Potential of Human Nucleus Pulposus-Like Cells Derived From Umbilical Cord to Treat Degenerative Disc Disease

Human umbilical cord derivatives regenerate intervertebral disc

(2017) Naimisha Beeravolu et al.   Journal of Tissue Engineering and Regenerative Medicine

Autogenous Mesenchymal Stem Cells from the Vertebral Body Enhance Intervertebral Disc Regeneration via Paracrine Interaction: An in Vitro Pilot Study

(2016) Eun-Kyung Shim et al.   CELL TRANSPLANTATION

Transplantation of CXCR4 Overexpressed Mesenchymal Stem Cells Augments Regeneration in Degenerated Intervertebral Discs

(2016) Ji-Nan Wei et al.   DNA AND CELL BIOLOGY

Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration

(2016) Stephen M. Richardson et al.   METHODS

Isolation and comparative analysis of potential stem/progenitor cells from different regions of human umbilical cord

(2016) Naimisha Beeravolu et al.   Stem Cell Research

BET protein inhibitor JQ1 inhibits growth and modulates WNT signaling in mesenchymal stem cells

(2016) Saeed Alghamdi et al.   Stem Cell Research & Therapy

Stem cells sources for intervertebral disc regeneration

(2016) Gianluca Vadalà et al.   World Journal of Stem Cells

An Animal Model of Modic Changes by Embedding Autogenous Nucleus Pulposus inside Subchondral Bone of Lumbar Vertebrae

(2016) Chao Han et al.   Scientific Reports

Effect of the mixture of bone marrow mesenchymal stromal cells and annulus fibrosus cells in repairing the degenerative discs of rabbits

(2015) Y.H. Wang et al.   GENETICS AND MOLECULAR RESEARCH

Inflammation in intervertebral disc degeneration and regeneration

(2015) M. Molinos et al.   Journal of the Royal Society Interface

Adipose-derived stem cells improve the viability of nucleus pulposus cells in degenerated intervertebral discs

(2015) KERAN SONG et al.   Molecular Medicine Reports

Differentiation of Human Ligamentum Flavum Stem Cells Toward Nucleus Pulposus-Like Cells Induced by Coculture System and Hypoxia

(2015) Xiao-Bo Han et al.   SPINE

TGF-β1 and GDF5 Act Synergistically to Drive the Differentiation of Human Adipose Stromal Cells towardNucleus Pulposus-like Cells

(2015) Pauline Colombier et al.   STEM CELLS

The effects of human Wharton’s jelly cell transplantation on the intervertebral disc in a canine disc degeneration model

(2015) Yan Zhang et al.   Stem Cell Research & Therapy

Transplantation of human Wharton’s jelly-derived mesenchymal stem cells highly expressing TGFβ receptors in a rabbit model of disc degeneration

(2015) Jongchan Ahn et al.   Stem Cell Research & Therapy

Cell-Based Therapies Used to Treat Lumbar Degenerative Disc Disease: A Systematic Review of Animal Studies and Human Clinical Trials

(2015) David Oehme et al.   Stem Cells International

Systematic Literature Review of Imaging Features of Spinal Degeneration in Asymptomatic Populations

(2014) W. Brinjikji et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Cervical Degenerative Disease

(2014) Matthew D. Alvin et al.   SPINE

Potential use of human adipose mesenchymal stromal cells for intervertebral disc regeneration: a preliminary study on biglycan-deficient murine model of chronic disc degeneration

(2014) Giovanni Marfia et al.   ARTHRITIS RESEARCH & THERAPY

Injection of human umbilical tissue–derived cells into the nucleus pulposus alters the course of intervertebral disc degeneration in vivo

(2013) Steven K. Leckie et al.   Spine Journal

Papain-induced in vitro disc degeneration model for the study of injectable nucleus pulposus therapy

(2013) Samantha C.W. Chan et al.   Spine Journal

Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging

(2013) Ling Liu et al.   Cell Reports

DNA Methylation Changes duringIn VitroPropagation of Human Mesenchymal Stem Cells: Implications for Their Genomic Stability?

(2013) Angela Bentivegna et al.   Stem Cells International

Identification of novel nucleus pulposus markers

(2013) R. Rodrigues-Pinto et al.   Bone & Joint Research

Exploring the cost–utility of stratified primary care management for low back pain compared with current best practice within risk-defined subgroups

(2012) David G T Whitehurst et al.   ANNALS OF THE RHEUMATIC DISEASES

Diversity of intervertebral disc cells: phenotype and function

(2012) Girish Pattappa et al.   JOURNAL OF ANATOMY

How to depolarise the ethical debate over human embryonic stem cell research (and other ethical debates too!)

(2012) Nicolas Espinoza et al.   JOURNAL OF MEDICAL ETHICS

Immunoselected STRO-3+mesenchymal precursor cells and restoration of the extracellular matrix of degenerate intervertebral discs

(2012) Peter Ghosh et al.   JOURNAL OF NEUROSURGERY-SPINE

Comparison of Animal Discs Used in Disc Research to Human Lumbar Disc

(2012) Brent L. Showalter et al.   SPINE

Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation

(2012) Andrew E Teschendorff et al.   Genome Medicine

Characterization of the age-dependent intervertebral disc changes in rabbit by correlation between MRI, histology and gene expression

(2011) Johann Clouet et al.   BMC MUSCULOSKELETAL DISORDERS

Tissue-engineered intervertebral discs produce new matrix, maintain disc height, and restore biomechanical function to the rodent spine

(2011) Robby D. Bowles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming Growth Factor-Beta 3 Stimulates Cartilage Matrix Elaboration by Human Marrow-Derived Stromal Cells Encapsulated in Photocrosslinked Carboxymethylcellulose Hydrogels: Potential for Nucleus Pulposus Replacement

(2011) Michelle S. Gupta et al.   TISSUE ENGINEERING PART A

Porcine Intervertebral Disc Repair Using Allogeneic Juvenile Articular Chondrocytes or Mesenchymal Stem Cells

(2011) Frank L. Acosta et al.   TISSUE ENGINEERING PART A

Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells

(2011) Devina Purmessur et al.   ARTHRITIS RESEARCH & THERAPY

Transplantation of Human Adipose-Derived Stem Cells in a Rabbit Model of Traumatic Degeneration of Lumbar Discs

(2011) Hyoung-Joon Chun et al.   World Neurosurgery

Regeneration of intervertebral discs in a rat disc degeneration model by implanted adipose-tissue-derived stromal cells

(2010) Je Hoon Jeong et al.   ACTA NEUROCHIRURGICA

Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation

(2010) Ben M. Minogue et al.   ARTHRITIS AND RHEUMATISM

Co-culture induces mesenchymal stem cell differentiation and modulation of the degenerate human nucleus pulposus cell phenotype

(2010) Sandra Strassburg et al.   Regenerative Medicine

Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype

(2010) Casey L Korecki et al.   Stem Cell Research & Therapy

Ethical Issues in Stem Cell Research

(2009) Bernard Lo et al.   ENDOCRINE REVIEWS

In vivo intervertebral disc regeneration using stem cell–derived chondroprogenitors

(2009) Hormoz Sheikh et al.   JOURNAL OF NEUROSURGERY-SPINE

Variations in gene and protein expression in human nucleus pulposus in comparison with annulus fibrosus and cartilage cells: potential associations with aging and degeneration

(2009) J. Rutges et al.   OSTEOARTHRITIS AND CARTILAGE

Transplantation of Human Mesenchymal Stems Cells Into Intervertebral Discs in a Xenogeneic Porcine Model

(2009) Helena B. Henriksson et al.   SPINE

Tissue engineering and the intervertebral disc: the challenges

(2008) Rita Kandel et al.   EUROPEAN SPINE JOURNAL

Future perspectives of cell-based therapy for intervertebral disc disease

(2008) Daisuke Sakai   EUROPEAN SPINE JOURNAL

Distinct Intervertebral Disc Cell Populations Adopt Similar Phenotypes in Three-Dimensional Culture

(2008) Alice I. Chou et al.   TISSUE ENGINEERING PART A

Biphasic scaffold for annulus fibrosus tissue regeneration

(2007) Yuqing Wan et al.   BIOMATERIALS