Article
Geriatrics & Gerontology
Emma L. Ducca, Gabriela T. Gomez, Priya Palta, Kevin J. Sullivan, Clifford R. Jack, David S. Knopman, Rebecca F. Gottesman, Jeremy Walston, B. Gwen Windham, Keenan A. Walker
Summary: The study found a strong association between cerebral white matter structure and current and future frailty. Specifically, white matter hyperintensity volume was significantly associated with frailty. However, measures of white matter microstructure were not generally associated with progression from nonfrail to frail status.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Stephanie Matijevic, Lee Ryan
Summary: The study found that age and sex have an impact on the cerebral white matter integrity of older adults, with a more significant effect on certain white matter tracts. Females exhibited lower global FA compared to males, but had higher MD in the anterior cingulum and superior longitudinal fasciculus. Age influenced both global FA and specific tract FA, while APOE epsilon 4 status did not show predictive power.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Matthew Kiely, Curtis Triebswetter, Luis E. Cortina, Zhaoyuan Gong, Maryam H. Alsameen, Richard G. Spencer, Mustapha Bouhrara
Summary: This study evaluated sex and age-related differences in white matter microstructure using diffusion tensor imaging (DTI) and magnetic resonance imaging (MRI). The results showed that myelin content and axonal density in white matter exhibited nonlinear changes with age, and the posterior white matter regions were more preserved from neurodegeneration compared to anterior regions. Additionally, DTI indices were moderately correlated with myelin content, indicating their sensitivity to other constituents of white matter tissue.
Article
Neurosciences
Natalia Del Campo, Owen Phillips, Francoise Ory-Magne, Christine Brefel-Courbon, Monique Galitzky, Claire Thalamas, Katherine L. Narr, Shantanu Joshi, Manpreet K. Singh, Patrice Peran, Anne Pavy-LeTraon, Olivier Rascol
Summary: Multiple system atrophy (MSA) is a rare neurodegenerative disorder characterized by widespread accumulation of alpha-synuclein, primarily in oligodendrocytes. Whole brain deep and superficial white matter diffusivity abnormalities were observed in MSA patients but not in Parkinson's disease (PD) patients. These abnormalities were associated with motor and cognitive functions in MSA patients.
HUMAN BRAIN MAPPING
(2021)
Article
Immunology
Kalen J. Petersen, Jeremy Strain, Sarah Cooley, Florin Vaida, Beau M. Ances
Summary: Older persons with HIV may experience changes in brain white matter similar to accelerated aging, with viral load and comorbidities playing a role in this process. These changes in white matter can contribute to cognitive impairment.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Neurosciences
Yuchao Jiang, Mingjun Duan, Xiangkui Li, Huan Huang, Guocheng Zhao, Xuan Li, Shicai Li, Xufeng Song, Hui He, Dezhong Yao, Cheng Luo
Summary: This study reveals a reversed pattern of structure and function in frontotemporal tracts in schizophrenia, with negative associations between structural deficits and functional disturbances in patients, exacerbated by long illness duration and severe negative symptoms. Additionally, white matter activations are significantly related to cognition and emotion.
HUMAN BRAIN MAPPING
(2021)
Article
Multidisciplinary Sciences
Ricardo Rios-Carrillo, Alonso Ramirez-Manzanares, Hiram Luna-Munguia, Mirelta Regalado, Luis Concha
Summary: Diffusion-weighted magnetic resonance imaging (DW-MRI) is a non-invasive technique sensitive to microstructural geometry in neural tissue and useful for detecting neuropathology. Tensor-valued diffusion encoding schemes (b-tensor) enrich the microstructural data obtained from DW-MRI. This study explores the application of machine learning in analyzing b-tensor encoding data to detect histopathology and neurodegeneration.
Article
Multidisciplinary Sciences
Roey Schurr, Aviv A. Mezer
Summary: The study developed a method based on Nissl staining technique to quantify the structure and orientation of axons, applicable to various datasets. Utilizing structure tensor analysis, fine details of axonal architecture can be extracted effectively.
Article
Neurosciences
Elodie Bertrand, Eelco van Duinkerken, Jerson Laks, Marcia Cristina Nascimento Dourado, Gabriel Bernardes, Jesus Landeira-Fernandez, Daniel C. Mograbi
Summary: The study found that extensive regions of the brain are linked to self-awareness, with particular frontal and temporal alterations leading to unawareness, in agreement with theoretical models indicating executive and mnemonic forms of anosognosia in AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zexuan Hu, Peng Sun, Ajit George, Xiangling Zeng, Mengyan Li, Tsen-Hsuan Lin, Zezhong Ye, Xinhua Wei, Xinqing Jiang, Sheng-Kwei Song, Ruimeng Yang
Summary: Using diffusion basis spectrum imaging (DBSI) to examine the microstructural changes in the substantia nigra (SN) and global white matter (WM) tracts of patients with early-stage PD. The results showed that DBSI could potentially detect and quantify inflammatory cell infiltration, fiber/dendrite loss, and edema in both SN and WM tracts in patients with early-stage PD.
EUROPEAN RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Maurizio Bergamino, Ryan R. Walsh, Ashley M. Stokes
Summary: Standard DTI and FW-DTI both showed decreased FA in AD, but higher AxD and RD were observed with standard DTI. The FW index was significantly elevated in AD, emphasizing the impact of free water on standard DTI in neurodegenerative pathologies. FW-DTI provided improved consistency in DTI metrics related to WM integrity in Alzheimer's disease.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Tomasz Pieciak, Guillem Paris, Dani Beck, Ivan I. Maximov, Antonio Tristan-Vega, Rodrigo de Luis-Garcia, Lars T. Westlye, Santiago Aja-Fernandez
Summary: The study examines the evolution of free-water volume fraction (FWVF) in human brain white matter across the adult lifespan. It found a non-linear increase in FWVF after the age of 60. The study also compares FW corrected diffusion tensor imaging (DTI) and standard DTI in studying mean diffusivity (MD) and fractional anisotropy (FA), finding a region-dependent flattening of age-related evolution and reduced variability using FW corrected DTI.
Article
Neurosciences
Shannon Kelley, John Plass, Andrew R. Bender, Thad A. Polk
Summary: This study investigated age-related white matter differences using fixel-based analysis (FBA). The results revealed that age-related differences in FA were strongly associated with differences in multi-fiber complexity, indicating differences in crossing fibers and individual fiber segments. FBA also provided insights into distinct microstructural changes underlying age-related effects in specific brain regions.
Article
Neurosciences
Elveda Gozdas, Hannah Fingerhut, Lauren Dacorro, Jennifer L. Bruno, S. M. Hadi Hosseini
Summary: Aging is associated with reduced neurite density and orientation dispersion in both cortical and white matter regions. Additionally, a widespread age-related decrease in neurite density along major white matter tracts was found in healthy older adults. Significant neurite morphology deficits in memory networks were also observed in patients with amnestic mild cognitive impairment.
Article
Rheumatology
Ettore Silvagni, Francesca Inglese, Alessandra Bortoluzzi, Massimo Borrelli, Jelle J. Goeman, Alfredo Revenaz, Elisabetta Groppo, Gerda M. Steup-Beekman, Tom W. J. Huizinga, Itamar Ronen, Jeroen de Bresser, Enrico Fainardi, Marcello Govoni, Ece Ercan
Summary: Longitudinal variations in diffusion tensor imaging metrics of different white matter tracts in newly diagnosed SLE patients were found to reflect compromised WM tissue microstructure at the initial stages of the disease, even in the absence of overt neuropsychiatric symptoms, emphasizing the importance of monitoring NP involvement in SLE shortly after diagnosis.
Article
Clinical Neurology
Valentina Perosa, Jan Oltmer, Leon P. Munting, Whitney M. Freeze, Corinne A. Auger, Ashley A. Scherlek, Andre J. van der Kouwe, Juan Eugenio Iglesias, Alessia Atzeni, Brian J. Bacskai, Anand Viswanathan, Matthew P. Frosch, Steven M. Greenberg, Susanne J. van Veluw
Summary: Enlarged perivascular spaces are associated with cerebral small vessel disease and cerebral amyloid angiopathy, impacting the pathophysiological processes related to arteriole perivascular clearance mechanisms.
ACTA NEUROPATHOLOGICA
(2022)
Review
Psychology, Clinical
Anneke Terneusen, Ieke Winkens, Caroline van Heugten, Sven Stapert, Heidi I. L. Jacobs, Rudolf Ponds, Conny Quaedflieg
Summary: Self-awareness is crucial for rehabilitation after acquired brain injury (ABI), however, ABI often affects self-awareness. This systematic review aimed to identify the neural correlates of self-awareness after ABI. The results showed that different levels of self-awareness are associated with variations in brain activation and connectivity, and further research is needed to confirm these findings.
NEUROPSYCHOLOGY REVIEW
(2023)
Article
Clinical Neurology
Heidi I. L. Jacobs, John Alex Becker, Kenneth Kwong, Diana Munera, Liliana Ramirez-Gomez, Nina Engels-Dominguez, Justin S. Sanchez, Clara Vila-Castelar, Ana Baena, Reisa A. Sperling, Keith A. Johnson, Francisco Lopera, Yakeel T. Quiroz
Summary: LC integrity is a marker of disease progression in preclinical ADAD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Rachel F. Buckley, Adrienne O'Donnell, Emer R. McGrath, Heidi I. L. Jacobs, Cristina Lois, Claudia L. Satizabal, Saptaparni Ghosh, Zoe B. Rubinstein, Joanne M. Murabito, Reisa A. Sperling, Keith A. Johnson, Sudha Seshadri, Alexandra S. Beiser
Summary: A study found that there are gender differences in tau protein deposition in middle-aged adults, with women after menopause being more susceptible compared to men. These differences occur in the middle frontal and parieto-occipital regions and are independent of Aβ protein burden or the APOEε4 gene.
ANNALS OF NEUROLOGY
(2022)
Article
Neurosciences
Heidi I. L. Jacobs, Adrienne O'Donnell, Claudia L. Satizabal, Cristina Lois, Daniel Kojis, Bernard J. Hanseeuw, Emma Thibault, Justin S. Sanchez, Rachel F. Buckley, Qiong Yang, Charles DeCarli, Ron Killiany, Muralidharan Sargurupremraj, Reisa A. Sperling, Keith A. Johnson, Alexa S. Beiser, Sudha Seshadri
Summary: The study found that lower volumes of the medulla, pons, or midbrain were associated with greater neocortical amyloid burden. However, no associations were found between brainstem volumes and tau deposition.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Joost M. Riphagen, Roy W. E. van Hooren, Gunter Kenis, Frans R. J. Verhey, Heidi I. L. Jacobs
Summary: This study investigates the associations between BDNF gene polymorphisms and APOE ε4 status or inflammation in a memory clinic population, and finds distinct pathways to Alzheimer's disease pathology. These findings help resolve inconsistencies in the BDNF literature and provide possible specific interventions for Aβ and tau based on BDNF polymorphisms.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Alexander J. Ehrenberg, Michael A. Kelberman, Kathy Y. Liu, Martin J. Dahl, David Weinshenker, Neus Falgas, Shubir Dutt, Mara Mather, Mareike Ludwig, Matthew J. Betts, Joseph R. Winer, Stefan Teipel, Alexandra J. Weigand, Oxana Eschenko, Dorothea Haemmerer, Marina Leiman, Scott E. Counts, James M. Shine, Ian H. Robertson, Allan I. Levey, Elisa Lancini, Gowoon Son, Chrisoph Schneider, Maxime Van Egroo, Claudio Liguori, Qin Wang, Elena M. Vazey, Federico Rodriguez-Porcel, Lena Haag, Mark W. Bondi, Sven Vanneste, Whitney M. Freeze, Yeo-Jin Yi, Mihovil Maldinov, Jennifer Gatchel, Abhijit Satpati, Claudio Babiloni, William S. Kremen, Robert Howard, Heidi I. L. Jacobs, Lea T. Grinberg
Summary: The nuclei in the neuromodulatory subcortical system (NSS) play critical roles in survival, hedonic tone, and homeostasis. Degeneration of NSS occurs early in the pathogenesis of Alzheimer's disease (AD), even before the emergence of memory dysfunction and cortical lesions. NSS dysfunction and degeneration are associated with the behavioral and neuropsychiatric symptoms observed in early AD stages. Experimental studies suggest that NSS degeneration contributes to the neuroinflammatory status and disease progression in AD. It is important to understand the mechanisms underlying NSS vulnerability and the clinical progression of NSS changes in AD.
ALZHEIMERS & DEMENTIA
(2023)
Editorial Material
Clinical Neurology
Elouise A. Koops, Heidi I. L. Jacobs
Article
Behavioral Sciences
Nina Engels-Dominguez, Elouise A. Koops, Prokopis C. Prokopiou, Maxime Van Egroo, Christoph Schneider, Joost M. Riphagen, Tarun Singhal, Heidi I. L. Jacobs
Summary: Primary prevention trials are now focusing on the earliest stages of Alzheimer's disease (AD). Autopsy data suggests that the nuclei of the neuromodulatory subcortical systems (NSS) are particularly susceptible to initial tau pathology, making them promising targets for early detection of AD in the aging brain. Recent advancements in imaging methods, such as ultra-high field scanners and new radioligands, have enabled more NSS neuroimaging studies on aging and neurodegeneration. This review highlights the findings of current imaging studies on the structure, function, and molecular changes of these nuclei and identifies challenges and future directions for improving in vivo imaging of the NSS in AD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Maxime Van Egroo, Joost M. Riphagen, Nicholas J. Ashton, Shorena Janelidze, Reisa A. Sperling, Keith A. Johnson, Hyun-Sik Yang, David A. Bennett, Kaj Blennow, Oskar Hansson, Henrik Zetterberg, Heidi I. L. Jacobs
Summary: Autopsy data suggests that the locus coeruleus (LC) is one of the first areas in the brain to accumulate tau pathology. Using advanced imaging technology, researchers investigated the relationship between LC imaging measures and tau pathology, and whether this relationship can be detected in early adulthood and associated with cognitive decline. They also validated these findings using autopsy data from the Rush Memory and Aging Project (MAP). The results showed a specific correlation between plasma measures of phosphorylated tau and LC integrity, highlighting the potential of LC imaging as an early marker of AD-related processes.
MOLECULAR PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Julian Dronse, Anna Ohndorf, Nils Richter, Gerard N. Bischof, Ronja Fassbender, Qumars Behfar, Hannes Gramespacher, Kim Dillen, Heidi I. L. Jacobs, Juraj Kukolja, Gereon R. Fink, Oezguer A. Onur
Summary: A study found that elevated cortisol levels are associated with memory decline in Alzheimer's disease patients, as well as hippocampal atrophy and memory impairment in healthy seniors.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Prokopis C. Prokopiou, Nina Engels-Dominguez, Aaron P. Schultz, Jorge Sepulcre, Elouise A. Koops, Kathryn V. Papp, Gad A. Marshall, Marc D. Normandin, Georges El Fakhri, Dorene Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs
Summary: The study found an association between LC activity and cortical tau deposition, specifically in the medial-lateral temporal cortex, as well as with memory decline. The relationship between LC activity and memory decline was partially mediated by EC tau, particularly in individuals with elevated beta-amyloid deposition.
Review
Radiology, Nuclear Medicine & Medical Imaging
Dimo Ivanov, Federico De Martino, Elia Formisano, Francisco J. Fritz, Rainer Goebel, Laurentius Huber, Sriranga Kashyap, Valentin G. Kemper, Denizhan Kurban, Alard Roebroeck, Shubharthi Sengupta, Bettina Sorger, Desmond H. Y. Tse, Kamil Uludag, Christopher J. Wiggins, Benedikt A. Poser
Summary: This article reviews the 9.4 T work done in Maastricht, including functional and anatomical imaging experiments. By utilizing specific techniques and optimized coils, the researchers were able to obtain high-quality imaging results and highlight the technical challenges and practical issues associated with ultra-high field MRI.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Article
Clinical Neurology
Ashley A. Scherlek, Mariel G. Kozberg, James A. R. Nicoll, Valentina Perosa, Whitney M. Freeze, Louise van der Weerd, Brian J. Bacskai, Steven M. Greenberg, Matthew P. Frosch, Delphine Boche, Susanne J. van Veluw
Summary: Ex vivo MRI was used to investigate haemorrhagic amyloid-related imaging abnormalities in Alzheimer's disease patients undergoing beta-amyloid immunotherapy. The study found a possible association between these abnormalities and cerebral amyloid angiopathy.
BRAIN COMMUNICATIONS
(2022)
Article
Clinical Neurology
Whitney M. Freeze, Maria Clara Zanon Zotin, Ashley A. Scherlek, Valentina Perosa, Corinne A. Auger, Andrew D. Warren, Louise van der Weerd, Dorothee Schoemaker, Mitchell J. Horn, M. Edip Gurol, Elif Gokcal, Brian J. Bacskai, Anand Viswanathan, Steven M. Greenberg, Yael D. Reijmer, Susanne J. van Veluw
Summary: This study found that corpus callosum lesions are common in cerebral amyloid angiopathy, and they independently contribute to cognitive impairment through microstructural disruption of white-matter tracts.
BRAIN COMMUNICATIONS
(2022)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
