Article
Neurosciences
David M. Cole, Philipp Stampfli, Robert Gandia, Louis Schibli, Sandro Gantner, Philipp Schuetz, Michael L. Meier
Summary: This study validated a novel method for mapping cortical representations of sensory afferents of the human back. The findings demonstrate significant differences in neural representations between high-frequency and low-frequency stimulation, as well as between thoracic and lumbar paraspinal locations, indicating different encoding of sensations in different body parts and frequencies.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Michael Asghar, Rosa Sanchez-Panchuelo, Denis Schluppeck, Susan Francis
Summary: Functional magnetic resonance imaging with high spatial resolution was used to map the sensory space in the human brain. Results showed that the pRFs in somatosensory areas had a strong preference for the within-digit axis. The 2D Gaussian pRF model better represented the pRF coverage generated by the data obtained from the 2D stimulation grid.
Article
Neurosciences
Spencer A. Arbuckle, J. Andrew Pruszynski, Jorn Diedrichsen
Summary: The integration of somatosensory signals across fingers plays a crucial role in dexterous object manipulation, and this integration mainly occurs in the primary somatosensory cortex. Through stimulating different finger combinations and using fMRI technology, researchers have discovered unique nonlinear interactions between fingers. This integration contributes to the flexible mapping from finger sensory inputs to motor responses.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Toshiki Kusano, Hiroki Kurashige, Isao Nambu, Yoshiya Moriguchi, Takashi Hanakawa, Yasuhiro Wada, Rieko Osu
Summary: Several fMRI studies have shown that resting-state brain activity is comprised of components corresponding to the spatial pattern induced by task performance, with components in motor-related areas corresponding to elementary movements of individual body parts. This suggests that resting-state brain activity may have a finer structure than previously thought.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Neurosciences
Garikoitz Lerma-Usabiaga, Jonathan Winawer, Brian A. Wandell
Summary: The study investigates accurate estimation of the RF of neuronal populations and its shape, finding that elliptical pRFs are common in the early visual cortex. Researchers also found discrepancies in estimation results using different software packages.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Sarah Khalife, Susan T. Francis, Denis Schluppeck, Rosa-Maria Sanchez-Panchuelo, Julien Besle
Summary: This study compared the efficiency and reliability of fast and slow event-related designs in mapping tactile tuning properties. The results showed that the fast design yielded more reliable responses, while the slow design was more efficient. The study also identified two separate somatotopically-organized tactile representations in the human cortex.
Article
Anatomy & Morphology
Ivan Alvarez, Samuel A. Hurley, Andrew J. Parker, Holly Bridge
Summary: The study investigates the neural mechanisms underlying the perception of binocular information and depth perception using ultra-high field fMRI. Results show larger population receptive fields for disparity compared with contrast and luminance in V1 and LOC areas, suggesting specific roles in binocular integration and cue for 3D shape. These findings offer new insights into the binocular receptive field properties for human stereoscopic vision processing.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jinglong Wu, Chenyu Wang, Luyao Wang, Yutong Wang, Jiajia Yang, Tianyi Yan, Dingjie Suo, Li Wang, Xin Liu, Jian Zhang
Summary: This study investigates the characteristics of human finger population receptive fields (pRF) in the primary somatosensory cortex using a multichannel tactile stimulation device. The results show that the device has no effect on the image's signal-to-noise ratio and can accurately characterize the representation of the right-hand somatosensory system.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Neurosciences
Luyao Wang, Zhilin Zhang, Tomohisa Okada, Chunlin Li, Duanduan Chen, Shintaro Funahashi, Jinglong Wu, Tianyi Yan
Summary: This study investigated the somatotopic map of the undominant hand using a Bayesian population receptive field (pRF) model, revealing an orderly representation between digits with elliptical pRF shapes and varying width changes across dimensions for different digits. These results provide new insights into neural mechanisms in the primary somatosensory cortex (S1) and allow for further exploration of somatosensory information processing and disease-related reorganization.
Article
Geriatrics & Gerontology
Alicia Northall, Juliane Doehler, Miriam Weber, Stefan Vielhaber, Stefanie Schreiber, Esther Kuehn
Summary: By acquiring quantitative structural and functional 7T-MRI data, this study reveals the microstructural differences and vulnerabilities in the primary motor cortex (M1) of the aging brain, providing a novel 3D model of M1 microstructure and implications for understanding sensorimotor organization and aging.
NEUROBIOLOGY OF AGING
(2023)
Article
Neurosciences
Jasmine L. Mirdamadi, Courtney R. Seigel, Stephen D. Husch, Hannah J. Block
Summary: When there is a mismatch between visual and proprioceptive estimates of hand position, the brain realigns them to reduce the discrepancy. This realignment affects not only the representation of the finger itself, but also extends to other parts of the limb.
Article
Biology
Giacomo Ariani, J. Andrew Pruszynski, Jorn Diedrichsen
Summary: Motor planning is crucial for producing fast and accurate movement. However, the neural processes in the primary motor and somatosensory cortex during planning and execution are still poorly understood. This study used functional magnetic resonance imaging to investigate the planning and execution of single finger movements, revealing finger-specific activity patterns in both the primary somatosensory cortex and primary motor cortex. These findings suggest that motor planning activates specific circuits in the somatosensory and motor cortex, which are also engaged during movement execution.
Article
Neurosciences
Chris C. Rodgers, Ramon Nogueira, B. Christina Pil, Esther A. Greeman, Jung M. Park, Y. Kate Hong, Stefan Fusi, Randy M. Bruno
Summary: In a study involving head-fixed mice, it was found that neurons in the sensory cortex encoded touch, whisker motion, and task-related signals with a task-specific focus. During a shape discrimination task, neurons responded most to behaviorally relevant whiskers, indicating that sensory cortex employs task-specific representations compatible with behaviorally relevant computations.
Review
Anatomy & Morphology
Daniel Janko, Kristina Thoenes, Dahye Park, W. R. Willoughby, Meredith Horton, Mark Bolding
Summary: Multiple studies have shown finger somatotopy using fMRI and other brain mapping techniques in humans and primates. There are discrepancies in the somatosensory maps of the hand and fingers depending on the stimulation method used, suggesting the need for comparative analysis.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Anatomy & Morphology
W. Schellekens, M. Thio, S. Badde, J. Winawer, N. Ramsey, N. Petridou
Summary: This study investigated the functional hierarchy of cyto-architectonically distinct regions in human S1, finding that pRF sizes increase from lower-order areas to higher-order areas and that the hemodynamic response peak in BA3 is earlier compared to BA1 and BA2. These results suggest a functional hierarchy of subregions in S1, with different mechanoreceptors feeding into the same cortical hierarchy.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Biochemical Research Methods
Matthias C. Meyer, Rene Scheeringa, Andrew G. Webb, Natalia Petridou, Oliver Kraff, David G. Norris
JOURNAL OF NEUROSCIENCE METHODS
(2020)
Article
Neurosciences
Laurentius Huber (Renzo), Emily S. Finn, Daniel A. Handwerker, Marlene Bonstrup, Daniel R. Glen, Sriranga Kashyap, Dimo Ivanov, Natalia Petridou, Sean Marrett, Jozien Goense, Benedikt A. Poser, Peter A. Bandettini
Article
Computer Science, Interdisciplinary Applications
Mark L. C. M. Bruurmijn, Wouter Schellekens, Mathijs A. H. Raemaekers, Nick F. Ramsey
Article
Biophysics
Arjan D. Hendriks, Federico D'Agata, Luisa Raimondo, Tim Schakel, Liesbeth Geerts, Peter R. Luijten, Dennis W. J. Klomp, Natalia Petridou
NMR IN BIOMEDICINE
(2020)
Article
Clinical Neurology
Anna Gaglianese, Mariana P. Branco, Iris I. A. Groen, Noah C. Benson, Mariska J. Vansteensel, Micah M. Murray, Natalia Petridou, Nick F. Ramsey
Article
Clinical Neurology
Jelle A. van Dijk, Alessio Fracasso, Natalia Petridou, Serge O. Dumoulin
Summary: Advancements in ultra-high field MRI have enabled sub-millimeter investigations of brain structure and function, with potential complications arising from directional blood pooling in laminar fMRI. Experimental results suggest that the temporal additivity assumption of linear systems theory holds true for sub-millimeter BOLD fMRI across cortical depth in early visual cortex.
Review
Neurosciences
Alessio Fracasso, Serge O. Dumoulin, Natalia Petridou
Summary: The study demonstrates that high-field MRI scanners can acquire data of brain columns and layers non-invasively. BOLD fMRI, which measures brain activity indirectly, is crucial for accurately resolving columns and layers, depending on the point-spread function of the BOLD response. By utilizing the stripe-based arrangement in V2 visual area and high-resolution MRI at different cortical depths, this research found that the maximal BOLD PSF is in the superficial part of the cortex and decreases with cortical depth.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Anatomy & Morphology
W. Schellekens, M. Thio, S. Badde, J. Winawer, N. Ramsey, N. Petridou
Summary: This study investigated the functional hierarchy of cyto-architectonically distinct regions in human S1, finding that pRF sizes increase from lower-order areas to higher-order areas and that the hemodynamic response peak in BA3 is earlier compared to BA1 and BA2. These results suggest a functional hierarchy of subregions in S1, with different mechanoreceptors feeding into the same cortical hierarchy.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Anatomy & Morphology
Alessio Fracasso, Anna Gaglianese, Mariska J. Vansteensel, Erik J. Aarnoutse, Nick F. Ramsey, Serge O. Dumoulin, Natalia Petridou
Summary: This study found that positive blood oxygenation level-dependent (BOLD) responses are correlated with high-frequency band (HFB) responses in electrodes responding to visual stimulation, while negative BOLD responses are associated with an absence of HFB power responses and an unexpected decrease in alpha power responses.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Biochemistry & Molecular Biology
Jelle A. van Dijk, Alessio Fracasso, Natalia Petridou, Serge O. Dumoulin
Summary: As neural signals travel through the visual hierarchy, neurons increase specificity for stimulus features while decreasing spatial precision. Similar laminar processing has been found in both visual and numerosity processing, indicating a potential universal pattern across different brain regions.
Article
Neurosciences
Giovanni Piantoni, Dora Hermes, Nick Ramsey, Natalia Petridou
Summary: ECoG is used to identify seizure focus and brain functions for surgical resection in epilepsy patients. Understanding the spatial smoothness of BOLD signal is crucial for optimal integration of fMRI and ECoG.
Review
Neurosciences
Alessio Fracasso, Serge O. Dumoulin, Natalia Petridou
Summary: This passage discusses the fundamental organizational units of the brain, columns and layers, and the importance of high field MRI technology in capturing this information. The study found that the BOLD PSF is maximal in the superficial part of the cortex, decreasing with increasing cortical depth.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Biochemical Research Methods
Wouter Schellekens, Carlijn Bakker, Nick F. Ramsey, Natalia Petridou
Summary: In this study, the relationships between different body part representations in cortical motor areas were investigated using fMRI and a newly developed pRF model and graph theory. The results showed different response patterns of various body parts in different motor cortices and identified reciprocal relationships among body parts. These findings are important for understanding the central nervous system's control of body movements.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Wouter Schellekens, Alex A. Bhogal, Emiel C. A. Roefs, Mario G. Baez-Yanez, Jeroen C. W. Siero, Natalia Petridou
Summary: Ultra-high field functional magnetic resonance imaging (fMRI) provides high spatial resolution for measuring neuronal activity at the scale of cortical layers. The current study investigates the influence of different vascular compartments on laminar BOLD fMRI using hypercapnic and hyperoxic breathing conditions. The results show that all venous vascular and micro-vascular compartments have comparable maximum signal intensities, but the capacity for vessel dilation is larger for venous vascular compartments. This study suggests that differences in dilation properties between macro- and micro-vascular compartments may contribute to BOLD signal differences across cortical depth.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.