sylvia Cheng, Glenda Hendson, Juliette Hukin, Christian Hartmann, Arend Koch, David Capper, Reiner Siebert, Werner Paulus, Karolina Nemes, Pascal D. Johann, Michael C. Fruehwald, Marcel Kool
Summary: Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant, is a distinctive low-grade lesion found in older children and young adults, showing epigenetic similarity with ATRT-MYC and having the potential for malignant progression.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Carolin Beuker, David Schafflick, Jan-Kolja Strecker, Michael Heming, Xiaolin Li, Jolien Wolbert, Antje Schmidt-Pogoda, Christian Thomas, Tanja Kuhlmann, Irene Aranda-Pardos, Noelia A-Gonzalez, Praveen Ashok Kumar, Yves Werner, Ertugrul Kilic, Dirk M. Hermann, Heinz Wiendl, Ralf Stumm, Gerd Meyer zu Hoerste, Jens Minnerup
Summary: The authors of this study found a stroke-associated myeloid cell population in the brain parenchyma that shares similarities with neurodegenerative microglia. These cells, primarily derived from resident microglia, exhibit a lipid-phagocytosing phenotype. Blocking specific markers on these cells can partially improve stroke outcomes.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Azadeh Ebrahimi, Andrey Korshunov, Guido Reifenberger, David Capper, Joerg Felsberg, Elena Trisolini, Bianca Pollo, Chiara Calatozzolo, Marco Prinz, Ori Staszewski, Leonille Schweizer, Jens Schittenhelm, Patrick N. Harter, Werner Paulus, Christian Thomas, Patricia Kohlhof-Meinecke, Marcel Seiz-Rosenhagen, Till Milde, Belen M. Casalini, Abigail Suwala, Annika K. Wefers, Annekathrin Reinhardt, Philipp Sievers, Christof M. Kramm, Nima Etminam, Andreas Unterberg, Wolfgang Wick, Christel Herold-Mende, Dominik Sturm, Stefan M. Pfister, Martin Sill, David T. W. Jones, Daniel Schrimpf, David E. Reuss, Ken Aldape, Zied Abdullaev, Felix Sahm, Andreas von Deimling, Damian Stichel
Summary: In this study, we compared the morphological and DNA methylation characteristics of pleomorphic xanthoastrocytoma (PXA) and found that PXA is more histologically diverse than previously assumed. DNA methylation analysis can assist in differentiating PXA from other tumor types with similar morphology. We also discovered that canonical pTERT mutations are associated with poor prognosis in PXA.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Clinical Neurology
Aniello Federico, Christian Thomas, Katarzyna Miskiewicz, Niklas Woltering, Francesca Zin, Karolina Nemes, Brigitte Bison, Pascal D. Johann, Debra Hawes, Susanne Bens, Uwe Kordes, Steffen Albrecht, Hildegard Dohmen, Peter Hauser, Kathy Keyvani, Frank K. H. van Landeghem, Eva Lobner Lund, David Scheie, Christian Mawrin, Camelia-Maria Monoranu, Benedicte Parm Ulhoi, Torsten Pietsch, Harald Reinhard, Markus J. Riemenschneider, Astrid Sehested, David Sumerauer, Reiner Siebert, Werner Paulus, Michael C. Fruehwald, Marcel Kool, Martin Hasselblatt
Summary: Atypical teratoid/rhabdoid tumor (ATRT) is an aggressive central nervous system tumor that can be divided into three subgroups based on molecular characteristics. These subgroups show differences in age of onset, tumor location, and molecular profiles, and these differences may have biological and clinical importance.
ACTA NEUROPATHOLOGICA
(2022)
Article
Pathology
Martin Hasselblatt, Christian Thomas, Aniello Federico, Karolina Nemes, Pascal D. Johann, Brigitte Bison, Susanne Bens, Sonja Dahlum, Uwe Kordes, Antje Redlich, Lienhard Lessel, Kristian W. Pajtler, Christian Mawrin, Ulrich Schuller, Kay Nolte, Christof M. Kramm, Felix Hinz, Felix Sahm, Caterina Giannini, Judith Penkert, Christian P. Kratz, Stefan M. Pfister, Reiner Siebert, Werner Paulus, Marcel Kool, Michael C. Fruhwald
Summary: Atypical teratoid/rhabdoid tumor (AT/RT) is a malignant central nervous system tumor predominantly affecting infants. Mutations of SMARCB1 or SMARCA4 causing loss of nuclear SMARCB1 or SMARCA4 protein expression are characteristic features. This study reports cases of malignant brain tumors with SMARCB1 or SMARCA4 deficiency, complex copy number alterations, and somatic TP53 mutations in children and young adults, which may represent the first clinical manifestation of Li-Fraumeni syndrome.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Clinical Neurology
Niklas Woltering, Anne Albers, Michael Muether, Walter Stummer, Werner Paulus, Martin Hasselblatt, Markus Holling, Christian Thomas
Summary: Hemangioblastomas (HBs) are highly vascular neoplasms that can occur sporadically or as a manifestation of VHL disease. This study identified two distinct subgroups of HBs based on DNA methylation profiles, which were mainly associated with anatomical location, cytogenetic profiles, and differences in cell type composition.
Article
Multidisciplinary Sciences
Asena Petek Ari, Burak Han Akkurt, Manfred Musigmann, Orkhan Mammadov, David A. Blomer, Dilek N. G. Kasap, Dylan J. H. A. Henssen, Nabila Gala Nacul, Elisabeth Sartoretti, Thomas Sartoretti, Philipp Backhaus, Christian Thomas, Walter Stummer, Walter Heindel, Manoj Mannil
Summary: Our study aims to evaluate the capabilities of radiomics and machine learning in predicting pseudoprogression in patients with high grade gliomas. By analyzing 131 patient cases, we found that the radiomics approach has a high accuracy in predicting the occurrence of pseudoprogression, potentially reducing the need for biopsies and invasive histopathology.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Cuneyt Soenmez, Johannes Woelfer, Markus Holling, Benjamin Brokinkel, Walter Stummer, Heinz Wiendl, Christian Thomas, Andreas Schulte-Mecklenbeck, Oliver M. Grauer
Summary: This study found that NK cells in glioblastoma (GBM) are scarce and functionally hypoactive. Blocking inhibitory KIR and stimulating tumor-derived NK cells with IL-2 can enhance NK cell responsiveness.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Anna M. Speicher, Lisanne Korn, Julia Csatari, Laura Gonzalez-Cano, Michael Heming, Christian Thomas, Christina B. Schroeter, David Schafflick, Xiaolin Li, Lukas Gola, Alexander Engler, Thilo Kaehne, Ludovic Vallier, Sven G. Meuth, Gerd Meyer zu Horste, Stjepana Kovac, Heinz Wiendl, Hans R. Scholer, Matthias Pawlowski
Summary: This study presents a forward programming protocol for generating microglia-like cells from human pluripotent stem cells. The generated cells exhibit similar characteristics to native microglia on a morphological, transcriptional, and functional level. The protocol can be used for reductionist studies and complex coculture systems, including 3D brain organoids, to investigate cellular interactions in healthy and diseased environments.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Malte Traeger, Leonille Schweizer, Eilis Perez, Simone Schmid, Elisabeth G. Hain, Carsten Dittmayer, Julia Onken, Kohei Fukuoka, Koichi Ichimura, Ulrich Schueller, Lasse Duehrsen, Michael Muether, Werner Paulus, Christian Thomas, Marielena Gutt-Will, Philippe Schucht, Theoni Maragkou, Jens Schittenhelm, Franziska Eckert, Maximilian Niyazi, Daniel F. Fleischmann, Mario M. Dorostkar, Petra Feyer, Sven-Axel May, Dag Moskopp, Harun Badakhshi, Cornelia Radke, Jan Walter, Felix Ehret, David Capper, David Kaul
Summary: DNA methylation profiling improves diagnostic accuracy and risk stratification in adult intracranial ependymoma. Gross total resection (GTR) and postoperative radiotherapy may represent key factors in determining the outcome of EPN-PFB patients.
Article
Clinical Neurology
Anne Albers, Dorothee Caecilia Spille, Eric Suero-Molina, Frieder Schaumburg, Walter Stummer, Werner Paulus, Christian Thomas
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Obstetrics & Gynecology
Karolina Nemes, Martin Benesch, Julia Kolarova, Pascal Johann, Martin Hasselblatt, Christian Thomas, Susanne Bens, Selina Glaser, Ole Ammerpohl, Olga Liaugaudiene, Alireza Sadeghipour, Nicolas von der Weid, Irene Schmid, Corrie Gidding, Anat Erdreich-Epstein, Claudia Khurana, Georg Ebetsberger-Dachs, Andreas Lemmer, Ziad Khatib, Carmen Hernandez Marques, Jane Pears, Franz Quehenberger, Uwe Kordes, Christian Vokuhl, Joachim Gerss, Heike Schwarz, Brigitte Bison, Jaclyn A. Biegel, Reiner Siebert, Michael C. Fruehwald
Summary: This study found clinical, therapeutic, and/or (epi-)genetic differences in children with rhabdoid tumors (RT) conceived following ART compared to those conceived without ART. The RT_ART cohort showed a significantly elevated female predominance and a lower median age at diagnosis compared to the control cohort.
HUMAN REPRODUCTION
(2023)
