Biographical-Item
Psychology, Clinical
Mary V. Seeman
Summary: Philip Seeman's discovery of the dopamine D2 receptor's isolation is an example of how a small step can lead to a major shift in our understanding of the etiology of schizophrenia.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Olga Plaza, Piotr Galecki, Agata Orzechowska, Malgorzata Galecka, Justyna Sobolewska-Nowak, Agata Szulc
Summary: Schizophrenia is a complex psychiatric disorder affected by both genetic and environmental factors. Pharmacogenetic research can help identify genetic variations that impact the response to antipsychotic medications, leading to more personalized and effective treatments. Genes involved in pharmacokinetics, as well as dopamine, serotonin, and glutamate neurotransmission, have been found to have a significant impact on antipsychotic response.
Review
Chemistry, Medicinal
Itaru Miura, Sho Horikoshi, Mizue Ichinose, Yuhei Suzuki, Kenya Watanabe
Summary: This review provides a comprehensive overview of the drug design, development, and therapy of lurasidone for schizophrenia treatment. Lurasidone has specific effects on different receptors and has been found to be effective in improving symptoms and preventing relapse in patients with schizophrenia. It also has minimal metabolic side effects and improves cognitive and functional performance.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Clinical Neurology
Matthew Harlin, Craig Chepke, Frank Larsen, Karimah S. Bell Lynum, Sanjeda R. Chumki, Heather Fitzgerald, Pedro Such, Jessica Madera-McDonough, Murat Yildirim, Moeen Panni, Stephen R. Saklad
Summary: Aripiprazole 2-month ready-to-use 960 mg and Aripiprazole lauroxil 1064 mg are both long-acting injectable formulations used for the treatment of schizophrenia. Comparing the drug concentrations, both formulations maintain therapeutic levels over the 2-month dosing interval.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Behavioral Sciences
Laszlo Peczely, Gabriella Kekesi, Veronika Kallai, Tamas Ollmann, Kristof Laszlo, Alexandra Biki, Laszlo Lenard, Gyongyi Horvath
Summary: The activation of VP D2 receptors in Wistar rats induces symptoms similar to those observed in schizophrenia model Wisket rats. Wisket rats show impaired food-related motivation, but treatment with quinpirole does not lead to further deterioration.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Cell Biology
Xiao-Yu Liu, Li-Fei Zheng, Yan-Yan Fan, Qian-Ying Shen, Yao Qi, Guang-Wen Li, Qi Sun, Yue Zhang, Xiao-Yan Feng, Jin-Xia Zhu
Summary: In this study, the researchers investigate the effect of dopamine on gastric pepsinogen secretion through dopamine receptors expressed on chief cells or potential D2 receptors expressed on D cells. The findings suggest that dopamine promotes gastric pepsinogen secretion directly through D1-like receptors on chief cells and indirectly through D2 receptor-mediated suppression of somatostatin release.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka A. Kaczor, Katarzyna M. Targowska-Duda, Piotr Stepnicki, Andrea G. Silva, Oliwia Koszla, Ewa Kedzierska, Angelika Grudzinska, Marta Kruk-Slomka, Grazyna Biala, Marian Castro
Summary: The study investigates a potential antipsychotic drug D2AAK3, which shows affinity to multiple receptors and demonstrates effects of reducing hyperactivity and improving memory consolidation in animal experiments.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Adiba Anam, Sean Lynch, Nafiz Mosharraf, Chloe Soukas, Dmitriy Gekhman
Summary: Schizophrenia is a common psychiatric illness with significant economic and social burden. Second generation antipsychotics, including Aripiprazole, Risperidone, and Paliperidone, have changed treatment practices for psychiatrists. Aripiprazole has high affinity for the dopamine D2 receptor, which is responsible for the antipsychotic effect, but may not be as potent as other second generation antipsychotics. This case study explores how Aripiprazole may worsen psychiatric symptoms by blocking the antipsychotic effects of Paliperidone due to its strong binding affinity for the D2 receptor. Prescribers should be cautious when initiating long-acting injectable forms of Aripiprazole to avoid this phenomenon.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yarim Elideth De la Luz-Cuellar, Ulises Coffeen, Francisco Mercado, Vinicio Granados-Soto
Summary: This study investigated the impact of sex on the antiallodynic activity of spinal dopamine D1 and D2-like receptors in a model of fibromyalgia-type pain in rats. The results showed that drugs targeting these receptors had a greater effect on female rats compared to male rats. Sex differences were also observed in a nerve injury model. These findings suggest that the antiallodynic effect of dopamine receptors in fibromyalgia-type pain is influenced by hormonal receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Psychology, Clinical
Rodrigo Ramirez-Rodriguez, Isabel Leon-Sequeda, Lazaro Salomon-Lara, Daniela Perusquia-Cabrera, Deissy Herrera-Covarrubias, Lauro Fernandez-Canedo, Luis I. Garcia, Jorge Manzo, James G. Pfaus, Maria-Leonor Lopez-Meraz, Genaro A. Coria-Avila
Summary: The study suggests that cohabitating with juvenile males under enhanced D2 agonism leads to atypical sexual responses and a higher brain response to the odor of young males, without changes in serum testosterone levels.
ARCHIVES OF SEXUAL BEHAVIOR
(2021)
Article
Psychiatry
Max Berg, Marcel Riehle, Winfried Rief, Tania Lincoln
Summary: This study investigated the effects of partial D2 receptor blockade on hedonic experiences by administering 300 mg of Amisulpride or placebo to 85 participants. The results showed that the Amisulpride group had lower positivity ratings and lower electrodermal responses compared to the placebo group across all stimulus categories. These findings suggest that D2 receptor blockade can reduce immediate hedonic responsivity in healthy volunteers.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Richard B. Mailman, Yang Yang, Xuemei Huang
Summary: Research suggests that selective D-1 agonists may play a critical role in the treatment of Parkinson's disease, providing profound symptomatic relief even when current drugs are ineffective. Existing Parkinson's medications have limited efficacy in severe cases, but high intrinsic activity D-1 agonists could offer a major therapeutic advance in improving patients' quality of life.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
B. F. G. Queiroz, F. C. S. Fonseca, R. C. M. Ferreira, T. R. L. Romero, A. C. Perez, I. D. G. Duarte
Summary: This study investigated the role of dopamine and its receptors in the peripheral processing of the nociceptive response in mice using a pharmacological approach and the paw pressure test. The results showed that dopamine at small doses produced antinociceptive effects via the activation of D-2-like receptors, while at higher doses it caused hyperalgesia via the activation of D-1-like receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Vindhya Nawaratne, Sean P. McLaughlin, Felix P. Mayer, Zayna Gichi, Alyssa Mastriano, Lucia Carvelli
Summary: The dopamine 2 receptors (D2R) play an important role in mediating the effects of amphetamine, which primarily rely on the ability of amphetamine to increase extracellular dopamine. This study found that prolonged exposure to amphetamine can decrease or increase endogenous hD2R at the cellular membrane in HEK293 cells. Moreover, the effects of amphetamine on D2R expression may occur independently of dopamine and DAT.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Olga Yu Fedorenko, Diana Z. Paderina, Elena G. Kornetova, Evgeniya G. Poltavskaya, Ivan Pozhidaev, Anastasiia A. Goncharova, Maxim B. Freidin, Anna Bocharova, Nikolay A. Bokhan, Anton J. M. Loonen, Svetlana A. Ivanova
Summary: This study investigated the role of glutamatergic system genes in the pathogenesis of tardive dyskinesia (TD). The results suggest that genes encoding for mGlu3, EAAT2, and EAAT1 may be involved in the development of TD in schizophrenia patients.
Correction
Psychiatry
Federico E. Turkheimer, Pierluigi Selvaggi, Mitul A. Mehta, Mattia Veronese, Fernando Zelaya, Paola Dazzan, Anthony C. Vernon
SCHIZOPHRENIA BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Maria Rogdaki, Celine Devroye, Mariasole Ciampoli, Mattia Veronese, Abhishekh Ashok, Robert A. McCutcheon, Sameer Jauhar, Ilaria Bonoldi, Maria Gudbrandsen, Eileen Daly, Therese van Amelsvoort, Marianne Van Den Bree, Michael J. Owen, Federico Turkheimer, Francesco Papaleo, Oliver D. Howes
Summary: Dopaminergic dysfunction is associated with genetic risk for psychosis, particularly in individuals with 22q11.2 deletion. This study found increased striatal dopamine synthesis capacity in individuals with 22q11.2 deletion compared to healthy controls and individuals with 22q11.2 duplication. Furthermore, dopamine synthesis was positively correlated with the severity of psychosis-risk symptoms.
MOLECULAR PSYCHIATRY
(2023)
Correction
Biochemistry & Molecular Biology
Maria Rogdaki, Celine Devroye, Mariasole Ciampoli, Mattia Veronese, Abhishekh H. Ashok, Robert A. McCutcheon, Sameer Jauhar, Ilaria Bonoldi, Maria Gudbrandsen, Eileen Daly, Therese van Amelsvoort, Marianne Van Den Bree, Michael J. Owen, Federico Turkheimer, Francesco Papaleo, Oliver D. Howes
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Robert A. Chesters, Fiona Pepper, Celia Morgan, Jonathan D. Cooper, Oliver D. Howes, Anthony C. Vernon, James M. Stone
Summary: Chronic ketamine use may lead to lower grey matter volumes and increased sub-threshold psychotic symptoms, suggesting distinct mechanisms in the development of schizophrenia-like symptoms.
PSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Amanda Kiemes, Felipe Gomes, Diana Cash, Daniela L. Uliana, Camilla Simmons, Nisha Singh, Anthony C. Vernon, Federico Turkheimer, Cathy Davies, James M. Stone, Anthony A. Grace, Gemma Modinos
Summary: The hippocampal GABA(A) and NMDA receptor abnormalities were observed in the MAM model of schizophrenia, with reduced alpha 5GABA(A)R density and increased dorsal hippocampus CA1 NMDA receptor density in MAM-treated rats. Peripubertal diazepam exposure partially rescued anxiety and schizophrenia-relevant behaviors, indicating potential therapeutic mechanisms for schizophrenia through more selective pharmacological agents.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rosa Mastrogiacomo, Gabriella Trigilio, Celine Devroye, Daniel Dautan, Valentina Ferretti, Gabriele Losi, Lucia Caffino, Genny Orso, Roberto Marotta, Federica Maltese, Enrica Vitali, Gessica Piras, Alessia Forgiarini, Giada Pacinelli, Annamaria Lia, Debora A. Rothmond, John L. Waddington, Filippo Drago, Fabio Fumagalli, Maria Antonietta De Luca, Gian Marco Leggio, Giorgio Carmignoto, Cynthia S. Weickert, Francesca Manago, Francesco Papaleo
Summary: The abnormal activity of astrocytes is related to the dopaminergic abnormalities in schizophrenia. Dys1A isoform has a significant impact on basal ganglia-related behaviors and dopaminergic regulation in astrocytes, but has minimal effect on cortical functioning.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Alessandra Borsini, Blair Merrick, Jonathan Edgeworth, Gargi Mandal, Deepak P. Srivastava, Anthony C. Vernon, Gaia Nebbia, Sandrine Thuret, Carmine M. Pariante
Summary: Delirium in COVID-19 patients can negatively impact hippocampal-dependent neurogenic processes through the production of IL12 and IL13 induced by IL6.
MOLECULAR PSYCHIATRY
(2022)
Article
Biophysics
Rachel L. C. Barrett, Diana Cash, Camilla Simmons, Eugene Kim, Tobias C. Wood, Richard Stones, Anthony C. Vernon, Marco Catani, Flavio Dell'Acqua
Summary: In this study, an optimization strategy for ex vivo diffusion imaging was developed to improve image quality and signal-to-noise ratio (SNR). The strategy successfully enabled the acquisition of high-resolution diffusion data with improved SNR efficiency and allowed for faster acquisitions in preclinical experiments.
NMR IN BIOMEDICINE
(2023)
Article
Psychiatry
Adam Pavlinek, Rugile Matuleviciute, Laura Sichlinger, Lucia Dutan Polit, Nikolaos Armeniakos, Anthony Christopher Vernon, Deepak Prakash Srivastava
Summary: Maternal immune activation during gestation is linked to increased risk for psychiatric disorders with neurodevelopmental origin. Animal and human cellular models suggest that inflammatory cytokines play a critical role in the impact of maternal infection on offspring brain and behavior development. However, the specific cytokines necessary for these effects and their impact on specific cell types are still unclear.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Andrea Luppi, Fernando E. Rosas, MaryAnn P. Noonan, Pedro A. M. Mediano, Morten L. Kringelbach, Robin L. Carhart-Harris, Emmanuel A. Stamatakis, Anthony C. Vernon, Federico E. Turkheimer
Summary: Scientific theories on human brain development require an understanding of its evolution and its relationship with oxygen and brain metabolism. Our proposed model suggests that the evolutionary expansion of specific brain regions led to reliance on nonoxidative glycolysis for energy supply due to insufficient oxygen delivery. This developmental process supports neural plasticity and ongoing learning, enabling complex group dynamics and intergenerational learning, and fueling further cortical expansion.
Article
Psychiatry
Amanda Kiemes, Maria Elisa Serrano Navacerrada, Eugene Kim, Karen Randall, Camilla Simmons, Loreto Rojo Gonzalez, Marija-Magdalena Petrinovic, David J. Lythgoe, Diana Rotaru, Davide Di Censo, Lydiane Hirschler, Emmanuel L. Barbier, Anthony C. Vernon, James M. Stone, Cathy Davies, Diana Cash, Gemma Modinos
Summary: This study found that specific disruption of cortical inhibitory interneurons in mice can reproduce some of the neuroimaging findings in patients with psychosis, linking inhibitory interneuron deficits to non-invasive measures of brain function and neurochemistry that can be used across species.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Biology
Jadna Bogado Lopes, Anna N. Senko, Klaas Bahnsen, Daniel Geisler, Eugene Kim, Michel Bernanos, Diana Cash, Stefan Ehrlich, Anthony C. Vernon, Gerd Kempermann
Summary: By continuously tracking the behavioral activity of mice in an enriched environment for 3 months and using ex vivo structural magnetic resonance imaging, it was found that behavioral activity can shape the connectivity of the mouse brain. Furthermore, there are differences in brain structural covariance between mice with different behavioral trajectories.
Article
Immunology
Amalie C. M. Couch, Shiden Solomon, Rodrigo R. R. Duarte, Alessia Marrocu, Yiqing Sun, Laura Sichlinger, Rugile Matuleviciute, Lucia Dutan Polit, Bjorn Hanger, Amelia Brown, Shahram Kordasti, Deepak P. Srivastava, Anthony C. Vernon
Summary: Research found that prenatal exposure to elevated interleukin-6 (IL-6) levels is associated with increased risk for psychiatric disorders. The study used human induced pluripotent stem cell-derived microglia-like cells and neural progenitor cells to investigate the cellular and molecular mechanisms of IL-6 response. The results showed that IL-6 had different effects on different cell types and induced the secretion of various cytokines.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Veronica Rivi, Cristina Benatti, Joan M. C. Blom, Luca Pani, Nicoletta Brunello, Filippo Drago, Francesco Papaleo, Filippo Caraci, Federica Geraci, Sebastiano Alfio Torrisi, Gian Marco Leggio, Fabio Tascedda
Summary: Cognitive impairment in schizophrenia is a challenging problem that hasn't been solved clinically or pharmacologically. Dysfunctional dysbindin and dopamine receptor D3 have been found to improve cognitive functions, but the underlying molecular mechanisms are not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Matthew R. Bruce, Amalie C. M. Couch, Simone Grant, Janna McLellan, Katherine Ku, Christina Chang, Angelica Bachman, Matthew Matson, Robert F. Berman, Richard J. Maddock, Douglas Rowland, Eugene Kim, Matthew D. Ponzini, Danielle Harvey, Sandra L. Taylor, Anthony C. Vernon, Melissa D. Bauman, Judy van de Water
Summary: Maternal immune dysregulation is a prenatal risk factor for autism spectrum disorder (ASD). Maternal autoantibodies (aAbs) may disrupt metabolic signaling and induce neuroanatomical changes in the brains of exposed offspring. Rats exposed to MAR-ASD aAbs present with alterations in behavior, brain structure, and neurometabolites, reminiscent of findings observed in clinical ASD.
MOLECULAR PSYCHIATRY
(2023)
Article
Behavioral Sciences
Edna C. Cieslik, Markus Ullsperger, Martin Gell, Simon B. Eickhoff, Robert Langner
Summary: Previous studies on error processing have primarily focused on the posterior medial frontal cortex, but the role of other brain regions has been underestimated. This study used activation likelihood estimation meta-analyses to explore brain activity related to committing errors and responding successfully in interference tasks. It was found that the salience network and the temporoparietal junction were commonly involved in both correct and incorrect responses, indicating their general involvement in coping with situations that require increased cognitive control. Error-specific convergence was observed in the dorsal posterior cingulate cortex, posterior thalamus, and left superior frontal gyrus, while successful responding showed stronger convergence in the dorsal attention network and lateral prefrontal regions. Underrecruitment of these regions in error trials may reflect failures in activating the appropriate stimulus-response contingencies necessary for successful response execution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2024)