Article
Multidisciplinary Sciences
Weifei Wu, Xiangxiang Li, Zong Yang, Neng Ru, Fan Zhang, Jie Liang, Ke Zhang
Summary: The microstructure of the cervical spinal cord in patients with syringomyelia differs from controls, with lower FA values and higher ADC values within the syrinx cavity. FA values were significantly lower in the group with clinical symptoms compared to the group with non-clinical symptoms, and there was a negative association between FA values and syrinx size, and a positive association between ADC values and syrinx size. DTI is a promising tool for quantitatively assessing pathological characteristics in syringomyelia patients that are not visible on conventional MRI.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Bogdan Costachescu, Adelina-Gabriela Niculescu, Marius Gabriel Dabija, Raluca Ioana Teleanu, Alexandru Mihai Grumezescu, Lucian Eva
Summary: This review focuses on the recent advancements in the treatment and repair of spinal cord injuries, including the use of nanocarriers, biomolecules, cell therapies, and biomaterial scaffolds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Jan Valosek, Rene Labounek, Tomas Horak, Magda Horakova, Petr Bednarik, Milos Kerkovsky, Jan Kocica, Tomas Rohan, Christophe Lenglet, Julien Cohen-Adad, Petr Hlustik, Eva Vlckova, Zdenek Kadanka, Josef Bednarik, Alena Svatkova
Summary: The study found diffusion abnormalities in the gray matter, dorsal and lateral tracts in chronic degenerative spinal cord compression, with more profound alterations in DCM than NMDC patients. Diffusion metrics were affected in the C3-6 area and above the compression level at C3, with more profound rostral deficits in DCM. Alterations in lateral motor and dorsal sensory tracts correlated with motor and sensory evoked potentials, while electromyography outcomes corresponded with gray matter microstructure. DCM disability corresponded with microstructure alteration in lateral columns.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Michael P. Trevarrow, Sarah E. Baker, Tony W. Wilson, Max J. Kurz
Summary: The study revealed that there are microstructural differences in the cervical-thoracic spinal cord of adults with cerebral palsy, with decreased total spinal cord area and gray matter proportion in CP adults. The magnetization transfer ratio (MTR) of the corticospinal tracts was also lower in CP adults, and individuals with reduced gray matter tended to have both reduced MTR in their corticospinal tracts and worse hand dexterity clinical scores.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Article
Clinical Neurology
Dong Dong, Koichi Hosomi, Nobuhiko Mori, Yoshi-ichiro Kamijo, Yohei Furotani, Daisuke Yamagami, Yu-ichiro Ohnishi, Yoshiyuki Watanabe, Takeshi Nakamura, Fumihiro Tajima, Haruhiko Kishima, Youichi Saitoh
Summary: Through contrastive analysis, we identified white matter brain regions that show microstructural changes in patients with neuropathic pain (NP) after spinal cord injury (SCI). The results showed that compared to the non-NP group, the NP group exhibited higher values of FA in the posterior body and splenium of the corpus callosum, which may be related to central sensitization or network hyperexcitability.
FRONTIERS IN NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Ali Ghasem-Zadeh, Mary P. Galea, Andrew Nunn, Maya Panisset, Xiao-Fang Wang, Sandra Iuliano, Steven K. Boyd, Mark R. Forwood, Ego Seeman
Summary: Patients with tetraplegia and paraplegia display significant deficits in bone mineral density, with varying differences observed among different regions of the body.
Review
Chemistry, Physical
Peng Yin, Weishi Liang, Bo Han, Yihan Yang, Duan Sun, Xianjun Qu, Yong Hai, Dan Luo
Summary: Spinal cord injury (SCI) is a severe neurodegenerative disease causing a loss of motor and sensory functions. Hydrogels and nanoparticles (NPs) have been widely studied and proven to be effective strategies for treatment. Hydrogels can fill the pathological gaps in SCI and provide a microenvironment for nerve cell regeneration, while NPs can penetrate the blood-spinal cord barrier, target SCI lesions, and deliver drugs. This review discusses the use of hydrogels and NPs as drug carriers and their role in the repair and regeneration of SCI, providing a multimodal treatment reference.
Review
Neurosciences
Yuan Feng, Yong Peng, Jing Jie, Yumin Yang, Pengxiang Yang
Summary: Regeneration of neural tissue following spinal cord injury is limited due to damage in the local microenvironment. The immune microenvironment, formed by immune cells and cytokines, plays a crucial role in both inflammation and regeneration. However, there is limited research on the role of the immune microenvironment in spinal cord regeneration.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Meng-Ze Zhang, Han-Qiang Ou-Yang, Jian-Fang Liu, Dan Jin, Chun-Jie Wang, Xian-Chang Zhang, Qiang Zhao, Xiao-Guang Liu, Zhong-Jun Liu, Ning Lang, Liang Jiang, Hui-Shu Yuan
Summary: This study investigated the relationship between DWI metrics and neurologic function in patients with CSM, finding that NODDI ODI correlated with pre-operative mJOA, while DTI FA, DKI FA, and NODDI ISOVF were correlated with the recovery rate. DTI FA, DKI FA, and NODDI ISOVF were identified as predictors for prognosis in CSM patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Chemistry, Multidisciplinary
Yiran Li, Ting Dong, Zhiwei Li, Shilei Ni, Fang Zhou, Olawale A. Alimi, Shaojuan Chen, Bin Duan, Mitchell Kuss, Shaohua Wu
Summary: Spinal cord injury is a devastating neurological condition, and neural tissue engineering combined with electrospinning technique shows great potential for its treatment.
MATERIALS TODAY CHEMISTRY
(2022)
Review
Neurosciences
Alexandra Tinnermann, Christian Buechel, Julien Cohen-Adad
Summary: Functional magnetic resonance imaging has been used to investigate pain perception in both health and disease, with recent developments allowing for simultaneous recording of neural activity in the brain and spinal cord. However, challenges remain in data acquisition and analysis strategies for this promising technique.
Review
Neurosciences
Abhishek Roy, Zarna Pathak, Hemant Kumar
Summary: The difficulties in regenerating after CNS injuries, including spinal cord injury, are attributed to factors such as hypertrophic scarring, inhibitory molecules, and the absence of mechanisms responsible for axonal regeneration in the adult CNS. Strategies to improve axon regeneration include neutralizing inhibitors/proteins and stabilizing microtubules. Furthermore, the focus on counteracting inhibitors of axonal growth and their downstream signaling through the RhoA/ROCK pathway is emphasized.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Immunology
Qi-Ming Pang, Si-Yu Chen, Qi-Jing Xu, Meng Zhang, Da-Fei Liang, Sheng-Ping Fu, Jiang Yu, Zu-Lin Liu, Qian Zhang, Tao Zhang
Summary: This study reviews the effects of neuroinflammation on SCI, with a focus on the contributions and interactions of microglia and astrocytes. It also discusses therapeutic strategies to regulate their immunophenotype in order to suppress inflammation and improve injury prognosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Engineering, Multidisciplinary
Chun Yao, Xin Tang, Yuqi Cao, Xuhua Wang, Bin Yu
Summary: Spinal cord injury is a devastating event that disrupts the neuronal circuits between the brain and body, resulting in functional deficits. Recent progress in SCI repair, based on the lesion microenvironment, neural circuits, and biomaterial scaffolds, has provided new insights for potential therapeutic treatments. The use of targeted-microRNA therapy, blood vessel interventions, and multiple treatment combinations are highlighted as important directions for future research.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chunyao Wang, Xiao Han, Xiaodong Ma, Wen Jiang, Jinchao Wang, Sisi Li, Hua Guo, Wei Tian, Huijun Chen
Summary: This study investigated the association between spinal cord perfusion and microstructural damage in CSM patients who underwent cervical laminoplasty using MR dynamic susceptibility contrast (DSC), diffusion tensor imaging (DTI), and neurite orientation dispersion and density imaging (NODDI) techniques. The results showed that increased spinal cord perfusion was associated with microstructural damage in postoperative CSM patients. The diffusion metrics and neurite density were significantly different between patients and healthy controls, and the perfusion metrics showed correlations with various diffusion metrics.
EUROPEAN RADIOLOGY
(2023)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.
