Article
Obstetrics & Gynecology
J. Stanhiser, A. M. Z. Jukic, D. R. McConnaughey, A. Z. Steiner
Summary: The study found that self-reported use of omega-3 fatty acid supplements was associated with an increased probability of conceiving.
HUMAN REPRODUCTION
(2022)
Article
Geriatrics & Gerontology
Roxana Coras, Brian Pedersen, Rekha Narasimhan, Anahy Brandy, Lourdes Mateo, Agueda Prior-Espanol, Arthur Kavanaugh, Aaron M. Armando, Mohit Jain, Oswald Quehenberger, Melania Martinez-Morillo, Monica Guma
Summary: The study revealed that arthritis symptoms in older adults were related to disturbances in serum oxylipins, suggesting that certain oxylipins may be key effectors in arthritis in this population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Noelia Rodriguez-Iglesias, Agnes Nadjar, Amanda Sierra, Jorge Valero
Summary: The dietary balance of n-6/n-3 PUFAs can affect adult hippocampal neurogenesis and glia in a sex-dependent manner. In mice, a deficiency in n-3 PUFAs exacerbates the reduction in neuroblast number caused by the bacterial endotoxin lipopolysaccharide.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Salvatore Coniglio, Maria Shumskaya, Evros Vassiliou
Summary: Diet can have both positive and negative effects on human health, with omega-3 polyunsaturated fatty acids being overall beneficial. These fatty acids are primarily found in plant seeds and fish. Consuming omega-3 fatty acids can reduce inflammation and markers associated with certain diseases. This reduction in inflammation occurs through specific metabolic and biochemical changes. Overall, a diet high in omega-3 and low in omega-6 fats is considered favorable.
Article
Nutrition & Dietetics
Kathleen A. Lee-Sarwar, Kasper Fischer-Rasmussen, Klaus Bonnelykke, Hans Bisgaard, Bo Chawes, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O'Connor, Leonard B. Bacharier, Vincent J. Carey, Nancy Laranjo, Augusto A. Litonjua, Scott T. Weiss
Summary: The association between omega-3 fatty acids (n-3) and allergic diseases varies due to genetic variation. This study aimed to identify and validate genetic variants that modify the relationship between n-3 and childhood asthma or atopy. Results showed that certain SNPs in the DPP10 region interacted with n-3 levels in plasma or diet and were associated with atopy in early childhood and at age 6.
Review
Biochemistry & Molecular Biology
Roberta Cardim Lessa, Fabio de Abreu Alves, Erika Fortunati, Jun Lu
Summary: Oral mucositis (OM) is a painful condition caused by cancer treatments, impacting patients' quality of life and recovery. Current management strategies are insufficient, necessitating a search for new approaches. Utilizing ω-3 fatty acids to manage OM may be an effective strategy based on preliminary evidence.
Article
Agricultural Engineering
Anil Kumar Patel, Ajeet Singh Chauhan, Prashant Kumar, Philippe Michaud, Vijai Kumar Gupta, Jo-Shu Chang, Chiu-Wen Chen, Cheng-Di Dong, Reeta Rani Singhania
Summary: This article provides an update on the production of essential fatty acids from potential microbes and explores novel strategies to promote the accumulation of omega-3 and omega-6 through engineering and omics approaches.
BIORESOURCE TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Xuefei Li, Zhengjie Lu, Yongjian Qi, Biao Chen, Bin Li
Summary: This study used the Mendelian randomization approach to explore the potential causal relationships between polyunsaturated fatty acids (PUFAs) and osteoarthritis (OA), and found that higher levels of omega-6 fatty acids may reduce the risk of knee OA and hip OA. These results highlight the importance of maintaining optimal levels of PUFAs, especially omega-6 fatty acids, in individuals with a genetic predisposition to OA.
Article
Nutrition & Dietetics
Estefania Aparicio, Carla Martin-Grau, Cristina Bedmar, Nuria Serrat Orus, Josep Basora, Victoria Arija
Summary: This study found that factors such as high education levels, older age, consumption of fish and seafood, and non-smoking are significantly associated with serum fatty acid concentrations in pregnant women, leading to a better omega-3 fatty acid profile. Further research is needed to explore the health consequences of these findings.
Article
Biochemistry & Molecular Biology
Rachel E. Walker, Chesney K. Richter, Ann C. Skulas-Ray, Michael R. Flock, Brian A. Harsch, Carmen E. Annevelink, Penny M. Kris-Etherton, Gordon L. Jensen, Gregory C. Shearer
Summary: This study investigated the effect of prescription ω-3 acid ethyl esters on the lipid response to an endotoxin challenge. The results showed that it can alter the lipid composition by increasing the availability of ω-3 oxylipins for resolution of the inflammatory response.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Nutrition & Dietetics
Masayuki Okuda, Aya Fujiwara, Satoshi Sasaki
Summary: The study found that in Japanese youths, high intake of omega-6 polyunsaturated fatty acids was associated with low levels of low-density-lipoprotein cholesterol, while high intake of saturated fatty acids was associated with high levels of gamma-glutamyl transpeptidase, indicating a close relationship between dietary fatty acid composition and cardiometabolic risk.
Article
Biotechnology & Applied Microbiology
Myroslav Sprynskyy, Fernanda Monedeiro, Maciej Monedeiro-Milanowski, Zuzanna Nowak, Aneta Krakowska-Sieprawska, Pawel Pomastowski, Renata Gadzala-Kopciuch, Boguslaw Buszewski
Summary: This study aimed to isolate EPA and DHA from diatom biomass using different extraction methods and analyze the extracts. Reflux extraction yielded the highest content of omega-3 fatty acids, while the extracts obtained from SFE had lower toxicity and could be directly used for product development.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Review
Food Science & Technology
Yi Wang, Ke Liu, Tingting Long, Jieyi Long, Ying Li, Jiaoyuan Li, Liming Cheng
Summary: Through a meta-analysis of observational studies, we found that dietary fish and marine omega-3 PUFA consumption are associated with improved cancer prognosis and reduced mortality in patients.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Jiaxin Feng, Qianwen Wang, Wei Yang, Jun Liu, Ming-Qing Gao
Summary: Ω-3 PUFAs have a positive effect on LPS-induced inflammatory response, possibly mediated by the NF-kappa B signaling pathway and the intestinal microbiota.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Claudia Sanfilippo, Angela Patti
Summary: The biocatalytic epoxidation of ethanolamides of omega-3 fatty acids EPA and DHA was investigated in the presence of a peroxygenase-containing preparation from oat flour. Good regio- and steroselectivity were observed, and acetone as cosolvent improved the concentration of starting substrates and selectivity in the epoxidation of DHA-EA. This method offers a valuable strategy for obtaining oxyfunctionalized derivatives of fatty acids due to the easy availability of the enzymatic preparation.
BIOORGANIC CHEMISTRY
(2021)
Article
Neurosciences
Kathryn E. Hopperton, Nicholas C. E. James, Dana Mohammad, Maha Irfan, Richard P. Bazinet
NUTRITIONAL NEUROSCIENCE
(2019)
Article
Nutrition & Dietetics
Michael A. Pitino, Shoug M. Alashmali, Kathryn E. Hopperton, Sharon Unger, Yves Pouliot, Alain Doyen, Deborah L. O'Connor, Richard P. Bazinet
BRITISH JOURNAL OF NUTRITION
(2019)
Article
Medicine, General & Internal
Michael Eiden, Nicolas Christinat, Anirikh Chakrabarti, Sarah Sonnay, John-Paul Miroz, Bernard Cuenoud, Mauro Oddo, Mojgan Masoodi
Article
Biochemistry & Molecular Biology
Nicolas Christinat, Armand Valsesia, Mojgan Masoodi
Article
Nutrition & Dietetics
Kathryn E. Hopperton, Michael A. Pitino, Raphael Chouinard-Watkins, Sara Shama, Natasha Sammut, Nicole Bando, Brock A. Williams, Kathryn Walton, Alex Kiss, Sharon L. Unger, Richard P. Bazinet, Deborah L. O'Connor
Summary: Factors such as maternal BMI, ethnicity, and gestational age impact the fat and fatty acid content of human milk fed to very low birth weight infants. Differences are also influenced by the source of milk (mother's own or donor). Care must be taken to ensure that fat and fatty acid intakes meet recommendations.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Andy Tran, Wenyuan He, Jim T. C. Chen, Leigh Wellhauser, Kathyrn E. Hopperton, Richard P. Bazinet, Denise D. Belsham
Summary: Consumption of a diet high in saturated fatty acids can lead to hypothalamic neuroinflammation, dysregulation of neuronal function, and induction of orexigenic neuropeptide Y (Npy). Intracellular metabolism of palmitate and metabolites like ceramide and phospholipids play a crucial role in mediating the effects of palmitate on Npy expression.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Gastroenterology & Hepatology
Mojgan Masoodi, Amalia Gastaldelli, Tuulia Hyotylainen, Enara Arretxe, Cristina Alonso, Melania Gaggini, Julia Brosnan, Quentin M. Anstee, Oscar Millet, Pablo Ortiz, Jose M. Mato, Jean-Francois Dufour, Matej Oresic
Summary: Metabolomics and lipidomics approaches are utilized to identify biomarkers for NAFLD, with significant contributions in clinical studies; key metabolic pathway alterations in NAFLD and NASH have been identified, potentially serving as biomarkers for non-invasive diagnostic tests. Despite the discovery of potential biomarkers, few have been validated for clinical use.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Kathryn Walton, Meghan McGee, Julie Sato, Nicole Law, Kathryn E. Hopperton, Nicole Bando, Alex Kiss, Sharon L. Unger, Deborah L. O'Connora
Summary: This study compared the dietary patterns and body composition of very low birth weight (VLBW) children with poor social-emotional functioning to those with typical functioning. The results showed that poor social-emotional functioning was positively associated with higher fruit juice intake and energy intake. Children with poor social-emotional functioning were more likely to have a limited food repertoire but less likely to exceed dietary fat recommendations. Overall diet quality and body composition did not differ between the two groups. Diet counselling is important to improve the nutrition of VLBW children and mitigate chronic disease risk.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Kathryn E. Hopperton, Michael A. Pitino, Kathryn Walton, Alex Kiss, Sharon L. Unger, Deborah L. O'Connor, Richard P. Bazinet
Summary: This study examines the association between DHA and ARA levels in human milk and finds a positive correlation, except in colostrum. This suggests that infant formulas containing relatively high concentrations of DHA without ARA, as permitted by new regulations, do not reflect the balance of these fatty acids in human milk.
Article
Multidisciplinary Sciences
Celine Jouffe, Benjamin D. Weger, Eva Martin, Florian Atger, Meltem Weger, Cedric Gobet, Divya Ramnath, Aline Charpagne, Delphine Morin-Rivron, Elizabeth E. Powell, Matthew J. Sweet, Mojgan Masoodi, N. Henriette Uhlenhaut, Frederic Gachon
Summary: Obesity and liver diseases disrupt the circadian clock regulated by BMAL1, which affects nutrient metabolism and storage. In liver fibrosis, the activity of BMAL1 is perturbed. Knockout mice lacking BMAL1 are prone to obesity but protected against insulin resistance, hepatic steatosis, inflammation, and fibrosis. The disruption of the growth hormone and sex hormone pathways plays a critical role in this protection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Nutrition & Dietetics
Jaspreet K. C. Ahuja, Kellie O. Casavale, Ying Li, Kathryn E. Hopperton, Subhadeep Chakrabarti, Erin P. Hines, Stephen P. J. Brooks, Genevieve S. Bondy, Amanda J. MacFarlane, Hope A. Weiler, Xianli Wu, Michael M. Borghese, Namanjeet Ahluwalia, Winnie Cheung, Ashley J. Vargas, Sonia Arteaga, Tania Lombo, Mandy M. Fisher, Deborah Hayward, Pamela R. Pehrsson
Summary: This article advocates for the establishment and reporting of a framework for human milk composition data, and the creation of a publicly available repository for human milk composition data. It emphasizes the importance of accurate data for assessing exposure to human milk, evaluating nutritional needs of infants and mothers, and informing public health policies and clinical practice.
ADVANCES IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Sofia Tsouka, Mojgan Masoodi
Summary: Pathway analysis is commonly used for functional interpretation of metabolomics data, but lacks standardization and understanding of its impact on functional outcome. In this study, we investigated the consideration of non-human native enzymatic reactions and interconnectivity of pathways in pathway analysis. Exclusion of non-human reactions resulted in loss of information, while considering pathway connectivity provided better emphasis on certain metabolites but occasionally overemphasized central compounds. We proposed a penalization scheme to mitigate the effect of such compounds. We also performed over-representation analysis to compare and assess different methodologies. Our findings raise awareness on the capabilities and shortcomings of current pathway analysis practices in metabolomics.
Article
Gastroenterology & Hepatology
Patcharamon Seubnooch, Matteo Montani, Sofia Tsouka, Emmanuelle Claude, Umara Rafiqi, Aurel Perren, Jean-Francois Dufour, Mojgan Masoodi
Summary: This study investigated the spatial distribution of hepatic lipid metabolism in different zones of the liver using mass spectrometry imaging. The results showed heterogeneous distribution of lipids across liver zones, with fatty acids mainly located in the periportal zone, phospholipids in both the periportal and pericentral zones, and triacylglycerols and diacylglycerols in the pericentral zone. This research provides important insights into lipid metabolism during the progression of liver disease.
Article
Biochemistry & Molecular Biology
Sarah Sonnay, Nicolas Christinat, Jonathan Thevenet, Andreas Wiederkehr, Anirikh Chakrabarti, Mojgan Masoodi
Article
Nutrition & Dietetics
Kathryn E. Hopperton, Deborah L. O'Connor, Nicole Bando, Aisling M. Conway, Dawn V. Y. Ng, Alex Kiss, Jacqueline Jackson, Linh Ly, Sharon L. Unger
CURRENT DEVELOPMENTS IN NUTRITION
(2019)
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)