Article
Public, Environmental & Occupational Health
Claudia Bull, Peta Howie, Emily J. Callander
Summary: There are inequalities in health service utilization among vulnerable children in Australia, with higher use of emergency department services but lower use of specialist, pathology, and diagnostic imaging services. Vulnerable children incur higher costs to public hospital funders and lower costs to private health insurers, Medicare, and out-of-pocket expenses.
Review
Urology & Nephrology
Clodagh Cogley, Claire Carswell, Kate Bramham, Joseph Chilcot
Summary: Individuals with severe mental illness have a higher risk of developing chronic kidney disease, partly due to known risk factors such as lithium treatment and cardiovascular disease. However, the reasons for the higher proportion of chronic kidney disease in this population still require further research. Similarly, there is a lack of data on the rates of severe mental illness in individuals with chronic kidney disease. Furthermore, individuals with severe mental illness and chronic kidney disease have poorer health outcomes and receive suboptimal kidney care. Education and closer collaboration between kidney healthcare staff and psychiatry may improve care for this population.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Nursing
Christin Iroegbu, Lisa Lewis, Lea Ann Matura
Summary: Social determinants such as socioeconomic status, education, race, and gender are consistently associated with patient awareness of chronic kidney disease. These findings provide valuable insights for future research on interventions to improve awareness and for guiding healthcare professionals in caring for this population.
JOURNAL OF ADVANCED NURSING
(2022)
Article
Public, Environmental & Occupational Health
Mengyi Liu, Yanjun Zhang, Ziliang Ye, Sisi Yang, Chun Zhou, Panpan He, Yuanyuan Zhang, Fan Fan Hou, Xianhui Qin
Summary: This study found an association between inflammatory bowel disease and higher risks of chronic kidney disease and acute kidney injury. The association was stronger in younger participants.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Pediatrics
Isabel de Padua Paz, Tulio Konstantyner, Ricardo de Castro Cintra Sesso, Cristine Campos de Xavier Pinto, Maria Fernanda Carvalho de Camargo, Paulo Cesar Koch Nogueira
Summary: The study identified potentially modifiable factors hindering children with CKD from accessing specialized treatment. The importance of social support in both outcomes should alert health managers and professionals to consider this aspect in the care process of children with CKD.
PEDIATRIC NEPHROLOGY
(2021)
Article
Health Care Sciences & Services
Sungchul Park, Jie Chen, Grace X. Ma, Alexander N. Ortega
Summary: The study found that Asian Americans without cancer experienced limited access to care due to a lack of a usual source of care. However, inequities were not observed among Asian Americans with cancer. Additionally, there were no or marginal differences in health care spending between Whites and Asian Americans with cancer.
Review
Biochemistry & Molecular Biology
Li-Fang Chou, Huang-Yu Yang, Cheng-Chieh Hung, Ya-Chung Tian, Shen-Hsing Hsu, Chih-Wei Yang
Summary: Leptospirosis is a neglected bacterial disease caused by leptospiral infection, which has a high mortality risk. It has been found that leptospiral infections, including acute, chronic, and asymptomatic infections, are closely linked to acute and chronic kidney disease (CKD) and renal fibrosis. Leptospires infiltrate kidney cells and survive in the kidney by evading the immune system. The binding of bacterial outer membrane protein LipL32 to toll-like receptor-2 in renal tubular epithelial cells (TECs) is the most well-known pathogenic mechanism of renal tubular damage caused by leptospiral infection.
BIOMEDICAL JOURNAL
(2023)
Article
Obstetrics & Gynecology
Audrey M. Kalindi, Brian Houle, Bruce M. Smyth, Vesper H. Chisumpa
Summary: The study reveals that gender inequities play a role in maternal health care utilization, as men and women have different expectations regarding gender roles. Men, who make most household decisions, often have the final say in accessing maternal health services, despite lacking comprehensive maternal health information.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Medicine, General & Internal
Tara Gomes, Tonya J. Campbell, Diana Martins, J. Michael Paterson, Laura Robertson, David N. Juurlink, Muhammad Mamdani, Richard H. Glazier
Summary: This study explored the likelihood of securing a new primary care provider among individuals with opioid use disorder (OUD) or chronic pain who had lost access to their primary care provider. The results showed that individuals receiving opioid agonist therapy (OAT) were less likely to find a new PCP within 1 year, while there was no significant difference for those on long-term opioid pain therapy (OPT) compared to those not exposed to opioids. Gaps in access to primary care were observed for individuals with OUD and chronic pain.
Review
Peripheral Vascular Disease
Nathan Rockey, Lilia Cervantes, Katherine Lemasters, Katherine Rizzolo
Summary: People who are incarcerated or have been previously incarcerated face disparities in care for hypertension and chronic kidney disease. The provision of care in prisons and jails is often limited and lacks sustained, chronic disease management. Transition from incarceration to community is associated with gaps in care. Structural racism in the criminal legal system contributes to overall disparities in care. Insurance coverage rates for formerly incarcerated individuals remain lower compared to the general population. More data is needed on kidney replacement therapy and dialysis modalities for this population. Transitions clinics play a crucial role in providing coordinated care upon release.
CURRENT HYPERTENSION REPORTS
(2023)
Review
Medicine, General & Internal
Jihan Sleiman, Gervasio Soler Pujol, Erika Montanez, Veronica Roatta, Gustavo Laham
Summary: Sex and gender are often used interchangeably, but gender is a more fluid and dynamic concept that encompasses psychosocial and cultural aspects. Inequality in medicine, particularly gender inequality, has been overlooked for a long time and is now a pressing concern. This study investigates gender equality in patients with chronic kidney disease (CKD) and highlights disparities in access to different treatment modalities.
FRONTIERS IN MEDICINE
(2023)
Article
Health Care Sciences & Services
Lorraine B. Johnson, Elizabeth L. Maloney
Summary: Patients with persistent Lyme disease/chronic Lyme disease (PLD/CLD) face difficulties in accessing medical care, and clinicians who provide care for this group of patients encounter multiple challenges related to clinical, regulatory, and financial aspects. These barriers may discourage clinicians from providing care to PLD/CLD patients and make it difficult to retain and recruit healthcare professionals for this rapidly expanding population.
Article
Critical Care Medicine
Javier A. Neyra, Lakhmir S. Chawla
Summary: Maladaptive repair pathways leading to inflammation and fibrosis in CKD have been identified, including factors such as cell cycle arrest, endothelial injury, and mitochondrial dysfunction. Limited epidemiological data exists on AKD, with studies having limited generalizability due to the heterogeneity of populations studied. AKI and CKD are interconnected syndromes that predispose to each other, leading to negative impacts either independently or synergistically.
CRITICAL CARE CLINICS
(2021)
Article
Oncology
Mariam F. Eskander, Lindsay Gil, Eliza W. Beal, Yaming Li, Ahmad Hamad, Bridget Oppong, Samilia Obeng-Gyasi, Allan Tsung
Summary: The study found that age, race, insurance, and geography are barriers to clinical trial enrollment for pancreatic cancer patients. Despite an overall increase in enrollment, Black patients and patients on Medicaid remain underrepresented. Social determinants of health are still associated with clinical trial enrollment after adjusting for cancer-specific factors, suggesting the need for targeted interventions.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Chih-Hsiang Chang, Shao-Wei Chen, Jia-Jin Chen, Yi-Hsin Chan, Chieh-Li Yen, Tao Han Lee, Yu-Ting Cheng
Summary: This study found that approximately one quarter of patients undergoing surgery for acute type A aortic dissection will develop AKD. Patients with AKD, with or without AKI, are at higher risk for MAKEs and readmission. Higher-stage AKD is associated with a trend of persistent decline in kidney function.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Urology & Nephrology
Rajiv Agarwal, James Burton, Maurizio Gallieni, Kamyar Kalantar-Zadeh, Gert Mayer, Carol Pollock, Jacek C. Szepietowski
Summary: Despite the limited increase in life expectancy for patients with end-stage kidney disease after the breakthrough of kidney replacement therapy, the quality of life and relief of symptoms have become increasingly important to patients. Currently, most dialysis-associated symptoms and adverse effects do not have approved treatments, and the few available treatments may add further adverse effects. This article demonstrates how understanding the pathophysiology of a particular symptom (chronic kidney disease-associated pruritus) in dialysis led to the development and regulatory approval of a treatment for that symptom. This approach can be applied to other dialysis-associated symptoms, improving the remaining years of patients' lives.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Dawn P. Edwards, Kamyar Kalantar-Zadeh, Elani Streja, Rebecca S. Ahdoot, Keith C. Norris, Donald Molony
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2023)
Review
Urology & Nephrology
Fawaz Al Ammary, Abimereki D. Muzaale, Ekamol Tantisattamoa, Ramy M. Hanna, Uttam G. Reddy, Suphamai Bunnapradist, Kamyar Kalantar-Zadeh
Summary: There has been a decrease in living kidney donation over the past two decades, particularly among low-income families and racial/ethnic minorities who face barriers to completing complex evaluations. Telemedicine, specifically the use of live-video visits, is seen as a potential solution to overcome these barriers and improve access to transplant centers for donor evaluation. However, providers perceive payor policy and out-of-state licensing as major obstacles to the growth of telemedicine.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2023)
Review
Urology & Nephrology
Maria Clarissa Tio, Tariq Shafi, Xiaoqian Zhu, Kamyar Kalantar-Zadeh, Alexandre Chan, Lee Nguyen
Summary: This review focuses on the evolution of GFR estimating equations, nuances in eGFR interpretation, and the utility of eGFR in drug dosing.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2023)
Review
Urology & Nephrology
Ekamol Tantisattamo, Kamyar Kalantar-Zadeh
Summary: Living donor kidney transplantation may lead to long-term complications, but dietary interventions have the potential to prevent them and improve the health outcomes of donors. Low protein and low sodium intake, as well as certain healthy dietary patterns, may help slow down the decline in kidney function. However, further research is needed to determine the optimal protein and sodium intake as well as the appropriate dietary patterns for living kidney donors.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2023)
Review
Urology & Nephrology
Dana Bielopolski, Elani Streja, Tali Steinmetz, Benaya Rozen-Zvi, Kamyar Kalantar-Zadeh
Summary: Assessing and estimating glomerular filtration rate (GFR) has been a long-standing challenge in medicine and public health. Current estimation formulas do not account for variations in body surface area (BSA) or metabolic rate compared to nephron number, and fail to define renal hyperfiltration accurately.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2023)
Article
Transplantation
Rianne Boenink, Anneke Kramer, Rosalie E. Tuinhout, Emilie Savoye, Anders Asberg, Alma Idrizi, Julia Kerschbaum, Ieva Ziedina, Edita Ziginskiene, Emanuel Farrugia, Liliana Garneata, Elena Zakharova, Samira Bell, Miha Arnol, Marten Segelmark, Kyriakos Ioannou, Kristine Hommel, Mai Rosenberg-Ots, Evgueniy Vazelov, Jaakko Helve, Sandor Mihaly, Runolfur Palsson, Maurizio Nordio, Nikola Gjorgjievski, Aiko P. J. de Vries, Nurhan Seyahi, Winnie A. Magadi, Halima Resic, Aleh Kalachyk, Axel O. Rahmel, Ana A. Galvao, Radomir Naumovic, Torbjörn Lundgren, Mustafa Arici, Johan M. de Meester, Alberto Ortiz, Kitty J. Jager, Vianda S. Stel
Summary: This study aimed to analyze the trends in kidney transplantation rates in European countries. The results showed an overall increase in kidney transplantation rates from 2010 to 2018, including both deceased donor and living donor transplants, with substantial variations among different countries.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Nutrition & Dietetics
Yoshikazu Miyasato, Ramy M. Hanna, Jun Morinaga, Masashi Mukoyama, Kamyar Kalantar-Zadeh
Summary: Prognostic nutritional index (PNI), calculated from serum albumin level and total lymphocyte count, is a useful prognostic marker for both cancer patients and patients undergoing hemodialysis.
Editorial Material
Nutrition & Dietetics
Kamyar Kalantar-Zadeh, Rachelle Bross, Christina Wang, Linda W. Moore
JOURNAL OF RENAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Mengjing Wang, Jiaying Zhang, Kamyar Kalantar-Zadeh, Jing Chen
Summary: Phosphorus is a crucial micromineral that plays a key role in cellular metabolism and tissue structure. The endocrine system coordinates the maintenance of serum phosphorus levels through the actions of hormones like FGF23, PTH, Klotho, and 1,25D. Phosphorus overload, characterized by higher than necessary phosphorus load, can be caused by diet, renal dysfunction, bone disease, dialysis insufficiency, and medications. Serum phosphorus remains the most commonly used indicator for phosphorus overload.
Review
Nutrition & Dietetics
Valentin Faerber, Katharina S. Kuhn, Liliana Garneata, Kamyar Kalantar-Zadeh, Sahir Kalim, Dominic S. Raj, Martin Westphal
Summary: In chronic kidney disease (CKD), a protein-restricted diet with essential amino acid (EAA) and their ketoanalogues (KA) supplementation can delay disease progression and improve clinical outcomes. This approach improves nitrogen balance and other metabolic disturbances, and also modulates gut dysbiosis and reduces the generation of gut-derived uremic toxins. Lowering urea levels can contribute to decreased morbidity and mortality, possibly through reducing protein carbamylation. Further studies are needed to investigate the effects on the gut microbiome, uremic toxin generation, and carbamylation markers.
Article
Medicine, General & Internal
Rebecca S. Ahdoot, Jui-Ting Hsiung, Abiy Agiro, Yasmin G. Brahmbhatt, Kerry Cooper, Souhiela Fawaz, Laura Westfall, Kamyar Kalantar-Zadeh, Elani Streja
Summary: Liver disease is commonly associated with potassium imbalance, but its role as a risk factor for hyperkalemia is not well-established. This study aimed to investigate the relationship between liver disease and recurrent hyperkalemia. The results showed that patients with liver disease had a significantly higher risk of recurrent hyperkalemia within one year after the initial event.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Urology & Nephrology
Ahmet Murt, Kamyar Kalantar-Zadeh
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Connie M. M. Rhee, Amy S. S. You, Victoria Page, Glen Hayashida, Merle Kataoka-Yahiro, James Davis, Linda L. L. Wong, Yoko Narasaki, Kamyar Kalantar-Zadeh
Summary: Several studies suggest that Asian-American and NHOPI racial/ethnic groups have a heightened risk of CKD, but provide limited inference due to the aggregation of these groups. In this study, we examined the association of granularly defined racial/ethnic groups with specific CKD indicators among a diverse group of participants.
Article
Pharmacology & Pharmacy
Praveen K. Potukuchi, Hamid Moradi, Frank Park, Cameron Kaplan, Fridtjof Thomas, Ankur A. Dashputre, Keiichi Sumida, Miklos Z. Molnar, Abduzhappar Gaipov, Justin D. Gatwood, Connie Rhee, Elani Streja, Kamyar Kalantar-Zadeh, Csaba P. Kovesdy
Summary: This observational study found no association between cannabis use and the risk of acute kidney injury in patients with advanced chronic kidney disease.
CANNABIS AND CANNABINOID RESEARCH
(2023)