Article
Cell Biology
Robert Luck, Andromachi Karakatsani, Bhavin Shah, Geza Schermann, Heike Adler, Janina Kupke, Nathalie Tisch, Hyun-Woo Jeong, Michaela Kerstin Back, Florian Hetsch, Anna D'Errico, Michele De Palma, Ellen Wiedtke, Dirk Grimm, Amparo Acker-Palmer, Jakob von Engelhardt, Ralf H. Adams, Hellmut G. Augustin, Carmen Ruiz de Almodovar
Summary: The neuro-vascular signaling axis of Angiopoietin/Tie2 is crucial for proper dendritic morphogenesis in Purkinje cells, requiring intercellular communication between neural cells, endothelial cells, and Purkinje cells. Deletion of Tie2 or its ligands results in altered dendritic arborization and gene expression, impacting cytoskeleton organization and cell functionality.
Article
Engineering, Marine
Lingling Jiang, Lanxuan An, Xinyu Zhang, Chengbo Wang, Xinjian Wang
Summary: This study proposes an attention-based deep reinforcement learning (ADRL) method for autonomous ship collision avoidance in multi-ship encounter situations. It includes a risk assessment module and a motion planning module, which calculate each ship's collision avoidance decision in the form of attention scores. Additionally, a composite learning method is designed to improve exploration efficiency and learning performance.
Article
Developmental Biology
Mohamed Ishan, Zhonghou Wang, Peng Zhao, Yao Yao, Steven L. Stice, Lance Wells, Yuji Mishina, Hong-Xiang Liu
Summary: This study reveals the importance of bone morphogenetic protein signaling mediated by ALK3 receptor in the differentiation of taste papillae during early embryo development in mice. The study demonstrates that ALK3-BMP signaling in mesenchyme is required for the activation of Wnt/I3-catenin pathway, which promotes taste papilla differentiation. The findings highlight the role of tongue mesenchyme in taste papilla cell differentiation.
Article
Neurosciences
Ann-Kristin Hoersting, Dietmar Schmucker
Summary: Recent progress in human genetics and single cell sequencing has expanded our understanding of brain wiring, while studies on the developmental causes of psychiatric diseases have shown significant advancements, emphasizing the importance of axonal branching and synapse formation. These findings highlight the need for increased efforts in understanding the developmental mechanisms of circuit assembly and the impact of neuronal shape diversity on specificity.
CURRENT OPINION IN NEUROBIOLOGY
(2021)
Article
Green & Sustainable Science & Technology
Zhongqiu Li, Caiquan Duan, Zhuo Lyu, Xin Xu
Summary: Supervisory developmental feedback positively influences employee innovative behavior through self-goal-setting, and this relationship is strengthened by uncertainty avoidance.
Article
Psychology, Applied
Xiao-min Xu, Danyang Du, Russell E. Johnson, Chang-qin Lu
Summary: Research suggests that justice change can impact employees' engagement and withdrawal from work through approach and avoidance paths. Employees' perceptions of employment opportunities and threats to job continuity will influence the effects along these paths.
JOURNAL OF APPLIED PSYCHOLOGY
(2022)
Article
Cell & Tissue Engineering
Matteo Mazzella, Keegan Walker, Christina Cormier, Michael Kapanowski, Albi Ishmakej, Azeem Saifee, Yashvardhan Govind, G. Rasul Chaudhry
Summary: This study investigated the self-renewal mechanism of primitive (p) MSCs and found that the Wnt pathway is associated with self-renewal potential, while senescence is linked to the TGF beta pathway. Transcriptomic and MNase-seq analysis revealed distinct gene expressions and nucleosome occupancies in pMSCs grown in xeno-free and fetal bovine serum medium, providing insights into the complex molecular mechanisms governing the self-renewal and senescence of MSCs.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell Biology
Sarah Robinson-Thiewes, Benjamin Dufour, Pier-Olivier Martel, Xavier Lechasseur, Amani Ange Danielle Brou, Vincent Roy, Yunqing Chen, Judith Kimble, Patrick Narbonne
Summary: The ERK/MAPK pathway plays a crucial role in cell proliferation regulation in Caenorhabditis elegans, with different isoforms of MPK-1 having specific effects on germline differentiation and stem cell proliferation. The study suggests a potential non-autonomous role of ERK/MAPK in stem cell proliferation across species and tissue types, with significant clinical implications for cancer and other diseases.
Article
Computer Science, Information Systems
Marsel Omeri, Ralvi Isufaj, Romualdo Moreno Ortiz
Summary: This paper proposes a self-separation method to ensure the safe separation of small Unmanned Aircraft Systems (sUAS) with different performances. The method is based on the concept of dynamic protection zone and a time-based "Detect and Avoid" self-separation approach. It outlines an engineering approach to defining well clear among sUAS and recommends appropriate thresholds and alerting times based on the severity of loss of well clear.
Article
Cell Biology
Nikolaos Doumpas, Simon Soderholm, Smarth Narula, Steven Moreira, Bradley W. Doble, Claudio Cantu, Konrad Basler
Summary: The study demonstrates that genetic deletion of TCF/LEF transcription factors allows mESCs to self-renew in N2B27 medium independently of specific chemical inhibitors, possibly through the regulation of genes such as Aire, Dnmt3l, and IcosL. TCF/LEF are shown to regulate specific genes in a beta-catenin independent manner, influencing the pluripotent state of mESCs.
Review
Immunology
Marvin Sylvestre, Selene E. Di Carlo, Lucie Peduto
Summary: The intestinal barrier is a complex structure that is crucial for absorbing nutrients and protecting against pathogens. Recent studies have highlighted the important role of mesenchymal cells in the development and maintenance of the intestinal barrier. These cells regulate both the epithelial and immune components of the barrier, and their heterogeneity has implications for intestinal regeneration and inflammatory pathologies.
MUCOSAL IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Jonathon M. Vivoda, Lisa J. Molnar, David W. Eby, Carolyn DiGuiseppi, Vanya Jones, Guohua Li, David Strogatz, Raymond Yung, Linda Nyquist, Jacqui Smith, Jennifer S. Zakrajsek, Renee M. St Louis, Nicole Zanier
Summary: In older adulthood, avoidance of nighttime driving is the most common initial self-regulation behavior. Variables related to situational driving comfort and driving ability are the best predictors of differences in driving self-regulation.
JOURNAL OF TRANSPORT & HEALTH
(2022)
Article
Psychology, Multidisciplinary
Weihua Niu, Li Cheng, Dana Duan, Qingyang Zhang
Summary: This study examined the relationships among student-perceived supportive learning environment (PSLE), mathematical achievement, autonomous self-regulation, and creative thinking. The results demonstrated positive associations between student PSLE and autonomous self-regulation, creative thinking, and mathematical achievement. Additionally, the study found that the influence of PSLE on mathematical achievement could be mediated through autonomous self-regulation and creative thinking.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Computer Science, Information Systems
Jie Zhang, Jianfa Sha, Guangjie Han, Jun Liu, Yujie Qian
Summary: The article proposes a cooperative-control-based algorithm called CUTE for escorting moving targets in underwater Internet of Things applications. The algorithm includes task assignment and formation control, achieving target escort through smooth path planning and formation rotation.
IEEE INTERNET OF THINGS JOURNAL
(2021)
Article
Psychiatry
Marek Wypych, Marc N. Potenza
Summary: Low self-regulation is associated with impulsivity, poor emotional regulation, and maladaptive behaviors; impaired error processing and learning from punishments may be important mechanisms underlying low self-regulation.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Genetics & Heredity
Tzu Lin, Hao-Hsiang Kao, Che-Hsuan Chou, Chih-Yu Chou, Yu-Ching Liao, Hsiu-Hsiang Lee
Review
Cell Biology
Yu-Chun Wu, Yueh-Chen Chiang, Shih-Hua Chou, Chun-Liang Pan
Summary: Wnt signalling pathway regulates development and morphogenesis in metazoans through endocytosis, with recent studies suggesting its involvement in cellular stress responses in adulthood. This review summarizes the molecular and cellular mechanisms of how endocytosis modulates Wnt signalling and discusses its potential repurposing to regulate mitochondrial stress response in the nematode C. elegans.
BIOLOGY OF THE CELL
(2021)
Article
Cell Biology
Li-Tzu Chen, Chih-Ta Lin, Liang-Yi Lin, Jiun-Min Hsu, Yu-Chun Wu, Chun-Liang Pan
Summary: In C. elegans, loss of neuronal fzo-1/mito-fusin induces nonautonomous UPRmt through multiple neurotransmitters and neurohormones. This triggers nonautonomous mitochondrial fragmentation, requiring genes involved in autophagy and mitophagy. The systemic activation of UPRmt and mitochondrial fragmentation improves resistance to pathogenic Pseudomonas infection in C. elegans.
DEVELOPMENTAL CELL
(2021)
Article
Neurosciences
Shih-Hua Chou, Yen-Ju Chen, Chien-Po Liao, Chun-Liang Pan
Summary: Physiological stress triggers aversive learning in animals, and mitochondrial disruption regulates dopamine signaling to affect the learned bacterial avoidance behavior of C. elegans.
NEUROSCIENCE RESEARCH
(2022)
Article
Biology
Yu-En Lin, Chin-Hsien Lin, En-Peng Ho, Yi-Ci Ke, Stavroula Petridi, Christopher J. H. Elliott, Lee-Yan Sheen, Cheng-Ting Chien
Summary: The water extracts of Gastrodia elata Blume (GE) show neuroprotective effects in G2019S-induced Parkinson's disease fruit flies and transgenic mice by improving motor abilities and protecting dopaminergic neurons. The mechanism involves the activation of the Nrf2 protein in glial cells, which inhibits degenerative signaling pathways in neurons, ultimately preventing neuronal loss and maintaining coordination.
Article
Multidisciplinary Sciences
Yueh-Chen Chiang, Chien-Po Liao, Chun-Liang Pan
Summary: Mitochondrial disruption in nonneural tissues of Caenorhabditis elegans induces learned aversion for nutritious bacterial food, involving the regulation of neurotransmitters such as serotonin. In addition, calcium imaging experiments reveal altered neural responses to bacterial cues in a fraction of stress-primed animals.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Materials Science, Ceramics
Chunliang Pan, Lingling Xie, Tao Zhou, XinXin Yin, Yu Niu, Jing Xu, Qing Han, Xinli Yang, Limin Zhu, Xiaoyu Cao
Summary: In this work, nitrogen-doped carbon-coated NaV3O8 materials were successfully synthesized using a rheological phase method with melamine as a nitrogen source. The nitrogen-doped carbon coating improved the thickness and properties of the surface coating without changing the crystal structure of NVO. The best electrochemical properties were observed in NVO@NC with a molar ratio of melamine to citric acid of 2.75:1.25. The nitrogen-doped carbon coating enhanced the discharge capacity and sodium ion diffusion coefficient, providing NVO materials with high-capacity and ultrafast Na-ion storage.
CERAMICS INTERNATIONAL
(2022)
Article
Developmental Biology
Chung-Kuan Chen, Chun-Liang Pan
Summary: This review summarizes recent advances and unsolved issues in cell polarity control by Wnt glycoproteins, focusing on their involvement in cytoskeletal mechanisms or transcriptional mechanisms. The importance of using the nematode Caenorhabditis elegans as a model organism to validate the role of polarity-inducing factors in vivo is emphasized.
DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Cell Biology
Chun-Liang Pan
Summary: The study shows that mechanosensory ion channels play a crucial role in mediating the effects of cell membrane guidance cues on the morphogenesis of neuronal dendrites.
DEVELOPMENTAL CELL
(2022)
Review
Biochemistry & Molecular Biology
Ailyn Irvita Ravinther, Hemaniswarri Dewi Dewadas, Shi Ruo Tong, Chai Nien Foo, Yu-En Lin, Cheng-Ting Chien, Yang Mooi Lim
Summary: Parkinson's disease is a common neurodegenerative disease affecting the ageing population, and its prevalence has increased in recent years. Mutations in Leucine-rich-repeat-kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease, and aberrant LRRK2 kinase activity is also associated with idiopathic Parkinson's disease. This review aims to categorize and synthesize current information on LRRK2-linked Parkinson's disease and identify potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Hsun Li, Hsin-Ho Sung, Yi-Chun Huang, Ying-Ju Cheng, Hsiao-Fong Yeh, Haiwei Pi, Edward Giniger, Cheng-Ting Chien
Summary: GOPs in the dendrites of Drosophila neurons have been found to play a role in promoting branch extension, but this study reveals their involvement in dendrite retraction as well. The glycosyltransferase Fng localizes increasingly at GOPs and its interaction with Fur2 affects the number of GOPs. Additionally, the Epidermal Delta ligand and neuronal Notch receptor negatively regulate dendrite growth.
Article
Engineering, Electrical & Electronic
Chunliang Pan, Yuning Pan
Summary: This study combines RBF neural network algorithm and dynamic weight-based NSC method to improve the effect of fractal art pattern design. The study shows the changing rules of competition relationship and the distribution of competitors under noise interference, and proposes a method to control the style of art pattern design in the spatial domain. Experimental results demonstrate that the CAD fractal art pattern design system proposed in this study has a good effect.
ADVANCES IN MULTIMEDIA
(2022)
Article
Biochemistry & Molecular Biology
Chien-Po Liao, Yueh-Chen Chiang, Wai Hou Tam, Yen-Ju Chen, Shih-Hua Chou, Chun-Liang Pan
Summary: Physiological stress induces aversive memory formation through neural circuits and neuromodulatory mechanisms.
Article
Neurosciences
Yen-Ju Chen, Chun-Liang Pan
Summary: In this study, a sensory-interneuron circuit for mitochondrial stress-induced avoidance behavior in C. elegans was characterized. Olfactory sensory neurons and the AIY interneuron were found to be essential, with olfactory neurons acting upstream of AIY. Unlike pathogen avoidance, stress-induced avoidance did not require AIB, AIZ, or RIA interneurons. Ablation or inhibition of the head motor neurons SMDD/V altered worm locomotion and reduced avoidance. These findings contribute to our understanding of the neural circuit mechanisms underlying learned avoidance behavior triggered by mitochondrial stress.
NEUROSCIENCE RESEARCH
(2023)
Article
Biochemical Research Methods
Chun-Hao Chen, Chun-Liang Pan
Summary: This protocol outlines how to use spinning-disk confocal microscopy to perform live-cell imaging of migrating PVD dendritic growth cones in C. elegans, allowing continuous observation for 4-6 hours and revealing dynamic molecular and cellular events in dendrite and axon development.
