Article
Multidisciplinary Sciences
Patricia Clement, Marco Castellaro, Thomas W. Okell, David L. Thomas, Pieter Vandemaele, Sara Elgayar, Aaron Oliver-Taylor, Thomas Kirk, Joseph G. Woods, Sjoerd B. Vos, Joost P. A. Kuijer, Eric Achten, Matthias J. P. van Osch, John A. Detre, Hanzhang Lu, David C. Alsop, Michael A. Chappell, Luis Hernandez-Garcia, Jan Petr, Henk J. M. M. Mutsaerts
Summary: ASL-BIDS is a standardized method for ASL data storage that can improve the reproducibility and data sharing of ASL research.
Article
Endocrinology & Metabolism
Joseph Benzakoun, Sylvain Charron, Guillaume Turc, Wagih Ben Hassen, Laurence Legrand, Gregoire Boulouis, Olivier Naggara, Jean-Claude Baron, Bertrand Thirion, Catherine Oppenheim
Summary: Machine Learning has been utilized for tissue fate prediction after acute ischemic stroke, with Gradient Boosting model showing superior predictive performance compared to other ML models and clinical methods. This suggests promising potential for future decision-making in stroke management.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Pharmacology & Pharmacy
Tao Sun, Ping Wang, Ting Deng, Xingbao Tao, Bin Li, Ying Xu
Summary: Panax notoginseng saponins (PNS) significantly reduces neurologic deficit scores and cerebral infarct volumes in focal cerebral ischemia-reperfusion rat models, inhibits inflammatory factors release, and shows better efficacy with combination therapy. Drug dosage and administration duration significantly affect the efficacy of PNS.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Isabel N. Christie, Rowan Windsor, Henk J. M. M. Mutsaerts, Therese Tillin, Carole H. Sudre, Alun D. Hughes, Xavier Golay, Alexander Gourine, Patrick S. Hosford
Summary: This study examined the link between systemic arterial blood pressure and cerebral perfusion in a tri-ethnic study in the UK. Results showed a significant negative correlation between blood pressure, age, and cerebral blood flow. The group of hypertensive patients prescribed with anti-hypertensive drugs but with uncontrolled blood pressure recorded the lowest cerebral blood flow values. These findings highlight the importance of blood pressure control for maintaining brain blood flow.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Multidisciplinary Sciences
Pauline Hall Barrientos, Katrina Knight, Douglas Black, Alexander Vesey, Giles Roditi
Summary: This pilot study used 4D flow MRI to analyze post-prandial blood flow changes in mesenteric vessels. The results showed a significant increase in blood flow post-meal in the portal vein and superior mesenteric artery in healthy volunteers, but not in CMI patients. This suggests that examining mesenteric venous vessels exclusively is a feasible method for measuring post-prandial flow changes in CMI patients.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Joseph S. R. Alisch, Nikkita Khattar, Richard W. Kim, Luis E. Cortina, Abinand C. Rejimon, Wenshu Qian, Luigi Ferrucci, Susan M. Resnick, Richard G. Spencer, Mustapha Bouhrara
Summary: Cerebral blood flow varies with age in different brain regions, with white matter regions showing increased blood flow with age and women having higher blood flow than men. The study results provide a foundation for further investigation of CNS perfusion in various scenarios.
Review
Endocrinology & Metabolism
Alasdair G. Morgan, Michael J. Thrippleton, Joanna M. Wardlaw, Ian Marshall
Summary: 4D flow is an advanced non-invasive MRI method that captures cerebral blood flow dynamics effectively and collects large amounts of information. Although data collection can be time-consuming, the development of new techniques and high-field MRI scanners is likely to make 4D flow a key method in cerebrovascular imaging studies in the future.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Longting Lin, Jianhong Yang, Chushuang Chen, Huiqiao Tian, Andrew Bivard, Neil J. Spratt, Christopher R. Levi, Mark W. Parsons
Summary: Collateral status is a major determinant of ischemic core growth, with better collaterals associated with slower core growth rate.
Article
Medicine, General & Internal
Benjamim Ficial, Iuri Corsini, Elena Bonafiglia, Enrico Petoello, Alice Iride Flore, Silvia Nogara, Nicola Tsatsaris, Alan M. Groves
Summary: This study aimed to improve the accuracy of ultrasound assessment of superior vena cava (SVC) flow by modifying the measurement method. The results showed that the modified ultrasound assessment had better agreement with phase contrast magnetic resonance imaging (PCMRI) compared to the original method and prior adaptation. Using the modifications described in this study led to enhanced accuracy and decreased variability in a small cohort of premature infants.
Article
Toxicology
Kevin Lee, Sara Bohnert, Cory Vair, John Mikler, Jeff F. Dunn
Summary: Exposure to nerve agents can lead to debilitating neurological damage, especially without direct neuroprotection. Seizures induced by nerve agents may be the main contributor to neuropathology, highlighting the importance of addressing metabolic impairment and reduced blood supply in treatment.
TOXICOLOGY LETTERS
(2021)
Article
Multidisciplinary Sciences
Zhensen Chen, Anders Gould, Duygu Baylam Geleri, Niranjan Balu, Li Chen, Baocheng Chu, Kristi Pimentel, Gador Canton, Thomas S. Hatsukami, Chun Yuan
Summary: The study aimed to explore the associations between intracranial vascular features extracted from NCE-MRA images and global cognition. The results showed that artery length and number of branches were positively associated with cognitive scores. These findings suggest that intracranial vascular features may serve as useful markers of cerebrovascular health and provide additional information in individuals with cognitive impairment.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tine Arts, Jeroen C. W. Siero, Geert Jan Biessels, Jaco J. M. Zwanenburg
Summary: A robust automated method was developed to exclude small perforators affected by ghosting artifacts, showing moderate to good reliability compared to manual censoring. This method can be used for studying cerebral small arteries.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Endocrinology & Metabolism
Jan Willem van Dalen, Henri J. M. M. Mutsaerts, Jan Petr, Matthan Wa Caan, Eric P. Moll van Charante, Bradley J. MacIntosh, Willem A. van Gool, Aart J. Nederveen, Edo Richard
Summary: This study found no associations between blood pressure measures and cerebral blood flow, but antihypertensive medication use was associated with lower cerebral blood flow and increased ASL signal heterogeneity.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Zhen-Gui Xu, Jin-Jing Xu, Yu-Chen Chen, Jinghua Hu, Yuanqing Wu, Yuan Xue
Summary: Chronic tinnitus patients exhibit reduced cerebral blood flow in the auditory and prefrontal cortex, and migraine may facilitate a decrease in cerebral blood flow in the context of tinnitus, underlying the neuropathological mechanisms of chronic tinnitus comorbid with migraine.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Endocrinology & Metabolism
Nicholas J. Luciw, Simina Toma, Benjamin Goldstein, Bradley J. MacIntosh
Summary: This study revealed that there is covariance between cerebral blood flow (CBF) and brain structure in adolescents, with differences observed in those with bipolar disorder compared to controls. The correspondence between CBF and structure was more pronounced in individuals with bipolar disorder.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Ku Mastura Ku Mohd Noor, Cathy Wyse, Lisa A. Roy, Stephany M. Biello, Christopher McCabe, Deborah Dewar
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2017)
Review
Endocrinology & Metabolism
Nathalie Percie du Sert, Alessio Alfieri, Stuart M. Allan, Hilary V. O. Carswell, Graeme A. Deuchar, Tracy D. Farr, Paul Flecknell, Lindsay Gallagher, Claire L. Gibson, Michael J. Haley, Malcolm R. Macleod, Barry W. McColl, Christopher McCabe, Anna Morancho, Lawrence D. F. Moon, Michael J. O'Neill, Isabel Perez de Puig, Anna Planas, C. Ian Ragan, Anna Rosell, Lisa A. Roy, Kathryn O. Ryder, Alba Simats, Emily S. Sena, Brad A. Sutherland, Mark D. Tricklebank, Rebecca C. Trueman, Lucy Whitfield, Raymond Wong, I. Mhairi Macrae
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2017)
Article
Cell & Tissue Engineering
Emma Reid, Jasenka Guduric-Fuchs, Christina L. O'Neill, Lynsey-Dawn Allen, Sarah E. J. Chambers, Alan W. Stitt, Reinhold J. Medina
STEM CELLS TRANSLATIONAL MEDICINE
(2018)
Article
Medicine, Research & Experimental
Karen Horsburgh, Joanna M. Wardlaw, Tom van Agtmael, Stuart M. Allan, Mike L. J. Ashford, Philip M. Bath, Rosalind Brown, Jason Berwick, M. Zameel Cader, Roxana O. Carare, John B. Davis, Jessica Duncombe, Tracy D. Farr, Jill H. Fowler, Jozien Goense, Alessandra Granata, Catherine N. Hall, Atticus H. Hainsworth, Adam Harvey, Cheryl A. Hawkes, Anne Joutel, Rajesh N. Kalaria, Patrick G. Kehoe, Catherine B. Lawrence, Andy Lockhart, Seth Love, Malcolm R. Macleod, I. Mhairi Macrae, Hugh S. Markus, Chris McCabe, Barry W. McColl, Paul J. Meakin, Alyson Miller, Maiken Nedergaard, Michael O'Sullivan, Terry J. Quinn, Rikesh Rajani, Lisa M. Saksida, Colin Smith, Kenneth J. Smith, Rhian M. Touyz, Rebecca C. Trueman, Tao Wang, Anna Williams, Steven C. R. Williams, Lorraine M. Work
Review
Endocrinology & Metabolism
Tuuli M. Hietamies, Caroline Ostrowski, Zhong Pei, Luyang Feng, Christopher McCabe, Lorraine M. Work, Terence J. Quinn
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2018)
Article
Clinical Neurology
Graeme A. Deuchar, Josie C. van Kralingen, Lorraine M. Work, Celestine Santosh, Keith W. Muir, Chris McCabe, I. Mhairi Macrae
TRANSLATIONAL STROKE RESEARCH
(2019)
Article
Clinical Neurology
Josie C. van Kralingen, Aisling McFall, Emily N. J. Ord, Thomas F. Coyle, Maria Bissett, John D. McClure, Christopher McCabe, I. Mhairi Macrae, Jesse Dawson, Lorraine M. Work
TRANSLATIONAL STROKE RESEARCH
(2019)
Article
Ophthalmology
Olivia E. O'Leary, Paul Canning, Emma Reid, Pietro M. Bertelli, Stuart McKeown, Michael Brines, Anthony Cerami, Xuan Du, Heping Xu, Mei Chen, Louise Dutton, Derek P. Brazil, Reinhold J. Medina, Alan W. Stitt
EXPERIMENTAL EYE RESEARCH
(2019)
Article
Multidisciplinary Sciences
M. M. C. Arroja, E. Reid, L. A. Roy, A. V. Vallatos, M. Holmes, S. A. Nicklin, L. M. Work, C. McCabe
SCIENTIFIC REPORTS
(2019)
Article
Endocrinology & Metabolism
Ifechukwude J. Biose, Deborah Dewar, I. Mhairi Macrae, Christopher McCabe
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2020)
Article
Clinical Neurology
Mohammed S. Alshuhri, Lindsay Gallagher, Christopher McCabe, William M. Holmes
TRANSLATIONAL STROKE RESEARCH
(2020)
Article
Endocrinology & Metabolism
Aisling McFall, Tuuli M. Hietamies, Ashton Bernard, Margaux Aimable, Stuart M. Allan, Philip M. Bath, Gaia Brezzo, Roxana O. Carare, Hilary Carswell, Andrew N. Clarkson, Gillian Currie, Tracy D. Farr, Jill H. Fowler, Mark Good, Atticus H. Hainsworth, Catherine Hall, Karen Horsburgh, Rajesh Kalaria, Patrick Kehoe, Catherine Lawrence, Malcolm Macleod, Barry W. McColl, Alison McNeilly, Alyson A. Miller, Scott Miners, Vincent Mok, Michael O'Sullivan, Bettina Platt, Emily S. Sena, Matthew Sharp, Patrick Strangeward, Stefan Szymkowiak, Rhian M. Touyz, Rebecca C. Trueman, Claire White, Chris McCabe, Lorraine M. Work, Terence J. Quinn
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2020)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.