Metformin potentiates cognitive and antidepressant effects of fluoxetine in rats exposed to chronic restraint stress and high fat diet: potential involvement of hippocampal c-Jun repression

Metformin activation of AMPK suppresses AGE-induced inflammatory response in hNSCs

(2017) Ming-Min Chung et al.   EXPERIMENTAL CELL RESEARCH

Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice

(2016) Joanne S. Allard et al.   BEHAVIOURAL BRAIN RESEARCH

Metformin pretreatment enhanced learning and memory in cerebral forebrain ischaemia: the role of the AMPK/BDNF/P70SK signalling pathway

(2016) Negar Ghadernezhad et al.   PHARMACEUTICAL BIOLOGY

Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons

(2016) Jacqueline A. Bayliss et al.   PLoS One

High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice

(2015) Juliane Zemdegs et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adipokines in health and disease

(2015) Mathias Fasshauer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Effects of Antidepressants “Fluoxetine and Imipramine” on Vascular Abnormalities and Toll Like Receptor-4 Expression in Diabetic and Non-Diabetic Rats Exposed to Chronic Stress

(2015) Mohamed Habib et al.   PLoS One

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy

(2014) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neuroprotective effect of metformin in MPTP-induced Parkinson’s disease in mice

(2014) S.P. Patil et al.   NEUROSCIENCE

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide

(2014) Krzysztof Łabuzek et al.   Pharmacological Reports

Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: Reversibility by imipramine and pentoxifylline

(2014) Al-Shaimaa A. Elgarf et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Ameliorating effect and potential mechanism of Rehmannia glutinosa oligosaccharides on the impaired glucose metabolism in chronic stress rats fed with high-fat diet

(2014) Ruxue Zhang et al.   PHYTOMEDICINE

Enhancement of Neural Stem Cells after Induction of Depression in Male Albino Rats (A histological & Immunohistochemical Study)

(2014) Zeinab Mohamed Kamel Ismail et al.   International Journal of Stem Cells

Short exposure to a diet rich in both fat and sugar or sugar alone impairs place, but not object recognition memory in rats

(2013) Jessica E. Beilharz et al.   BRAIN BEHAVIOR AND IMMUNITY

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

Damaging effects of a high-fat diet to the brain and cognition: A review of proposed mechanisms

(2013) Linnea R. Freeman et al.   NUTRITIONAL NEUROSCIENCE

Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats

(2013) Sawsan Aboul-Fotouh   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons

(2012) Ikram Ullah et al.   BMC NEUROSCIENCE

Cardioprotective Effects of Metformin and Vildagliptin in Adult Rats with Insulin Resistance Induced by a High-Fat Diet

(2012) Nattayaporn Apaijai et al.   ENDOCRINOLOGY

Obesity Comorbidity in Unipolar Major Depressive Disorder

(2012) Robert D. Levitan et al.   JOURNAL OF CLINICAL PSYCHIATRY

Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats

(2012) Hiranya Pintana et al.   LIFE SCIENCES

Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression

(2012) Frankie D. Heyward et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Fluoxetine reverses depressive-like behaviors and increases hippocampal acetylcholinesterase activity induced by olfactory bulbectomy

(2012) Daniele G. Machado et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice

(2012) Jiejie Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity

(2012) Jing Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Pharmacokinetics of Metformin

(2011) Garry G. Graham et al.   CLINICAL PHARMACOKINETICS

TheIn VivoAntidiabetic Activity ofNigella sativaIs Mediated through Activation of the AMPK Pathway and Increased Muscle Glut4 Content

(2011) Ali Benhaddou-Andaloussi et al.   Evidence-based Complementary and Alternative Medicine

Adiponectin Stimulates Proliferation of Adult Hippocampal Neural Stem/Progenitor Cells through Activation of p38 Mitogen-activated Protein Kinase (p38MAPK)/Glycogen Synthase Kinase 3β (GSK-3β)/β-Catenin Signaling Cascade

(2011) Di Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation

(2011) Yi-Fang Tu et al.   Journal of Neuroinflammation

Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice

(2011) E Beurel et al.   MOLECULAR PSYCHIATRY

Reduced Cell Proliferation and Neuroblast Differentiation in the Dentate Gyrus of High Fat Diet-Fed Mice are Ameliorated by Metformin and Glimepiride Treatment

(2011) Dae Young Yoo et al.   NEUROCHEMICAL RESEARCH

Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet

(2010) Vanessa Souza-Mello et al.   CLINICAL SCIENCE

A high-fat diet impairs neurogenesis: Involvement of lipid peroxidation and brain-derived neurotrophic factor

(2010) Hee Ra Park et al.   NEUROSCIENCE LETTERS

Association between Repeated Unpredictable Chronic Mild Stress (UCMS) Procedures with a High Fat Diet: A Model of Fluoxetine Resistance in Mice

(2010) Elsa Isingrini et al.   PLoS One

The Roles of BDNF, pCREB and Wnt3a in the Latent Period Preceding Activation of Progenitor Cell Mitosis in The Adult Dentate Gyrus by Fluoxetine

(2010) Scarlett B. Pinnock et al.   PLoS One

Chronic Stress, Combined with a High-Fat/High-Sugar Diet, Shifts Sympathetic Signaling toward Neuropeptide Y and Leads to Obesity and the Metabolic Syndrome

(2009) Lydia E. Kuo et al.   Annals of the New York Academy of Sciences

Desipramine prevents stress-induced changes in depressive-like behavior and hippocampal markers of neuroprotection

(2009) Javier A. Bravo et al.   BEHAVIOURAL PHARMACOLOGY

Stress hormones: physiological stress and regulation of metabolism

(2009) Ioannis Kyrou et al.   CURRENT OPINION IN PHARMACOLOGY

Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression

(2009) Denis J. David et al.   NEURON

Diet-induced obesity alters behavior as well as serum levels of corticosterone in F344 rats

(2009) T. Buchenauer et al.   PHYSIOLOGY & BEHAVIOR

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats

(2008) Alexis M. Stranahan et al.   HIPPOCAMPUS

Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory

(2008) F. D. Lubin et al.   JOURNAL OF NEUROSCIENCE

Inhibition of hepatic interleukin-18 production by rosiglitazone in a rat model of nonalcoholic fatty liver disease

(2008) Hai-Ning Wang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Rat behavior after chronic variable stress and partial lesioning of 5-HT-ergic neurotransmission: Effects of citalopram

(2007) Margus Tõnissaar et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY