Article
Engineering, Environmental
Ying Ma, Hao Wang, Qiqi Wang, Xiaodong Cao, Huichang Gao
Summary: This study developed a multi-channel nerve guidance conduit (NGC) with dual electrical activity of piezoelectricity and conductivity to enhance peripheral nerve regeneration. In vitro and in vivo experiments demonstrated that the electroactive NGC promoted cell proliferation, differentiation, axonal regeneration, and functional recovery of peripheral nerves, indicating its great potential in repairing peripheral nerve injuries.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Cell Biology
Ya-Nan Zhao, Ping Wu, Zi-Yuan Zhao, Fei-Xiang Chen, Ao Xiao, Zhi-Yi Yue, Xin-Wei Han, Yong Zheng, Yun Chen
Summary: In this study, chitosan/graphene oxide (GO) films were prepared using an electrodeposition technique, and their effects on Schwann cell proliferation and adhesion abilities were evaluated. The results showed that the films promoted the expression of nerve regeneration-related factors and that a nerve guidance conduit with a GO content of 0.25% improved functional and histological outcomes in a rat sciatic nerve defect model.
NEURAL REGENERATION RESEARCH
(2023)
Article
Clinical Neurology
Alan Pestronk, Robert E. Schmidt, Robert Bucelli, Julia Sim
Summary: This study examined the protein components of Schwann cells and myelin in normal and diseased human peripheral nerves, and found that the molecular composition of the central nervous system varies with age, axon size, and nerve pathology.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Review
Neurosciences
Qing Min, David B. Parkinson, Xin-Peng Dun
Summary: Schwann cells in the peripheral nervous system have the ability to promote repair of various tissues, including nerve gaps, skin wounds, digit tips, and tooth regeneration. They are highly motile, secrete signaling molecules, attract macrophages, support neuronal survival, promote axonal regrowth, and interact with other cell types in the regeneration process. The migration of Schwann cells is essential for successful tissue repair, especially in cases of peripheral nerve transection injuries where the cells form cords to guide axon regeneration. Understanding the molecular mechanisms of Schwann cell migration may lead to new therapeutic strategies for peripheral nerve repair.
Article
Engineering, Biomedical
Ping Wu, Zan Tong, Lihua Luo, Yanan Zhao, Feixiang Chen, Yinping Li, Celine Huselstein, Qifa Ye, Qingsong Ye, Yun Chen
Summary: The combination of VEGF and Schwann cells in peripheral nerve repair shows promising results in promoting nerve regeneration. The HSPS conduits loaded with VEGF-A overexpressing Schwann cells demonstrate high durability and efficiency in repairing nerve tissue, making them a potential new avenue for nerve tissue engineering.
BIOACTIVE MATERIALS
(2021)
Article
Neurosciences
Deepak Prasad Gupta, Anup Bhusal, Md Habibur Rahman, Jae-Hong Kim, Youngshik Choe, Jaemyung Jang, Hyun Jin Jung, Un-Kyung Kim, Jin-Sung Park, Lee-so Maeng, Kyoungho Suk, Gyun Jee Song
Summary: This study reveals the essential role of EBP50 in the repair function of Schwann cells and regeneration following nerve injury. EBP50 deficiency leads to deficits in Schwann cell functions and delays nerve repair and functional recovery. Additionally, EBP50 enhances regeneration by binding and activating ErbB2.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Neurosciences
Min You, Haizhu Xing, Ming Yan, Jie Zhang, Jiayi Chen, Yang Chen, Xiaoli Liu, Jing Zhu
Summary: Paclitaxel-induced peripheral neuropathy (PIPN) is a neurological disorder caused by paclitaxel (PTX) treatment in cancer patients. Schwann cell-derived exosomes (SC-EXOs) have been found to effectively improve PIPN both in vitro and in vivo. SC-EXOs alleviate PTX-induced mechanical nociceptive sensitization, ameliorate nerve fiber loss and DRG injury, and protect damaged neurons by upregulating miR-21 to repress the PTEN signaling pathway. These findings provide a novel strategy for the treatment of PIPN.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yaxian Wang, Fuchao Zhang, Yunsong Zhang, Qi Shan, Wei Liu, Fengyuan Zhang, Feiyu Zhang, Sheng Yi
Summary: Research findings indicate that Btc plays essential roles in regulating Schwann cell migration and axon elongation, suggesting the potential application of Btc as a regenerative strategy for treating peripheral nerve injury.
MOLECULAR MEDICINE
(2021)
Article
Neurosciences
Yunsong Zhang, Qian Zhao, Qianqian Chen, Lingchi Xu, Sheng Yi
Summary: Transcription factors play important roles in nerve regeneration after peripheral nerve injury, including regulating axon elongation and Schwann cell phenotype modulation. Understanding these transcription factors can help promote functional recovery of injured peripheral nerves.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Qisong Su, Moussa Ide Nasser, Jiaming He, Gang Deng, Qing Ouyang, Donglin Zhuang, Yuzhi Deng, Haoyun Hu, Nanbo Liu, Zhetao Li, Ping Zhu, Ge Li
Summary: Compared to the central nervous system, the peripheral nervous system has a greater capacity for regeneration due to the plasticity of Schwann cells (SCs). This review examines the potential of using genetically modified SCs or tissue-engineered nerves for the repair of peripheral nervous injuries (PNIs). The therapeutic effects of these strategies resemble autologous transplantation, which is currently the gold standard for PNI repair.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Chaoying Zhang, Jiaxing Gong, Jingyu Zhang, Ziyu Zhu, Ying Qian, Kejie Lu, Siyi Zhou, Tianyi Gu, Huiming Wang, Yong He, Mengfei Yu
Summary: The replacement of autograft with a nerve guidance conduit (NGC) in peripheral nerve injury is challenging due to the limited conductivity and biocompatibility of current NGCs in vivo. In this review, the authors explore the superior factors for nerve conduction, the construction of a more conductive regenerative scaffold, and the next steps in nerve regeneration for NGCs. The analysis of NGC-related references suggests that conductive materials, manufacturing technologies of neural scaffolds, and electrical stimulation (ES) play essential roles in accelerating nerve conduction.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Polina Klimovich, Kseniya Rubina, Veronika Sysoeva, Ekaterina Semina
Summary: Recent advances in studying molecular and cellular mechanisms of peripheral nerve regeneration have shown the nervous system's ability to repair itself. However, serious injuries pose a challenge, calling for new treatment strategies. Understanding the basic mechanisms of nerve regeneration and the role of exosomes can lead to the development of new clinical strategies for full regeneration in the peripheral nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Sara Saffari, Tiam M. Saffari, Dietmar J. O. Ulrich, Steven E. R. Hovius, Alexander Y. Shin
Summary: The microenvironment at the site of injury plays a crucial role in altering the degree of nerve regeneration after peripheral nerve injury. Stem cells and vascularity are proposed to be important factors in enhancing peripheral nerve regeneration, with stem cells secreting various angiogenic factors and regulating angiogenesis to promote nerve regeneration and vascular expansion.
NEURAL REGENERATION RESEARCH
(2021)
Review
Neurosciences
Frederic A. A. Vallejo, Anthony Diaz, Emily L. L. Errante, Taylor Smartz, Aisha Khan, Risset Silvera, Adriana E. E. Brooks, Yee-Shuan Lee, Stephen Shelby Burks, Allan D. D. Levi
Summary: This study systematically evaluated the therapeutic use of Schwann cells (SC) in the repair of peripheral nerve injuries. The results showed that SCs have clear potential in improving morphological and functional outcomes in animal studies of long gap peripheral nerve injuries. However, the optimal nerve conduit or graft for delivering and retaining SCs for nerve regeneration has yet to be determined.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Neill Y. Li, Brandon Vorrius, Jonathan Ge, Zhen Qiao, Shuang Zhu, Julia Katarincic, Qian Chen
Summary: This study developed a biomimetic scaffold by incorporating matrilin-2 within a chitosan-derived porous scaffold to enhance peripheral nerve regeneration. Matrilin-2 was found to induce Schwann cell (SC) migration and enhance its adhesion, and a 2% chitosan with matrilin-2 formulation provided an optimal 3D porous architecture for SC interaction. Chemical modification of chitosan with lysine further improved neuronal adhesion and axonal outgrowth. Overall, the matrilin-2/K-chitosan scaffold has high potential for enhancing nerve repair through stimulating SC migration, neuronal adhesion, and axonal outgrowth.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Neurosciences
Suraj Sulhan, Kristopher A. Lyon, Lee A. Shapiro, Jason H. Huang
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
Fengfei Wang, Shuang Zhou, Dan Qi, Shi-Hua Xiang, Eric T. Wong, Xuejing Wang, Ekokobe Fonkem, Tze-chen Hsieh, Jianhua Yang, Batool Kirmani, John B. Shabb, Joseph M. Wu, Min Wu, Jason H. Huang, Wei-Hsuan Yu, Erxi Wu
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Review
Clinical Neurology
Victor M. Lu, Panagiotis Kerezoudis, Nitesh P. Patel, David T. Jones, Jeremy K. Cutsforth-Gregory, Jonathan Graff-Radford, Neill R. Graff-Radford, Benjamin D. Elder
WORLD NEUROSURGERY
(2020)
Review
Medicine, General & Internal
Kristin A. Keith, Jason H. Huang
Article
Clinical Neurology
Jose M. Soto, Dongxia Feng, Huaiyu Sun, Yilu Zhang, Kristopher A. Lyon, Buqing Liang, Laura K. Reed, Jason H. Huang
Summary: The novel technique described in the article aims to preserve the vascular supply of scalp flap by modifying the incision site, potentially reducing wound complications and operative times. Hospital chart review of 7 cases showed successful preservation of superficial temporal and postauricular arteries, with rapid healing of the scalp flap and reduced complications.
WORLD NEUROSURGERY
(2021)
Letter
Clinical Neurology
Dongxia Feng, Jason H. Huang
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Anthony L. Mikula, Jeffery D. St. Jeor, Ryan M. Naylor, James T. Bernatz, Nitesh P. Patel, Jeremy L. Fogelson, Annalise Noelle Larson, Ahmad Nassr, Arjun S. Sebastian, Brett Freedman, Bradford L. Currier, Mohamad Bydon, Kurt A. Kennel, Michael J. Yaszemski, Paul A. Anderson, Benjamin D. Elder
Summary: This retrospective chart review compared the effect of teriparatide on bone density and Hounsfield Units (HU) in different spinal regions. Results showed a greater increase in HU in the thoracolumbar spine compared to the cervical spine, with lumbar HU correlating better with BMD measured on DXA.
CLINICAL SPINE SURGERY
(2021)
Review
Neurosciences
Jie Dong, Tingwei Xiao, Qiuyue Xu, Fei Liang, Simeng Gu, Fushun Wang, Jason H. Huang
Summary: This study provides a review of the development of personality theories and emotional dimensional theory, exploring the relationship between them and the neural mechanisms involved. The results suggest a correlation between personality traits and emotions, both of which are influenced by monoamine neurotransmitters.
Review
Chemistry, Medicinal
Yao Jiang, Di Zou, Yumeng Li, Simeng Gu, Jie Dong, Xianjun Ma, Shijun Xu, Fushun Wang, Jason H. Huang
Summary: This study reviews the advancements in monoamine neurotransmitters in the field of Major Depressive Disorder (MDD) and their impact on new pathways such as inflammation, oxidative stress, neurotrophins, and neurogenesis. The monoamine hypothesis is extended to basic emotions, with dopamine, norepinephrine, and serotonin playing different roles. The paper also briefly discusses the potential of monoamine neurotransmitters as a therapeutic approach for MDD, along with their limited clinical efficacy, side effects, and delayed onset of action.
Article
Genetics & Heredity
Dan Qi, Yiqun Geng, Jacob Cardenas, Jinghua Gu, S. Stephen Yi, Jason H. H. Huang, Ekokobe Fonkem, Erxi Wu
Summary: Peripheral blood is being explored as a noninvasive alternative to tissue biopsy for developing biomarkers for glioblastoma (GBM), but the lack of a robust detection approach has hindered the identification of widely utilized blood-based biomarkers in clinical settings. This study introduces WBGR, a globin reduction technique for RNA sequencing of whole blood, and demonstrates its ability to detect GBM-associated transcriptomic changes. Through transcriptomic analysis of tumor tissues, a 10-gene panel (GBM-Dx panel) consisting of mRNA, long noncoding RNA, and microRNA was identified as a potential tool for early detection and clinical management of GBM. The integrated approach of WBGR offers comprehensive analytic capacity for blood-based marker identification.
NPJ GENOMIC MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Simeng Gu, Yumeng Li, Yao Jiang, Jason H. Huang, Fushun Wang
Summary: This paper reviews the role of trauma-induced glymphatic system impairment and ROS-mediated inflammation in Major Depressive Disorder (MDD).
Review
Biochemistry & Molecular Biology
Matthew Su, Damir Nizamutdinov, Hanli Liu, Jason H. H. Huang
Summary: Alzheimer's disease is a neurodegenerative disease and the leading cause of dementia worldwide, characterized by progressive memory and intellectual decline. There is currently no known cure or treatment to stop its irreversible progression. Photobiomodulation using light in the red to near-infrared spectrum has shown promise in improving brain function. This review discusses recent advancements and mechanisms in Alzheimer's disease pathogenesis, as well as the potential therapeutic benefits of transcranial near-infrared light treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anthony V. Nguyen, Jose M. Soto, Sarah-Marie Gonzalez, Jennifer Murillo, Eric R. Trumble, Frank Y. Shan, Jason H. Huang
Summary: The 2021 World Health Organization Classification of Tumors of the Central Nervous System introduced the H3.3-G34R/V mutant glioma alongside the already recognized H3-K27M altered glioma, reflecting advances in understanding the roles of oncohistones in gliomagenesis. However, the prognosis remains poor for patients with these disease entities and the H3.3-G34R/V mutant gliomas are particularly understudied. Further research is needed to explore the molecular mechanisms underlying gliomagenesis and develop effective diagnosis, treatment, and future therapeutics.
Article
Surgery
Samantha Dayawansa, David Garrett, Marcus Wong, Jason H. Huang
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2019)
Article
Endocrinology & Metabolism
Qiuqian Wu, Chun Mathers, Ernest W. Wang, Sen Sheng, David Wenkert, Jason H. Huang